EDC Science Weekly, Aug. 18 – 24, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Check out the new July/August issue of HEEDS News for a bunch of upcoming events.

Regulations/Policy

Toxic Substances Control Act (TSCA) Implementation: How the Amended Law Has Failed to Protect Vulnerable Populations from Toxic Chemicals in the United States [also see PRHE’s related blog, EPA’s failure to properly implement TSCA puts lives at risk]

The need for environmental regulation of tires: Challenges and recommendations.

Methods/Tools/Screening

Identification of nonmonotonic concentration-responses in Tox21 high-throughput screening estrogen receptor assays.

A framework for establishing scientific confidence in new approach methodologies.

Bayesian inference of chemical exposures from NHANES urine biomonitoring data.

Zeitotox: Toxicology and the Rhythms of Life.

Amphibian toxicity testing for identification of thyroid disrupting chemicals.

A novel procedure for predicting chronic toxicities and ecological risks of perfluorinated compounds in aquatic environment.

Framework for developing an exposure science curriculum as part of the European Exposure Science Strategy 2020-2030.

Commentaries

Taking the “F” out of forever chemicals [Perspective in Science], How to destroy ‘forever chemicals’: cheap method breaks down PFAS [News item in Nature], and Terry Collins: PFAS removal discovery not yet a ‘powerful solution’ [EHN], re the article, Low-temperature mineralization of perfluorocarboxylic acids.

Commentary: cumulative risk assessment of perfluoroalkyl carboxylic acids and perfluoralkyl sulfonic acids: what is the scientific support for deriving tolerable exposures by assembling 27 PFAS into 1 common assessment group?

Microplastics Are Found Outside in Nature and Inside the Body-but Evidence of Health Risks Is Inconclusive.

Effects of Plastics on Human Health and Mechanisms of Action.

“Potentially Toxic Element”─Something that Means Everything Means Nothing. [OK point taken, I will go back to using “Metals/Metalloids”…]

The End of the World As We Have Known It? An Introduction to Collapsology. [not really EDCs but interesting!]

Reviews

Numerous Chemicals/Mixtures

Chemical Effects on Breast Development, Function, and Cancer Risk: Existing Knowledge and New Opportunities.

Environmental health influences in pregnancy and risk of gestational diabetes mellitus: a systematic review.

Environmental Medicine: Exploring the Pollutome for Solutions to Chronic Diseases.

Review of ecologically relevant in vitro bioassays to supplement current in vivo tests for whole effluent toxicity testing – Part 2: Non-apical endpoints.

Combined toxicity of food-borne mycotoxins and heavy metals or pesticides.

Protective activities of ellagic acid and urolithins against kidney toxicity of environmental pollutants: A review.

Elements That Influence the Development of Attention Deficit Hyperactivity Disorder (ADHD) in Children.

[Human Biomonitoring for Europe (HBM4EU)-first insights into the results of the initiative]. [in German]

Perfluoroalkyl Substances

Exposure to per- and polyfluoroalkyl substances (PFAS) and type 2 diabetes risk.

Flame Retardants

A systematic scoping review of epidemiological studies on the association between organophosphate flame retardants and neurotoxicity.

Pesticides

Curcumin Combats Against Organophosphate Pesticides Toxicity: A Review of the Current Evidence and Molecular Pathways.

Metals/Metalloids

Perinatal Metal and Metalloid Exposures and Offspring Cardiovascular Health Risk.

A systematic review of adverse health effects associated with oral cadmium exposure.

Neurotoxicity and the Global Worst Pollutants: Astroglial Involvement in Arsenic, Lead, and Mercury Intoxication.

Environmental Metal Exposure, Neurodevelopment, and the Role of Iron Status: a Review.

Microplastics/Nanomaterials

Environmental impacts of post-consumer plastic wastes: Treatment technologies towards eco-sustainability and circular economy.

A review of potential human health impacts of micro- and nanoplastics exposure.

Analytical and toxicological aspects of nanomaterials in different product groups: Challenges and opportunities.

Air Pollution

Birth Outcomes, Health, and Health Care Needs of Childbearing Women following Wildfire Disasters: An Integrative, State-of-the-Science Review. [see related Invited Perspective: What Do We Know about Fetal-Maternal Health and Health Care Needs after Wildfires? Not Nearly Enough.]

Pharmaceuticals/Personal Care Products

Occurrence, transformation, bioaccumulation, risk and analysis of pharmaceutical and personal care products from wastewater: a review.

Human Health Studies

Numerous Chemicals/Mixtures

Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case-Control Study in Pennsylvania, 2009-2017.

Impact of chronic exposure to legacy environmental contaminants on the corpus callosum microstructure: A diffusion MRI study of Inuit adolescents.

