EDC Science Weekly, July 7-13, 2022 – HEEDS

EDC Science Weekly, July 7-13, 2022

Post author:HEEDS
Post published:July 13, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Preservatives in non-cosmetic products: increasing human exposure requires action for protection of health.

Methods/Tools/Screening

Mixture Math: Deciding What to Add in a Cumulative Risk Assessment.

Development of the InTelligence And Machine LEarning (TAME) Toolkit for Introductory Data Science, Chemical-Biological Analyses, Predictive Modeling, and Database Mining for Environmental Health Research.

Candidate Proficiency Test Chemicals to Address Industrial Chemical Applicability Domains for in vitro Human Cytochrome P450 Enzyme Induction.

A rodent thyroid-liver chip to capture thyroid toxicity on organ functional level.

High-throughput “read-on-ski” automated imaging and label-free detection system for toxicity screening of compounds using personalised human kidney organoids.

Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity.

Automating Predictive Toxicology Using ComptoxAI.

Machine learning in the identification, prediction and exploration of environmental toxicology: Challenges and perspectives.

ToxCast chemical library Wnt screen identifies diethanolamine as an activator of neural progenitor proliferation.

Development a High Throughput Zebrafish Embryo acute toxicity Testing Method based on OECD TG 236.

Reviews

Numerous Chemicals/Mixtures

Clinical encounter with three cancer patients affected by groundwater contamination at Camp Lejeune: a case series and review of the literature.

BPA/Phenols

Bibliometric Analysis of the Toxicity of Bisphenol A.

The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence.

Systematic evaluation of the evidence for identification of endocrine disrupting properties of Bisphenol F

Perfluoroalkyl Substances

A review of omics-based PFAS exposure studies reveals common biochemical response pathways.

Flame Retardants

Effects of Polybrominated Diphenyl Ethers on Hormonal and Reproductive Health in E-Waste-Exposed Population: A Systematic Review.

Pesticides

The environmental and occupational influence of pesticides on male fertility: a systematic review of human studies.

Microplastics/Nanomaterials

Nanoplastic Toxicity: Insights and Challenges from Experimental Model Systems.

Miscellaneous

The Association between Urinary Polycyclic Aromatic Hydrocarbons Metabolites and Type 2 Diabetes Mellitus.

Human Health Studies

Numerous Chemicals/Mixtures

Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children.

Does Older Age Modify Associations between Endocrine Disrupting Chemicals and Fecundability? [BPA, phthalates, UV filters]

Association of Serum Levels of Plasticizers Compounds, Phthalates and Bisphenols, in Patients and Survivors of Breast Cancer: A Real Connection?

BPA/Phenols

Associations of bisphenol exposure with thyroid hormones in pregnant women: a prospective birth cohort study in China.

Phthalates

Associations Between Prenatal Urinary Biomarkers of Phthalate Exposure and Preterm Birth: A Pooled Study of 16 US Cohorts.

Gender-specific effects of prenatal mixed exposure to serum phthalates on neurodevelopment of children aged 2-3 years:the Guangxi Birth Cohort Study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

New emerging polybromobiphenyls in serum of general population and their disruption on thyroid hormone receptor β₁.

Perfluoroalkyl Substances

Associations of prenatal exposure to perfluoroalkyl substances with preterm birth: A family-based birth cohort study.

Pesticides

Occupational exposure to pesticides in mothers and fathers and risk of cancer in the offspring: A register-based case-control study from Sweden (1960-2015).

Prenatal Exposure to Organophosphorus Pesticides and Preschool ADHD in the Norwegian Mother, Father and Child Cohort Study.

Maternal exposure to DDT, DDE, and pyrethroid insecticides for malaria vector control and hypospadias in the VHEMBE birth cohort study, Limpopo, South Africa.

In-utero exposure to DDT and pyrethroids and child behavioral and emotional problems at 2 years of age in the VHEMBE cohort, South Africa.

The Association Between 2, 4-Dichlorophenoxyacetic Acid and Erectile Dysfunction.

Potentially Toxic Elements

Prenatal and early childhood critical windows for the association of nephrotoxic metal and metalloid mixtures with kidney function.

Sex-Specific Associations of Urinary Metals with Renal Function: a Cross-sectional Study in China.

The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships

Laboratory Studies

Numerous Chemicals/Mixtures

Exposure to a human relevant mixture of persistent organic pollutants or to perfluorooctane sulfonic acid alone dysregulates the developing cerebellum of chicken embryo.

Migration study of phenolic endocrine disruptors from pacifiers to saliva simulant by solid phase microextraction with amino-functionalized microporous organic network coated fiber.

BPA/Phenols

Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation.

Developmental programming: Impact of prenatal bisphenol-A exposure on liver and muscle transcriptome of female sheep.

Dimethylbisphenol A inhibits the differentiation of stem Leydig cells in adult male rats by androgen receptor (NR3C4) antagonism.

Does bisphenol-A affect alteration of gut microbiome after bariatric/metabolic surgery? a comparative metagenomic analysis in a long-term high-fat diet induced-obesity rat model.

