EDC Science Weekly, Feb. 10-16, 2023

Post author:HEEDS
Post published:February 16, 2023
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Feb 23: Environmental Justice and the Built Environment: Protecting Children and Families (CHE)

CME Course May 6: Environmental Chemicals and Children’s Health (in person at NYU Langone Health)

Regulations/Policy

Is the EU chemicals strategy for sustainability a green deal?

United States and United Nations pesticide policies: Environmental violence against the Yaqui indigenous nation.

Methods/Tools/Screening

Mixture risk assessment and human biomonitoring: Lessons learnt from HBM4EU.

New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians.

Inconsistencies in variable reporting and methods in larval zebrafish behavioral assays.

Human risk associated with exposure to mixtures of antiandrogenic chemicals evaluated using in vitro hazard and human biomonitoring data

A Pragmatic Framework for the Application of New Approach Methodologies in One Health Toxicological Risk Assessment.

Application of a new approach methodology (NAM)-based strategy for genotoxicity assessment of data-poor compounds.

The State of the Art and Challenges of In Vitro Methods for Human Hazard Assessment of Nanomaterials in the Context of Safe-by-Design.

Dietary Exposure to Toxic Elements and the Health of Young Children: Methodological Considerations and Data Needs.

Investigating nanoplastics toxicity using advanced stem cell-based intestinal and lung in vitro models.

Choice of experimental model determines translational impact: The link between bisphenol A and cardiotoxicity.

ECETOC TRAv3: An In-depth Comparison of Publicly Available Measurement Data Sets With Modelled Estimates of Occupational Inhalation Exposure to Chemicals.

Commentaries

Innovating human chemical hazard and risk assessment through an holistic approach

Reviews

Numerous Chemicals/Mixtures

Endocrine Disruptor Chemicals and Children’s Health.

Association of Preterm Birth and Exposure to Endocrine Disrupting Chemicals.

Occurrence of some legacy and emerging contaminants in feed and food and their ranking priorities for human exposure.

Environmental estrogens shape disease susceptibility.

The impact of endocrine disrupting compounds and carcinogens in wastewater: Implications for breast cancer.

Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification.

Endocrine-Disrupting Chemicals and Their Effects in Pet Dogs and Cats: An Overview.

Hormesis-tempting stressors driven by evolutionary factors for mitigating negative impacts instigated over extended exposure to chemical elements.

Bisphenols/Phthalates

Association between bisphenol A exposure and thyroid dysfunction in adults: a systematic review and meta-analysis.

Endocrine modulating chemicals in food packaging: A review of phthalates and bisphenols.

Exposure to phthalate increases the risk of eczema in children: Findings from a systematic review and meta-analysis.

Parabens/Triclosan/Antimicrobials

A holistic review on triclosan and triclocarban exposure: Epidemiological outcomes, antibiotic resistance, and health risk assessment.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Chlorinated organic pollutants in global flooded soil and sediments: Pollution status and potential risk.

Agent Orange Reviewed: Potential Role in Peripheral Neuropathy and Neurodegeneration.

Perfluoroalkyl Substances

The Association between Prenatal Per- and Polyfluoroalkyl Substances Exposure and Neurobehavioral Problems in Offspring: A Meta-Analysis.

Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature.

Flame Retardants

Relationships of prenatal organophosphate ester exposure with pregnancy and birth outcomes: A systematic scoping review of epidemiological studies.

Pesticides

Pesticides and tremor: An overview of association, mechanisms and confounders.

Developmental origins of Parkinson disease: improving the rodent models.

A systematic review of the toxic effects of a nanopesticide on non-target organisms: Estimation of protective concentrations using a species sensitivity distribution (SSD) approach – The case of atrazine.

Metals/Metalloids

Microglial Activation in Metal Neurotoxicity: Impact in Neurodegenerative Diseases.

Our evolved understanding of the human health risks of mercury.

Microplastics/Nanomaterials

Microplastic migration and distribution in the terrestrial and aquatic environments: A threat to biotic safety.

Microplastics: A Real Global Threat for Environment and Food Safety: A State of the Art Review.

Microplastic Pollution: Chemical Characterization and Impact on Wildlife.

Air Pollution

Association of air pollution and fine particulate matter (PM2.5) exposure with gestational diabetes: a systematic review and meta-analysis.

UV radiation and air pollution as drivers of major autoimmune conditions.

Air pollution exposure and heart failure: A systematic review and meta-analysis.

