EDC Science Weekly, July 21 – 27, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Leveraging Systematic Reviews to Explore Disease Burden and Costs of Per- and Polyfluoroalkyl Substance Exposures in the United States

Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments.

Methods/Tools/Screening

A discovery-based undergraduate laboratory exercise to investigate the effect of potential endocrine disruptors on sex hormones using human cell culture.

Toxicoepigenetics for Risk Assessment: Bridging the Gap Between Basic and Regulatory Science.

Technical framework for enabling high-quality measurements in new approach methodologies (NAMs).

Machine learning and artificial intelligence in toxicological sciences.

The DevTox Germ Layer Reporter Platform: An Assay Adaptation of the Human Pluripotent Stem Cell Test.

FindPFΔS: Non-Target Screening for PFAS─Comprehensive Data Mining for MS² Fragment Mass Differences.

Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events.

Advances in Single-Cell Toxicogenomics in Environmental Toxicology.

The Amphibian Short Term Assay (ASTA): Evaluation of a New Ecotoxicological Method for Amphibians Using Two Organophosphate Pesticides Commonly Found in Nature. Assessment of Biochemical, Morphological and Life History Traits.

Polyfluorinated compound biodegradation: An annotated selection of World Wide Web sites relevant to the topics in environmental microbiology.

Commentaries

A global plastics treaty to protect endocrine health.

The plastic pandemic: COVID-19 has accelerated plastic pollution, but there is a cure.

Integrating Multiscale Geospatial Environmental Data into Large Population Health Studies: Challenges and Opportunities.

The plastic pandemic: COVID-19 has accelerated plastic pollution, but there is a cure.

Bisphenol A leaching from polycarbonate baby bottles into baby food causes potential health issues.

Current Trends in Safety Assessment of Cosmetics Ingredients. [intro to a special issue of Regulatory Toxicology and Pharmacology]

Editorial for the Special Issue “Microplastics in Aquatic Environments: Occurrence, Distribution and Effects”. [in Toxics]

Editorial: Sex Hormone Fluctuations Across the Female Lifespan: Mechanisms of Action on Brain Structure, Function, and Behavior. [not EDCs but interesting; a research topic in Frontiers in Behavioral Neuroscience]

Reviews

Numerous Chemicals/Mixtures

Phenols, Parabens, Phthalates and Puberty: a Systematic Review of Synthetic Chemicals Commonly Found in Personal Care Products and Girls’ Pubertal Development.

Toxicoepigenetics and Environmental Health: Challenges and Opportunities.

Cardiotoxicity of Chemical Substances: An Emerging Hazard Class.

Protective effects of polyphenols against endocrine disrupting chemicals.

From Dark to Light – An Overview of Over 70 Years of Endocrine Disruption Research on Marine Mollusks.

Environmental Epigenetics in Soil Ecosystems: Earthworms as Model Organisms.

Phthalates

Adverse cardiovascular effects and potential molecular mechanisms of DEHP and its metabolites-A review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated Biphenyls (PCBs) in the Environment: Occupational and Exposure Events, Effects on Human Health and Fertility.

Research on the Relationship between Exposure to Dioxins and Cancer Incidence in Vietnam.

Metabolomics: A New Approach in the Evaluation of Effects in Human Beings and Wildlife Associated with Environmental Exposition to POPs.

Perfluoroalkyl Substances

A Review on Removal and Destruction of Per- and Polyfluoroalkyl Substances (PFAS) by Novel Membranes.

Pesticides

Pyrethroids and developmental neurotoxicity – A critical review of epidemiological studies and supporting mechanistic evidence.

Assessing the genotoxicity and carcinogenicity of 2-chloroethanol through structure activity relationships and in vitro testing approaches.

Microplastics/Nanomaterials

Scaling up resource recovery of plastics in the emergent circular economy to prevent plastic pollution: Assessment of risks to health and safety in the Global South.

A whale of a plastic tale: A plea for interdisciplinary studies to tackle micro- and nanoplastic pollution in the marine realm.