Phthalates

Endogenous sex hormones homeostasis disruption combined with exogenous phthalates exposure increase the risks of childhood high blood pressure: A cohort study in China.

Urinary phthalate metabolites and their mixtures are associated with advanced sperm epigenetic aging in a general population.

Parabens/Triclosan/Antimicrobials

Urinary parabens and breast cancer risk: Modification by LINE-1 and LUMA global DNA methylation, and associations with breast cancer defined by tumor promoter methylation status.

Perfluoroalkyl Substances

Associations between PFAS occurrence and multimorbidity as observed in an electronic health record cohort.

Associations of single and multiple perfluoroalkyl substances exposure with folate among adolescents in NHANES 2007-2010.

Metals/Metalloids

Association between exposure to cadmium and risk of all-cause and cause-specific mortality in the general US adults: A prospective cohort study.

Identification for heavy metals exposure on osteoarthritis among aging people and Machine learning for prediction: A study based on NHANES 2011-2020.

Exposure to multiple metals and diabetes mellitus risk in dong ethnicity in China: from the China multi-ethnic cohort study.

Association of blood mercury exposure with depressive symptoms in the Chinese oldest old.

Machine learning model for depression based on heavy metals among aging people: A study with National Health and Nutrition Examination Survey 2017-2018.

Contribution of gut bacteria to arsenic metabolism in the first year of life in a prospective birth cohort.

Air Pollution

Integrated single-cell RNA-seq and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion.

Laboratory Studies

BPA/Phenols

The Effect of bisphenol A and Photobiomodulation Therapy on Autophagy-Related Genes Induction in Adipose Tissue-Derived Stem Cells.

Fluorene-9-bisphenol regulates steroidogenic hormone synthesis in H295R cells through the AC/cAMP/PKA signaling pathway.

Endocrine-disrupting potential and toxicological effect of para-phenylphenol on Daphnia magna.

Parabens/Triclosan/Antimicrobials

GC-MS and HPLC supported phytochemical analysis of watercress and the protective role against paraben toxicity.

Perfluoroalkyl Substances

Enhanced toxicity effects of iron particles together with PFOA in drinking water.

Toxicity of perfluoroalkyl substances (PFAS) toward embryonic stages of mahi-mahi (Coryphaena hippurus).

The human fecal microbiome contributes to the biotransformation of the PFAS surfactant 8:2 monosubstituted polyfluoroalkyl phosphate ester.

PFOS promotes hepatic lipid accumulation and steatosis in high-fat diet mice through AMPK/ACC pathway.

Chronic toxicity of PFAS-free AFFF alternatives in terrestrial plant Brassica rapa.

Flame Retardants

Decabromodiphenyl ethane induces locomotion neurotoxicity and potential Alzheimer’s disease risks through intensifying amyloid-beta deposition by inhibiting transthyretin/transthyretin-like proteins.

Organotins

The organotin triphenyltin disrupts cholesterol signaling in mammalian ovarian steroidogenic cells through a combination of LXR and RXR modulation.

Pesticides

The impact of temperature on insecticide sensitivity depends on transgenerational effects.

Alternation between toxic and proliferative effects of Roundup® on human thyroid cells at different concentrations.

Roundup and glyphosate’s impact on GABA to elicit extended proconvulsant behavior in Caenorhabditis elegans.

Feeding on grains containing pesticide residues is detrimental to offspring development through parental effects in grey partridge.

The stress effect of atrazine on the inducible defense traits of Daphnia pulex in response to fish predation risk: Evidences from morphology, life history traits, and expression of the defense-related genes.

Metals/Metalloids

Prepubertal exposure to Pb alters autophagy in the brain of aging mice: a time-series based model.

The role of exposure window and dose in determining lead toxicity in developing Zebrafish.

Effects of Lead and Cadmium Combined Heavy Metals on Liver Function and Lipid Metabolism in Mice.

Quantitative Assessment of Arsenite-Induced Perturbation of Ubiquitinated Proteome.

Arsenic Induces GSK3β-dependent p-tau, neuronal apoptosis and cognitive impairment via an interdependent hippocampal ERα and IL-1/IL-1R1 mechanism in female rats.

Microplastics/Nanomaterials

Co-exposure to polystyrene microplastics and lead aggravated ovarian toxicity in female mice via the PERK/eIF2α signaling pathway.

Internalization and cytotoxicity of polystyrene microplastics in human umbilical vein endothelial cells (HUVECs).

Can aged microplastics be transport vectors for organic micropollutants? – Sorption and phytotoxicity tests.

Mechanistic toxicity assessment of differently sized and charged polystyrene nanoparticles based on human placental cells.

Effects of life cycle exposure to polystyrene microplastics on medaka fish (Oryzias latipes).

Pharmaceuticals/Personal Care Products

In vitro spermiotoxicity and in vivo adults’ biochemical pattern after exposure of the Mediterranean mussel to the sunscreen avobenzone.

