EDC Science Weekly, June 16-29, 2022

Post author:HEEDS
Post published:June 29, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed the past two weeks (it’s a little longer this time due to the 2 week period).

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Implementing the EU Chemicals Strategy for Sustainability: The case of Food Contact Chemicals of Concern

Glyphosate, Roundup and the Failures of Regulatory Assessment.

Improving the Risk Assessment of Pesticides through the Integration of Human Biomonitoring and Food Monitoring Data: A Case Study for Chlorpyrifos.

Methods/Tools/Screening

Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland.

A harmonized chemical monitoring database for support of exposure assessments.

In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays.

Monte Carlo Models for Sub-Chronic Repeated-Dose Toxicity: Systemic and Organ-Specific Toxicity.

Organotypic Rat Testicular Organoids for the Study of Testicular Maturation and Toxicology.

StemPanTox: A fast and wide-target drug assessment system for tailor-made safety evaluations using personalized iPS cells.

Predicting Combined Effects of Chemical Stressors: Population-Level Effects of Organic Chemical Mixtures With DEB-IBM.

Evaluation of the developmental toxicity of solvents, metals, drugs, and industrial chemicals using a freshwater snail (Biomphalaria glabrata) assay.

Determination of whole mixture-based potency factors for cancer risk assessment of complex environmental mixtures by in vitro testing of standard reference materials.

Analytical strategies to profile the internal chemical exposome and the metabolome of human placenta.

Commentaries

What’s Gender Got to Do with It? Dismantling the Human Hierarchies in Evolutionary Biology and Environmental Toxicology for Scientific and Social Progress.

Bone accrual during adolescence: do endocrine disrupting chemicals play a role?

Phthalate Exposure: From Quantification to Risk Assessment. [intro to a special issue of Toxics]

Editorial: Disruptors on Male Reproduction – Emerging Risk Factors. [intro to a Frontiers in Endocrinology Research Topic]

Editorial: Environmental Exposures and Cardiometabolic Disease. [intro to a Frontiers in Public Health Research Topic]

Bisphenol A and Child Vascular Health: A Preview of Future Heart Disease Risk? [Science Selection in EHP]

Invited Perspective: A Wise Choice: Using Murine Models to Demonstrate Dental Effects following Exposure to Endocrine-Disrupting Compounds. re Use of Dental Defects Associated with Low-Dose di(2-Ethylhexyl)Phthalate as an Early Marker of Exposure to Environmental Toxicants. [in EHP]

Reviews

Numerous Chemicals/Mixtures

A review of transgenerational and multigenerational toxicology in the in vivo model animal Caenorhabditis elegans.

Predicting the impacts of chemical pollutants on animal groups.

BPA/Phenols

Knowledge Gap in Understanding the Steroidogenic Acute Regulatory Protein Regulation in Steroidogenesis Following Exposure to Bisphenol A and Its Analogues.

A systematic review on the effects of acrylamide and bisphenol A on the development of Drosophila melanogaster.

Potential Pro-Tumorigenic Effect of Bisphenol A in Breast Cancer via Altering the Tumor Microenvironment.

Maternal bisphenol A and triclosan exposure and allergic diseases in childhood: a meta-analysis of cohort studies.

Triclosan

The Influence of Triclosan on the Thyroid Hormone System in Humans – A Systematic Review.

Triclosan: A Small Molecule with Controversial Roles.

Triclosan and triclocarban as potential risk factors of colitis and colon cancer: Roles of gut microbiota involved.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of Organochlorine Pesticide Residues in Maternal Body on Infants.

An evidence map of polychlorinated biphenyl exposure and health outcome studies among residents of the Akwesasne Mohawk Nation.

Perfluoroalkyl Substances

Recent progress and challenges on the removal of per- and poly-fluoroalkyl substances (PFAS) from contaminated soil and water.

Perfluoroalkyl substance pollution: detecting and visualizing emerging trends based on CiteSpace.

Toward a Mechanistic Understanding of Poly- and Perfluoroalkylated Substances and Cancer.

Associations between Polyfluoroalkyl Substances Exposure and Breast Cancer: A Meta-Analysis.

Pesticides

Identifying global trends and gaps in research on pesticide fipronil: a scientometric review.

