EDC Science Weekly, Nov. 4 – 10, 2022

Post author:HEEDS
Post published:November 10, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Nov. 12: Celebrating 20 Years of Amplifying Science for Health Collaborative on Health and the Environment (CHE)’s 20th anniversary in person and online event.

Webinar Nov. 16: Protecting Brain Development in Children: Phthalates in Food & the Critical Need for Policy Reform (CHE Alaska)

Webinar Nov. 30: PFAS Health Effects: National Academy of Sciences, Engineering, and Medicine’s Recommendations for At-Risk Populations (CHE Alaska)

Webinar Dec. 2: CHE Café: What’s Next in Environmental Health?

Methods/Tools/Screening

Applying the adverse outcome pathway concept for assessing non-monotonic dose responses: biphasic effect of bis(2-ethylhexyl) phthalate (DEHP) on testosterone levels.

Assessing How Social Exposures Are Integrated in Exposome Research: A Scoping Review. [see related Invited Perspective: The Mysterious Case of Social Determinants of Health.]

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals.

The development and function of the brain barriers – an overlooked consideration for chemical toxicity.

Real-time bioelectronic sensing of environmental contaminants.

Approaches to implement safe by design in early product design through combining risk assessment and Life Cycle Assessment.

Pristina longiseta reproduction test: chronic exposure to environmental contaminants.

Perspectives on the Use of Toxicogenomics to Assess Environmental Risk.

Simulating toxicokinetic variability to identify susceptible and highly exposed populations.

From correlation to causation: The new frontier of transgenerational epigenetic inheritance.

Exposure forecasting – ExpoCast – for data-poor chemicals in commerce and the environment.

Establishing a Quantitative Framework for Regulatory Interpretation of Genetic Toxicity Dose-Response Data: MOE (Margin of Exposure) Case Study of 48 Compounds with both in vivo Mutagenicity and Carcinogenicity Dose-Response Data.

Models as Much Needed Tools in Ecotoxicology: Integrative Approaches to Cross Barriers.

Commentaries

Effects of as-if risk framing of hazards on risk perception and its rebuttal.

Air pollution and trajectory of cardiometabolic multimorbidity.

A GeoHealth Call to Action: Moving Beyond Identifying Environmental Injustices to Co-Creating Solutions.

Reviews

Numerous Chemicals/Mixtures

Developmental toxicant exposures and sex-specific effects on epigenetic programming and cardiovascular health across generations. [lead, phthalates, PFAS]

Environmental toxicants, brown adipose tissue, and potential links to obesity and metabolic disease.

Public health implications of endocrine disrupting chemicals in drinking water and aquatic food resources in Nigeria: A state-of-the-science review.

Assessing the role of the gut microbiome at the interface between environmental chemical exposures and human health: Current knowledge and challenges

[Mechanisms of Cancer Malignancy Elicited by Environmental Chemicals: Analysis Focusing on Cadmium and Bisphenol A]. [in Japanese]

BPA/Phenols

Bisphenol A exposure links to exacerbation of memory and cognitive impairment: A systematic review of the literature.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of dioxins on animal spermatogenesis: A state-of-the-art review.

Transfer of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans (PCDD/Fs) and Polychlorinated Biphenyls (PCBs) from Oral Exposure into Cow’s Milk – Part II: Toxicokinetic Predictive Models for Risk Assessment.

Perfluoroalkyl Substances

The effects of perfluoroalkyl and polyfluoroalkyl substances on female fertility: A systematic review and meta-analysis.

Flame Retardants

A review on organophosphate esters: Physiochemical properties, applications, and toxicities as well as occurrence and human exposure in dust environment.

Pesticides

Neurotoxicity evoked by organophosphates and available countermeasures.

A narrative review of converging evidence addressing developmental toxicity of pyrethroid insecticides.

Microplastics/Nanomaterials

Transgenerational impacts of micro(nano)plastics in the aquatic and terrestrial environment.

Plastic wastes in the time of COVID-19: Their environmental hazards and implications for sustainable energy resilience and circular bio-economies.

Toxicity of nanoplastics to aquatic organisms: Genotoxicity, cytotoxicity, individual level and beyond individual level.

Potential risk of microplastics in processed foods: Preliminary risk assessment concerning polymer types, abundance, and human exposure of microplastics.

Ecotoxicological perspectives of microplastic pollution in amphibians.

