EDC Science Weekly, May 5 – 11, 2023

Post author:HEEDS
Post published:May 11, 2023
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Highlights: Humans, dogs, horses all show sperm quality decline; Quats, a new concern.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar May 17: Reducing Breast Cancer Risk by Eliminating Parabens and Phthalates [EDC Strategies Partnership]

Webinar May 23: Industry Influence and Scientists: Protecting Scientific Integrity [CHE]

Webinar June 8: The Chemical Footprint of a Plastic Bottle [CHE]

Webinar June 13: CHE Café: Science, Storytelling & A New War on Cancer [re the new book by Kristina Marusic just released!]

Regulations/Policy

Benchmark dose calculations for PFAS exposure based on two data sets on immunotoxic effects.

Analysis of Persistent Organic Pollutants for the Stockholm Convention’s Global Monitoring Plan.

Toxicity Tests for Chemical Pesticide Registration: Requirement Differences among the United States, the European Union, Japan, and China?

Methods/Tools/Screening

Coordination of chemical analyses under the European Human Biomonitoring Initiative (HBM4EU): Concepts, procedures and lessons learnt.

Incorporating biological knowledge in analyses of environmental mixtures and health.

Innovative screening for functional improved aromatic amine derivatives: Toxicokinetics, free radical oxidation pathway and carcinogenic adverse outcome pathway.

Development of physiologically-based gut absorption model for probabilistic prediction of environmental chemical bioavailability.

A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides.

DeepAR: a novel deep learning-based hybrid framework for the interpretable prediction of androgen receptor antagonists.

Commentaries

Editorial: Sex steroid hormones: effects on breast cancer risk and etiology. [Intro to a Research Topic in Frontiers in Endocrinology]

Reviews

Numerous Chemicals/Mixtures

Environmental pollutants exposure and gestational diabetes mellitus: Evidence from epidemiological and experimental studies.

Single-cell transcriptomics allows novel insights into the endocrine-disrupting chemicals induced mammalian reproductive disorder.

The contribution of the exposome to the burden of cardiovascular disease.

Applications of a powerful model organism Caenorhabditis elegans to study the neurotoxicity induced by heavy metals and pesticides.

Phthalates

Phthalates and their effects on human health: Focus on erythrocytes and the reproductive system.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of exposure to chlorinated paraffins on human health: A scoping review.

A review on structural mechanisms of protein-persistent organic pollutant (POP) interactions.

Perfluoroalkyl Substances

Determinants of maternal and neonatal PFAS concentrations: a review.

A review of the occurrence, transformation, and removal technologies for the remediation of per- and polyfluoroalkyl substances (PFAS) from landfill leachate.

Pesticides

Organophosphate pesticide-induced toxicity through DNA damage and DNA repair mechanisms.

Metals/Metalloids

Arsenic and Diabetes Mellitus: A Putative Role for the Immune System.

Mercury and neurodevelopmental disorders in children: A systematic review.

Epigenetics of methylmercury.

The inter- and multi- generational epigenetic alterations induced by maternal cadmium exposure.

Association between metal(loid)s in serum and leukemia: a systematic review and meta-analysis.

Microplastics/Nanomaterials

NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity.

Air Pollution

A systematic review on the association between exposure to air particulate matter during pregnancy and the development of hypertensive disorders of pregnancy and gestational diabetes mellitus.

Miscellaneous

Temporal trends in equine sperm progressive motility: a systematic review and meta-regression

DOHaD: A MENAGERIE OF ADAPTATIONS AND PERSPECTIVES: Large animal models of developmental programming: sustenance, stress, and sex matter

Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern.

B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles.

From a toxin to an obesogen: a review of potential obesogenic roles of acrylamide with a mechanistic approach.

Remediation of environmental toxicants using carbonaceous materials: opportunity and challenges.

Human Health Studies

Phthalates

Phthalate exposure with sperm quality among healthy Chinese male adults: The role of sperm cellular function.

Associations between prenatal phthalate exposure and childhood epigenetic age acceleration.

Urinary phthalate metabolites and heart rate variability: A panel study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

High quality diet attenuated the positive association between polychlorinated biphenyls and premature mortality among middle-aged and older adults.

Perfluoroalkyl Substances

Associations between Per- and Polyfluoroalkyl Substances Exposures and Blood Lipid Levels among Adults-A Meta-Analysis.

