EDC Science Weekly, July 7-13, 2022 – HEEDS

EDC Science Weekly, July 7-13, 2022

Post author:HEEDS
Post published:July 13, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Preservatives in non-cosmetic products: increasing human exposure requires action for protection of health.

Methods/Tools/Screening

Mixture Math: Deciding What to Add in a Cumulative Risk Assessment.

Development of the InTelligence And Machine LEarning (TAME) Toolkit for Introductory Data Science, Chemical-Biological Analyses, Predictive Modeling, and Database Mining for Environmental Health Research.

Candidate Proficiency Test Chemicals to Address Industrial Chemical Applicability Domains for in vitro Human Cytochrome P450 Enzyme Induction.

A rodent thyroid-liver chip to capture thyroid toxicity on organ functional level.

High-throughput “read-on-ski” automated imaging and label-free detection system for toxicity screening of compounds using personalised human kidney organoids.

Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity.

Automating Predictive Toxicology Using ComptoxAI.

Machine learning in the identification, prediction and exploration of environmental toxicology: Challenges and perspectives.

ToxCast chemical library Wnt screen identifies diethanolamine as an activator of neural progenitor proliferation.

Development a High Throughput Zebrafish Embryo acute toxicity Testing Method based on OECD TG 236.

Reviews

Numerous Chemicals/Mixtures

Clinical encounter with three cancer patients affected by groundwater contamination at Camp Lejeune: a case series and review of the literature.

BPA/Phenols

Bibliometric Analysis of the Toxicity of Bisphenol A.

The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence.

Systematic evaluation of the evidence for identification of endocrine disrupting properties of Bisphenol F

Perfluoroalkyl Substances

A review of omics-based PFAS exposure studies reveals common biochemical response pathways.

Flame Retardants

Effects of Polybrominated Diphenyl Ethers on Hormonal and Reproductive Health in E-Waste-Exposed Population: A Systematic Review.

Pesticides

The environmental and occupational influence of pesticides on male fertility: a systematic review of human studies.

Microplastics/Nanomaterials

Nanoplastic Toxicity: Insights and Challenges from Experimental Model Systems.

Miscellaneous

The Association between Urinary Polycyclic Aromatic Hydrocarbons Metabolites and Type 2 Diabetes Mellitus.

Human Health Studies

Numerous Chemicals/Mixtures

Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children.

Does Older Age Modify Associations between Endocrine Disrupting Chemicals and Fecundability? [BPA, phthalates, UV filters]

Association of Serum Levels of Plasticizers Compounds, Phthalates and Bisphenols, in Patients and Survivors of Breast Cancer: A Real Connection?

BPA/Phenols

Associations of bisphenol exposure with thyroid hormones in pregnant women: a prospective birth cohort study in China.

Phthalates

Associations Between Prenatal Urinary Biomarkers of Phthalate Exposure and Preterm Birth: A Pooled Study of 16 US Cohorts.

Gender-specific effects of prenatal mixed exposure to serum phthalates on neurodevelopment of children aged 2-3 years:the Guangxi Birth Cohort Study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

New emerging polybromobiphenyls in serum of general population and their disruption on thyroid hormone receptor β₁.

Perfluoroalkyl Substances

Associations of prenatal exposure to perfluoroalkyl substances with preterm birth: A family-based birth cohort study.

Pesticides

Occupational exposure to pesticides in mothers and fathers and risk of cancer in the offspring: A register-based case-control study from Sweden (1960-2015).

Prenatal Exposure to Organophosphorus Pesticides and Preschool ADHD in the Norwegian Mother, Father and Child Cohort Study.

Maternal exposure to DDT, DDE, and pyrethroid insecticides for malaria vector control and hypospadias in the VHEMBE birth cohort study, Limpopo, South Africa.

In-utero exposure to DDT and pyrethroids and child behavioral and emotional problems at 2 years of age in the VHEMBE cohort, South Africa.

The Association Between 2, 4-Dichlorophenoxyacetic Acid and Erectile Dysfunction.

Potentially Toxic Elements

Prenatal and early childhood critical windows for the association of nephrotoxic metal and metalloid mixtures with kidney function.

Sex-Specific Associations of Urinary Metals with Renal Function: a Cross-sectional Study in China.

The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships

Laboratory Studies

Numerous Chemicals/Mixtures

Exposure to a human relevant mixture of persistent organic pollutants or to perfluorooctane sulfonic acid alone dysregulates the developing cerebellum of chicken embryo.

Migration study of phenolic endocrine disruptors from pacifiers to saliva simulant by solid phase microextraction with amino-functionalized microporous organic network coated fiber.

BPA/Phenols

Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation.