Review of the state of science and evaluation of currently available in silico prediction models for reproductive and developmental toxicity: A case study on pesticides.

Exposure Routes and Health Risks Associated with Pesticide Application.

Lethal, sublethal, and combined effects of pesticides on bees: A meta-analysis and new risk assessment tools.

Fungicides and bees: a review of exposure and risk.

Potentially Toxic Elements

Iodine as a potential endocrine disruptor-a role of oxidative stress.

Fish and the Thyroid: A Janus Bifrons Relationship Caused by Pollutants and the Omega-3 Polyunsaturated Fatty Acids.

Impacts of cadmium on male fertility: Lessons learnt so far.

Heavy Metal Pollution and Male Fertility: An Overview on Adverse Biological Effects and Socio-Economic Implications.

Microplastics/Nanomaterials

Plastic Interactions with Pollutants and Consequences to Aquatic Ecosystems: What We Know and What We Do Not Know.

Scientific Evidence about the Risks of Micro and Nanoplastics (MNPLs) to Human Health and Their Exposure Routes through the Environment.

A review on microplastics and nanoplastics in the environment: Their occurrence, exposure routes, toxic studies, and potential effects on human health.

Plastics in the environment as potential threat to life: an overview.

Micro(nano)plastics and plastic additives effects in marine annelids: A literature review.

Priorities to inform research on marine plastic pollution in Southeast Asia.

Scientometric analysis and scientific trends on microplastics research.

Pharmaceuticals/Personal Care Products

UV filters and their impact on marine life: state of the science, data gaps, and next steps.

Miscellaneous

Influences of polycyclic aromatic hydrocarbon on the epigenome toxicity and its applicability in human health risk assessment.

Human Health Studies

Numerous Chemicals/Mixtures

Environmental mixtures and breast cancer: identifying co-exposure patterns between understudied vs breast cancer-associated chemicals using chemical inventory informatics.

Urinary concentrations of polycyclic aromatic hydrocarbon and phthalate metabolite mixtures in relation to semen quality among men attending an infertility clinic.

BPA/Phenols

Relationship between bisphenol A, bisphenol S, and bisphenol F and serum uric acid concentrations among school-aged children.

The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes.

Phthalates

Association of Urinary Phthalate and Phthalate Replacement Metabolite Concentrations with Serum Lipid Biomarker Levels among Pregnant Women Attending a Fertility Center.

Association of prenatal phthalate exposure with pubertal development in Spanish boys and girls.

Exploring associations between urine levels of phthalates and autism spectrum disorder symptoms: a case-control study in Tianjin, China.

The effect of phthalates exposure during pregnancy on asthma in infants aged 0 to 36 months: a birth cohort study.

Urine Di-(2-ethylhexyl) Phthalate Metabolites Are Independently Related to Body Fluid Status in Adults: Results from a U.S. Nationally Representative Survey.

Phthalate Exposure and Oxidative/Nitrosative Stress in Childhood Asthma: A Nested Case-Control Study with Propensity Score Matching.

Associations of exposure to melamine, cyanuric acid, phthalates with markers of early kidney impairment, and their interactions in US adults: analyses of NHANES 2003-2004 data.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations between autoimmune dysfunction and pollutants in Akwesasne Mohawk women: Dichlorodiphenyltrichloroethane and polychlorinated biphenyl exposure.

Prenatal exposure to multiple organochlorine compounds and childhood body mass index.

Associations of polychlorinated biphenyls exposure with plasma glucose and diabetes in general Chinese population: The mediating effect of lipid peroxidation.

Histopathological Alterations in the Livers of Chronic Hepatitis Patients Exposed to Agent Orange/Dioxin in Vietnam.

Perfluoroalkyl Substances

Exposure to Per- and Polyfluoroalkyl Substances and Mortality in U.S. Adults: A Population-Based Cohort Study.

Per- and polyfluoroalkyl substances in drinking water and hypertensive disorders of pregnancy in the United States during 2013-2015.

Global DNA methylation mediates the association between serum perfluorooctane sulfonate and carotid intima-media thickness in young and middle-aged Taiwanese populations.

Environmental exposure to per- and polyfluoroalkyl substances and sleep disturbance in pregnant women: A prospective cohort study.

Lipoprotein profiles associated with exposure to poly- and perfluoroalkyl substances (PFASs) in the EuroMix human biomonitoring study.

