EDC Science Weekly: Nov. 11 – 17, 2022

Post author:HEEDS
Post published:November 17, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Nov. 30: PFAS Health Effects: National Academy of Sciences, Engineering, and Medicine’s Recommendations for At-Risk Populations (CHE Alaska)

Webinar Dec. 2: CHE Café: What’s Next in Environmental Health?

Webinar Dec. 8: Embryonic BPA Exposure Causes Liver Disease in Generations of Fish (EDC Strategies Partnership, HEEDS Young EDC Scientists Showcase)

Regulations/Policy

Petroleum in Pesticides: A Need to Change Regulatory Toxicology.

US Government agencies consider action on PFAS.

Health implications of the West Virginia v Environmental Protection Agency US Supreme Court decision.

Methods/Tools/Screening

Interpreting biomonitoring data: Introducing the international human biomonitoring (i-HBM) working group’s health-based guidance value (HB2GV) dashboard.

A New Method for Environmental Risk Assessment of Pollutants Based on Multi-Dimensional Risk Factors.

Confirmation of high-throughput screening data and novel mechanistic insights into FXR-xenobiotic interactions by orthogonal assays.

Bring Your Own Location Data: Use of Google Smartphone Location History Data for Environmental Health Research. [see related Invited Perspective: Can My Smartphone Assess My Exposure? The Potential to Retroactively Estimate Personalized Exposures using Smartphone Location Data.]

Leveraging Multiple Data Streams for Prioritization of Mixtures for Hazard Characterization.

Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications.

Tumor Organoids as a Research Tool: How to Exploit Them.

Chemicals of environmental concern as inhibitors of human placental 3β-hydroxysteroid dehydrogenase 1 and aromatase: Screening and docking analysis.

Commentaries

Environmental Pollution with Bisphenol A and Phthalates-A Serious Risk to Human and Animal Health.[intro to a special issue on this topic]

Micro(nano)plastic toxicity and health effects: Special issue guest editorial.

Reviews

Numerous Chemicals/Mixtures

Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries.

Endocrine-Disrupting Chemicals, Gut Microbiota, and Human (In)Fertility-It Is Time to Consider the Triad.

Role of microRNA in Endocrine Disruptor-Induced Immunomodulation of Metabolic Health.

Environmental Impacts on Infectious Disease: A Literature View of Epidemiological Evidence.

Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress.

Recent Advances in the Synthesis, Characterization, and Application of Carbon Nanomaterials for the Removal of Endocrine-Disrupting Chemicals: A Review.

Health Risks Associated with Informal Electronic Waste Recycling in Africa: A Systematic Review.

Safety of recycled plastics and textiles: Review on the detection, identification and safety assessment of contaminants.

Phthalates

Phthalates and bone mineral density: a systematic review.

Parabens/Triclosan/Antimicrobials

Neurotoxic mechanisms of triclosan: The antimicrobial agent emerging as a toxicant.

Perfluoroalkyl Substances

A review of microbial degradation of per- and polyfluoroalkyl substances (PFAS): Biotransformation routes and enzymes.

Pesticides

Impact of Pesticides on Cancer and Congenital Malformation: A Systematic Review.

Plant based natural products as potential ecofriendly and safer biopesticides: A comprehensive overview of their advantages over conventional pesticides, limitations and regulatory aspects.

Cardiotoxicity of pyrethroids: molecular mechanisms and therapeutic options for acute and long-term toxicity.

Metals/Metalloids

Metabolic effects of long-term cadmium exposure: an overview.

Genetics and Epigenetics of Manganese Toxicity.

Interventions to reduce cadmium exposure in low- and middle-income countries during pregnancy and childhood: A systematic review.

Microplastics/Nanomaterials

Plastics and Microplastic in the Cosmetic Industry: Aggregating Sustainable Actions Aimed at Alignment and Interaction with UN Sustainable Development Goals.

Oxidative Stress and Inflammatory Biomarkers for Populations with Occupational Exposure to Nanomaterials: A Systematic Review and Meta-Analysis.

Biodegradation of macro- and micro-plastics in environment: A review on mechanism, toxicity, and future perspectives.

Air Pollution

Wildfire Smoke Exposure during Pregnancy: A Review of Potential Mechanisms of Placental Toxicity, Impact on Obstetric Outcomes, and Strategies to Reduce Exposure.