Pesticides

Co-exposure of organophosphorus pesticides is associated with increased risk of type 2 diabetes mellitus in a Chinese population.

Pesticides exposure in pregnant Argentinian women: Potential relations with the residence areas and the anthropometric neonate parameters.

Occupational exposure to pesticides: DNA damage in horticulturist from Nativitas, Tlaxcala in Mexico.

Metals/Metalloids

Association of blood metals with serum sex hormones in adults: A cross-sectional study.

Exposure to endocrine-disrupting metals and serum estrogen levels among US women.

The Association Between Environmental Cadmium Exposure and Parathyroid Hormone Levels.

Concurrent serum lead levels and cognitive function in older adults.

Type 2 diabetes affects arsenic metabolism via transporters in arsenic trioxide treated acute promyelocytic leukemia patients.

Association between environmental cadmium exposure and increased mortality in the U.S. National Health and Nutrition Examination Survey (1999-2018).

Elevated serum lead and cadmium levels associated with increased risk of dyslipidemia in children aged 6 to 9 years in Shenzhen, China.

Air Pollution

Interplay of gestational parent exposure to ambient air pollution and diet characteristics on preterm birth.

Exposure to ambient air pollution from the preconceptional period and risk of gestational hypertension.

Exposure-response relationships for personal exposure to fine particulate matter (PM_2·5), carbon monoxide, and black carbon and birthweight: an observational analysis of the multicountry Household Air Pollution Intervention Network (HAPIN) trial.

Living in environmental justice areas worsens asthma severity and control: Differential interactions with disease duration, age of onset and pollution.

Early-Life Exposure to Ambient Air Pollution from Multiple Sources and Asthma Incidence in Children: A Nationwide Birth Cohort Study from Denmark.

Pharmaceuticals/Personal Care Products

In utero exposure to diethylstilbestrol and blood DNA methylation in adult women: Results from a meta-analysis of two cohort studies.

Miscellaneous

Association between mixed exposure of polycyclic aromatic hydrocarbons and telomere length in general population: NHANES 2001-2002.

Laboratory Studies

Numerous Chemicals/Mixtures

Safety assessment of organic micropollutants in reclaimed water: Chemical analyses, ecological risk assessments, and in vivo endocrine-disrupting studies.

BPA/Phenols

Bisphenol A release from commercially available 3-dimensionally printed resins and human cell apoptosis to bisphenol A: an in-vitro study.

Effects and mechanism of perinatal nonylphenol exposure on cardiac function and myocardial mitochondria in neonatal rats.

Effects of bisphenols on lipid metabolism and neuro-cardiovascular toxicity in marine medaka larvae.

Potentiation of Adipogenesis by Reactive Oxygen Species is a Unifying Mechanism in the Pro-adipogenic Properties of Bisphenol A and its New Structural Analogues.

Interactive effects of temperature and bisphenol A on phytoplankton growth and community structure.

Neonatal exposure to bisphenol analogues disrupts genital development in male mice.

Phthalates

Leaching of Phthalates from Medical Supplies and Their Implications for Exposure.

Prenatal DEHP exposure predicts neurological disorders via transgenerational epigenetics.

Di-butyl phthalate disrupts muscle, motor and sensory neuron development in embryonic zebrafish.

Identification of phthalate mixture exposure targets in the human and mouse ovary in vitro.

Parabens/Triclosan/Antimicrobials

Analysis of the effect of triclosan on gonadal differentiation of zebrafish based on metabolome.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Development of binary classification models for grouping hydroxylated polychlorinated biphenyls into active and inactive thyroid hormone receptor agonists.

Transcriptional, hormonal and histological alterations in the ovaries of BALB/c mice exposed to TCDD in connection with multigenerational female infertility.

Perfluoroalkyl Substances

Perfluorooctane sulfonic acid modulates expression of placental steroidogenesis-associated genes and hormone levels in pregnant rats.

Quantifying the impact of PFOA Exposure on B cell development and antibody production.

Perfluoroalkyl substances promote breast cancer progression via ERα and GPER mediated PI3K/Akt and MAPK/Erk signaling pathways.

Perfluorohexane sulfonate (PFHxS) disturbs the estrous cycle, ovulation rate, oocyte cell communication and calcium homeostasis in mice.

A comprehensive untargeted metabolomics study in zebrafish embryos exposed to perfluorohexane sulfonate (PFHxS).