Developmental programming: Impact of prenatal bisphenol-A exposure on liver and muscle transcriptome of female sheep.

Dimethylbisphenol A inhibits the differentiation of stem Leydig cells in adult male rats by androgen receptor (NR3C4) antagonism.

Does bisphenol-A affect alteration of gut microbiome after bariatric/metabolic surgery? a comparative metagenomic analysis in a long-term high-fat diet induced-obesity rat model.

Phthalates

Repair mechanism of Wuwei Fuzheng Yijing formula in di-2-ethylhexyl phthalate-induced sperm DNA fragmentation in mice.

Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain.

Parabens/Triclosan/Antimicrobials

Comprehensive assessment of estrogenic activities of parabens by in silico approach and in vitro assays.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The effects of endosulfan on cell migration and invasion in prostate cancer cells via the KCNQ1OT1/miR-137-3p/PTP4A3 axis.

Insight into 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of zebrafish spermatogenesis via single cell RNA-seq.

Perfluoroalkyl Substances

Perfluorooctanoic acid affects mouse brain and liver tissue through oxidative stress.

Comparative Evaluation of the Effects of Legacy and New Generation Perfluoralkyl Substances (PFAS) on Thyroid Cells In Vitro.

Flame Retardants

In utero exposure to Decabromodiphenyl ethane causes rapid growth in mice cubs by activating glycogenolysis and lipid synthesis.

Factors Influencing Dechlorane plus Distributions in Various Sheep Tissues.

Pesticides

Feeding behavior of early life stages of the zebrafish Danio rerio is altered by exposure to glyphosate.

2,4-Dichlorophenoxyacetic acid (2,4-D) affects DNA integrity and retina structure in zebrafish larvae.

Investigation of cypermethrin toxicity in Swiss albino mice with physiological, genetic and biochemical approaches.

Glyphosate exposure deteriorates oocyte meiotic maturation via induction of organelle dysfunctions in pigs.

Isoprocarb causes neurotoxicity of zebrafish embryos through oxidative stress-induced apoptosis.

Mechanism of the distinct toxicity level of imidacloprid and thiacloprid against honey bees: An in silico study based on cytochrome P450 9Q3.

Potentially Toxic Elements

Evaluating the mouse model for estimation of arsenic bioavailability: Comparison of estimates of absolute bioavailability of inorganic arsenic in mouse, humans, and other species.

An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice.

Arsenic exposure during juvenile and puberty significantly affected reproductive system development of female SD rats.

Microplastics/Nanomaterials

Polystyrene microplastics induce apoptosis and necroptosis in swine testis cells via ROS/MAPK/HIF1α pathway.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Aquatic and human health risk assessment of Humanogenic Emerging Contaminants (HECs), Phthalate Esters from the Indian Rivers.

BPA/Phenols

Biomarker-Determined Nonylphenol Exposure and Associated Risks in Children of Thailand, Indonesia, and Saudi Arabia.

Phthalates

Dietary exposure and risk assessment of phthalic acid esters through a total diet study in Shenzhen, South China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Signatures of Indian endosulfan usage in China’s environment.

Spatial distribution and temporal trends of classical and emerging persistent organic pollutants (POPs) in black-tailed gull (Larus crassirostris) eggs from Korea.

Levels, time trends, and distribution of dioxins and polychlorinated biphenyls in fishes from the Baltic Sea.

A large geographic-scale characterization of organochlorine pesticides (OCPs) in surface sediments and multiple aquatic foods of inland freshwater aquaculture ponds in China: Co-occurrence, source and risk assessment.

Perfluoroalkyl Substances

Grouping of PFAS for human health risk assessment: Findings from an independent panel of experts.

Bioaccumulation and trophic magnification of emerging and legacy per- and polyfluoroalkyl substances (PFAS) in a St. Lawrence River food web.

Changing bioavailability of per- and polyfluoroalkyl substances (PFAS) to plant in biosolids amended soil through stabilization or mobilization.

Flame Retardants

Organophosphate Esters in Foodstuffs from Multiple Provinces in China: Possible Sources during Food Processing and Implications for Human Exposure.

Significant input of organophosphate esters through particle-mediated transport into the Pearl River Estuary, China.

Pesticides

Development of a US national-scale, mixed-source, pesticide, rural well database for use in drinking water risk assessment: an atrazine case study.

Detection and Concentration of Neonicotinoids and Other Pesticides in Honey from Honey Bee Colonies Located in Regions That Differ in Agricultural Practices: Implications for Human and Bee Health.

Do pesticide and pathogen interactions drive wild bee declines?

Potentially Toxic Elements

A mass-balance approach to evaluate arsenic intake and excretion in different populations.

Microplastics/Nanomaterials

Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.