Neuroinflammation and Neurodegeneration of the Central Nervous System from Air Pollutants: A Scoping Review.

Pharmaceuticals/Personal Care Products

Current research trends on emerging contaminants pharmaceutical and personal care products (PPCPs): A comprehensive review.

Utility of a non-target screening method to explore the chlorination of similar sulfonamide antibiotics: Pathways and NCl intermediates.

What approaches should be used to prioritize PPCPs for research on environmental and human health exposure and effects?

Environmental impacts due to the use of sunscreen products: a mini-review.

Miscellaneous

Environmental occurrence, toxicity and remediation of perchlorate – A review.

Human Health Studies

Numerous Chemicals/Mixtures

Mixtures of environmental contaminants and diabetes.

Human exposure to a mixture of endocrine disruptors and serum levels of thyroid hormones: A cross-sectional study.

Personal airborne chemical exposure and epigenetic ageing biomarkers in healthy Chinese elderly individuals: Evidence from mixture approaches.

BPA/Phenols/Parabens

Association between exposure to phenols and parabens and cognitive function in older adults in the United States: A cross-sectional study.

Phthalates

Phthalate Metabolites in Urine of Chinese Children and Their Association with Asthma and Allergic Symptoms.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations between Maternal Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Serum Concentrations and Pulse Pressure in Early Pregnancy: A Cross-Sectional Study.

Perfluoroalkyl Substances

Association between serum concentrations of perfluoroalkyl substances and global DNA methylation levels in peripheral blood leukocytes of Japanese women: A cross-sectional study.

High maternal glucose exacerbates the association between prenatal per- and polyfluoroalkyl substance exposure and reduced birth weight.

Perfluoroalkyl Mixture Exposure in Relation to Fetal Growth: Potential Roles of Maternal Characteristics and Associations with Birth Outcomes.

Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study.

High exposure to perfluoroalkyl substances in drinking water is associated with increased risk of osteoporotic fractures – A cohort study from ronneby, Sweden.

Plasma PFOA and PFOS Levels, DNA Methylation, and Blood Lipid Levels: A Pilot Study.

Flame Retardants

Adipose tissue levels of polybrominated diphenyl ethers in relation to prognostic biomarkers and progression-free survival time of breast cancer patients in eastern area of southern China: A hospital-based study.

Prenatal Exposure of Organophosphate Esters and Its Trimester-Specific and Gender-Specific Effects on Fetal Growth.

Pesticides

Childhood exposure to non-persistent pesticides and pubertal development in Spanish girls and boys: Evidence from the INMA (Environment and Childhood) cohort.

Occupational Exposure to Pesticides Affects Pivotal Immunologic Anti-Tumor Responses in Breast Cancer Women from the Intermediate Risk of Recurrence and Death.

Metals/Metalloids

Association of maternal and cord blood barium exposure with preschoolers’ intellectual function: Evidence from the Ma’anshan Birth Cohort (MABC) study.

Arsenic exposure induces urinary metabolome disruption in Pakistani male population.

Effects of mercury exposure on fetal body burden and its association with growth of infants.

Exposure to Metal Mixtures and Overweight or Obesity Among Chinese Adults.

Association of blood cadmium and metabolic syndrome: a cross-sectional analysis of National Health and Nutrition Examination Survey 2017-2020.

Epigenome-wide DNA methylation in leukocytes and toenail metals: The normative aging study.

Occupational exposure to arsenic, mercury and UV radiation and risk of melanoma: a case-control study from Italy.

Air Pollution

Association between Short-Term Exposure to Air Pollution and COVID-19 Mortality: A Population-Based Case-Crossover Study Using Individual-Level Mortality Registry Confirmed by Medical Examiners.

Association of Short-Term Exposure to PM_2.5 with Blood Lipids and the Modification Effects of Insulin Resistance: A Panel Study in Wuhan.

Long-term Exposure to Ambient PM2.5 and Its Components Associated With Diabetes: Evidence From a Large Population-Based Cohort From China.

Associations of fine particulate matter and its metal constituents with blood pressure: A panel study during the seventh World Military Games.

Personal exposure to PM_2.5 oxidative potential and its association to birth outcomes.

