EDC Science Weekly, Feb. 17-23, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Feb 23: Environmental Justice and the Built Environment: Protecting Children and Families (CHE)

Webinar Feb 28: PFAS in the Canadian Arctic: Identifying exposure sources and health effects in Nunavik, Canada (CHE Alaska)

Webinar Mar 1: Promoting Environmental Justice with Safer Building Materials (CHE)

Webinar Mar 9: Strengthening Federal Rules and Resources to Support Healthier Homes (CHE)

CME Course May 6: Environmental Chemicals and Children’s Health (in person at NYU Langone Health)

Regulations/Policy

From old pollutants to the regulation of bisphenol A: Lessons learned for health promotion and disease prevention.

The FDA’s action plan to reduce dietary exposure to arsenic, lead, cadmium and mercury for infants and young children.

Pesticide active substances that do not require a review of the existing maximum residue levels under Article 12 of Regulation (EC) No 396/2005.

Towards harmonisation of testing of nanomaterials for EU regulatory requirements on chemical safety – A proposal for further actions.

Impact of historical legacy pesticides on achieving legislative goals in Europe.

Methods/Tools/Screening

Methods

Standardizing non-targeted analysis reporting to advance exposure science and environmental epidemiology.

Evaluation of in vitro toxicity information for zebrafish as a promising alternative for chemical hazard and risk assessment.

Screening

Identification of activity cliffs in structure-activity landscape of androgen receptor binding chemicals.

Cytotoxicity, endocrine disrupting activity, and chemical analysis of 42 food contact silicone rubber products.

Commentaries

Editorial: Environmental exposures and thyroid health [intro to a Research Topic in Frontiers in Endocrinology]

Editorial: Pharmaceuticals, personal care products and endocrine disrupting chemicals: The physiological consequences of exposure to pollutants in aquatic animals. [intro to a Research Topic in Frontiers in Physiology]

The possible role of the endocrine disrupting chemicals on the premature and early menopause associated with the altered oxidative stress metabolism [part of the Research Topic, Endocrine Disruptors Affecting the Human and Companion Animal Endocrine Functions – Similarities and Indicators in ONE Health Concept, in Frontiers in Endocrinology]

The Lancet Series on One Health and Global Health Security [the series includes numerous articles on the One Health approach]

Getting Health Hazards of Inhaled Nano/Microplastics into Focus: Expectations and Challenges.

EPA’s Unprecedented Interim Drinking Water Health Advisories for PFOA and PFOS.

Reviews

Numerous Chemicals/Mixtures

Impact of endocrine disrupting chemicals and pharmaceuticals on Sertoli cell development and functions.

Protective effects of melatonin against the toxic effects of environmental pollutants and heavy metals on testicular tissue: A systematic review and meta-analysis of animal studies.

Exposure to endocrine-disrupting chemicals and implications for neurodevelopment.

The effect of endocrine-disrupting chemicals on placental development

The Exposome Approach to Study Children’s Health [part of a special issue, Woman and Child’s Environmental Health 2023: Impacts of Pollutants in Children, in Current Opinion in Environmental Science and Health]

Chronic kidney disease with unknown cause across the global spectrum.

Nine decades of data on environmental chemical pollutant exposure in dogs: a bibliometric analysis.

BPA/Phenols

Negative effects of endocrine disruptor bisphenol A on ovarian granulosa cells and the protective role of folic acid.

Perfluoroalkyl Substances

Toxic effects of per- and polyfluoroalkyl substances on sperm: Epidemiological and experimental evidence

Pesticides

Perspective: Organic food consumption during pregnancy and the potential effects on maternal and offspring health.

Metals/Metalloids

Heavy metals and arsenic stress in food crops: Elucidating antioxidative defense mechanisms in hyperaccumulators for food security, agricultural sustainability, and human health.

Microplastics/Nanomaterials

Research progress on the cellular toxicity caused by micro- and nanoplastics.

Air Pollution

The relationship between air pollutants and gestational diabetes: an updated systematic review and meta-analysis.

Pharmaceuticals/Personal Care Products

Benzophenone-3: Comprehensive review of the toxicological and human evidence with meta-analysis of human biomonitoring studies.

Miscellaneous

Cyclic volatile methyl siloxanes (D4, D5, and D6) as the emerging pollutants in environment: environmental distribution, fate, and toxicological assessments.

Human Health Studies

Numerous Chemicals/Mixtures

The association of prenatal phthalates, organophosphate pesticides, and organophosphate esters with early child language ability in Norway.

