EDC Science Weekly, June 2-8, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Current ecotoxicity testing needs among selected U.S. federal agencies.

Methods/Tools/Screening

A comparative study of the effects of 3 testicular toxicants in cultures of seminiferous tubules of rats or of domestic cats (veterinary waste): An alternative method for reprotoxicology.

Identification of combinations of endocrine disrupting chemicals in household chemical products that require mixture toxicity testing.

Uncovering PFAS and Other Xenobiotics in the Dark Metabolome Using Ion Mobility Spectrometry, Mass Defect Analysis, and Machine Learning.

Investigating the association of environmental exposures and all-cause mortality in the UK Biobank using sparse principal component analysis.

Human adrenocortical carcinoma cell line (NCI-H295R): An in vitro screening model for the assessment of endocrine disruptors’ actions on steroidogenesis with an emphasis on cell ultrastructural features.

Artificial Intelligence-Based Toxicity Prediction of Environmental Chemicals: Future Directions for Chemical Management Applications.

Assessment of the applicability of the threshold of toxicological concern for per- and polyfluoroalkyl substances.

Computational protocol for predicting ¹⁹ F NMR chemical shifts for PFAS and connection to PFAS structure.

Commentaries

How science could aid the US quest for environmental justice. [News item in Nature]

Reviews

Numerous Chemicals/Mixtures

Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical Exposures.

Role of Environmental Toxicants on Neurodegenerative Disorders.

Endometriosis and environmental factors: a critical review.

Bioremediation of Endocrine Disrupting Chemicals- Advancements and Challenges.

Hair Dye Ingredients and Potential Health Risks from Exposure to Hair Dyeing.

[Main endocrine disruptors related to female reproductive health: biological basis of their association]. [in Spanish]

Perfluoroalkyl Substances

A review of recent studies on toxicity, sequestration, and degradation of per- and polyfluoroalkyl substances (PFAS)

Potentially Toxic Elements

Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms.

Relationship between maternal heavy metal exposure and congenital heart defects: a systematic review and meta-analysis.

Cadmium exposure and the risk of GDM: evidence emerging from the systematic review and meta-analysis.

Microplastics/Nanomaterials/Plastics

Drosophila melanogaster as a dynamic in vivo model organism reveal the hidden effects of interactions between micro-/nanoplastics and heavy metals.

Plastics in scene: A review of the effect of plastics in aquatic crustaceans.

Plastic particles in medicine: A systematic review of exposure and effects to human health.

Human Health Studies

Numerous Chemicals/Mixtures

Co-exposure to perfluoroalkyl acids and heavy metals mixtures associated with impaired kidney function in adults: A community-based population study in China.

Urinary phenols and parabens in relation to hearing loss: The National Health and Nutrition Examination Survey.

BPA/Phenols

Prenatal Bisphenol A exposure in relation to behavioral outcomes in girls aged 4 – 5 and modification by socio-demographic factors in The Infant Development and Environment Study (TIDES).

Phthalates

Urinary phthalate concentrations are associated with total fat mass in Thai children.

Relationship of individual and mixed prenatal phthalate exposure with placental structure and efficiency in the prospective Ma’anshan Birth Cohort Study.

Association of phthalate exposure with cause-specific and all-cause mortality among people with hypertension: The U.S. National Health and Nutrition Examination Survey, 2003-2014

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association between mixed dioxin exposure and hyperuricemia in U.S. adults: A comparison of three statistical models.

Public healthcare costs associated with long-term exposure to mixtures of persistent organic pollutants in two areas of Southern Spain: A longitudinal analysis.

Perfluoroalkyl Substances

Association of emerging and legacy per- and polyfluoroalkyl substances with unexplained recurrent spontaneous abortion.

Interaction of Per- and Polyfluoroalkyl Substances and Allostatic Load among Adults in Various Occupations.

Flame Retardants

Penetration of Organophosphate Triesters and Diesters across the Blood-Cerebrospinal Fluid Barrier: Efficiencies, Impact Factors, and Mechanisms.

Pesticides

Comparing impact of pesticide exposure on cognitive abilities of Latinx children from rural farmworker and urban non-farmworker families in North Carolina.

Association between pesticide exposure and obesity: A cross-sectional study of 20,295 farmers in Thailand.

Association between pesticide exposure and neurobehavioral performance of agricultural workers: A cross-sectional study.

Levels of anti-cyclic citrullinated peptide and antinuclear antibodies on Brazilian agricultural workers exposed to pesticides and fertilizers.

Mosquito Control Workers in Malaysia: Is Lifetime Occupational Pesticide Exposure Associated With Poorer Neurobehavioral Performance?

Dietary Magnesium Intake Ameliorates the Association Between Household Pesticide Exposure and Type 2 Diabetes: Data From NHANES, 2007-2018.

Potentially Toxic Elements

Placental Gene Transcript Proportions are Altered in the Presence of In Utero Arsenic and Cadmium Exposures, Genetic Variants, and Birth Weight Differences.

Associations between exposure to different heavy metals and self-reported erectile dysfunction: a population-based study using data from the 2001-2004 National Health and Nutrition Examination Survey.