Miscellaneous

Prenatal exposure to polycyclic aromatic hydrocarbons is not associated with adverse behavior in preschool and early school-aged children: A prospective multi-cohort study.

Exposure to Organic Solvents and Neurobehavioral Assessment of Working Children of Informal Footwear Units of Agra, India.

Blood trihalomethane concentrations in relation to sperm mitochondrial DNA copy number and telomere length among 958 healthy men.

Laboratory Studies

Numerous Chemicals/Mixtures

Combination of Donepezil and Memantine Attenuated Cognitive Impairment Induced by Mixed Endocrine-Disrupting Chemicals: an In Silico Study.

Synergistic effect of environmental food pollutants: Pesticides and marine biotoxins.

BPA/Phenols

Morin improves Bisphenol-A-induced toxicity in the rat testicular mitochondria and sperms.

Analysis of Blood Biochemistry and Pituitary-Gonadal Histology after Chronic Exposure to Bisphenol-A of Mice.

Glucuronidated Metabolites of Bisphenols A and S Alter the Properties of Normal Urothelial and Bladder Cancer Cells.

Reproductive and developmental toxicity screening of bisphenol F by oral gavage in rats.

TET1 involved in bisphenol A induced TM3 Leydig cell toxicity by regulating Cav3.3 hydroxymethylation.

Dynamics and mechanisms of bioaccumulation and elimination of nonylphenol in zebrafish.

Single and repeated bisphenol A treatment induces ROS, Aβ and hyperphosphorylated-tau accumulation, and insulin pathways disruption, through HDAC2 and PTP1B overexpression, leading to SN56 cholinergic apoptotic cell death.

Phthalates

The p-Phthalates Terephthalic Acid and Dimethyl Terephthalate Used in the Manufacture of PET Induce In Vitro Adipocytes Dysfunction by Altering Adipogenesis and Thermogenesis Mechanisms.

DEHP triggers a damage severity grade increase in the jejunum in quail (Coturnix japonica) by disturbing nuclear xenobiotic receptors and the Nrf2-mediated defense response.

Di-2-ethylhexyl phthalate (DEHP) exposure induces sperm quality and functional defects in mice.

Molecular mechanism of di-n-butyl phthalate promotion of bladder cancer development.

Parabens/Triclosan/Antimicrobials

Mechanisms regarding cardiac toxicity triggered by up-regulation of miR-144 in larval zebrafish upon exposure to triclosan.

Triclocarban and triclosan exacerbate high-fat diet-induced hepatic lipid accumulation at environmental related levels: The potential roles of estrogen-related receptors pathways.

Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Aroclor 1254 induced inhibitory effects on osteoblast differentiation in murine MC3T3-E1 cells through oxidative stress.

Low-Dose Dioxin Reduced Glucose Uptake in C2C12 Myocytes: The Role of Mitochondrial Oxidative Stress and Insulin-Dependent Calcium Mobilization.

Toxicity Assessment of Octachlorostyrene in Human Liver Carcinoma (HepG2) Cells.

TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells.

Environmental pollutant, polychlorinated biphenyl 126, alters liver function in a rodent model of alcohol-associated liver disease.

Organotin and organochlorine toxicants activate key translational regulatory proteins in human immune cells.

Perfluoroalkyl Substances

Impacts of PFOA_C8, GenX_C6, and their mixtures on zebrafish developmental toxicity and gene expression provide insight about tumor-related disease.

Hexafluoropropylene oxide trimer acid (HFPO-TA) disturbs embryonic liver and biliary system development in zebrafish.

Rutin ameliorates perfluorooctanoic acid-induced testicular injury in mice by reducing oxidative stress and improving lipid metabolism.

Transcriptomic Interaction between Young Fecal Transplantation and Perfluorobutanesulfonate in Aged Zebrafish Gonads.

Flame Retardants

Adverse effects of thyroid-hormone-disrupting chemicals 6-propyl-2-thiouracil and tetrabromobisphenol A on Japanese medaka (Oryzias latipes).

Ubiquitin proteasomal system is a potential target of the toxic effects of organophosphorus flame retardant triphenyl phosphate.

Triphenyl phosphate induces clastogenic effects potently in mammalian cells, human CYP1A2 and 2E1 being major activating enzymes.

PBDEs disrupt homeostasis maintenance and regeneration of planarians due to DNA damage, proliferation and apoptosis anomaly.