Modeling historic environmental pollutant exposures and non-Hodgkin lymphoma risk.

BPA/Phenols

Association of urinary bisphenol A with cardiovascular and all-cause mortality: National Health and Nutrition Examination Survey (NHANES) 2003-2016.

The evaluation of serum bisphenol A in patients with preeclampsia.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Brominated flame retardants and legacy organochlorines in archived human placenta samples: Sex differences, temporal analysis and associations with infant birth weight.

An Analysis of Birth Defects and Developmental Disabilities for Children of Participants of the Air Force Health Study.

Perfluoroalkyl Substances

Exposure to high levels of PFAS through drinking water is associated with increased risk of type 2 diabetes-findings from a register-based study in Ronneby, Sweden.

Prenatal Exposure to Legacy and Alternative Per- and Polyfluoroalkyl Substances and Neuropsychological Development Trajectories over the First 3 Years of Life.

Exposure to perfluoroalkyl substances and women’s fertility outcomes in a Singaporean population-based preconception cohort.

Pesticides

Glyphosate exposure and preterm birth: a nested case-control pilot study.

Prenatal exposure to pesticides and domain-specific neurodevelopment at age 12 and 18 months in Nanjing, China.

Metals/Metalloids

Maternal DNA methylation signatures of Arsenic exposure is associated with adult offspring insulin resistance in the Strong Heart Study.

Placental Barrier on Cadmium Transfer from Mother to Fetus in Related to Pregnancy Complications.

Identification of the regulatory network and potential markers for type 2 diabetes mellitus related to internal exposure to metals in Chinese adults.

Association between levels of exposure to heavy metals and renal function indicators of residents in environmentally vulnerable areas.

Air Pollution

Effects of Sociodemographic Characteristics, Comorbidity, and Coexposures on the Association between Air Pollution and Type 2 Diabetes: A Nationwide Cohort Study.

Association of PM_2.5 Components with Acceleration of Aging: Moderating Role of Sex Hormones.

Miscellaneous

Urinary metabolites of multiple volatile organic compounds among pregnant women across pregnancy: Variability, exposure characteristics, and associations with selected oxidative stress biomarkers.

Laboratory Studies

Bisphenols/Phthalates

Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged females.

Transcriptomic analysis of lipid metabolism in zebrafish offspring of parental long-term exposure to bisphenol A.

In Vitro Effects of Bisphenol Analogs on Immune Cells Activation and Th Differentiation.

Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus.

Structure-based developmental toxicity and ASD-phenotypes of bisphenol A analogues in embryonic zebrafish.

Exposure to bisphenol A alternatives bisphenol AF and fluorene-9-bisphenol induces gonadal injuries in male zebrafish.

Protective effect of Anoectochilus burmannicus extracts and its active compound, kinsenoside on adipocyte differentiation induced by benzyl butyl phthalate and bisphenol A.

Parabens/Triclosan/Antimicrobials

Triclosan and triclocarban weaken the olfactory capacity of goldfish by constraining odorant recognition, disrupting olfactory signal transduction, and disturbing olfactory information processing.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes.

Perfluoroalkyl Substances

Verification of In Vivo Estrogenic Activity for Four Per- and Polyfluoroalkyl Substances (PFAS) Identified as Estrogen Receptor Agonists via New Approach Methodologies.

Effects of Perfluorooctanoic Acid on Endoplasmic Reticulum Stress and Lipid Metabolism-related Genes in Human Pancreatic Cells.

Perfluorononanoic Acid Induces Neurotoxicity via Synaptogenesis Signaling in Zebrafish.

Mitochondrial iron overload mediated by cooperative transfer of plasma membrane ATP5B and TFR2 to mitochondria triggers hepatic insulin resistance under PFOS exposure.

Embryonic exposure to PFAS causes long-term, compound-specific behavioral alterations in zebrafish.

Toxicity of perfluorobutanesulfonate on gill functions of marine medaka (Oryzias melastigma): A time course and hypoxia co-exposure study.

Pesticides

The Effect of Increasing the Dose of Acetamiprid and Dichlorvos Pesticides on the Reproductive Performance of Laboratory Mice.

Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase-NLRP3 inflammasome axis-dependent microglial activation.

Evaluation of the risk of human exposure to thiamethoxam by extrapolation from a toxicokinetic experiment in rats and literature data.

Intergenerational reproductive toxicity of parental exposure to prothioconazole and its metabolite on offspring and epigenetic regulation associated with DNA methylation in zebrafish.

