EDC Science Weekly, Sept. 8 – 14, 2022 – HEEDS

EDC Science Weekly, Sept. 8 – 14, 2022

Post author:HEEDS
Post published:September 14, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Methods/Tools/Screening

Development of an Evidence-Based Risk Assessment Framework.

Use of Human iPSC-CMs in Nonclinical Regulatory Studies for Cardiac Safety Assessment.

Characterization of primary canine Sertoli cells as a model to test male reproductive toxicant.

Commentaries

Environmental justice: What’s racism got to do with it?

Fossil fuel is the common denominator between climate change and petrochemical exposures, and effects on women and children’s health.

Robust risk assessments require probabilistic approaches.

Bisphenol A, T_H17 cells, and allergy: a commentary.

Reviews

Numerous Chemicals/Mixtures

Maternal Supplementation of Probiotics, Prebiotics or Postbiotics to Prevent Offspring Metabolic Syndrome: The Gap between Preclinical Results and Clinical Translation.

Metabolomics for exposure assessment and toxicity effects of occupational pollutants: current status and future perspectives.

Endocrine-Disrupting Chemicals Exposure Alter Neuroendocrine Factors, Disrupt Cardiac Functions and Provokes Hypoxia Conditions in Zebrafish Model.

Systematic review and meta-analysis of cancer risks in relation to environmental waste incinerator emissions: meta-analysis of case-control and cohort studies.

Environmental contamination status with common ingredients of household and personal care products exhibiting endocrine-disrupting potential.

BPA/Phenols

Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use.

Phthalates

Connexin-43 is a promising target for lycopene preventing phthalate-induced spermatogenic disorders.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A bibliometric analysis of pre- and post-Stockholm Convention research publications on the Dirty Dozen Chemicals (DDCs) in the African environment.

Pesticides

Pesticides and pancreatic adenocarcinoma: A transversal epidemiological, environmental and mechanistic narrative review.

Pesticide exposure and child growth in low- and middle-income countries: A systematic review.

Metals/Metalloids

The Duality of Arsenic Metabolism: Impact on Human Health.

Microplastics/Nanomaterials

From natural environment to animal tissues: A review of microplastics(nanoplastics) translocation and hazards studies.

Miscellaneous

The Role of Epigenetics in Multi-generational Transmission of Asthma: an NIAID Workshop Report-based narrative review.

Human Health Studies

Numerous Chemicals/Mixtures

Associations between internal concentrations of fluorinated and organochlorinated chemicals in women and in vitro fertilization outcomes: A multi-pollutant study.

Molecular Alterations and Severe Abnormalities in Spermatozoa of Young Men Living in the “Valley of Sacco River” (Latium, Italy): A Preliminary Study.

Is residential proximity to polluted sites during pregnancy associated with preterm birth or low birth weight? Results from an integrated exposure database in North Carolina (2003-2015).

BPA/Phenols

Association of serum BPA levels with changes in lipid levels and dyslipidemia risk in middle-aged and elderly Chinese.

Phthalates

Association between phthalate exposure and accelerated bone maturation in Chinese girls with early puberty onset: a propensity score-matched case-control analysis.

Prenatal single and combined exposure to phthalates associated with girls’ BMI trajectory in the first six years.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

National temporal trend for organophosphate pesticide DDT exposure and associations with chronic kidney disease using age-adapted eGFR model.

Perfluoroalkyl Substances

Associations of perfluoroalkyl and polyfluoroalkyl substances with gestational hypertension and blood pressure during pregnancy: A cohort study.

Drinking Water-Associated PFAS and Fluoroethers and Lipid Outcomes in the GenX Exposure Study.

Flame Retardants

Exposure assessment of aryl-organophosphate esters based on specific urinary biomarkers and their associations with reproductive hormone homeostasis disruption in women of childbearing age.

Prenatal exposure to polybrominated diphenyl ethers and BMI Z-scores from 5 to 14 years.

Comprehensive analysis of triphenyl phosphate: An environmental explanation of colorectal cancer progression.

Pesticides

Simultaneous exposure to both Zika virus and household insecticides during pregnancy, and fetal growth and infant developmental behavior outcomes at 18 months, in Guadeloupe.