Neurotoxicity of nanoparticles: Insight from studies in zebrafish.

Nanomaterial Ecotoxicology in the Terrestrial and Aquatic Environment: A Systematic Review.

Risk associated with microplastics in urban aquatic environments: A critical review.

Miscellaneous

Effects of licorice on sex hormones and the reproductive system.

Human Health Studies

Numerous Chemicals/Mixtures

Associations between combined exposure to environmental hazards and social stressors at the neighborhood level and individual perinatal outcomes in the ECHO-wide cohort.

BPA/Phenols

Bisphenol A Promotes the Progression of Colon Cancer Through Dual-Targeting of NADPH Oxidase and Mitochondrial Electron-Transport Chain to Produce ROS and Activating HIF-1α/VEGF/PI3K/AKT Axis. [human and lab study]

Phthalates

High exposure to phthalates is associated with HbA1_c worsening in type 2 diabetes subjects with and without edentulism: a prospective pilot study.

The associations between prenatal phthalate exposure measured in child meconium and cognitive functioning of 12-month-old children in two cohorts at elevated risk for adverse neurodevelopment.

Di-(2-ethylhexyl) phthalate exposure links to inflammation and low bone mass in premenopausal and postmenopausal females: Evidence from ovariectomized mice and humans.

Associations between repeated measures of urinary phthalate metabolites and biomarkers of oxidative stress in a rural agricultural cohort of children with asthma.

Exposure to DEHP is potential to increase the risk of overactive bladder, evidence from NHANES 2003-2008.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association between trichlorophenols and neurodegenerative diseases: A cross-sectional study from NHANES 2003-2010.

Exocrine pancreatic cancer and living near to waste sites containing hazardous organic chemicals, New York State, USA – an 18-year population-based study.

Perfluoroalkyl Substances

Association of single and multiple prefluoroalkyl substances exposure with preterm birth: Results from a Chinese birth cohort study.

Association of per- and polyfluoroalkyl substances with thyroid homeostasis during pregnancy in the SELMA study.

Associations of serum perfluoroalkyl substances with concentrations of blood manganese and selenium.

Pesticides

Somatic DNA Damage Response and Homologous Repair Gene Alterations and Its Association With Tumor Variant Burden in Breast Cancer Patients With Occupational Exposure to Pesticides.

Thyroid Cancer and Pesticide Use in a Central California Agricultural Area: A Case Control Study.

Potentially Toxic Elements

Association between gestational arsenic exposure and intrauterine growth restriction: the role of folate content.

Selenium and mercury concentrations in biological samples from patients with COVID-19.

Cadmium exposure is associated with testosterone levels in men: A cross-sectional study from the China national human biomonitoring.

Laboratory Studies

Numerous Chemicals/Mixtures

Transgenerational effects of co-exposure to cadmium and carbofuran on zebrafish based on biochemical and transcriptomic analyses.

Hydra bioassay for the evaluation of chlordecone toxicity at environmental concentrations, alone or in complex mixtures with dechlorinated byproducts: experimental observations and modeling by experimental design.

BPA/Phenols

Species Differences in Response to Binding Interactions of BPA and its Analogs with the Modeled Estrogen Receptor 1 and In Vitro Reporter Gene Assay in Human and Zebrafish.

Bisphenol-A reduces DNA methylation after metabolic activation.

Phthalates

Gestational and lactational exposure to the emergent alternative plasticizer 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) impairs lipid metabolism to a greater extent than the commonly used Di(2-ethylhexyl) phthalate (DEHP) in the adult rat mammary gland.

Effects of DEHP, DEHT and DINP Alone or in a Mixture on Cell Viability and Mitochondrial Metabolism of Endothelial Cells In Vitro.

Di-isononyl phthalate induces apoptosis and autophagy of mouse ovarian granulosa cells via oxidative stress.