Exposure to cypermethrin pesticide disturbs the microbiome and disseminates antibiotic resistance genes in soil and the gut of Enchytraeus crypticus.

Lambda cyhalothrin and chlorantraniliprole caused biochemical, histological, and immunohistochemical alterations in male rabbit liver: ameliorative effect of vitamins A, D, E, C mixture.

Ferroptosis contribute to neonicotinoid imidacloprid-evoked pyroptosis by activating the HMGB1-RAGE/TLR4-NF-κB signaling pathway.

Betulinic acid protects against cardiotoxicity of the organophosphorus pesticide chlorpyrifos by suppressing oxidative stress, inflammation, and apoptosis in rats.

Next-generation effects of fetal and lactational exposure to the neonicotinoid pesticide clothianidin on the immune system and gut microbiota.

Metals/Metalloids

Alternations of Fertility Parameters by Graded Dose of Inorganic Arsenic in Adult Male White Pekin Ducks.

Impaired white adipose tissue fatty acid metabolism in mice fed a high-fat diet worsened by arsenic exposure, primarily affecting retroperitoneal adipose tissue.

Atorvastatin prevents cadmium-induced renal toxicity in a rat model.

Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats.

Co-exposure to arsenic and fluoride to explore the interactive effect on oxidative stress and autophagy in myocardial tissue and cell.

Microplastics/Nanomaterials

Oxidative stress and gene expression induced by biodegradable microplastics and imidacloprid in earthworms (Eisenia fetida) at environmentally relevant concentrations.

Polystyrene microplastics induce endoplasmic reticulum stress, apoptosis and inflammation by disrupting the gut microbiota in carp intestines.

Polystyrene microplastics alleviate adverse effects of benzo[a]pyrene on tissues and cells of the marine mussel, Mytilus galloprovincialis.

Pharmaceuticals/Personal Care Products

In vitro investigation of immunomodulatory activities of selected UV-filters.

Evaluating the applicability of the Ames test for cosmetic packaging assessment by comparing carcinogenic risk levels of migrants from plastics with biological detection limits.

Miscellaneous

Evaluation of pancreatic δ- cells as a potential target site of graphene oxide toxicity in Japanese medaka (Oryzias latipes) fish.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Cross-sectional study protocol to assess the environmental exposure of endocrine disruptive chemicals: bisphenol-A and heavy metals in children.

BPA/Phenols

Toxicity and Estrogenicity of Bisphenol TMC in Oryzias melastigma via In Vivo and In Silico Studies.

Phthalates

Current exposure to phthalates and DINCH in European children and adolescents – Results from the HBM4EU Aligned Studies 2014 to 2021.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated dibenzo-p-dioxins and dibenzofurans and dioxin-like polychlorinated biphenyls in human milk from national human breast milk monitoring in 2016-2019 in China.

Perfluoroalkyl Substances

Integration of target, suspect, and nontarget screening with risk modeling for per- and polyfluoroalkyl substances prioritization in surface waters.

Per- and polyfluoroalkyl substances and volatile methyl siloxanes in global air: Spatial and temporal trends.

Occurrence of quantifiable and semi-quantifiable poly- and perfluoroalkyl substances in united states wastewater treatment plants.

Warming Affects Bioconcentration and Bioaccumulation of Per- and Polyfluoroalkyl Substances by Pelagic and Benthic Organisms in a Water-Sediment System.

Estimation of Per- and Polyfluorinated Alkyl Substance Induction Equivalency Factors for Humpback Dolphins by Transactivation Potencies of Peroxisome Proliferator-Activated Receptors.

Pesticides

Screening of pesticides in serum, urine and cerebrospinal fluid collected from an urban population in China.

Proportionality Principle revisited – Relationship between application rates and pesticide residue concentrations in food commodities.

Metals/Metalloids

The microbiome of a brownfield highly polluted with mercury and arsenic.

The importance of in-year seasonal fluctuations for biomonitoring of apex predators: A case study of 14 essential and non-essential elements in the liver of the common buzzard (Buteo buteo) in the United Kingdom.

Microplastics/Nanomaterials

Effects of biodegradable and non-biodegradable microplastics on bacterial community and PAHs natural attenuation in agricultural soils.

Miscellaneous

Overlooked Iodo-Disinfection Byproduct Formation When Cooking Pasta with Iodized Table Salt.

Assessment of silicone wristbands for monitoring personal exposure to chlorinated paraffins (C_8-36): A pilot study.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!