Phthalates

Repair mechanism of Wuwei Fuzheng Yijing formula in di-2-ethylhexyl phthalate-induced sperm DNA fragmentation in mice.

Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain.

Parabens/Triclosan/Antimicrobials

Comprehensive assessment of estrogenic activities of parabens by in silico approach and in vitro assays.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The effects of endosulfan on cell migration and invasion in prostate cancer cells via the KCNQ1OT1/miR-137-3p/PTP4A3 axis.

Insight into 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of zebrafish spermatogenesis via single cell RNA-seq.

Perfluoroalkyl Substances

Perfluorooctanoic acid affects mouse brain and liver tissue through oxidative stress.

Comparative Evaluation of the Effects of Legacy and New Generation Perfluoralkyl Substances (PFAS) on Thyroid Cells In Vitro.

Flame Retardants

In utero exposure to Decabromodiphenyl ethane causes rapid growth in mice cubs by activating glycogenolysis and lipid synthesis.

Factors Influencing Dechlorane plus Distributions in Various Sheep Tissues.

Pesticides

Feeding behavior of early life stages of the zebrafish Danio rerio is altered by exposure to glyphosate.

2,4-Dichlorophenoxyacetic acid (2,4-D) affects DNA integrity and retina structure in zebrafish larvae.

Investigation of cypermethrin toxicity in Swiss albino mice with physiological, genetic and biochemical approaches.

Glyphosate exposure deteriorates oocyte meiotic maturation via induction of organelle dysfunctions in pigs.

Isoprocarb causes neurotoxicity of zebrafish embryos through oxidative stress-induced apoptosis.

Mechanism of the distinct toxicity level of imidacloprid and thiacloprid against honey bees: An in silico study based on cytochrome P450 9Q3.

Potentially Toxic Elements

Evaluating the mouse model for estimation of arsenic bioavailability: Comparison of estimates of absolute bioavailability of inorganic arsenic in mouse, humans, and other species.

An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice.

Arsenic exposure during juvenile and puberty significantly affected reproductive system development of female SD rats.

Microplastics/Nanomaterials

Polystyrene microplastics induce apoptosis and necroptosis in swine testis cells via ROS/MAPK/HIF1α pathway.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Aquatic and human health risk assessment of Humanogenic Emerging Contaminants (HECs), Phthalate Esters from the Indian Rivers.

BPA/Phenols

Biomarker-Determined Nonylphenol Exposure and Associated Risks in Children of Thailand, Indonesia, and Saudi Arabia.

Phthalates

Dietary exposure and risk assessment of phthalic acid esters through a total diet study in Shenzhen, South China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Signatures of Indian endosulfan usage in China’s environment.

Spatial distribution and temporal trends of classical and emerging persistent organic pollutants (POPs) in black-tailed gull (Larus crassirostris) eggs from Korea.

Levels, time trends, and distribution of dioxins and polychlorinated biphenyls in fishes from the Baltic Sea.

A large geographic-scale characterization of organochlorine pesticides (OCPs) in surface sediments and multiple aquatic foods of inland freshwater aquaculture ponds in China: Co-occurrence, source and risk assessment.

Perfluoroalkyl Substances

Grouping of PFAS for human health risk assessment: Findings from an independent panel of experts.

Bioaccumulation and trophic magnification of emerging and legacy per- and polyfluoroalkyl substances (PFAS) in a St. Lawrence River food web.

Changing bioavailability of per- and polyfluoroalkyl substances (PFAS) to plant in biosolids amended soil through stabilization or mobilization.

Flame Retardants

Organophosphate Esters in Foodstuffs from Multiple Provinces in China: Possible Sources during Food Processing and Implications for Human Exposure.

Significant input of organophosphate esters through particle-mediated transport into the Pearl River Estuary, China.

Pesticides

Development of a US national-scale, mixed-source, pesticide, rural well database for use in drinking water risk assessment: an atrazine case study.

Detection and Concentration of Neonicotinoids and Other Pesticides in Honey from Honey Bee Colonies Located in Regions That Differ in Agricultural Practices: Implications for Human and Bee Health.

Do pesticide and pathogen interactions drive wild bee declines?

Potentially Toxic Elements

A mass-balance approach to evaluate arsenic intake and excretion in different populations.

Microplastics/Nanomaterials

Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."
Pesticide use linked to increased prostate cancer risk
by EHN Curators on November 18, 2024 at 11:22 am
A study finds 22 pesticides associated with prostate cancer risk in the U.S., with four also tied to higher death rates. Andrea Tamayo reports for Science News.
PFAS levels increase throughout pregnancy, study finds
by Katherine McMahon,Sarah Howard on November 15, 2024 at 9:32 pm
A recent study published in Environmental Health Perspectives examines trends in PFAS exposure in pregnant Black women and their newborns in Atlanta. “Investigating the changes in PFAS exposure levels throughout pregnancy… is crucial for identifying critical exposure periods and guiding public health policies to reduce PFAS exposure.”

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.