Parabens/Triclosan/Antimicrobials

Triclosan-induced Oxidative Stress Injury and Apoptosis by Regulating the PI3K/Akt/Caspase-3 Signaling Pathway in Human Renal Glomerular Endothelial Cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Investigation of obesogenic effects of hexachlorobenzene, DDT and DDE in male rats.

Perfluoroalkyl Substances

Perfluorooctanoic acid (PFOA) exposure affects early embryonic development and offspring oocyte quality via inducing mitochondrial dysfunction.

Young fecal transplantation mitigates the toxicity of perfluorobutanesulfonate and potently refreshes the reproductive endocrine system in aged recipients.

Dietary Perfluorohexanoic Acid (PFHxA) Exposures in Juvenile Zebrafish Produce Subtle Behavioral Effects across Generations.

Flame Retardants

Developmental exposure to the brominated flame retardant DE-71 reduces serum thyroid hormones in rats without hypothalamic-pituitary-thyroid axis activation or neurobehavioral changes in offspring.

Characterization of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47)-induced testicular toxicity via single-cell RNA-sequencing.

Hesperidin partly ameliorates the decabromodiphenyl ether-induced reproductive toxicity in pubertal mice.

Organotins

Brain Region and Sex-specific Changes in Mitochondrial Biogenesis Induced by Acute Trimethyltin Exposure.

Pesticides

The pyrethroid insecticide permethrin confers hepatotoxicity through DNA damage and mitochondria-associated apoptosis induction in rat: Palliative benefits of Fumaria officinalis.

Transcriptional responses of fluxapyroxad-induced dysfunctional heart in zebrafish (Danio rerio) embryos.

Reproductive toxicity of long-term exposure to environmental relevant concentrations of cyprodinil in female zebrafish (Danio rerio).

Parental exposure to propiconazole at environmentally relevant concentrations induces thyroid and metabolism disruption in zebrafish (Danio rerio) offspring: An in vivo, in silico and in vitro study.

Atrazine Exposure Induces Hepatic Metabolism Disorder in Male Adult Zebrafish.

In Vitro Assessment of Pesticides Toxicity and Data Correlation with Pesticides Physicochemical Properties for Prediction of Toxicity in Gastrointestinal and Skin Contact Exposure.

Developmental Toxic Effects of Thiram on Developing Zebrafish (Danio rerio) Embryos.

The Use of Non-targeted Lipidomics and Histopathology to Characterize the Neurotoxicity of Bifenthrin to Juvenile Rainbow Trout (Oncorhynchus mykiss).

Potentially Toxic Elements

In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury.

Protective effect of resveratrol against cadmium-induced toxicity on ovine oocyte in vitro maturation and fertilization.

Distinct responses from triglyceride and cholesterol metabolism in common carp (Cyprinus carpio) upon environmental cadmium exposure.

Nano-Curcumin Prevents Copper Reproductive Toxicity by Attenuating Oxidative Stress and Inflammation and Improving Nrf2/HO-1 Signaling and Pituitary-Gonadal Axis in Male Rats.

Developmental arsenic exposure induces dysbiosis of gut microbiota and disruption of plasma metabolites in mice.

Microplastics/Nanomaterials

Microplastics and di (2-ethylhexyl) phthalate synergistically induce apoptosis in mouse pancreas through the GRP78/CHOP/Bcl-2 pathway activated by oxidative stress.

Microplastics induce immune suppression via S100A8 downregulation.

Chronic toxic effects of polystyrene microplastics on reproductive parameters of male rats.

Pharmaceuticals/Personal Care Products

Environmental Impact of Pharmaceutical Pollutants: Synergistic Toxicity of Ivermectin and Cypermethrin.

Miscellaneous

Antiestrogenic property of 9,9-bis[4-(2-hydroxyethoxy)phenyl]fluorene (BPEF) and its effects on female development in CD-1 mice.

Developmental effects of siloxane exposure in zebrafish: a comparison study using laboratory-mixed and environmental water samples.

Evaluation of Placental Toxicity of Five Essential Oils and Their Potential Endocrine-Disrupting Effects.