Assessment of Mancozeb Exposure, Absorbed Dose, and Oxidative Damage in Greenhouse Farmers.

Organic food consumption and fecundability in a preconception cohort study of Danish couples trying to conceive.

Exposure of patients with chronic kidney disease on dialysis to pesticides.

Metals/Metalloids

Exploring the relationship between blood toxic metal(oid)s and serum insulin levels through benchmark modelling of human data: Possible role of arsenic as a metabolic disruptor.

Maternal exposure to metal mixtures during early pregnancy and fetal growth in the Jiangsu Birth Cohort, China.

Down-regulation of RdRp complex and activated immune response due to increased arsenic level leads to decreased corona virus replication.

Arsenic exposure and respiratory outcomes during childhood in the INMA study.

Docosahexaenoic Acid Effect on Prenatal Exposure to Arsenic and Atopic Dermatitis in Mexican Preschoolers.

The First Exposure Assessment of Mercury Levels in Hair among Pregnant Women and Its Effects on Birth Weight and Length in Semarang, Central Java, Indonesia.

Air Pollution

Fetal Exposure to Air Pollution in Late Pregnancy Significantly Increases ADHD-Risk Behavior in Early Childhood.

Pharmaceuticals/Personal Care Products

The mediating function of obesity on endocrine-disrupting chemicals and insulin resistance in children. [benzophenone-3]

Laboratory Studies

Numerous Chemicals/Mixtures

Endocrine disrupting chemicals interfere with decidualization of human primary endometrial stromal cells in vitro.

Assessment of health risk and dose-effect of DNA oxidative damage for the thirty chemicals mixture of parabens, triclosan, benzophenones, and phthalate esters.

Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae.

BDE-209 and TCDD enhance metastatic characteristics of melanoma cells after chronic exposure.

BPA/Phenols

Effect of bisphenol S on testicular tissue after low-dose nursing exposure.

Effects of low-dose bisphenol AF on mammal testis development via complex mechanisms: alterations are detectable in both infancy and adulthood.

Experimental Exposure to Bisphenol A Has Minimal Effects on Bone Tissue in Growing Rams-A Preliminary Study.

Zinc Deficiency Exacerbates Bisphenol A-Induced Hepatic and Renal Damage: Delineation of Molecular Mechanisms.

Azanza garckeana ameliorates Bisphenol A-induced reproductive toxicities in rabbit bucks.

Nonylphenol Promoted Epithelial-Mesenchymal Transition in Colorectal Cancer Cells by Upregulating the Expression of Regulator of Cell Cycle.

Phthalates

Phthalate promotes atherosclerosis through interacting with long-non coding RNA and induces macrophage foam cell formation and vascular smooth muscle damage.

Dibutyl phthalate promotes angiogenesis in EA.hy926 cells through estrogen receptor-dependent activation of ERK1/2, PI3K-Akt, and NO signaling pathways.

[Diethylhexyl phthalate induces anxiety-like behavior and learning and memory impairment in mice probably by damaging blood-brain barrier]. [in Chinese]

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Transcriptomics provides insights into toxicological effects and molecular mechanisms associated with the exposure of Chinese mitten crab, Eriocheir sinensis, to dioxin.

Perfluoroalkyl Substances

Investigating the cytotoxicity of per- and polyfluoroalkyl substances in HepG2 cells: a Structure-Activity Relationship approach.

Physiological and transcriptomic effects of hexafluoropropylene oxide dimer acid in Caenorhabditis elegans during development.

Chronic aquatic toxicity of perfluorooctane sulfonic acid (PFOS) to Ceriodaphnia dubia, Chironomus dilutus, Danio rerio, and Hyalella azteca.

Flame Retardants

Organophosphorus flame retardant TDCPP induces neurotoxicity via mitophagy-related ferroptosis in vivo and in vitro.

Exposure to tris(1,3-dichloro-2-propyl) phosphate for two generations aggravates the adverse effects on survival and growth of zebrafish at environmentally relevant concentrations.

Sex-dependent effect of triphenyl phosphate on hepatic energy metabolism at the intersection of diet pattern in pubertal mice.

Triphenyl phosphate disturbs placental tryptophan metabolism and induces neurobehavior abnormal in male offspring.

Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters.

Biphasic effects of typical chlorinated organophosphorus flame retardants on Microcystis aeruginosa.

Organotins

Perinatal exposure to tributyltin affects feeding behavior and expression of hypothalamic neuropeptide Y in the paraventricular nucleus of adult mice.

Pesticides

Persistent and transgenerational effects of pesticide residues in zebrafish.

Exposure to the environmentally toxic pesticide maneb induces Parkinson’s disease-like neurotoxicity in mice: A combined proteomic and metabolomic analysis.

The Mechanistic Basis for the Toxicity Difference Between Juvenile Rats and Mice following Exposure to the Agricultural Insecticide Chlorpyrifos.

Unravelling the Polytoxicology of Chlorfenapyr on Non-Target HepG2 Cells: The Involvement of Mitochondria-Mediated Programmed Cell Death and DNA Damage.

Early-Stage High-Concentration Thiacloprid Exposure Induced Persistent Behavioral Alterations in Zebrafish.

Azole-Induced Color Vision Deficiency Associated with Thyroid Hormone Signaling: An Integrated In Vivo, In Vitro, and In Silico Study.

Influence of co-exposure to sulfamethazine on the toxicity and bioaccumulation kinetics of chlorpyrifos in zebrafish (Danio rerio).

Melatonin ameliorates renal dysfunction in glyphosate- and hard water-treated mice.

Chronic atrazine exposure increases the expression of genes associated with GABAergic and glutamatergic systems in the brain of male albino rat.

Exploring the binding mechanism and adverse toxic effects of chiral phenothrin to human serum albumin: Based on multi-spectroscopy, biochemical and computational approach.

Metals/Metalloids

Glycine protects the male reproductive system against lead toxicity via alleviating oxidative stress, preventing sperm mitochondrial impairment, improving kinematics of sperm, and blunting the downregulation of enzymes involved in the steroidogenesis.

Betaine protects against sodium arsenite-induced diabetes and hepatotoxicity in mice.

Arsenic exposure diminishes ovarian follicular reserve and induces abnormal steroidogenesis by DNA methylation.

Arsenic Activates the NLRP3 Inflammasome and Disturbs the Th1/Th2/Th17/Treg Balance in the Hippocampus in Mice.

Maternal cadmium exposure impairs placental angiogenesis in preeclampsia through disturbing thyroid hormone receptor signaling.

Mitochondrial disruption in isolated human monocytes: an underlying mechanism for cadmium-induced immunotoxicity.

Microplastics/Nanomaterials

Combined effect of polystyrene microplastics and bisphenol A on the human embryonic stem cells-derived liver organoids: The hepatotoxicity and lipid accumulation.

Modulation of acdysteroid and juvenile hormone signaling pathways by bisphenol analogues and polystyrene beads in the brackish water flea Diaphanosoma celebensis.

Intestinal permeability and gene expression after polyethylene and polyamide microplastic ingestion in Wistar rats.

Toxic effects of polystyrene microplastics exposed on the intestine of Amphioctopus fangsiao (Mollusca: Cephalopoda): From physiological responses to underlying molecular mechanisms.

Alterations of gut and oral microbiota in the individuals consuming take-away food in disposable plastic containers.

A comparative study in healthy and diabetic mice followed the exposure of polystyrene microplastics: Differential lipid metabolism and inflammation reaction.

Alteration in Wnt signaling mediates induction of transgenerational toxicity of polystyrene nanoplastics in C. elegans.

Polystyrene microplastic particles in combination with pesticides and antiviral drugs: Toxicity and genotoxicity in Ceriodaphnia dubia.

Pharmaceuticals/Personal Care Products

Multimarker Responses of Zebrafish to the Effect of Ibuprofen and Gemfibrozil in Environmentally Relevant Concentrations.

Sunscreen Ingredient Octocrylene’s Potency to Disrupt Vitamin D Synthesis.

Miscellaneous

Embryonic exposure to benzo[a]pyrene causes age-dependent behavioral alterations and long-term metabolic dysfunction in zebrafish.

Developmental trichloroethylene exposure enhances predictive markers of autoimmunity in a sex-specific manner in disease-resistant female mice.