Developmental exposure to the flame retardant, triphenyl phosphate, causes long-lasting neurobehavioral and neurochemical dysfunction.

Organotins

ROS/ER stress contributes to trimethyltin chloride-mediated hepatotoxicity; Tea polyphenols alleviate apoptosis and immunosuppression.

A ubiquitous endocrine disruptor tributyltin induces muscle wasting and retards muscle regeneration.

Pesticides

Oocyte Development and Quality in Young and Old Mice following Exposure to Atrazine.

Glyphosate mimics 17β-estradiol effects promoting estrogen receptor alpha activity in breast cancer cells.

Effect of Phorate on the Development of Hyperglycaemia in Mouse and Resistance Genes in Intestinal Microbiota.

Global warming and glyphosate toxicity (I): Adult zebrafish modelling with behavioural, immunohistochemical and metabolomic approaches.

Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations.

Behavioural incongruities in juvenile Cyprinus carpio exposed to organophosphate compounds.

The endocrine disruptor, fenoxycarb modulates gut immunity and gut bacteria titer in the cotton bollworm, Helicoverpa armigera.

Epigallocatechin gallate improves meiosis maturation against Diazinon exposure in porcine oocytes.

Preconception exposure to malathion and glucose homeostasis in rats: Effects on dams during pregnancy and post-term periods, and on their progeny.

Metals/Metalloids

Can the mouse model successfully predict mixed metal(loid)s bioavailability in humans from contaminated soils?

Biochemical Parameters of Female Wistar Rats and Their Offspring Exposed to Inorganic Mercury in Drinking Water during the Gestational and Lactational Periods.

Chronic Lead Exposure Disrupts Neurometabolic Activity in Mouse Brain: An ex vivo¹H-[¹³C]-NMR Study.

Short-term trivalent arsenic and hexavalent chromium exposures induce gut dysbiosis and transcriptional alteration in adipose tissue of mice.

Microplastics/Nanomaterials

Influence of ultraviolet-aging and adsorbed pollutants on toxicological effects of polyvinyl chloride microplastics to zebrafish.

Short-Term Exposure to Nanoplastics Does Not Affect Bisphenol A Embryotoxicity to Marine Ascidian Ciona robusta.

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats.

Polystyrene nanoplastics aggravates lipopolysaccharide-induced apoptosis in mouse kidney cells by regulating IRE1/XBP1 endoplasmic reticulum stress pathway via oxidative stress.

A Comparative Systematic Analysis of The Influence of Microplastics on Colon Cells, Mouse and Colon Organoids.

Air Pollution

Computational Approach to Link Chemicals in Anthropogenic Smoke Particulate Matter with Toxicity.

Pharmaceuticals/Personal Care Products

Toxicokinetics, Percutaneous Absorption and Tissue Distribution of Benzophenone-3, an UV Filtering Agent, in Rats.

Oxidative stress mediates end-organ damage in a novel model of acetaminophen-toxicity in Drosophila.

Proteomic analysis of zebrafish (Danio rerio) embryos exposed to benzyl benzoate.

Miscellaneous

Rxrs and Their Partner Receptor Genes Inducing Masculinization Plausibly Mediated by Endocrine Disruption in Paralichthys olivaceus.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Fetal exposure to organic contaminants revealed by infant hair: A preliminary study in south China.

Legacy and emerging contaminants in flamingos’ chicks’ blood from the Ebro Delta Natural Park.

Assessment of contaminants of emerging concern in European apex predators and their prey by LC-QToF MS wide-scope target analysis.

BPA/Phenols

The First Evidence on the Occurrence of Bisphenol Analogues in the Aqueous Humor of Patients Undergoing Cataract Surgery.

A Pilot Study on Monomer and Bisphenol A (BPA) Release from UDMA-Based and Conventional Indirect Veneering Composites.

Phthalates

Medical devices used in NICU: The main source of plasticisers’ exposure of newborns.

Dietary patterns and urinary phthalate exposure among postmenopausal women of the Women’s Health Initiative.

Source tracing and health risk assessment of phthalate esters in household tap-water: A case study of the urban area of Quanzhou, Southeast China.

Fate of phthalates in a river receiving wastewater treatment plant effluent based on a multimedia model.

