EDC Science Weekly, July 14 – 20, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

An Analysis of the Use of the Relative Source Contribution Term in Derivation of Drinking Water Standards Using Perfluorooctanoic Acid as an Example.

Focusing Points on FSCJ’s Guideline Recently Established: Risk Assessment of Food Contact Materials.

Methods/Tools/Screening

To be or not to be degraded: in defense of persistence assessment of chemicals.

The potential of organoids in toxicologic pathology: role of toxicologic pathologists in in vitro chemical hepatotoxicity assessment.

AI for predicting chemical-effect associations at the chemical universe level-deepFPlearn.

Assessing author willingness to enter study information into structured data templates as part of the manuscript submission process: A pilot study.

Commentaries

Editorial: Microplastics and Microorganisms in the Environment. [intro to a research topic in Frontiers in Microbiology]

Environmental, Health, and Legislation Considerations for Rational Design of Nonreactive Flame-Retardant Additives for Polymeric Materials: Future Perspectives.

Speaking the Same Language: The Need for Accurate and Consistent Reporting of Novel Per- and Polyfluoroalkyl Substances.

Reviews

Numerous Chemicals/Mixtures

Environmental fate and toxicity of androgens: A critical review.

Pesticides

Cultural appropriateness in randomized controlled trials (RCTs) aimed at reducing pesticide exposure among farmers and farmworkers: a systematic review.

Chronic Effects of Dietary Pesticides on the Gut Microbiome and Neurodevelopment.

Potentially Toxic Elements

Cadmium exposures and deteriorations of cognitive abilities: estimation of a reference dose for mixture risk assessments based on a systematic review and confidence rating.

A Narrative Review of Toxic Heavy Metal Content of Infant and Toddler Foods and Evaluation of United States Policy.

Microplastics/Nanomaterials

Is There Evidence of Health Risks From Exposure to Micro- and Nanoplastics in Foods?

Microplastics alter multiple biological processes of marine benthic fauna.

Pharmaceuticals/Personal Care Products

Assessment of human exposure to benzophenone-type UV filters: A review.

Human Health Studies

Numerous Chemicals/Mixtures

Geographical variations of cancer incidence in Guadeloupe, French West Indies.

Environmental Factors Involved in the High Incidence of Bladder Cancer in an Industrialized Area in North-Eastern Spain.

BPA/Phthalates

Associations of maternal urinary bisphenol and phthalate concentrations with offspring reproductive development

Associations between phthalate exposure and thyroid function in pregnant women during the first trimester.

Prenatal DEHP exposure and placental telomere length.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Long-term Effects of Defoliant Exposure on Brain Atrophy Progression in Humans.

Perfluoroalkyl Substances

Exposure to perfluoroalkyl substances and neurodevelopment in 2-year-old children: A prospective cohort study.

Associations between prenatal exposure to perfluoroalkyl substances and neurobehavioral development in early childhood: A prospective cohort study.

Association of increased risk of cardiovascular diseases with higher levels of perfluoroalkylated substances in the serum of adults.

Flame Retardants

Exposure of men living in the greater Montreal area to organophosphate esters: Association with hormonal balance and semen quality.

Pesticides

Effects of exposure to glyphosate on oxidative stress, inflammation, and lung function in maize farmers, Northern Thailand.

Potentially Toxic Elements

A prospective study of arsenic and manganese exposures and maternal blood pressure during gestation.

Cadmium, lead, and mercury mixtures interact with non-alcoholic fatty liver diseases.

Metal exposure and breast cancer among Northern Mexican women: assessment of genetic susceptibility.

Maternal serum concentrations of one-carbon metabolism factors modify the association between biomarkers of arsenic methylation efficiency and birth weight.

Miscellaneous

Urinary Polycyclic Aromatic Hydrocarbons in a Longitudinal Cohort of Children with CKD: A Case of Reverse Causation?

Laboratory Studies

Numerous Chemicals/Mixtures

Neurotoxicity of tetrabromobisphenol A and SiO2 nanoparticle co-exposure in zebrafish and barrier function of the embryonic chorion.

BPA/Phenols

Selenium deficiency aggravates bisphenol A-induced autophagy in chicken kidney through regulation of nitric oxide and adenosine monophosphate activated protein kinase/mammalian target of rapamycin signaling pathway.

Exposure to either bisphenol A or S represents a risk for crucial behaviors for pup survival, such as spontaneous maternal behavior in mice.

Prenatal exposure to bisphenol S and bisphenol a differentially affects male reproductive system in the adult offspring.

Multi-biomarker approach and IBR index to evaluate the effects of Bisphenol A on embryonic stages of zebrafish (Danio rerio).

Cytogenetic and developmental toxicity of bisphenol A and bisphenol S in Arbacia lixula sea urchin embryos.

Phthalates

Therapeutic efficacy of N-acetylcysteine and zinc sulphate against di-(2-ethylhexyl) phthalate-induced testicular oxido-nitrergic stress in male Wistar rat.

Single-cell transcriptomic profiling to evaluate the effects of Di(2-ethylhexyl)phthalate exposure on early meiosis of female mouse germ cells.

Di-2-ethylhexyl phthalate affects zinc metabolism and neurogenesis in the developing rat brain.

