EDC Science Weekly: June 30 – July 6, 2022 – HEEDS

EDC Science Weekly: June 30 – July 6, 2022

Post author:HEEDS
Post published:July 6, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

July 6 webinar starting soon! FDA’s Missed Opportunities to Tackle Endocrine Disrupting Chemicals in Food (EDC Strategies Partnership)

September 14 webinar: Exposure to Per- and Polyfluoroalkyl Substances and Markers of Liver Injury (EDC Strategies Partnership)

Methods/Tools/Screening

How to analyse and account for interactions in mixture toxicity with toxicokinetic-toxicodynamic models.

Commentaries

Plastic pollution: Where are we regarding research and risk assessment in support of management and regulation?

Sturgeons Are Biodiversity Priorities Needing Special Protection from Chemicals and Waste.

Reviews

Numerous Chemicals/Mixtures

Endocrine disruptors and female fertility: a review of pesticide and plasticizer effects.

Soil and water pollution and human health: what should cardiologists worry about?

Flame Retardants

New Insights into Human Biotransformation of BDE-209: Unique Occurrence of Metabolites of Ortho-Substituted Hydroxylated Higher Brominated Diphenyl Ethers in the Serum of e-Waste Dismantlers.

Pesticides

The growing concern of chlorpyrifos exposures on human and environmental health.

Pesticides Exposure-Induced Changes in Brain Metabolome: Implications in the Pathogenesis of Neurodegenerative Disorders.

A meta-analysis of ecotoxicological models used for plant protection product risk assessment before their placing on the market.

Toxic effects of pesticides on cellular and humoral immunity: an overview.

Effects of the Herbicide Atrazine on Crustacean Reproduction. Mini-Review.

Potentially Toxic Elements

Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis.

Microplastics/Nanomaterials

A systematic review and risk matrix of plastic litter impacts on aquatic wildlife: A case study of the Mekong and Ganges River Basins.

Health Effects and Safety Assurance of Nanoparticles in Vulnerable Generations.

Safety and Toxicity Implications of Multifunctional Drug Delivery Nanocarriers on Reproductive Systems In Vitro and In Vivo.

Pharmaceuticals/Personal Care Products

Evaluation of toxicity of Personal Care Products (PCPs) in freshwaters: zebrafish as a model.

Human Health Studies

Numerous Chemicals/Mixtures

Expanded assessment of xenobiotic associations with antinuclear antibodies in the United States, 1988-2012.

A multipollutant low-grade exposure regulates the expression of miR-30b, Let-7a and miR-223 in maternal sera: Evidence from the NEHO cohort.

Phthalates

The Relationship Between Daily Dietary Intake of Fiber and Short Sleep Duration in the Presence of Di(2-Ethylhexyl) Phthalate: A Population-Based Study.

Parabens/Triclosan/Antimicrobials

Parabens and Menopause-Related Health Outcomes in Midlife Women: A Pilot Study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

High Levels of Organochlorines Are Associated with Induction of ABL1 Promoter Methylation in Children with Acute Lymphoblastic Leukemia.

Perfluoroalkyl Substances

Exposure to perfluoroalkyl substances and neonatal immunoglobulin profiles in the upstate KIDS study (2008-2010).

Pesticides

Impact of Micronutrient Supplementation on Pesticide Residual, Acetylcholinesterase Activity, and Oxidative Stress Among Farm Children Exposed to Pesticides.

Potentially Toxic Elements

The impact of prenatal and early-life arsenic exposure on epigenetic age acceleration among adults in Northern Chile.

Miscellaneous

Vitamin D status in relation to inflammatory risk and albuminuria associated with polycyclic aromatic hydrocarbon exposure in the US population.

Laboratory Studies

BPA/Phenols

The alternative analog plasticizer BPS displays similar phenotypic and metabolomic responses to BPA in HepG2 and INS-1E cells.

Bisphenol A Enhances Apoptosis, Fibrosis, and Biochemical Fluctuations in the Liver of Adult Male Rats with Possible Regression after Recovery.