Pesticides

Associations of organophosphate metabolites with thyroid hormone and antibody levels: findings from U.S. National Health and Nutrition Examination Survey (NHANES).

Pesticides and farmers’ health: an analysis of variables related to management and property.

Occupational exposure to pesticides in farmworkers and the oxidative markers.

Pesticide Exposure in Relation to the Incidence of Abnormal Glucose Regulation: A Retrospective Cohort Study.

Chronic Pesticide Exposure in Farm Workers Is Associated with the Epigenetic Modulation of hsa-miR-199a-5p.

Pyrimethanil and chlorpyrifos air concentrations and pregnant women’s urinary metabolites in the Infants’ Environmental Health Study (ISA), Costa Rica.

Interactive effects of maternal exposure to chemical fertilizer and socio-economic status on the risk of low birth weight.

Potentially Toxic Elements

The association between heavy metal exposure and erectile dysfunction in the United States.

Total arsenic, dimethylarsinic acid, lead, cadmium, total mercury, methylmercury and hypertension among Asian populations in the United States: NHANES 2011-2018.

Miscellaneous

Association between urinary polycyclic aromatic hydrocarbon metabolites and diabetes mellitus among the US population: a cross-sectional study.

Urinary polycyclic aromatic hydrocarbon metabolites were associated with hypertension in US adults: data from NHANES 2009-2016.

Laboratory Studies

Numerous Chemicals/Mixtures

Feminizing effects of ethinylestradiol in roach (Rutilus rutilus) populations with different estrogenic pollution exposure histories.

Transcriptomics-based analysis of co-exposure of cadmium (Cd) and 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) indicates mitochondrial dysfunction induces NLRP3 inflammasome and inflammatory cell death in renal tubular epithelial cells.

Effects of perfluoroalkyl substances (PFASs) and benzo[a]pyrene (BaP) co-exposure on phase I biotransformation in rainbow trout (Oncorhynchus mykiss).

Developmental exposure to real-life environmental chemical mixture programs a Testicular Dysgenesis Syndrome-like phenotype in prepubertal lambs.

BPA/Phenols

Systematic multi-omics reveals the overactivation of T cell receptor signaling in immune system following bisphenol A exposure.

Histone deacetylase 2 inhibitor valproic acid attenuates bisphenol A-induced liver pathology in male mice.

Prenatal Bisphenol a Exposure and Postnatal Trans Fat Diet Alter Small Intestinal Morphology and Its Global DNA Methylation in Male Sprague-Dawley Rats, Leading to Obesity Development.

Intestinal Microecology of Mice Exposed to TiO₂ Nanoparticles and Bisphenol A.

The Effect of BPA-Treated Water on the Small Intestine via an In Vivo Study.

Metabolic profiling of bisphenol A diglycidyl ether in vitro and in vivo.

The Mixture of Bisphenol-A and Its Substitutes Bisphenol-S and Bisphenol-F Exerts Obesogenic Activity on Human Adipose-Derived Stem Cells

Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats.

Oxidative Stress and Apoptosis in Bisphenol AF-induced Neurotoxicity in Zebrafish Embryos.

Fluornen-9-bisphenol increases Leydig cell proliferation but inhibits maturation in pubertal male rats via interacting with androgen receptor as an antagonist and estrogen receptor α as an agonist.

Phthalates

Multigenerational effects of an environmentally relevant phthalate mixture on reproductive parameters and ovarian miRNA expression in female rats.

Interaction of Phthalates with Lipid Bilayer Membranes.

Prenatal di-(2-ethylhexyl) phthalate exposure induced myocardial cytotoxicity via the regulation of the NRG1-dependent ErbB2/ErbB4-PI3K/AKT signaling pathway in fetal mice.

Effects of bis (2-butoxyethyl) phthalate on adrenocortical function in male rats in puberty partially via down-regulating NR5A1/NR4A1/NR4A2 pathways.

Parabens/Triclosan/Antimicrobials

Molecular mechanism of ethylparaben on zebrafish embryo cardiotoxicity based on transcriptome analyses.

The Effect of Early Life Exposure to Triclosan on Thyroid Follicles and Hormone Levels in Zebrafish.