Associations between time-weighted postnatal methylmercury exposure from fish consumption and neurodevelopmental outcomes through 24 years of age in the Seychelles Child Development Study Main Cohort.

Mercury levels in hair are associated with reduced neurobehavioral performance and altered brain structures in young adults.

Maternal urinary fluoride during pregnancy and birth weight and length: Results from ELEMENT cohort study.

Arsenic Exposure, Blood DNA Methylation, and Cardiovascular Disease.

Associations of exposure to lead and cadmium with risk of all-cause and cardiovascular disease mortality among patients with type 2 diabetes.

Miscellaneous

Associations of urinary polycyclic aromatic hydrocarbon metabolites and blood pressure with the mediating role of cytokines: A panel study among children.

Laboratory Studies

Numerous Chemicals/Mixtures

In utero exposure to a mixture of the perfluoroalkyl-isopropyl pesticide pyrifluquinazon with dibutyl phthalate cumulatively disrupts male rat reproductive development via different mechanisms of action.

A Role for Gene-Environment Interactions in Autism Spectrum Disorder Is Supported by Variants in Genes Regulating the Effects of Exposure to Xenobiotics.

Bisphenol A and 2,3,7,8-tetrachlorodibenzo-p-dioxin at non-cytotoxic doses alter the differentiation potential and cell function of rat adipose-stem cells.

BPA/Phenols

The impact of preconceptional exposure of F0 male mice to bisphenol A alone or in combination with X-rays on the intrauterine development of F2 progeny.

Hesperidin abrogates bisphenol A endocrine disruption through binding with fibroblast growth factor 21 (FGF-21), α-amylase and α-glucosidase: an in silico molecular study.

Nattokinase attenuates bisphenol A or gamma irradiation-mediated hepatic and neural toxicity by activation of Nrf2 and suppression of inflammatory mediators in rats.

Sex-specific influence of maternal exposure to bisphenol A on sodium and fluid balance in response to dipsogenic challenges in rats.

State-of-the-art progress of metal-organic framework-based electrochemical and optical sensing platforms for determination of bisphenol A as an endocrine disruptor.

Bisphenol A Analogs Induce Cellular Dysfunction in Human Trophoblast Cells in a Thyroid Hormone Receptor-Dependent Manner: In Silico and In Vitro Analyses.

Developmental Exposure to Bisphenol a Degrades Auditory Cortical Processing in Rats.

Bisphenol A in edible tissues of rams exposed to repeated low-level dietary dose by high-performance liquid chromatography with fluorescence detection.

BPA disrupts meiosis I in oogonia by acting on pathways including cell cycle regulation, meiosis initiation and spindle assembly.

Phthalates

Investigation into the protective effects of Naringenin in phthalates-induced reproductive damage.

Di-(2-ethyl hexyl) phthalate induced oxidative stress promotes microplastics mediated apoptosis and necroptosis in mice skeletal muscle by inhibiting PI3K/AKT/mTOR pathway.

Chronic exposure to environmentally relevant levels of di(2-ethylhexyl) phthalate (DEHP) disrupts lipid metabolism associated with SBP-1/SREBP and ER stress in C. elegans.

Effect of aqueous garlic (Allium sativum) extract against di-(2-ethylhexyl) phthalate induced reproductive toxicity in male mice.

Di-(2-ethylhexyl) Phthalate Promotes Allergic Lung Inflammation by Modulating CD8α⁺ Dendritic Cell Differentiation via Metabolite MEHP-PPARγ Axis.

Parabens/Triclosan/Antimicrobials

Significant impairment of intestinal health in zebrafish after subchronic exposure to methylparaben.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

CORAL: Development of A hybrid descriptor based QSTR model to predict the toxicity of Dioxins and Dioxin-like Compounds with Correlation Intensity Index and Consensus Modelling.

Health impact assessment of pet cats caused by organohalogen contaminants by serum metabolomics and thyroid hormone analysis.

Perfluoroalkyl Substances

Perfluorooctane Sulfonamide (PFOSA) Induces Cardiotoxicity via Aryl Hydrocarbon Receptor Activation in Zebrafish.

Concentration-dependent toxicokinetics of novel PFOS alternatives and their chronic combined toxicity in adult zebrafish.

Comparison of sub-lethal metabolic perturbations of select legacy and novel perfluorinated alkyl substances (PFAS) in Daphnia magna.

Is the use of paper food contact materials treated with per- and polyfluorinated alkyl substances safe for high-temperature applications? – Migration study in real food and food simulants.

Spatially revealed perfluorooctane sulfonate-induced nephrotoxicity in mouse kidney using atmospheric pressure MALDI mass spectrometry imaging.

Disturbed glucose metabolism by perfluorobutanesulfonate pollutant and benefit of young fecal transplantation in aged zebrafish.

Flame Retardants

Exposure to BDE-47 and BDE-209 impaired antioxidative defense mechanisms in Brachionus plicatilis.

The respiratory cytotoxicity of typical organophosphorus flame retardants on five different respiratory tract cells: Which are the most sensitive one?