Hepatoprotective effect of curcumin against bisphenol A-induced hepatic steatosis via modulating gut microbiota dysbiosis and related gut-liver axis activation in CD-1 mice.

Bisphenol-A impairs synaptic formation and function by RGS4-mediated negative regulation of BDNF/NTRK2 signaling in the cerebral cortex.

Bisphenol A inhibits osteogenic activity and causes bone resorption via the activation of retinoic acid-related orphan receptor α.

The effect of selected bisphenols on model erythrocyte membranes of different cholesterol content.

Melatonin protects against nonylphenol caused pancreatic β-cells damage through MDM2-P53-P21 axis.

Phthalates

Mapping DEHP to the adverse outcome pathway network for human female reproductive toxicity.

Parabens/Triclosan/Antimicrobials

Study on the toxic-mechanism of triclosan chronic exposure to zebrafish (Danio rerio) based on gut-brain axis.

Perfluoroalkyl Substances

Perfluorooctanoic acid promotes pancreatic β cell dysfunction and apoptosis through ER stress and the ATF4/CHOP/TRIB3 pathway.

Comparative Hepatotoxicity of a Novel Perfluoroalkyl Ether Sulfonic Acid, Nafion Byproduct 2 (H-PFMO2OSA), and Legacy Perfluorooctane Sulfonate (PFOS) in Adult Male Mice.

Flame Retardants

Low concentration triphenyl phosphate fuels proliferation and migration of hepatocellular carcinoma cells.

Tris (2-chloroethyl) phosphate (TCEP) induces obesity and hepatic steatosis via FXR-mediated lipid accumulation in mice: Long-term exposure as a potential risk for metabolic diseases.

Pesticides

Histopathological, immunohistochemical, and molecular investigation of atrazine toxic effect on some organs of adult male albino rats with a screening of Acacia nilotica as a protective trial.

Glyphosate-induced liver and kidney dysfunction, oxidative stress, immunosuppression in Nile tilapia, but ginger showed a protection role.

Chlorpyrifos oxon crosslinking of amyloid beta 42 peptides is a new route for generation of self-aggregating amyloidogenic oligomers that promote Alzheimer’s disease.

Ameliorative Potential of Vitamin C and E against Roundup-GLP Induced Genotoxicity Triggering Apoptosis in Caprine Granulosa Cells.

Chronic and Acute Effects of Imidacloprid on a Simulated BEEHAVE Honeybee Colony.

Lobaric acid prevents the adverse effects of tetramethrin on the estrous cycle of female albino Wistar rats.

Imidacloprid-based commercial pesticide causes behavioral, biochemical, and hematological impairments in Wistar rats.

Different cellular mechanism of imidacloprid and acetamiprid by a combined targeted lipidomics and metabolomics approach in Neuro-2a cells.

A fungicide, fenhexamid, is involved in the migration and angiogenesis in breast cancer cells expressing estrogen receptors.

Potentially Toxic Elements

Immobilization stress exacerbates arsenic-induced reprotoxic effects in adult rats.

Comparison of the toxic effects of organic and inorganic arsenic in Caenorhabditis elegans using a multigenerational approach.

Sacubitril/valsartan protects against arsenic trioxide induced cardiotoxicity in vivo and in vitro.

Microplastics/Nanomaterials

Combined effects of micro-/nano-plastics and oxytetracycline on the intestinal histopathology and microbiome in zebrafish (Danio rerio).

Digestion of plastics using in vitro human gastrointestinal tract and their potential to adsorb emerging organic pollutants.

Low-dose silver nanoparticles plus methyl mercury exert embryotoxic effects on mouse blastocysts via endoplasmic reticulum stress and mitochondrial apoptosis.

Miscellaneous

Gestational Exposure to Perchlorate in the Rat: Thyroid Hormones in Fetal Thyroid Gland, Serum, and Brain.

Assessment of parental benzo[a]pyrene exposure-induced cross-generational neurotoxicity and changes in offspring sperm DNA methylome in medaka fish.