Air Pollution

A comparison of fine particulate matter (PM_2.5) in vivo exposure studies incorporating chemical analysis.

Miscellaneous

Perchlorate, nitrate, and thiocyanate: Environmental relevant NIS-inhibitors pollutants and their impact on thyroid function and human health.

Assessment of Environmental Impacts on Health: Examples from the Pacific Basin.

Human Health Studies

Phenols/Phthalates/Parabens

Phenol and Phthalate Effects on Thyroid Hormone Levels during Pregnancy: Relying on In Vitro Assays and Adverse Outcome Pathways to Inform an Epidemiological Analysis. [see related Invited Perspective: Inroads to Biology-Informed Exposomics.]

A case-control study of urinary concentrations of bisphenol A, bisphenol F, and bisphenol S and the risk of papillary thyroid cancer.

Associations between mixed urinary phenols and parabens metabolites and bone mineral density: Four statistical models.

Combined effects of prenatal phthalate exposure on cardiometabolic risk score among 4- to 7-year-old children: MABC study.

Phthalate exposure is associated with more rapid body fat gain in midlife women: The Study of Women’s Health Across the Nation (SWAN) Multi-Pollutant Study.

Urinary phenol concentrations and fecundability and early pregnancy loss.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Impact of mixtures of persistent organic pollutants on breast cancer aggressiveness.

Perfluoroalkyl Substances

Exposure to per- and polyfluoroalkyl substances and glycemic control in older US adults with type 2 diabetes mellitus.

Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies.

Association between exposure to perfluoroalkyl substances and uric acid in Chinese adults.

Flame Retardants

Associations of gestational exposure to organophosphate esters with gestational age and neonatal anthropometric measures: The HOME study.

Environmental exposure to organophosphate esters and suspected non-alcoholic fatty liver disease among US adults: A mixture analysis.

Handwipes as indicators to assess organophosphate flame retardants exposure and thyroid hormone effects in e-waste dismantlers.

Associations between exposure to brominated flame retardants and metabolic syndrome and its components in U.S. adults.

Metals/Metalloids

Lead exposure is non-linearly associated with subclinical myocardial injury in the general population without cardiovascular disease.

Significance of the prime factors regulating arsenic toxicity and associated health risk: a hypothesis-based investigation in a critically exposed population of West Bengal, India.

Chelation trial in patients with cardiovascular disease.

Environmental uranium exposures and cytokine profiles among mother-newborn baby pairs from the Navajo Βirth Cohort Study.

Prepregnancy exposure to dietary arsenic and congenital heart defects.

Development of an interpretable machine learning model associated with heavy metals’ exposure to identify coronary heart disease among US adults via SHAP: Findings of the US NHANES from 2003 to 2018.

Serum lead, mercury, manganese, and copper and DNA methylation age among adults in Detroit, Michigan.

Interactions between heavy metals and sleep duration among pre-and postmenopausal women: A current approach to molecular mechanisms involved.

Air Pollution

Effects of prenatal exposure to PM_2.5 and its composition on cognitive and motor functions in children at 12 months of age: The Shanghai Birth Cohort Study.

Association of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort study.

Association between long-term air pollution exposure and insulin resistance independent of abdominal adiposity in Korean adults.

Air pollution, road traffic noise and lack of greenness and risk of type 2 diabetes: A multi-exposure prospective study covering Denmark.

Ambient fine particulate matter exposures and oxidative protein damage in early pregnant women.

Laboratory Studies

Numerous Chemicals/Mixtures

Nitro-Oxidative Stress and Mitochondrial Dysfunction in Human Cell Lines Exposed to the Environmental Contaminants PFOA and BPA.

Toxicity assessment of SARS-CoV-2-derived peptides in combination with a mix of pollutants on zebrafish adults: A perspective study of behavioral, biometric, mutagenic, and biochemical toxicity.

BPA/Phenols

BPA exposure in L6 myotubes increased basal glucose metabolism in an estrogen receptor-dependent manner but induced insulin resistance.

In vivo hypoglycemic effects of bisphenol F exposure in high-fat diet mice.

Exploring oxidative stress and endothelial dysfunction as a mechanism linking bisphenol S exposure to vascular disease in human umbilical vein endothelial cells and a mouse model of postnatal exposure.

