EDC Science Weekly, Mar. 3 – 9, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar March 22: The Ohio Train Derailment: Impacts and Emerging Lessons (EDC Strategies Partnership)

CME course May 6: Environmental chemicals and children’s health (NYU Langone Health, in person)

Virtual Symposium July 18-19: Endocrine Disrupting Chemicals and Women’s Health (Health and Human Services Office on Women’s Health. Abstracts due Apr. 21)

Regulations/Policy

Analyzing golf course pesticide risk across the US and Europe-The importance of regulatory environment.

Risk assessment in the 21st century: where are we heading?

Methods/Tools/Screening

Methods

How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU.

Wastewater-based epidemiology for the assessment of population exposure to chemicals: The need for integration with human biomonitoring for global One Health actions.

A New CSRML Structure-Based Fingerprint Method for Profiling and Categorizing Per- and Polyfluoroalkyl Substances (PFAS).

Artificial intelligence and machine learning disciplines with the potential to improve the nanotoxicology and nanomedicine fields: a comprehensive review.

Tools

Environmental Exposure Assessment of Co-formulants in Plant Protection Products under REACH.

Improving annotation propagation on molecular networks through random walks: Introducing ChemWalker.

Generative AI as a Tool for Environmental Health Research Translation. [preprint]

Screening

The use of gas chromatography – high resolution mass spectrometry for suspect screening and non-targeted analysis of per- and polyfluoroalkyl substances.

Non-target estrogenic screening of 60 pesticides, six plant protection products, and tomato, grape, and wine samples by planar chromatography combined with the planar yeast estrogen screen bioassay.

Role of bioavailability and protein binding of four anionic perfluoroalkyl substances in cell-based bioassays for quantitative in vitro to in vivo extrapolations.

Commentaries

Invited Perspective: PFAS in Breast Milk and Infant Formula-It’s Time to Start Monitoring. [re Emerging and Legacy Perfluoroalkyl Substances in Breastfed Chinese Infants: Renal Clearance, Body Burden, and Implications.]

Paraquat, Parkinson’s Disease, and Agnotology.

PFAS pollution threatens ecosystems worldwide. [letter in Science]

CICTA2021 Conference: Microplastics and nanoparticles ecotoxicity studies in Iberoamerica.

Reviews

Numerous Chemicals/Mixtures

The exposome and liver disease – how environmental factors affect liver health.

Exposure, toxicological mechanism of endocrine disrupting compounds and future direction of identification using nano-architectonics.

The potential role of environmental factors in modulating mitochondrial DNA epigenetic marks.

Comparison between pollutants found in breast milk and infant formula in the last decade: A review.

Chemical exposures and suspected impact on Gulf War Veterans.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Human 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure and thyroid cancer risk.

Pesticides

Effect of Pesticides on Peroxisome Proliferator-Activated Receptors (PPARs) and Their Association with Obesity and Diabetes.

Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories.

Biopesticides as a promising alternative to synthetic pesticides: A case for microbial pesticides, phytopesticides, and nanobiopesticides.

A holistic review on trend, occurrence, factors affecting pesticide concentration, and ecological risk assessment.

Metals/Metalloids

The protective effect of natural or chemical compounds against arsenic-induced neurotoxicity: Cellular and molecular mechanisms.

Does fluoride exposure impact on the human microbiome?

Microplastics/Nanomaterials

Review of microplastics in the indoor environment: Distribution, human exposure and potential health impacts.

To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity.

Mini review of microplastic pollutions and its impact on the environment and human health.

Microbial colonization and degradation of marine microplastics in the plastisphere: A review.

Contribution of plastic and microplastic to global climate change and their conjoining impacts on the environment – A review.

Microplastics in aquatic environments: A comprehensive review of toxicity, removal, and remediation strategies.

Nano/micro-Plastics Toxicity on Food Quality and Food Safety [a volume of Advances in Food and Nutrition Research] includes chapters such as:

Air Pollution

Cellular mechanisms linking to outdoor and indoor air pollution damage during pregnancy.

In vitro data for fire pollutants: contribution of studies using human cell models towards firefighters’ occupational.

Miscellaneous

Reconsidering “low-dose”-Impacts of oral estrogen exposure during preimplantation embryo development.

Early-life AFB1 exposure: DNA methylation and hormone alterations.

Human Health Studies

Numerous Chemicals/Mixtures

Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study.

Dietary exposure to thyroid disrupting chemicals: a community-based study in Canada.

BPA/Phenols

Prenatal bisphenol a and S exposure and atopic disease phenotypes at age 6.

Comparison of urine bisphenol A levels in transient tachypnea of the newborn and healthy newborns.

Relationship between bisphenol A and the cardiovascular disease metabolic risk factors in American adults: A population-based study.

Phthalates

Associations of urinary metabolite concentrations of phthalates and phthalate replacements with body composition from mid-childhood to early adolescence.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association Between Serum Trace Heavy Metals and Liver Function Among Adolescents.

Serum persistent organic pollutants and diminished ovarian reserve: a single-exposure and mixture exposure approach from a French case-control study.