Parabens/Triclosan/Antimicrobials

Parabens in indoor dust from houses, university dormitories, and cosmetics stores in Nanjing, China: occurrence and human exposure.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Changes in Polychlorinated Biphenyl Residues in Milk during Lactation: Levels of Contamination, Influencing Factors, and Infant Risk Assessment.

Serum levels of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in a sample of Lebanese pregnant women: The role of dietary, anthropometric, and environmental factors.

Food safety concerns on polycyclic aromatic hydrocarbon contamination in fish products from estuarine bays throughout the American continent.

Temporal trends (1968-2019) of legacy persistent organic pollutants (POPs) in seabird eggs from the northeast Pacific: Is it finally twilight for old POPs?

A Review of Polychlorinated Biphenyls (PCBs) Pollution in the Air: Where and How Much Are We Exposed to?

Perfluoroalkyl Substances

Apparent Half-Lives of Chlorinated-Perfluorooctane Sulfonate and Perfluorooctane Sulfonate Isomers in Aviation Firefighters.

Paints: A Source of Volatile PFAS in Air─Potential Implications for Inhalation Exposure.

Vital Environmental Sources for Multitudinous Fluorinated Chemicals: New Evidence from Industrial Byproducts in Multienvironmental Matrices in a Fluorochemical Manufactory.

Factors associated with elevated Per- and Polyfluoroalkyl substances serum levels in older adults.

Per- and Poly-Fluoroalkyl Substances in Runoff and Leaching from AFFF-Contaminated Soils: a Rainfall Simulation Study.

Interface hydrogen bonding dominated perfluorooctanoic acid (PFOA) accumulation by iron particles in drinking water pipes.

Perfluoroalkyl acids (PFAAs) in urban surface water of Shijiazhuang, China: Occurrence, distribution, sources and ecological risks.

Poly- and Perfluoroalkyl Substances (PFAS) in Landfills: Occurrence, Transformation and Treatment.

A sensitive and robust method for the simultaneous determination of thirty-three legacy and emerging per- and polyfluoroalkyl substances in human plasma and serum.

Flame Retardants

Legacy and novel brominated flame retardants in animal-derived foods from China Total Diet Study (CTDS): Temporal trends, evidence of substitution, and dietary exposure assessment.

Mixed bromine/chlorine transformation products of tetrabromobisphenol A formed in the combustion of printed circuit boards: Emission characteristics and transformation pathways.

Presence of novel and legacy flame retardants and other pollutants in an e-waste site in China and associated risks.

Occurrence and ecological risk assessment of 2,2′,4,4′-tetrabromodiphenyl ether and decabromodiphenyl ether in surface waters across China.

Pesticides

Characterization of Urinary Pesticide Metabolite Concentrations of Pregnant Women in Suriname.

Exposure to glyphosate in the United States: Data from the 2013-2014 National Health and Nutrition Examination Survey.

Metals/Metalloids

The effect of an organic food intervention treatment on biomarkers of exposure to lead and cadmium in primary school children of Cyprus: A cluster-randomized crossover trial.

A Systematic Review of Mercury Exposures from Skin-Lightening Products.

Mercury, silver and selenium in serum before and after removal of amalgam restorations: results from a prospective cohort study in Norway.

Microplastics/Nanomaterials

Plastic and Placenta: Identification of Polyethylene Glycol (PEG) Compounds in the Human Placenta by HPLC-MS/MS System.

Airborne microplastics: Occurrence, sources, fate, risks and mitigation.

Plastics and waterbirds in Brazil: A review of ingestion, nest materials and entanglement reveals substantial knowledge gaps and opportunities for research.

Concentrations of tire wear microplastics and other traffic-derived non-exhaust particles in the road environment.

Plastic burdens in northern fulmars from Svalbard: Looking back 25 years.

Can a Sediment Core Reveal the Plastic Age? Microplastic Preservation in a Coastal Sedimentary Record.

Pharmaceuticals/Personal Care Products

Origin, transport and ecological risk assessment of illicit drugs in the environment – A review.

Occurrence and Distribution of Antibiotics in the Water, Sediment, and Biota of Freshwater and Marine Environments: A Review.

Miscellaneous

Simultaneous trace determination of three natural estrogens and their sulfate and glucuronide conjugates in municipal waste and river water samples with UPLC-MS/MS.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.