Miscellaneous

Developmental programming of the neuroendocrine axis by steroid hormones: Insights from the sheep model of PCOS.

Prenatal Sex Hormone Exposure Is Associated with the Development of Autism Spectrum Disorder.

The potential health risks of short-chain chlorinated paraffin: A mini-review from a toxicological perspective.

Benzophenones in the Environment: Occurrence, Fate and Sample Preparation in the Analysis.

Human Health Studies

Numerous Chemicals/Mixtures

A Mixture of Chemicals Found in Human Amniotic Fluid Disrupts Brain Gene Expression and Behavior in Xenopus laevis.

Mixed exposure to phthalates and organic UV filters affects Children’s pubertal development in a gender-specific manner.

Phthalates

Associations of Urinary Phthalate Metabolites with Thyroid Function and the Mediated Role of Cytokines: A Panel Study of Healthy Children.

Perfluoroalkyl Substances

The Associations between Erythropoietic Response with Inflammation Markers and Perfluorinated Chemicals in Hemodialysis Patients.

Early-life exposure to per- and polyfluoroalkyl substances and infant gut microbial composition.

Developmental language disorders in preschool children after high exposure to perfluoroalkyl substances from contaminated drinking water in Ronneby, Sweden.

Serum Concentrations of Selected Poly- and Perfluoroalkyl Substances (PFASs) in Pregnant Women and Associations with Birth Outcomes. A Cross-Sectional Study from Southern Malawi.

Flame Retardants

Exposure to novel brominated and organophosphate flame retardants and associations with type 2 diabetes in East China: A case-control study.

Pesticides

Pesticide exposure and asthma morbidity in children residing in urban, multi-family housing.

Metals/Metalloids

Association of blood lead with estradiol and sex hormone-binding globulin in 8-19-year-old children and adolescents

Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort.

Alterations in Microbial-Associated Fecal Metabolites in Relation to Arsenic Exposure Among Infants.

Chemical Element Mixtures and Kidney Function in Mining and Non-Mining Settings in Northern Colombia.

Association of Urinary Lead and Cadmium Levels, and Serum Lipids with Subclinical Arteriosclerosis: Evidence from Taiwan.

Chronic Kidney Disease: Combined Effects of Gene Polymorphisms of Tissue Inhibitors of Metalloproteinase 3, Total Urinary Arsenic, and Blood Lead Concentration.

Air Pollution

Prenatal exposure to fine particulate matter and newborn anogenital distance: a prospective cohort study.

Air pollution and plasma amyloid beta in a cohort of older adults: Evidence from the Ginkgo Evaluation of Memory study.

Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil.

Large-Scale Analysis of the Association between Air Pollutants and Leucocyte Telomere Length in the UK Biobank.

Maternal Exposure to PM_2.5 and the Risk of Congenital Heart Defects in 1.4 Million Births: A Nationwide Surveillance-Based Study.

Pharmaceuticals/Personal Care Products

Birth Outcomes in DES Children and Grandchildren: A Multigenerational National Cohort Study on Informative Families.

Miscellaneous

Blood trihalomethane concentrations and allergic sensitization: A nationwide cross-sectional study.

Mutation pattern of Cancer suppressor p53 gene in factory workers exposed to Polypropylene and impact on their reproductive hormones.

Laboratory Studies

Numerous Chemicals/Mixtures

Metabolism of benzo[a]pyrene after low-dose subchronic exposure to an industrial mixture of carcinogenic polycyclic aromatic hydrocarbons in rats: a cocktail effect study.

Reproductive toxicity of emerging plasticizers, flame-retardants and bisphenols, using culture of the rat fetal testis.

Consequences of prenatal exposure to contaminants in elasmobranchs: Biochemical outcomes during the embryonic development of Pseudobatos horkelii

BPA/Phenols

Modulation of Unfolded Protein Response Restores Survival and Function of β-Cells Exposed to the Endocrine Disruptor Bisphenol A.

An Insight into the Metabolism of 2,5-Disubstituted Monotetrazole Bearing Bisphenol Structures: Emerging Bisphenol A Structural Congeners.

Molecular characterization of physis tissue and hormonal profiles of female rats neonatally exposed to low-dose bisphenol A.

Vitamin D ameliorates liver pathology in mice caused by exposure to endocrine disruptor bisphenol A.

Phthalates

Nicotinamide mononucleotide restores oxidative stress-related apoptosis of oocyte exposed to benzyl butyl phthalate in mice.