Metabolomics and Data-Driven Bioinformatics Revealed Key Maternal Metabolites Related to Fetal Lethality via Di(2-ethylhexyl)phthalate Exposure in Pregnant Mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

d-ribose- l-cysteine abrogates testicular maladaptive responses induced by polychlorinated bisphenol intoxication in rats via activation of the mTOR signaling pathway mediating inhibition of apoptosis, inflammation, and oxidonitrergic flux.

Perfluoroalkyl Substances

Perfluorooctanoic acid alternatives hexafluoropropylene oxides exert male reproductive toxicity by disrupting blood-testis barrier.

Maternal PFOS exposure during rat pregnancy causes hypersensitivity to angiotensin II and attenuation of endothelium-dependent vasodilation in the uterine arteries.

Evaluation of Transcriptomic Responses in Livers of Mice Exposed to the Short-Chain PFAS Compound HFPO-DA.

Toxicological effects of polystyrene nanoplastics and perfluorooctanoic acid to Gambusia affinis.

Lack of interaction of the fluorosurfactant C6O4 with human renal transporters: in vitro/in silico analysis.

GenX Induces Fibroinflammatory Gene Expression in Primary Human Hepatocytes.

Flame Retardants

Developmental exposure to the brominated flame retardant DE-71 reduces serum thyroid hormones in rats without hypothalamic-pituitary-thyroid axis activation or neurobehavioral changes in offspring.

Vitamin C supplementation rescued meiotic arrest of spermatocytes in Balb/c mice exposed to BDE-209.

Pesticides

In vitro investigation of endocrine disrupting effects of pesticides on Ca²⁺-signaling in human sperm cells through actions on the sperm-specific and steroid-activated CatSper Ca²⁺-channel.

Toxicity of pesticides widely applied on soybean cultivation: Synergistic effects of fipronil, glyphosate and imidacloprid in HepG2 cells.

Metabolomics analysis of the potential toxicological mechanisms of diquat dibromide herbicide in adult zebrafish (Danio rerio) liver.

Exposure to fluopimomide at sublethal doses causes oxidative stress in Caenorhabditis elegans regulated by insulin/insulin-like growth factor 1-like signaling pathway.

Potentially Toxic Elements

Environmental cadmium exposure during gestation impairs fetal brain and cognitive function of adult offspring via reducing placental-derived E2 level.

Bioaccessibility of arsenic from contaminated soils and alteration of the gut microbiome in an in vitro gastrointestinal model.

Microplastics/Nanomaterials

Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway.

Microplastics-perturbed gut microbiota triggered the testicular disorder in male mice: Via fecal microbiota transplantation.

Polystyrene nanoplastics exacerbated lipopolysaccharide-induced necroptosis and inflammation via the ROS/MAPK pathway in mice spleen.

Bioaccumulation of differently-sized polystyrene nanoplastics by human lung and intestine cells.

Pharmaceuticals/Personal Care Products

Melanin interference toxicity or transgenerational toxicity of organic UV filter ethylhexyl salicylate on zebrafish.

Dysfunctional Ovarian Stem Cells Due to Neonatal Endocrine Disruption Result in PCOS and Ovarian Insufficiency in Adult Mice. [DES]

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Variability and correlations of synthetic chemicals in urine from a New York City-based cohort of pregnant women.

Identification of occupations susceptible to high exposure and risk associated with multiple toxicants in an observational study: National Health and Nutrition Examination Survey 1999-2014.

The strategy for estrogen receptor mediated-risk assessment in environmental water: A combination of species sensitivity distributions and in silico approaches.

Occurrence and Ecological Impact of Chemical Mixtures in a Semiclosed Sea by Suspect Screening Analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The concentration and biomagnification of PCBs and PBDEs across four trophic levels in a marine food web.

New and legacy persistent organic pollutants (POPs) in breeding seabirds from the East Antarctic.

Perfluoroalkyl Substances

Target analysis and suspect screening of per- and polyfluoroalkyl substances in paired samples of maternal serum, umbilical cord serum, and placenta near fluorochemical plants in Fuxin, China.

Per- and polyfluoroalkyl substances (PFAS) in sludge from wastewater treatment plants in Sweden – First findings of novel fluorinated copolymers in Europe including temporal analysis.

Suspect screening and nontargeted analysis of per- and polyfluoroalkyl substances in representative fluorocarbon surfactants, aqueous film-forming foams, and impacted water in China.

Neutral Per- and Polyfluoroalkyl Substances, Butyl Carbitol, and Organic Corrosion Inhibitors in Aqueous Film-Forming Foams: Implications for Vapor Intrusion and the Environment.

Organotins

Organotins in a food web from the Three Gorges Reservoir, China: Trophic enrichment and potential health risk.

Pesticides

Variability of urinary biomarkers of neonicotinoid insecticides in Chinese population: Implications for human exposure assessment.

Prioritizing agricultural pesticides to protect human health: A multi-level strategy combining life cycle impact and risk assessments.

Risk assessment of organophosphorus pesticide residues in drinking water resources: Statistical and Monte-Carlo approach.

Potentially Toxic Elements

Health Risk Assessment in Mexican Children Exposed to Fluoride from Sweetened Beverages.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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