Miscellaneous

Estrogenic in vitro evaluation of zearalenone and its phase I and II metabolites in combination with soy isoflavones.

An amphibian high fat diet model confirms that endocrine disruptors can induce a metabolic syndrome in wild green frogs (Pelophylax spp. complex).

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Comprehensive suspect screening for the identification of contaminants of emerging concern in urine of Flemish adolescents by liquid chromatography high-resolution mass spectrometry.

Emerging Plasticizers in South China House Dust and Hand Wipes: Calling for Potential Concern?

Halocyclopentadienes: An Emerging Class of Toxic DBPs in Chlor(am)inated Drinking Water.

Hydrothermal carbonization of digested sewage sludge: The fate of heavy metals, PAHs, PCBs, dioxins and pesticides.

Heavy metal and phthalate contamination and labeling integrity in a large sample of US commercially available cannabidiol (CBD) products.

BPA/Phthalates

Unravelling sex-specific BPA toxicokinetics in children using a pediatric PBPK model.

Phthalate and bisphenol a exposures during pregnancy: Findings from the National Children’s study.

Gas-phase and PM_2.5-bound phthalates in nail salons: characteristics, exposure via inhalation, and influencing factors.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Maternal dietary patterns during pregnancy and exposure to persistent endocrine disrupting chemicals in two European birth cohorts. [includes PFAS]

Particulate PCDD/F size distribution and potential deposition in respiratory system from a hazardous waste thermal treatment process.

Influence of different kinds of incinerators on PCDD/Fs: a case study of emission and formation pathway.

National and provincial dioxin emissions from municipal solid waste incineration in China.

Perfluoroalkyl Substances

Comprehensive investigation of persistent and mobile chemicals and per- and polyfluoroalkyl substances in urine of flemish adolescents using a suspect screening approach.

Perfluoroalkane substances in national samples from global monitoring plan projects (2017-2019).

Distributions and sources of traditional and emerging per- and polyfluoroalkyl substances among multiple environmental media in the Qiantang River watershed, China.

Long-distance transport of per- and polyfluoroalkyl substances (PFAS) in a Swedish drinking water aquifer.

Enrichment of poly- and perfluoroalkyl substances (PFAS) in the surface microlayer and foam in synthetic and natural waters.

Per- and polyfluoroalkyl substances (PFAS) Exposure Through Munitions in Russia-Ukraine Conflict.

Occurrence of Perfluoroalkyl and Polyfluoroalkyl Substances in Ice Cream, Instant Noodles, and Bubble Tea.

Occurrence and distribution of per-and polyfluoroalkyl substances (PFAS) in surface and groundwaters in an urbanized and agricultural area, Southern Brazil.

Detection methods for sub-nanogram level of emerging pollutants – Per and polyfluoroalkyl substances.

Flame Retardants

Pre- and post-natal exposure of children to organophosphate flame retardants: A nationwide survey in France.

Organophosphate tri- and diesters in source water supply and drinking water treatment systems of a metropolitan city in China.

Novel brominated and organophosphate flame retardants in the atmosphere of Fildes Peninsula, West Antarctica: Continuous observations from 2011 to 2020.

Pesticides

Statewide Evaluation of the California Medical Supervision Program Using Cholinesterase Electronic Laboratory Reporting Data: An Update.

Urinary glyphosate kinetics after occupational exposure.

A large scale multi-laboratory suspect screening of pesticide metabolites in human biomonitoring: From tentative annotations to verified occurrences.

Individual-level permethrin exposure biomarkers in U.S. army soldiers: comparison of two treatment formulations for military uniforms.

Citizen science monitoring reveals links between honeybee health, pesticide exposure and seasonal availability of floral resources.

Metals/Metalloids

Blood cadmium, lead, manganese, mercury, and selenium levels in American Indian populations: The Strong Heart Study.

Rare earth elements in the upland soils of northern China: Spatial variation, relationships, and risk assessment.

Heavy metal contamination of soil, sediment and water due to galena mining in Ebonyi State Nigeria: Economic costs of pollution based on exposure health risks.

Urinary concentrations of metals before and after volcanic eruption: a natural experiment surrounding the eruption of Volcán de Fuego, 2018.

Microplastics/Nanomaterials

Exposure to microplastics in the upper respiratory tract of indoor and outdoor workers.

International quantification of microplastics in indoor dust: Prevalence, exposure and risk assessment.

Is the impact of atmospheric microplastics on human health underestimated? Uncertainty in risk assessment: A case study of urban atmosphere in Xi’an, Northwest China.

Pharmaceuticals/Personal Care Products

Analysis of the contribution of locally derived wastewater to the occurrence of Pharmaceuticals and Personal Care Products in Antarctic coastal waters.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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