EDC Science Weekly, July 28 – Aug. 3, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Outside the Safe Operating Space of a New Planetary Boundary for Per- and Polyfluoroalkyl Substances (PFAS).

Comparing Environmental Policies to Reduce Pharmaceutical Pollution and Address Disparities.

Preparing for future challenges in risk assessment in the European Union.

Methods/Tools/Screening

The PFAS-Tox Database: A systematic evidence map of health studies on 29 per- and polyfluoroalkyl substances.

Exposure modelling in Europe: how to pave the road for the future as part of the European Exposure Science Strategy 2020-2030.

An expert-driven literature review of “negative” chemicals for developmental neurotoxicity (DNT) in vitro assay evaluation.

From target analysis to suspect and non-target screening of endocrine-disrupting compounds in human urine.

Transgenic zebrafish (Danio rerio) as an emerging model system in ecotoxicology and toxicology: Historical review, recent advances, and trends.

Evaluation of rapid transepithelial electrical resistance (TEER) measurement as a metric of kidney toxicity in a high-throughput microfluidic culture system.

The SH-SY5Y human neuroblastoma cell line, a relevant in vitro cell model for investigating neurotoxicology in human: focus on organic pollutants.

10% Body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis.

PIWI-Interacting RNA (piRNA) and Epigenetic Editing in Environmental Health Sciences.

PreS/MD: Predictor of Sensitization hazard for chemical substances released from Medical Devices.

Commentaries/Conference Summaries

Should we worry about the accumulation of microplastics in human organs?

Zeitotox: Toxicology and the Rhythms of Life.

A critical appraisal of clinical epigenetics.

Interventions to Reduce Pesticide Exposure from the Agricultural Sector in Africa: A Workshop Report.

On Target: Environmental Health Messaging That Hits the Mark. [Focus in EHP]

Reviews

Numerous Chemicals/Mixtures

Impact of Environmental Pollutants on Gut Microbiome and Mental Health via the Gut-Brain Axis.

Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature.

Critical review and analysis of literature on low dose exposure to chemical mixtures in mammalian in vivo systems.

Epigenetics as a Biomarker for Early-Life Environmental Exposure.

The Relationship of Historical Redlining with Present-Day Neighborhood Environmental and Health Outcomes: A Scoping Review and Conceptual Model.

Retinal Toxicity Induced by Chemical Agents.

Neurotoxicants, the Developing Brain, and Mental Health.

[Research progress on cardiac developmental toxicity induced by environmental endocrine disruptors exposure]. [Chinese]

BPA/Phenols

Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review.

Phthalates

Association between exposures to phthalate metabolites and preterm birth and spontaneous preterm birth: A systematic review and meta-analysis.

Parabens/Triclosan/Antimicrobials

Impact of Triclosan on Female and Male Reproductive System and Its Consequences on Fertility: A Literature Review.

Pesticides

Carbamate Pesticides: Shedding Light on Their Impact on the Male Reproductive System.

Occupational exposure to pesticides and its association with telomere length – A systematic review and meta-analysis.

Potentially Toxic Elements

Heavy metals research in Nigeria: a review of studies and prioritization of research needs.

Arsenic, Oxidative Stress and Reproductive System.

Influence of heavy metals in Parkinson’s disease: an overview.

The Effects of Toxic Heavy Metals Lead, Cadmium and Copper on the Epidemiology of Male and Female Infertility.

Association of urinary or blood heavy metals and mortality from all causes, cardiovascular disease, and cancer in the general population: a systematic review and meta-analysis of cohort studies.

Microplastics/Nanomaterials

Trojan horse in the intestine: A review on the biotoxicity of microplastics combined environmental contaminants.

Pollution caused by nanoplastics: adverse effects and mechanisms of interaction via molecular simulation.

A systematic review on the effects of nanomaterials on gut microbiota.

Air Pollution

Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic Programming.

Pharmaceuticals/Personal Care Products

Environmental Fate of Organic Sunscreens during Water Disinfection Processes: The Formation of Degradation By-Products and Their Toxicological Profiles.

Use of Tox21 Screening Data to Evaluate the COVID-19 Drug Candidates for Their Potential Toxic Effects and Related Pathways.

Miscellaneous

Urinary Metabolites of Polycyclic Aromatic Hydrocarbons in Firefighters: A Systematic Review and Meta-Analysis.

Research Progress of the Endocrine-Disrupting Effects of Disinfection Byproducts.

Human Health Studies

Numerous Chemicals/Mixtures

Preliminary Findings from the Gulf War Women’s Cohort: Reproductive and Children’s Health Outcomes among Women Veterans.

Occupation and Semen Parameters in a Cohort of Fertile Men. [pesticides, solvents, lead]

Parental occupational exposure to combustion products, metals, silica and asbestos and risk of childhood leukaemia: Findings from the Childhood Cancer and Leukaemia International Consortium (CLIC).