Maternal exposure to triclosan during lactation alters social behaviors and the hippocampal ultrastructure in adult mouse offspring.

Involvement of sirtuins (Sirt1 and Sirt3) and aryl hydrocarbon receptor (AhR) in the effects of triclosan (TCS) on production of neurosteroids in primary mouse cortical neurons cultures.

An in vivo study of the toxic effects of triclosan on Xenopus laevis (Daudin, 1802) frog: Assessment of viability, tissue damage and mitochondrial dysfunction.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Cross-species metabolomic analysis of tau- and DDT-related toxicity.

Developmental Exposure to Endocrine Disrupter DDT Interferes with Age-Related Involution of Thymus.

Exposure to the Dioxin-like Pollutant PCB 126 Afflicts Coronary Endothelial Cells via Increasing 4-Hydroxy-2 Nonenal: A Role for Aldehyde Dehydrogenase 2.

Interindividual variation contributes to differential PCB 126 induced gene expression in primary breast epithelial cells and tissues.

Polyhalogenated carbazoles (PHCZs) induce cardiotoxicity and behavioral changes in zebrafish at early developmental stages.

Perfluoroalkyl Substances

The Role of Fecal Microbiota in Liver Toxicity Induced by Perfluorooctane Sulfonate in Male and Female Mice.

Pulmonary exposure of mice to ammonium perfluoro(2-methyl-3-oxahexanoate) (GenX) suppresses the innate immune response to carbon black nanoparticles and stimulates lung cell proliferation.

Perfluorooctanesulfonic acid exposure altered hypothalamic metabolism and disturbed male fecundity.

Multi- and Transgenerational Effects of Developmental Exposure to Environmental Levels of PFAS and PFAS Mixture in Zebrafish (Danio rerio).

Aberrant hepatic lipid metabolism associated with gut microbiota dysbiosis triggers hepatotoxicity of novel PFOS alternatives in adult zebrafish.

Pre-differentiation exposure of PFOA induced persistent changes in DNA methylation and mitochondrial morphology in human dopaminergic-like neurons.

Flame Retardants

A single-cell survey unveils cellular heterogeneity and sensitive responses in mouse cortices induced by oral exposure to triphenyl phosphate.

Biomarker Responses, Gene Expression Alterations, and Histological Changes in Zebrafish (Danio rerio) After In Vivo Exposure to Polychlorinated Diphenyl Ethers.

Exposure to Polybrominated Diphenyl Ether Flame Retardants Causes Deoxyribonucleic Acid Damage in Human Thyroid Cells In Vitro.

Organophosphate flame retardant TDCPP: A risk factor for renal cancer?

Pesticides

Developmental Exposure to Trace Concentrations of Chlorpyrifos Results in Nonmonotonic Changes in Brain Shape and Behavior in Amphibians.

Low trifloxystrobin-tebuconazole concentrations induce cardiac and developmental toxicity in zebrafish by regulating notch mediated-oxidative stress generation.

Sublethal toxicity, transgenerational effects, and transcriptome expression of the neonicotinoid pesticide cycloxaprid on demographic fitness of Coccinella septempunctata.

Short and long term effects of chlorpyrifos on thyroid hormone axis and brain development in Xenopus laevis.

Deltamethrin-Evoked ER Stress Promotes Neuroinflammation in the Adult Mouse Hippocampus.

Deltamethrin and Its Nanoformulations Induce Behavioral Alteration and Toxicity in Rat Brain through Oxidative Stress and JAK2/STAT3 Signaling Pathway.

The Survival Response of Earthworm (Eisenia fetida L.) to Individual and Binary Mixtures of Herbicides.

Genetic variation of the interaction type between two stressors in a single population: From antagonism to synergism when combining a heat spike and a pesticide.

The exposure in ovo of embryos belonging to Amazonian turtle species Podocnemis expansa (testudines) to commercial glyphosate and fipronil formulations impairs their growth and changes their skeletal development.

Pentachloronitrobenzene Reduces the Proliferative Capacity of Zebrafish Embryonic Cardiomyocytes via Oxidative Stress.

Aryl hydrocarbon receptor agonist diuron and its metabolites cause reproductive disorders in male marine medaka (Oryzias melastigma).

The sesquiterpenoid valerenic acid protects neuronal cells from the detrimental effects of the fungicide benomyl on apoptosis and DNA oxidation.