Resveratrol Butyrate Ester Supplementation Blunts the Development of Offspring Hypertension in a Maternal Di-2-ethylhexyl Phthalate Exposure Rat Model.

DEHP Decreases Steroidogenesis through the cAMP and ERK1/2 Signaling Pathways in FSH-Stimulated Human Granulosa Cells.

Exposure to Di-(2-Ethylhexyl) phthalate drives ovarian dysfunction by inducing granulosa cell pyroptosis via the SLC39A5/NF-κB/NLRP3 axis.

Impact of Plasticizer on the Intestinal Epithelial Integrity and Tissue-Repairing Ability within Cells in the Proximity of the Human Gut Microbiome.

Simplified Unified BARGE Method to Assess Migration of Phthalate Esters in Ingested PVC Consumer Products.

Parabens/Triclosan/Antimicrobials

The administration of methyl and butyl parabens interferes with the enzymatic antioxidant system and induces genotoxicity in rat testis: possible relation to male infertility.

Effects of an Endocrine Disruptor Triclosan on Ruditapes decussatus: Multimarker and Histological Approaches.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Developmental Exposure to DDT Disrupts Transcriptional Regulation of Postnatal Growth and Cell Renewal of Adrenal Medulla.

Perfluoroalkyl Substances

Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst.

Toxicity Effects of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) on Two Green Microalgae Species.

Inhibition of human sulfotransferases (SULTs) by per- and polyfluoroalkyl substances (PFASs) and structure-activity relationship.

Flame Retardants

Associated long-term effects of decabromodiphenyl ethane on the gut microbial profiles and metabolic homeostasis in Sprague-Dawley rat offspring.

Downregulation of miRNA-155-5p contributes to the adipogenic activity of 2-ethylhexyl diphenyl phosphate in 3T3-L1 preadipocytes.

Multi- and Transgenerational Developmental Impairments Are Induced by Decabromodiphenyl Ethane (DBDPE) in Zebrafish Larvae.

Pesticides

Thermal Performance Curves in a Polluted World: Too Cold and Too Hot Temperatures Synergistically Increase Pesticide Toxicity.

Maternal procymidone exposure has lasting effects on murine gut-liver axis and glucolipid metabolism in offspring.

Study effect and mechanism of levofloxacin on the neurotoxicity of Rana nigromaculata tadpoles exposed to imidacloprid based on the microbe-gut-brain axis.

Lycopene ameliorates atrazine-induced spatial learning and memory impairments by inhibiting ferroptosis in the hippocampus of mice.

Zinc Oxide Nanoparticles and Vitamin C Ameliorate Atrazine-Induced Hepatic Apoptosis in Rat via CYP450s/ROS Pathway and Immunomodulation.

Oleuropein confers neuroprotection against rotenone-induced model of Parkinson’s disease via BDNF/CREB/Akt pathway.

Sublethal exposure to agrochemicals impairs zooplankton ability to face future global change challenges.

The effects of glyphosate, pure or in herbicide formulation, on bumble bees and their gut microbial communities.

Prolonged exposure to the herbicide atrazine promotes kidney fibrosis by activating Wnt/β-catenin signaling in rats.

Mixture effects of thiamethoxam and seven pesticides with different modes of action on honey bees (Aplis mellifera).

Metals/Metalloids

Long-term reproductive effects in male rats prenatally exposed to sodium arsenite.

Intestinal homeostasis disruption in mice chronically exposed to arsenite-contaminated drinking water.

Melatonin protects against cadmium-induced oxidative stress via mitochondrial STAT3 signaling in human prostate stromal cells.

Interactions between cadmium, lead, mercury, and arsenic and depression: A molecular mechanism involved.

Microplastics/Nanomaterials

Dysregulation of the microbiota-brain axis during long-term exposure to polystyrene nanoplastics in rats and the protective role of dihydrocaffeic acid.

Desorption behavior of antibiotics by microplastics (tire wear particles) in simulated gastrointestinal fluids.

Low particle concentrations of nanoplastics impair the gut health of medaka.

Multigenerational effects of microplastic fragments derived from polyethylene terephthalate bottles on duckweed Lemna minor: Size-dependent effects of microplastics on photosynthesis.

Adsorption of 2-hydroxynaphthalene, naphthalene, phenanthrene, and pyrene by polyvinyl chloride microplastics in water and their bioaccessibility under in vitro human gastrointestinal system.

Polystyrene-microplastics and DEHP co-exposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production.

Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos.