Bisphenol A Exposure Modulates Reproductive and Endocrine System, Mitochondrial Function and Cellular Senescence in Female Adult Rats: A Hallmarks of Polycystic Ovarian Syndrome Phenotype.

Abnormal histone replacement following BPA exposure affects spermatogenesis and fertility sequentially.

Bisphenol A alters sexual dimorphism and gene expression in marine medaka Oryzias melastigma.

Bisphenol AF induces multiple behavioral and biochemical changes in zebrafish (Danio rerio) at different life stages.

Phthalates

Integrated bioinformatic analysis to understand the association between phthalate exposure and breast cancer progression.

Role of estrogen receptors in thyroid toxicity induced by mono (2-ethylhexyl) phthalate via endoplasmic reticulum stress: An in vitro mechanistic investigation.

Identification of Glucocorticoid Receptor Antagonistic Activities and Responsible Compounds in House Dust: Bioaccessibility Should Not Be Ignored.

Parabens/Triclosan/Antimicrobials

Environmentally relevant concentrations of Triclosan cause transcriptomic and biomolecular alterations in the hatchlings of Labeo rohita.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic mice.

Polychlorinated biphenyls alter hepatic m6A mRNA methylation in a mouse model of environmental liver disease.

Perfluoroalkyl Substances

Metabolomic, Lipidomic, Transcriptomic, and Metagenomic Analyses in Mice Exposed to PFOS and Fed Soluble and Insoluble Dietary Fibers. [also see related Invited Perspective: PFOS-Pick Fiber, Oust Sulfonate.]

Perfluorooctane sulfonate exposure induces preeclampsia-like syndromes by damaging trophoblast mitochondria in pregnant mice.

Perfluoroalkyl substances (PFASs) decrease the expression of recombination-activating genes (RAG1 and RAG2) in human B lymphoma Namalwa cells.

PFOA exposure causes variations of Acot1 among tissues in rats, and Acot1 in serum can be potentially used as a sensitive marker for health monitoring.

Genotoxicity assessment of per- and polyfluoroalkyl substances mixtures in human liver cells (HepG2).

Controlled uptake of PFOA in adult specimens of Paracentrotus lividus and evaluation of gene expression in their gonads and embryos.

Sub-lethal Exposure of Per- and Polyfluoroalkyl Substances (PFAS) of Varying Chain Length and Polar Functionality Results in Distinct Metabolic Responses in Daphnia magna.

Unraveling the joint toxicity of transition-metal dichalcogenides and per- and polyfluoroalkyl substances in aqueous mediums by experimentation, machine learning and molecular dynamics.

Flame Retardants

Aryl-, halogenated- and alkyl- organophosphate esters induced oxidative stress, endoplasmic reticulum stress and NLRP3 inflammasome activation in HepG2 cells.

Pesticides

Suspect screening strategy for Pesticide application history based on characteristics of trace metabolites.

Quantitative elucidation of the transfer of the neonicotinoid pesticide clothianidin to the breast milk in mice.

Dietary pattern interfered with the impacts of pesticide exposure by regulating the bioavailability and gut microbiota.

Malathion exposure during juvenile and peripubertal periods downregulate androgen receptor and 17-ß-HSD testicular gene expression and compromised sperm quality in rats.

Intermittent exposure to chlorpyrifos results in cardiac hypertrophy and oxidative stress in rats.

Widening the Lens on Prothioconazole and Its Metabolite Prothioconazole-Desthio: Aryl Hydrocarbon Receptor-Mediated Reproductive Disorders through in Vivo, in Vitro, and in Silico Studies.

Chlorphoxim induces neurotoxicity in zebrafish embryo through activation of oxidative stress.

Organophosphate insecticides disturb neuronal network development and function via non-AChE mediated mechanisms.

Vitamin B12 alleviates malathion-induced toxicity in zebra fish by regulating cytochrome P450 and PgP expressions.

Metals/Metalloids

Oxidative Stress Induced by 30 Days of Mercury Exposure Accelerates Hypertension Development in Prehypertensive Young SHRs.

ROS and ERK Pathway Mechanistic Approach on Hepatic Insulin Resistance After Chronic Oral Exposure to Cadmium NOAEL Dose.

Microplastics/Nanomaterials

Adverse effects of polystyrene nanoplastic and its binary mixtures with nonylphenol on zebrafish nervous system: From oxidative stress to impaired neurotransmitter system.