Are Green Household Consumer Products Less Toxic than Conventional Products? An Assessment Involving Grass Shrimp (Palaemon pugio) and Daphnia magna.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Simultaneous determination of 31 endocrine disrupting chemicals in fish plasma by solid phase extraction coupled with ultraperformance liquid chromatography-tandem mass spectrometry.

BPA/Phenols

Elimination of endocrine disrupting phenolic compounds via feathers and claws in seabirds moulting in the Baltic and Russian Arctic.

Phthalates

Transfer of Frictional Contact Derived Phthalates from Pad Surface Enhances Dermal Exposure.

Occurrences and potential lipid-disrupting effects of phthalate metabolites in humpback dolphins from the South China Sea.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Using food waste to cultivate safe, good-quality Sabah (giant hybrid) grouper: Dioxins and dioxin-like polychlorinated biphenyls.

Transfer of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans (PCDD/Fs) and Polychlorinated Biphenyls (PCBs) from Oral Exposure into Cow’s Milk – Part I: State of Knowledge and Uncertainties.

Contamination of food crops by unintentionally released PCB 47, PCB 51 and PCB 68 in the vicinity of silicone production sites and their relevance for human health assessment.

Levels of non-dioxin-like PCBs (NDL-PCBs) in liver of loggerhead turtles (Caretta caretta) from the Tyrrhenian Sea (Southern Italy).

Perfluoroalkyl Substances

Home-produced eggs: An important human exposure pathway of perfluoroalkylated substances (PFAS).

Survey of per- and polyfluoroalkyl substances (PFAS) in surface water collected in Pensacola, FL.

Pollutant source or sink? Adsorption and mobilization of PFOS and PFOA from sediments in a large shallow lake with extended reed belt.

Spatiotemporal patterns of PFAS in water and crop tissue at a beneficial wastewater reuse site in central Pennsylvania.

[Comparison of Health Risk from Sources of Perfluoroalkyl Substances in Taihu Lake for Different Years]. [in Chinese]

[Pollution Characteristics and Source Apportionment of Typical and Emerging Per- and Polyfluoroalkylated Substances in Tuojiang River Basin]. [Chinese]

Flame Retardants

Potential Health Risk to Brazilian Infants by Polybrominated Diphenyl Ethers Exposure via Breast Milk Intake.

Physiologically based pharmacokinetic (PBPK) modeling of BDE-209 following oral exposure in Chinese population.

Biotransformation of Dec-604 and potential effect on thyroid deiodinase activity in highly flame retardant-exposed gulls.

Pesticides

Determinants of organophosphorus pesticide urinary metabolite levels in pregnant women from the CHAMACOS cohort.

Effects of a Neonicotinoid Insecticide and Population Density on Behavior and Development of Wood Frogs (Rana sylvatica).

Metals/Metalloids

Environmental impact and health risk assessment of potentially toxic metals emanating from different anthropogenic activities related to E-wastes.

Whiskers provide time-series of toxic and essential trace elements, Se:Hg molar ratios, and stable isotope values of an apex Antarctic predator, the leopard seal.

Avian influenza antibody prevalence increases with mercury contamination in wild waterfowl.

Targeted Private Well Outreach Following a Change in Drinking Water Standard: Arsenic and the New Jersey Private Well Testing Act.

Microplastics/Nanomaterials

Release of microplastics from disposable cups in daily use.

Microplastic contamination in processed and unprocessed sea salts from a South Asian country and potential risk assessment.

Can microplastics in offshore waters reflect plastic emissions from coastal regions?

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."
Pesticide use linked to increased prostate cancer risk
by EHN Curators on November 18, 2024 at 11:22 am
A study finds 22 pesticides associated with prostate cancer risk in the U.S., with four also tied to higher death rates. Andrea Tamayo reports for Science News.
PFAS levels increase throughout pregnancy, study finds
by Katherine McMahon,Sarah Howard on November 15, 2024 at 9:32 pm
A recent study published in Environmental Health Perspectives examines trends in PFAS exposure in pregnant Black women and their newborns in Atlanta. “Investigating the changes in PFAS exposure levels throughout pregnancy… is crucial for identifying critical exposure periods and guiding public health policies to reduce PFAS exposure.”

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.