Pharmaceuticals/Personal Care Products

Embryonic benzophenone-3 exposure inhibited fertility in later-life female zebrafish and altered developmental morphology in offspring embryos.

Chronic exposure to environmentally relevant concentrations of carbamazepine interferes with anxiety response of adult female zebrafish through GABA /5-HT pathway and HPI axis.

Miscellaneous

Quantum dots are time bomb: Multiscale toxicological study.

Risk Assessment of Transgender People: Development of Rodent Models Mimicking Gender-Affirming Hormone Therapies and Identification of Sex-Dimorphic Liver Genes as Novel Biomarkers of Sex Transition.

Potential Disrupting Effects of Wastewater-Derived Disinfection Byproducts on Chinese Rare Minnow (Gobiocypris rarus) Transthyretin: An In Vitro and In Silico Study.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021).

E-waste in Vietnam: a narrative review of environmental contaminants and potential health risks.

Suspect Screening of Chemicals in Hospital Wastewaters Using Effect-Directed Analysis Approach as Prioritization Strategy.

High resolution mass spectrometric suspect screening, wide-scope target analysis of emerging contaminants and determination of legacy pollutants in adult black-tailed godwit Limosa limosa limosa in the Netherlands – A pilot study.

Bishenols/Parabens

Characterization of pregnant women exposure to halogenated parabens and bisphenols through water consumption.

Evaluation of Parabens and Bisphenol A Concentration Levels in Wild Bat Guano Samples.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants in hospitalized individuals in the municipality of Petropolis, Brazil.

Source identification of PCBs in Antarctic air by compound-specific isotope analysis of chlorine (CSIA-Cl) using HRGC/HRMS.

Perfluoroalkyl Substances

Exposure of children and adolescents from Northeastern Slovenia to per- and polyfluoroalkyl substances.

Per- and polyfluoroalkyl substances (PFAS) distribution in landfill gas collection systems: leachate and gas condensate partitioning.

Evaluation of per- and polyfluoroalkyl substances (PFAS) in leachate, gas condensate, stormwater and groundwater at landfills.

Occurrence, Fate, and Related Health Risks of PFAS in Raw and Produced Drinking Water.

Transport and transformation of perfluoroalkyl acids, isomer profiles, novel alternatives and unknown precursors from factories to dinner plates in China: New insights into crop bioaccumulation prediction and risk assessment.

Microbial biotransformation mechanisms of PFPiAs in soil unveiled by metagenomic analysis.

Per- and Poly-Fluoroalkyl Substances in Portuguese Rivers: Spatial-Temporal Monitoring.

Flame Retardants

First insight into accumulation of characteristics and tissue distribution of PCBs, PBDEs, and other BFRs in the living Indonesian coelacanth (Latimeria menadoensis).

Bioaccumulation Behavior and Human Health Risk of Polybrominated Diphenyl Ethers in a Freshwater Food Web of Typical Shallow Lake, Yangtze River Delta.

Distribution, sources and dispersion of polybrominated diphenyl ethers in the water column of the Strait of Georgia, British Columbia, Canada.

Pesticides

Human health risks and hepatotoxicity associated with exposure to atrazine surveyed in drinking water from Ijebu-North, Southwest, Nigeria.

Role of herbicides in the decline of butterfly population and diversity.

Pesticide contamination of bird species from Doñana National park (southwestern Spain): Temporal trends (1999-2021) and reproductive impacts.

Neonicotinoids: Still present in farmland birds despite their ban.

Metals/Metalloids

Geographic differences in exposures to metals and essential elements in pregnant women living in Suriname.

Airborne levels of cadmium are correlated with urinary cadmium concentrations among young children living in the New York state city of Syracuse, USA.

Children’s blood lead levels in Latin America and the Caribbean – recommendations to combat this well-known persistent public health problem

Microplastics/Nanomaterials

Microplastics in infant milk powder.

Extruded polystyrene microplastics as a source of brominated flame retardant additives in the marine environment: long-term field and laboratory experiments.

Large-scale monitoring and risk assessment of microplastics in the Amazon River.

Microplastics in wastewater treatment plants: Sources, properties, removal efficiency, removal mechanisms, and interactions with pollutants.

Air Pollution

Health risk assessment of the European inhabitants exposed to contaminated ambient particulate matter by potentially toxic elements.

Pharmaceuticals/Personal Care Products

Usage of Children’s Makeup and Body Products in the United States and Implications for Childhood Environmental Exposures.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.