In vitro toxicity assessment of polyethylene terephthalate and polyvinyl chloride microplastics using three cell lines from rainbow trout (Oncorhynchus mykiss).

Dose-effect of polystyrene microplastics on digestive toxicity in chickens (Gallus gallus): Multi-omics reveals critical role of gut-liver axis.

Molecular effects of polystyrene nanoplastics toxicity in zebrafish embryos (Daniorerio).

Assessing the size-dependent effects of microplastics on zebrafish larvae through fish lateral line system and gut damage.

Polystyrene microparticles can affect the health status of freshwater fish – Threat of oral microplastics intake.

Pharmaceuticals/Personal Care Products

Multiple tissue-specific epigenetic alterations regulate persistent gene expression changes following developmental DES exposure in mouse reproductive tissues.

Antibiotics disrupt lipid metabolism in zebrafish (Danio rerio) larvae and 3T3-L1 preadipocytes.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Endocrine disrupting chemicals entering European rivers: Occurrence and adverse mixture effects in treated wastewater.

Petroleum refinery effluent contribution to chemical mixture toxic pressure in the environment.

Brominated flame retardants (PBDEs and HBCDs) and perfluoroalkyl substances (PFASs) in wild boars (Sus scrofa) from Central Italy.

Parabens/Triclosan/Antimicrobials

Infant exposure to parabens, triclosan, and triclocarban via breastfeeding and formula supplementing in southern China.

Ecological Risk Analysis for Benzalkonium Chloride, Benzethonium Chloride, and Chloroxylenol in US Disinfecting and Sanitizing Products.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The accumulation of organic contaminants in hair with different biological characteristics.

Polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) soil contamination in Lausanne, Switzerland: Combining pollution mapping and human exposure assessment for targeted risk management.

Polychlorinated biphenyls (PCB) and polychlorinated dibenzo-para-dioxins and dibenzofurans (PCDD/F) in ambient air and deposition in the German background.

A global review of the temporal and spatial patterns of DDT and dieldrin monitoring in raptors.

Influence of Life-History Parameters on Persistent Organic Pollutant Concentrations in Blubber of Eastern North Pacific Gray Whales (Eschrichtius robustus).

Perfluoroalkyl Substances

PFAS levels and determinants of variability in exposure in European teenagers – Results from the HBM4EU aligned studies (2014-2021).

Nontarget Identification of Novel Per- and Polyfluoroalkyl Substances in Cord Blood Samples.

Organic Fluorine as an Indicator of Per- and Polyfluoroalkyl Substances in Dust from Buildings with Healthier versus Conventional Materials.

Legacy and emerging airborne per- and polyfluoroalkyl substances (PFAS) collected on PM_2.5 filters in close proximity to a fluoropolymer manufacturing facility.

Non-targeted identification and semi-quantitation of emerging per- and polyfluoroalkyl substances (PFAS) in US rainwater.

PFAS accumulation in several terrestrial plant and invertebrate species reveals species-specific differences.

Flame Retardants

Partitioning behavior-oriented health risk assessment on internal organophosphorus flame retardants exposure.

Organotins

First assessment of butyltins (BuTs) contamination of the Montenegrin coast (Southeast Adriatic): Tributyltin (TBT) poses a threat to the marine ecosystem.

Pesticides

Wild bees are exposed to low levels of pesticides in urban grasslands and community gardens.

Plant growers’ environmental consciousness may not be enough to mitigate pollinator declines: a questionnaire-based case study in Hungary.

Field evaluation of spray drift and non-targeted soybean injury from unmanned aerial spraying system (UASS) herbicide application under acceptable operation conditions.

Metals/Metalloids

Estimation of blood and urine levels of eight metals and essential trace elements collected from living Subjects compared to urine, cardiac and femoral postmortem blood, and other postmortem samples: A forensic toxicology study.

Heavy metals in children’s blood from the rural region of Popokabaka, Democratic Republic of Congo: a cross-sectional study and spatial analysis.

130 years of heavy metal pollution archived in the shell of the intertidal dog whelk, Nucella lapillus (Gastropoda, Muricidae).

Microplastics/Nanomaterials

Microplastic in northern anchovies (Engraulis mordax) and common murres (Uria aalge) from the Monterey Bay, California USA – Insights into prevalence, composition, and estrogenic activity.

Pharmaceuticals/Personal Care Products

Chemicals of concern in personal care products used by women of color in three communities of California.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.