Potentially Toxic Elements

Chronic coexposure to arsenic and estrogen potentiates genotoxic estrogen metabolic pathway and hypermethylation of DNA glycosylase MBD4 in human prostate epithelial cells.

Synergistic effects of arsenic and fluoride on oxidative stress and apoptotic pathway in Leydig and Sertoli cells.

Microplastics/Nanomaterials

Aging relieves the promotion effects of polyamide microplastics on parental transfer and developmental toxicity of TDCIPP to zebrafish offspring.

Polystyrene microplastics exacerbate experimental colitis in mice tightly associated with the occurrence of hepatic inflammation.

Polystyrene nanoplastics induce profound metabolic shift in human cells as revealed by integrated proteomic and metabolomic analysis.

Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-κB-NLRP3-GSDMD and AMPK-PGC-1α axes.

Polystyrene microplastics induced male reproductive toxicity and transgenerational effects in freshwater prawn.

In Vitro High-Throughput Toxicological Assessment of Nanoplastics.

Microplastics- and copper-induced changes in neurogenesis and DNA methyltransferases in the early life stages of zebrafish.

Effects of nanoplastics on zebrafish embryo-larval stages: A case study with polystyrene (PS) and polymethylmethacrylate (PMMA) particles.

Nanoplastics cause transgenerational toxicity through inhibiting germline microRNA mir-38 in C. elegans.

Whole transcriptome sequencing analysis revealed key RNA profiles and toxicity in mice after chronic exposure to microplastics.

Nano- and micro-polystyrene plastics disturb gut microbiota and intestinal immune system in honeybee.

Air Pollution

Maternal exposure to PM_2.5 disrupting offspring spermatogenesis through induced sertoli cells apoptosis via inhibin B hypermethylation in mice.

Miscellaneous

Endocrine-disrupting metabolic activation of 2-nitrofluorene catalyzed by human cytochrome P450 1A1: A QM/MM approach.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Maternal and child biomonitoring strategies and levels of exposure in western Canada during the past seventeen years: The Alberta Biomonitoring Program: 2005-2021.

Investigating children’s chemical exposome – Description and possible determinants of exposure in the region of Luxembourg based on hair analysis.

Validated single urinary assay designed for exposomic multi-class biomarkers of common environmental exposures.

Analysis of pesticide and persistent organic pollutant residues in German bats.

BPA/Phenols

Human risk assessment of 4-n-nonylphenol (4-n-NP) using physiologically based pharmacokinetic (PBPK) modeling: analysis of gender exposure differences and application to exposure analysis related to large exposure variability in population.

Parabens

Cumulative risk assessment and exposure characteristics of parabens in the general Taiwanese using multiple hazard indices approaches.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Dioxin Congener Patterns in Breast Milk Samples from Areas Sprayed with Herbicide during the Vietnam War 40 Years after the War Ended.

Perfluoroalkyl Substances

Serum concentrations of selected perfluoroalkyl substances for US females compared to males as they age.

Occurrence, distribution, and input pathways of per- and polyfluoroalkyl substances in soils near different sources in Shanghai.

Antioxidant Responses Induced by PFAS Exposure in Freshwater Fish in the Veneto Region.

Spatial distribution, vertical profiles and transport of legacy and emerging per- and polyfluoroalkyl substances in the Indian Ocean.

Flame Retardants

Global PBDE contamination in cetaceans. A critical review.

Spatial distribution and risk assessment of 11 organophosphate flame retardants in soils from different regions of agricultural farmlands in mainland China.

Pesticides

Simultaneous quantification of pyrethroid metabolites in urine of non-toilet-trained children in Japan.

Pesticides and their metabolites in European groundwater: Comparing regulations and approaches to monitoring in France, Denmark, England and Switzerland.

Air Pollution

Polycyclic aromatic hydrocarbons in breast milk of nursing mothers: Correlates with household fuel and cooking methods used in Uganda, East Africa.

Pharmaceuticals/Personal Care Products

Linking Mechanistic Effects of Pharmaceuticals and Personal Care Products to Ecologically Relevant Outcomes: A Decade of Progress.

Pharmaceutical and Personal Care Products as emerging environmental contaminants in Nigeria: A Systematic Review.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.