BPA/Phenols

Gestational exposure to bisphenol analogues and kisspeptin levels in pregnant women and their children: A pregnancy-birth cohort study.

Phthalates

Are Phthalate Exposure Related to Oxidative Stress in Children and Adolescents with Asthma? A Cumulative Risk Assessment Approach.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A case-control study of polychlorinated biphenyl association with metabolic and hormonal outcomes in polycystic ovary syndrome.

The Association between Blood Concentrations of PCDD/DFs, DL-PCBs and the Risk of Type 2 Diabetes Mellitus and Thyroid Cancer in South Korea.

Perfluoroalkyl Substances

Prenatal and early postnatal exposure to perfluoroalkyl substances and bone mineral content and density in the Odense child cohort.

Pesticides

Association between new onset type 1 diabetes and real-world antibiotics and neonicotinoids’ exposure-related gut microbiota perturbation.

Miscellaneous

Urinary biomarkers of polycyclic aromatic hydrocarbons (PAHs) and timing of pubertal development: The California PAH Study.

Estimating National Exposures and Potential Bladder Cancer Cases Associated with Chlorination DBPs in U.S. Drinking Water. [see related Invited Perspective: Existing Rules for Disinfection By-Products Are Good, but They Are Not Enough.]

Laboratory Studies

Numerous Chemicals/Mixtures

Morin Augmented Myocardial eNOS/cGMP/PKG Signaling Pathway and Abated Oxidative and Inflammo-apoptotic Responses in Diethyl Phthalate and Bisphenol-S Co-Exposed Male Albino Rats.

BPA/Phenols

Are BPA-free plastics safe for aquatic life? – Fluorene-9-bisphenol induced thyroid-disrupting effects and histopathological alterations in adult zebrafish (Danio rerio).

The Role of Cholesterol in the Interaction of the Lipid Monolayer with the Endocrine Disruptor Bisphenol-A.

Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats.

Effects of Bisphenol A and Bisphenol F on Porcine Uterus Contractility.

The BDNF-TrkB-CREB Signalling Pathway Is Involved in Bisphenol S-Induced Neurotoxicity in Male Mice by Regulating Methylation.

Bisphenol-A incite dose-dependent dissimilitude in the growth pattern, physiology, oxidative status, and metabolite profile of Azolla filiculoides.

Visible-light-driven photocatalytic dual-layer hollow fibre membrane ameliorates the changes of bisphenol A exposure in gastrointestinal tract.

Phthalates

Combined Toxicological Effects of Di (2-Ethylhexyl) Phthalate and UV-B Irradiation through Endoplasmic Reticulum Stress-Tight Junction Disruption in Human HaCaT Keratinocytes.

A preliminary cumulative risk assessment of Diethylhexyl phthalate and Dibutyl phthalate based on the inhibition of embryonic development via the PPARγ pathway.

Parabens/Triclosan/Antimicrobials

Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood.

CYP1A1, VEGFA and Adipokine Responses of Human Adipocytes Co-exposed to PCB126 and Hypoxia.

Effects of Aroclor 1254 on Intestinal Immunity, Metabolism, and Microflora in Zebrafish.

Perfluoroalkyl Substances

Is Mixtures’ Additivity Supported by Empirical Data? A Case Study of Developmental Toxicity of PFOS and 6:2 FTS in Wildtype Zebrafish Embryos.

Low Doses of PFOA Promote Prostate and Breast Cancer Cells Growth through Different Pathways.

Perfluorononanoate and perfluorobutane sulfonate induce cardiotoxic effects in zebrafish.

Perfluorooctane sulfonate (PFOS) enhanced polystyrene particles uptake by human colon adenocarcinoma Caco-2 cells.

Persistent impairment of gonadal development in rare minnow (Gobiocypris rarus) after chronic exposure to chlorinated polyfluorinated ether sulfonate.

Perfluorooctanoic Acid Affects Thyroid Follicles in Common Carp (Cyprinus carpio).

Flame Retardants

Metabolism toxicity and susceptibility of decabromodiphenyl ether (BDE-209) exposure on BRL cells with insulin resistance.

Hormesis-Like Effects of Tetrabromobisphenol A on Anaerobic Digestion: Responses of Metabolic Activity and Microbial Community.

Pesticides

Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders.

An Investigation of the Neurotoxic Effects of Malathion, Chlorpyrifos, and Paraquat to Different Brain Regions.

Pre- and Postnatal Dietary Exposure to a Pesticide Cocktail Disrupts Ovarian Functions in 8-Week-Old Female Mice.

A Cheminformatics Study Regarding the Human Health Risks Assessment of the Stereoisomers of Difenoconazole.

Molecular Physicochemical Properties of Selected Pesticides as Predictive Factors for Oxidative Stress and Apoptosis-Dependent Cell Death in Caco-2 and HepG2 Cells.