The antagonistic effect of melatonin on TBBPA-induced apoptosis and necroptosis via PTEN/PI3K/AKT signaling pathway in swine testis cells.

Triphenyl phosphate (TPP) promotes hepatocyte toxicity via induction of endoplasmic reticulum stress and inhibition of autophagy flux.

Exposure to tris(2-butoxyethyl) phosphate induces abnormal sperm morphology and testicular histopathology in male rats.

Diversity-oriented synthesis of marine polybrominated diphenyl ethers as potential KCNQ potassium channel activators.

Pesticides

Hormonal profile changes induced by pesticide mixture exposure in female rats revealed by hair analysis.

Potency matters: Impacts of embryonic exposure to nAChR agonists thiamethoxam and nicotine on hatching success, growth, and neurobehavior in larval zebrafish.

Glyphosate-based herbicide causes spermatogenesis disorder and spermatozoa damage of the Chinese mitten crab (Eriocheir sinensis) by affecting testes characteristic enzymes, antioxidant capacities and inducing apoptosis.

Low-toxic herbicides Roundup and Atrazine disturb free radical processes in Daphnia in environmentally relevant concentrations.

Honey bee toxicological responses do not accurately predict environmental risk of imidacloprid to a solitary ground-nesting bee species.

Microplastics/Nanomaterials

Nano-sized polystyrene plastic particles affect many cancer-related biological processes even in the next generations; zebrafish modeling.

Effects of pristine or contaminated polyethylene microplastics on zebrafish development.

Disentangling the influence of microplastics and their chemical additives on a model detritivore system.

Multiple perspectives reveal the gut toxicity of polystyrene microplastics on Eisenia fetida: Insights into community signatures of gut bacteria and their translocation.

Silica Nanoparticle-Induced Reproductive Toxicity in Male Albino Rats via Testicular Apoptosis and Oxidative Stress.

Pharmaceuticals/Personal Care Products

Exposure to Low Doses of Oxybenzone During Perinatal Development Alters Mammary Gland Stroma in Female Mice.

Miscellaneous

Endocrine disruption: Reproductive toxicity of glyceryl trinitrate and isosorbide mononitrate in male Wistar rats.

The SARS-CoV-2 spike protein binds and modulates estrogen receptors.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

PFAS and PBDEs in traditional subsistence foods from Sivuqaq, Alaska.

Dataset of pollutants in organic and non-organic food.

Occurrence and seasonal disparity of emerging endocrine disrupting chemicals in a drinking water supply system and associated health risk.

Rapid and simultaneous determination of multiple endocrine-disrupting chemicals and their metabolites in human serum and urine samples.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Sexually Dimorphic Accumulation of Persistent Organic Pollutants in Fetuses.

Persistent Problem: Global Challenges to Managing PCBs.

Hepatic Burdens of PCB and PCDD/F Congeners in Federally Endangered Shortnose Sturgeon and Atlantic Sturgeon from the Hudson River, New York, USA: Burden Patterns and Potential Consequences in Offspring.

PAHs, PCBs, PBDEs, and OCPs trapped and remobilized in the Lake of Cavazzo (NE Italy) sediments: Temporal trends, quality, and sources in an area prone to anthropogenic and natural stressors.

Perfluoroalkyl Substances

Estimated daily intake of per- and polyfluoroalkyl substances related to different particle size fractions of house dust.

Perturbation of the gut microbiome in wild-caught freshwater turtles (Emydura macquarii macquarii) exposed to elevated PFAS levels.

Perfluoroalkyl substances in the surface water and fishes in Chaohu Lake, China.

Perfluoroalkyl acids in representative edible aquatic species from the lower Yangtze River: Occurrence, distribution, sources, and health risk.

Simulation modelling the structure related bioaccumulation and biomagnification of per- and polyfluoroalkyl substances in aquatic food web

Flame Retardants

Occupational exposure to organophosphate esters in e-waste dismantling workers: Risk assessment and influencing factors screening.

Riverine transport dynamics of PBDEs and OPFRs within a typical e-waste recycling zone: Implications for sink-source interconversion.

Pesticides

The spatial-temporal chemical footprint of pesticides in China from 1999 to 2018.

Study of feces of neotropical otters (Lontra longicaudis) in the Ayuquila-Armería basin, Mexico as biomonitors of the spatiotemporal distribution of pesticides.

Potentially Toxic Elements

Patterns of Children’s Blood Lead Screening and Blood Lead Levels in North Carolina, 2011-2018-Who Is Tested, Who Is Missed?

Assessment of U and As in groundwater of India: A meta-analysis.

Microplastics/Nanomaterials

Microplastics and their Additives in the Indoor Environment.

Plastitar: A new threat for coastal environments.

Huge quantities of microplastics are “hidden” in the sediment of China’s largest urban lake-Tangxun Lake.

Pharmaceuticals/Personal Care Products

Occurrence and removal of drugs and endocrine disruptors in water supply systems in the metropolitan region of Belo Horizonte (Minas Gerais State, Brazil).

Fate of selected pharmaceuticals in hospital and municipal wastewater effluent: occurrence, removal, and environmental risk assessment.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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