Occupational exposure in automobile repair workshops: toxicological effects of contaminated soil in Wistar rats.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Untargeted metabolomics reveals that multiple reproductive toxicants are present at the endometrium.

Implications for the seafood industry, consumers and the environment arising from contamination of shellfish with pharmaceuticals, plastics and potentially toxic elements: A case study from Irish waters with a global orientation.

Is water quality in British rivers “better than at any time since the end of the Industrial Revolution”?

Phthalates

Micro-contaminant, but immense impact: Source and influence of diethyl phthalate plasticizer on bottom-dwelling fishes.

Perfluoroalkyl Substances

Spatial distribution of per- and polyfluoroalkyl substances (PFAS) in waters from Central and South Florida.

Volatilisation Potential of Per- and Poly- Fluoroalkyl Substances from Airfield Pavements and During Recycling of Asphalt.

Flame Retardants

Distribution and source of and health risks associated with polybrominated diphenyl ethers in dust generated by public transportation.

Pharmaceuticals/Personal Care Products

Antidepressants as Endocrine Disrupting Compounds in Fish.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on December 16, 2024 at 3:52 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on December 16, 2024 at 3:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Webinar: EDC exposure and gonadal function: consequences and interventions
by Sarah Howard on December 16, 2024 at 3:36 pm
This two part webinar series is sponsored by the Endocrine Society's Special Interest Group (SIG) on endocrine disrupting chemicals (EDCs). The first webinar is scheduled for Jan. 30, 2025, and the second for Feb. 13.

EHN EHN

The plastics crisis: A neuropsychiatric problem hidden in plain sight
by EHN Curators on December 18, 2024 at 7:47 pm
The impact of plastics on health is an area of increasing concern.
Scientists lay out new framework to identify toxics contributing to metabolic disorders
by Katherine McMahon,Sarah Howard on December 17, 2024 at 10:00 am
A new consensus statement published in Nature Reviews Endocrinology proposes a set of 12 characteristics that can be used to identify metabolic-disrupting agents - chemicals, pharmaceuticals, and environmental hazards that increase the risk of metabolic disorders like diabetes and obesity. “This approach will enable a more comprehensive mechanistic understanding of how environmental chemicals and other agents disrupt metabolism and cause adverse outcomes.”
2024 Lou Guillette Jr Outstanding Young Investigator Award Winner: Dr. Chris Kassotis
by Sarah Howard on December 16, 2024 at 4:00 pm
Chris Kassotis, Ph.D., is the 2024 winner of the Lou Guillette, Jr. Outstanding Young Investigator Award, sponsored by Healthy Environment and Endocrine Disruptor Strategies (HEEDS). The award, in honor of scientist and mentor Lou Guillette, Jr., is given to an early-career scientist working in some aspect of endocrine disruptor research. The Kassotis lab focuses on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human and animal health, with a particular focus on metabolic health. He takes on critical public health issues, such as the health effects of chemicals found in fracking fluids and in artificial turf.

EHN EHN

Pesticide industry fights state efforts to regulate PFAS in farming
by EHN Curators on December 19, 2024 at 11:21 am
Pesticide trade groups are using lobbyists and grassroots networks to delay state laws aimed at curbing PFAS contamination in food and water, citing economic concerns. Lisa Held reports for Civil Eats.
Safe drinking water law marks 50 years, but challenges persist
by EHN Curators on December 19, 2024 at 11:19 am
Fifty years after the Safe Drinking Water Act became law, millions still lack reliable access to clean water, particularly in marginalized communities and small towns. Brett Walton reports for Circle of Blue.
RFK Jr. plans to eliminate fluoride in water, but states hold the power
by EHN Curators on December 18, 2024 at 11:47 am
President-elect Donald Trump's health appointee, Robert F. Kennedy Jr., aims to end fluoride in drinking water nationwide, but many states maintain mandates that the federal government cannot override. Hannah Recht reports for The Washington Post.