Predicting and assessing the toxicity and ecological risk of seven widely used neonicotinoid insecticides and their aerobic transformation products to aquatic organisms.

Chlorpyrifos induces apoptosis and necroptosis via the activation of CYP450s pathway mediated by nuclear receptors in LMH cells.

Potentially Toxic Elements

Maternal exposure to cadmium from puberty through lactation induces abnormal reproductive development in female offspring.

Ascorbic acid ameliorated the sperm quality of rainbow trout (Oncorhynchus mykiss) against arsenic toxicity: Impact on oxidative stress, fertility ability and embryo development.

Microplastics/Nanomaterials

Adsorption of pesticides and personal care products on pristine and weathered microplastics in the marine environment. Comparison between bio-based and conventional plastics.

Toxic Effect of Combined Exposure of Microplastics and Copper on Goldfish (Carassius auratus): Insight from Oxidative Stress, Inflammation, Apoptosis and Autophagy in Hepatopancreas and Intestine.

Blood uptake and urine excretion of nano- and micro-plastics after a single exposure.

Pharmaceuticals/Personal Care Products

Parental transfer of an antibiotic mixture induces cardiotoxicity in early life-stage zebrafish: A cross-generational study.

Miscellaneous

Benzene Exposure Leads to Lipodystrophy and Alters Endocrine Activity In Vivo and In Vitro.

Oral ingestion of the environmental toxicant trichlorethylene in rats induces alterations in the gut microbiome: Relevance to idiopathic Parkinson’s disease.

Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

HRMS screening of organophosphate flame retardants and poly-/perfluorinated substances in dust from cars and trucks: Occurrence and human exposure implications.

Simultaneous assessment of organophosphate flame retardants, plasticizers, trace metals, and house dust mite allergens in settled house dust.

Application of wastewater-based epidemiology for estimating population-wide human exposure to phthalate esters, bisphenols, and terephthalic acid.

Evaluating chemicals of emerging concern in the Ganga River at the two major cities Prayagraj and Varanasi through validated analytical approaches.

Phthalates

Urinary metabolites and handwipe phthalate levels among adults and children in southern China: Implication for dermal exposure.

Parabens/Triclosan/Antimicrobials

Mass trends of parabens, triclocarban and triclosan in Arizona wastewater collected after the 2017 FDA ban on antimicrobials and during the COVID-19 pandemic.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Evidence of stockpile contamination for legacy polychlorinated biphenyls and organochlorine pesticides in the urban environment of Cyprus (Eastern Mediterranean): Influence of meteorology on air level variability and gas/particle partitioning based on equilibrium and steady-state models.

Presence and risks of polycyclic aromatic hydrocarbons, dioxins and dioxin-like PCBs in dietary plant supplements as elucidated by a combined DR CALUX^® bioassay and GC-HRMS based approach.

Perfluoroalkyl Substances

Longitudinal Changes in Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances from Pregnancy to Two Years Postpartum.

Predicting Exposure to Perfluorinated Alkyl Substances (PFAS) among US Infants.

Occurrence and Distribution of Per- and Polyfluoroalkyl Substances from Multi-Industry Sources to Water, Sediments and Plants along Nairobi River Basin, Kenya.

Per- and polyfluoroalkyl substances in the atmosphere of waste management infrastructures: Uncovering secondary fluorotelomer alcohols, particle size distribution, and human inhalation exposure.

Gas Chromatography-(Cyclic) Ion Mobility Mass Spectrometry: A Novel Platform for the Discovery of Unknown Per-/Polyfluoroalkyl Substances.

Pesticides

Determination of glyphosate in breast milk of lactating women in a rural area from Paraná state, Brazil.

Human induced fish declines in North America, how do agricultural pesticides compare to other drivers?

Meta-analysis of neonicotinoid insecticides in global surface waters.

Potentially Toxic Elements

A Generalizable Evaluated Approach, Applying Advanced Geospatial Statistical Methods, to Identify High Lead Exposure Locations at Census Tract Scale: Michigan Case Study. [see related Invited Perspective: Identifying Childhood Lead Exposure Hotspots for Action.]

Fluoride Exposure from Soybean Beverage Consumption: A Toxic Risk Assessment.

Dimethylated Thioarsenates: A Potentially Dangerous Blind Spot in Current Worldwide Regulatory Limits for Arsenic in Rice.

Non-Carcinogenic Health Risk Evaluation of Elevated Fluoride in Groundwater and Its Suitability Assessment for Drinking Purposes Based on Water Quality Index.

Microplastics/Nanomaterials

Consuming microplastics? Investigation of commercial salts as a source of microplastics (MPs) in diet.

Exponential decrease of airborne microplastics: From megacity to open ocean.

The persistently breaking trade-offs of three-decade plastic film mulching: Microplastic pollution, soil degradation and reduced cotton yield.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!