Perfluoroalkyl Substances

Gene-environment interactions in the associations of PFAS exposure with insulin sensitivity and beta-cell function in a Faroese cohort followed from birth to adulthood.

Association of perfluoroalkyl substances with pulmonary function in adolescents (NHANES 2007-2012).

Plasma concentrations of per- and polyfluoroalkyl substances are associated with perturbations in lipid and amino acid metabolism.

Flame Retardants

The association between organophosphate esters exposure and body mass index in children and adolescents: The mediating effect of sex hormones.

Polybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls: Repeated measurements prior to and after diagnosis.

Associations of urinary organophosphate esters metabolites and diet quality with nonalcoholic/metabolic dysfunction-associated fatty liver diseases in adults.

Metals/Metalloids

Association between toxic metals, vitamin D and preterm birth in the Maternal-Infant research on environmental chemicals study.

Association between heavy metals exposure and infertility among American women aged 20-44 years: A cross-sectional analysis from 2013 to 2018 NHANES data.

The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China.

Air Pollution

Joint effect of ambient PM_2.5 exposure and vitamin B₁₂ during pregnancy on the risk of gestational diabetes mellitus.

Association between maternal exposure to air pollution and gestational diabetes mellitus in Taiyuan, North China.

Exposure to ambient air pollution and metabolic kidney diseases: evidence from the Northeast China Biobank.

Exposure to environmental air pollutants as a risk factor for primary Sjögren’s syndrome.

Pharmaceuticals/Personal Care Products

Use of personal care products during pregnancy and birth outcomes – A pilot study.

Laboratory Studies

Numerous Chemicals/Mixtures

Adipogenic and endocrine disrupting mixture effects of organic and inorganic pollutant mixtures.

Effect of long-term exposure to dyeing wastewater treatment plant effluent on growth and gut microbiota of adult zebrafish (Danio rerio).

BPA/Phenols

Safer alternatives? Bisphenol F and Bisphenol S induce oxidative stress in Drosophila melanogaster larvae and trigger developmental damage.

Prenatal BPA exposure disrupts male reproductive functions by interfering with DNA methylation and GDNF expression in the testes of male offspring rats.

Effects of Dietary Resveratrol, Bile Acids, Allicin, Betaine, and Inositol on Recovering the Lipid Metabolism Disorder in the Liver of Rare Minnow Gobiocypris rarus Caused by Bisphenol A.

Inhibition of VDAC1 prevents oxidative stress and apoptosis induced by bisphenol A in spermatogonia via AMPK/mTOR signaling pathway.

Direct inhibition of bisphenols on human and rat 11β-hydroxysteroid dehydrogenase 2: Structure-activity relationship and docking analysis.

FTO-Nrf2 axis regulates bisphenol F-induced leydig cell toxicity in an m6A-YTHDF2-dependent manner.

Bisphenol B and bisphenol AF exposure enhances uterine diseases risks in mouse.

Repeated exposure to 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) accelerates ligand-independent activation of estrogen receptors in long-term estradiol-deprived MCF-7 cells. [a BPA metabolite]

Phthalates

Endocrine-disrupting chemical exposure augments neutrophilic inflammation in severe asthma through the autophagy pathway.

DEHP exposure elevated cardiovascular risk in obese mice by disturbing the arachidonic acid metabolism of gut microbiota.

Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP.

Perfluoroalkyl Substances

Metabolic perturbations in pregnant rats exposed to low-dose perfluorooctanesulfonic acid: An integrated multi-omics analysis.

Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells.

Hexafluoropropylene oxide trimer acid causes fibrosis in mice liver via mitochondrial ROS/cGAS-STING/NLRP3-mediated pyroptosis.

Insights into the circadian rhythm alterations of the novel PFOS substitutes F-53B and OBS on adult zebrafish.

Bile acid metabolism disorder mediates hepatotoxicity of Nafion by-product 2 and perfluorooctane sulfonate in male PPARα-KO mice.

Direct inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by per- and polyfluoroalkyl substances: structure-activity relationship and in silico docking analysis.

Taurine protects against perfluorooctanoic acid-induced hepatotoxicity via inhibition of oxidative stress, inflammatory, and apoptotic pathways.

Pesticides

Single and mixed exposure to distinct groups of pesticides suggests endocrine disrupting properties of imidacloprid in zebrafish embryos.

Neuroprotective Effect of Propolis Polyphenol-Based Nanosheets in Cellular and Animal Models of Rotenone-Induced Parkinson’s Disease.

Atrazine promotes breast cancer development by suppressing immune function and upregulating MMP expression.

Household based-pyrethroids on adult Zebrafish (Danio rerio) exert behavioral and cholinergic changes in different brain regions.

Glutathione attenuated lambda-cyhalothrin-induced alteration of serum total cholesterol concentration and oxidative stress parameters in rats.

Mancozeb-induced hepatotoxicity: protective role of curcumin in rat animal model.

Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats.

Toxic effects of isofenphos-methyl on zebrafish embryonic development.

Evaluation of single and combined effects of mancozeb and metalaxyl on the transcriptional and biochemical response of zebrafish (Danio rerio).