EGCG exposure during pregnancy affects uterine histomorphology in F1 female mice and the underlying mechanisms.

Forskolin Induces Endocrine Disturbance in Human JEG-3 Placental Cells.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Review of contaminant levels and effects in shorebirds: Knowledge gaps and conservation priorities.

Improved method for the determination of endocrine-disrupting chemicals in urine of school-age children using microliquid-liquid extraction and UHPLC-MS/MS.

BPA/Phenols

Temporal trend of bisphenol S occurrence in meat samples from 2008-2020 Canadian total diet study.

Cross-Generational Impacts of Diet Shift on Bisphenol Analogue Loads in Indo-Pacific Humpback Dolphins (Sousa chinensis).

Phthalates

Risk Assessment of Phthalates and Their Metabolites in Hospitalized Patients: A Focus on Di- and Mono-(2-ethylhexyl) Phthalates Exposure from Intravenous Plastic Bags.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Human Biomonitoring of Polychlorinated Biphenyls (PCBs) in the Breast Milk of Colombian Mothers.

Occurrence, Distribution, and Environmental Behavior of Persistent, Mobile, and Toxic (PMT) and Very Persistent and Very Mobile (vPvM) Substances in the Sources of German Drinking Water.

A First Record of Organochlorine Pesticides in Barn Owls (Tyto alba) from Portugal: Assessing Trends from Variation in Feather and Liver Concentrations.

Particulate PCDD/F size distribution and potential deposition in respiratory system from a hazardous waste thermal treatment process.

Perfluoroalkyl Substances

Serum per- and polyfluoroalkyl substance concentrations in four municipal US fire departments.

Internal Relative Potency Factors for the Risk Assessment of Mixtures of Per- and Polyfluoroalkyl Substances (PFAS) in Human Biomonitoring.

Oysters for legacy and emerging per- and polyfluoroalkyl substances (PFASs) monitoring in estuarine and coastal waters: Phase distribution and bioconcentration profile.

Optimization and application of a method to determine 24 perfluorinated compounds in umbilical cord serum by using liquid chromatography tandem mass spectrometry.

Increasing Accumulation of Perfluorocarboxylate Contaminants Revealed in an Antarctic Firn Core (1958-2017).

Flame Retardants

Human exposure to polybrominated diphenyl ethers (PBDEs) through the diet: An update of the scientific literature.

Pesticides

Pesticide residues in milk and dairy products: An overview of processing degradation and trends in mitigating approaches.

Occurrence, Distribution, and Risk Assessment of Organophosphorus Pesticides in the Aquatic Environment of the Sele River Estuary, Southern Italy.

Pesticide risk assessment: honeybee workers are not all equal regarding the risk posed by exposure to pesticides.

Bumblebees can be exposed to the herbicide glyphosate when foraging.

Predicted dermal and dietary exposure of bats to pesticides.

Dichlorvos and Paraquat induced avoidance responses in tadpoles (Amietophrynus regularis reuss, 1833) and their contribution to population decline.

Emerging Contaminant Imidacloprid in Mediterranean Soils: The Risk of Accumulation Is Greater than the Risk of Leaching.

Potentially Toxic Elements

The research trend on arsenic pollution in freshwater: a bibliometric review.

The effects of acidification on arsenic concentration and speciation in offshore shallow water system.

Microplastics/Nanomaterials

Microplastics and nanoplastics released from a PPE mask under a simulated bushfire condition.

Synthetic polymers in personal care and cosmetics products (PCCPs) as a source of microplastic (MP) pollution.

Pharmaceuticals/Personal Care Products

Occurrence, hazard, and risk of psychopharmaceuticals and illicit drugs in European surface waters.

Miscellaneous

Harbours as unique environmental sites of multiple anthropogenic stresses on fish hormonal systems.

Levels, profiles and potential human health risks of brominated and parent polycyclic aromatic hydrocarbons in soils around three different types of industrial areas in China.

Early-Life Exposure to Formaldehyde through Clothing.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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