Locomotion and brain gene expression exhibit sex-specific non-monotonic dose-response to HFPO-DA during Drosophila melanogaster lifespan.

Flame Retardants

Evaluation of the cytotoxic activity of triphenyl phosphate on mouse spermatocytes cells.

Organotins

Organotin mixtures reveal interactions that modulate adipogenic differentiation in 3T3-L1 preadipocytes.

Toxic effects of triphenyltin on the development of zebrafish (Danio rerio) embryos.

Triphenyltin (TPT) exposure causes SD rat liver injury via lipid metabolism disorder and ER stress revealed by transcriptome analysis.

Postnatal exposure to trimethyltin chloride induces retinal developmental neurotoxicity in mice via glutamate and its transporter related changes.

Pesticides

Thiacloprid impairs honeybee worker learning and memory with inducing neuronal apoptosis and downregulating memory-related genes.

Chlorpyrifos induced autophagy and mitophagy in common carp livers through AMPK pathway activated by energy metabolism disorder.

Developmental Exposure of Zebrafish to Neonicotinoid Pesticides: Long-term Effects on Neurobehavioral Function.

Ovaries of guppies (Poecilia reticulata) investigated in pre-embryonic, embryonic and post-embryonic stages after exposure to maghemite nanoparticles (y-Fe₂O₃) associated with Roundup® and glyphosate, followed by recovery period evaluation.

Effects of glyphosate, 2,4-D, chlorantraniliprole, and imidacloprid formulations, separately and in mixtures in Caiman latirostris hatchlings.

Bensulide-induced oxidative stress causes developmental defects of cardiovascular system and liver in zebrafish (Danio rerio).

The neuroprotective effect of ascorbic acid against imidacloprid-induced neurotoxicity and the role of HO-1 in mice.

Chronic larval exposure to thiacloprid impairs honeybee antennal selectivity, learning and memory performances.

Effects of a Neonicotinoid on Indigenous Earthworm Perionyx excavatus Biochemical and Histopathological Alterations.

Metals/Metalloids

Toxicological effect of endocrine disrupting heavy metal (Pb) on Mekong silurid Pangasius catfish, Pangasius hypophthalmus.

Pubertal lead exposure affects ovary development, folliculogenesis and steroidogenesis by activation of IRE1α-JNK signaling pathway in rat.

Effects of cadmium exposure during the breeding period on development and reproductive functions in rare minnow (Gobiocypris rarus).

Disruption of the tumor suppressor-like activity of aryl hydrocarbon receptor by arsenic in epithelial cells and human lung cancer.

Cadmium exposure impairs skeletal muscle function by altering lipid signature and inducing inflammation in C57BL/6J mice.

Transgenerational endocrine disruptor effects of cadmium in zebrafish and contribution of standing epigenetic variation to adaptation.

Chronic dietary exposure to arsenic at environmentally relevant concentrations impairs cognitive performance in adult zebrafish (Danio rerio) via oxidative stress and dopaminergic dysfunction.

Microplastics/Nanomaterials

Reduced dietary Ca, Cu, Zn, Mn, and Mg bioavailability but increased Fe bioavailability with polyethylene microplastic ingestion in a mouse model: Changes in intestinal permeability and gut metabolites.

Immunotoxicological effects of perfluorooctanesulfonic acid on European seabass are reduced by polyethylene microplastics.

Combined effects of high-fat diet and polystyrene microplastic exposure on microplastic bioaccumulation and lipid metabolism in zebrafish.

Air Pollution

Intrinsic sexual dimorphism in the placenta determines the differential response to benzene exposure.

Pharmaceuticals/Personal Care Products

Reproductive endocrine disruption and gonadal intersex induction in male Japanese medaka chronically exposed to betamethasone at environmentally relevant levels.

Miscellaneous

Dietary phytoestrogen diosgenin interrupts metabolism, physiology, and reproduction of Swiss albino mice: Possible mode of action as an emerging environmental contaminant, endocrine disruptor and reproductive toxicant.

Benzo[a]pyrene-induced multigenerational changes in gene expression, behavior, and DNA methylation are primarily influenced by paternal exposure.

3-tert-Butyl-4-hydroxyanisole perturbs renal lipid metabolism in vitro by targeting androgen receptor-regulated de novo lipogenesis.

Rapid generation of aged tire-wear particles using dry-, wet-, and cryo-milling for ecotoxicity testing.