Metals/Metalloids

Fate of arsenicals in mice carrying the human AS3MT gene exposed to environmentally relevant levels of arsenite in drinking water.

Zinc restores functionality in porcine prepubertal Sertoli cells exposed to subtoxic cadmium concentration via regulating the Nrf2 signaling pathway.

Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain.

Cadmium aggravates the blood-brain barrier disruption via inhibition of the Wnt7A/β-catenin signaling axis.

Microplastics/Nanomaterials

‘Plasticosis’: Characterising macro- and microplastic-associated fibrosis in seabird tissues.

Microplastics affect arsenic bioavailability by altering gut microbiota and metabolites in a mouse model.

The joint effects of nanoplastics and TBBPA on neurodevelopmental toxicity in Caenorhabditis elegans.

Oligomer nanoparticle release from polylactic acid plastics catalysed by gut enzymes triggers acute inflammation.

Sulfate-modified nanosized polystyrene impairs memory by inhibiting ionotropic glutamate receptors and the cAMP-response element binding protein (CREB) pathway in Caenorhabditis elegans.

Polystyrene microplastics-induced macrophage extracellular traps contributes to liver fibrotic injury by activating ROS/TGF-β/Smad2/3 signaling axis.

Integrated fecal microbiome and metabolome analysis explore the link between polystyrene nanoplastics exposure and male reproductive toxicity in mice.

Pharmaceuticals/Personal Care Products

Adverse thyroid hormone and behavioral alterations induced by three frequently used synthetic musk compounds in embryo-larval zebrafish (Danio rerio).

Benzophenone-1 and -2 UV-filters potently inhibit human, rat, and mouse gonadal 3β-hydroxysteroid dehydrogenases: structure-activity relationship and in silico docking analysis.

Exposure/Environment Studies

BPA/Phenols

An integrated human health risk assessment framework for alkylphenols due to drinking water and crops’ food consumption.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Preliminary trends over ten years of persistent organic pollutants in air – Comparison of two sets of data in the same countries.

Persistent organic pollutants in air from Asia, Africa, Latin America, and the Pacific.

Perfluoroalkyl Substances

Biomonitoring of perfluoroalkyl and polyfluoroalkyl substances (PFAS) from the Survey of the Health of Wisconsin (SHOW) 2014-2016 and comparison with the National Health and Nutrition Examination Survey (NHANES).

Up in the air: Polyfluoroalkyl phosphate esters (PAPs) in airborne dust captured by air conditioning (AC) filters.

Per- and polyfluoroalkyl substances in marine organisms along the coast of China.

Per- and polyfluoroalkyl substances (PFAS) in surface sediments: Occurrence, patterns, spatial distribution and contribution of unattributed precursors in French aquatic environments.

Psychological distress in three Australian communities living with environmental per- and polyfluoroalkyl substances contamination.

Immobilization of per- and polyfluoroalkyl substances (PFAS): Comparison of leaching behavior by three different leaching tests.

Sex-Specific Bioaccumulation, Maternal Transfer, and Tissue Distribution of Legacy and Emerging Per- and Polyfluoroalkyl Substances in Snakes (Enhydris chinensis) and the Impact of Pregnancy.

Flame Retardants

Human exposure to short-chain chlorinated paraffins and organophosphate flame retardants in relation to paired multiple sources.

An additional threat to populations predicted to collapse: Organobromine compounds of natural and anthropogenic sources in rough-toothed dolphins from the Southwestern Atlantic Ocean.

First evidence and potential sources of novel brominated flame retardants and BDE 209 in the deepest ocean.

Organophosphate esters in source, finished, and tap water in Wuhan, China.

The aomogeneous and heterogeneous oxidation of organophosphate esters (OPEs) in the atmosphere: Take diphenyl phosphate (DPhP) as an example.

Levels, distribution, childhood exposure assessment, and influencing factors of polybrominated diphenyl ethers (PBDEs) in household dust from nine cities in China.

Regional Distribution of Atmospheric Organophosphate Tri-/Diesters in the Pearl River Delta: Possible Emission, Photo-degradation, and Atmospheric Transportation.

Pesticides

Assessment of Preschool Children’s Exposure Levels to Organophosphate and Pyrethroid Pesticide: A Human Biomonitoring Study in Two Turkish Provinces.

Metals/Metalloids

Heavy metal(loid) effect on multi-biomarker responses in apex predator: Novel assays in the monitoring of white stork nestlings.

Microplastics/Nanomaterials

Microplastics exacerbate co-occurrence and horizontal transfer of antibiotic resistance genes.

Air Pollution

Effect of residential relocation on environmental exposures in European cohorts: An exposome-wide approach.

Inequitable Exposures to U.S. Coal Power Plant-Related PM2.5: 22 Years and Counting. [see related Invited Perspective: Leveraging Air Quality Research Advancements to Assess and Address Exposure Inequities.]

Miscellaneous

Predicting the environmental fates of emerging contaminants: Synergistic effects in ozone reactions of nitrogen-containing alkenes.

Ecological risk assessment of tire and road wear particles: A preliminary screening for freshwater sources in Canada.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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