Do new cement-based mortars pose a significant threat to the aquatic environment?

Developmental exposure to polycyclic aromatic hydrocarbons (PAHs): focus on benzo[a]pyrene neurotoxicity.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

A case study of neurodevelopmental risks from combined exposures to lead, methyl-mercury, inorganic arsenic, polychlorinated biphenyls, polybrominated diphenyl ethers and fluoride.

Biochemical Effects of Heavy Metals and Organochlorine Compounds Accumulated in Different Tissues of Yellow-Legged Gulls (Larus Michahellis).

Monitoring long-term chemical exposome by characterizing the hair metabolome using a high-resolution mass spectrometry-based suspect screening approach.

Incorporation of Fast-Elimination Chemicals in Hair Is Governed by Pharmacokinetics-Implications for Exposure Assessment.

Occurrence of persistent and mobile chemicals and other contaminants of emerging concern in Spanish and Portuguese wastewater treatment plants, transnational river basins and coastal water.

BPA/Phenols

Multi-immunoaffinity column for the simultaneous analysis of bisphenol A and its analogues in Chinese foods by liquid chromatography tandem mass spectrometry.

Trends of bisphenol A occurrence in canned food products from 2008-2020.

Phthalates

Atmospheric phthalate esters in a multi-function area of Hangzhou: Temporal variation, gas/particle phase distribution, and population exposure risk.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Chlorinated persistent organic pollutants in human breast milk in the Miyagi Prefecture disaster-affected area 1 year after the Great East Japan Earthquake of 2011.

Investigation of polychlorinated biphenyls in breast milk from two regions in Bulgaria.

Monitoring persistent organic chemicals in Antarctica in support of global chemical policy: a horizon scan of priority actions and challenges.

Polychlorinated dibenzo-p-dioxin/dibenzofurans (PCDD/Fs) contamination in sediments and fish from Msimbazi River in Dar es Salam, Tanzania: patterns, sources, and their exposure to humans.

Occurrence, distribution, and risk assessment of halogenated organic pollutants (HOPs) in marine fish muscle: The case study of Vietnam.

Perfluoroalkyl Substances

Dietary and maternal sociodemographic determinants of perfluoroalkyl and polyfluoroalkyl substance levels in pregnant women.

Dietary per- and polyfluoroalkyl substance (PFAS) exposure in adolescents: The HOME study.

High Persistence of Novel Polyfluoroalkyl Betaines in Aerobic Soils.

Multifunctionalized Covalent Organic Frameworks for Broad-Spectrum Extraction and Ultrasensitive Analysis of Per- and Polyfluoroalkyl Substances.

Mechanisms of propeller jet-induced migration, release, and distribution of perfluoroalkyl acids in sediment-water systems.

Aquatic Vegetation, an Understudied Depot for PFAS.

Flame Retardants

Characterization and distribution of polybrominated diphenyl ethers in shellfish in Shenzhen coastal waters and assessment of human health risks.

Pesticides

Within-person variability of urinary neonicotinoids and their metabolites and recommendation for sampling strategy.

[Exposure level of neonicotinoid pesticides and their metabolites in pregnant women in the suburb of Shanghai]. [in Chinese]

Metals/Metalloids

The variability of arsenic in blood and urine of humans.

Environmental tobacco smoke exposure is associated with increased levels of metals in children’s saliva.

Different levels of arsenic exposure through cooked rice and its associated benefit-risk assessment from rural and urban populations of West Bengal, India: a probabilistic approach with sensitivity analysis.

Heavy metal pollution levels and health risk assessment of dust storms in Jazmurian region, Iran.

The metabolome of pink-footed goose: Heavy metals and lipid metabolism.

Heavy metals and metalloid in aquatic invertebrates: A review of single/mixed forms, combination with other pollutants, and environmental factors.

Complexities in attributing lead contamination to specific sources in an industrial area of Philadelphia, PA.

Miscellaneous

Occurrences and migration of organophosphite and organophosphate esters into food simulants from single-use food packaging in China.

Water Pollution Increases the Risk of Chytridiomycosis in Mexican Amphibians.

A meta-analysis of the occurrence of alkylphenols and alkylphenol ethoxylates in surface waters and sediments in the United States between 2010 and 2020.

A yearlong monitoring campaign of polycyclic aromatic compounds and other air pollutants at three sites in Sweden: Source identification, in vitro toxicity and human health risk assessment.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.