EDC Science Weekly, May 5 – 11, 2022 – HEEDS

EDC Science Weekly, May 5 – 11, 2022

Post author:HEEDS
Post published:May 11, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar May 12: Personal Care Product Use and Chemical Exposure among Black, Latina, and Vietnamese Women in California: Findings from the CAPABLE Project

Webinar May 19: Obesogens and the Obesity Pandemic: A focus on prevention (EDC Strategies Partnership)

Methods/Tools/Screening

On the Utility of ToxCast-Based Predictive Models to Evaluate Potential Metabolic Disruption by Environmental Chemicals.

Effects of consumer products chemicals ingredients and their mixtures on the estrogen receptor/androgen receptor transcriptional activation.

Assessment of a New Approach Method for Grouped Chemical Hazard Estimation: The Toxicity-Normalized Species Sensitivity Distribution (SSDn).

A microfluidic thyroid-liver platform to assess chemical safety in humans.

The Next Frontier of Environmental Unknowns: Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials (UVCBs).

Harmonization of transcriptomic and methylomic analysis in environmental epidemiology studies for potential application in chemical risk assessment. [case study on arsenic]

Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment – A case study with parabens.

Strengthening Causal Inference in Exposomics Research: Application of Genetic Data and Methods.

TeachOpenCADD 2022: open source and FAIR Python pipelines to assist in structural bioinformatics and cheminformatics research.

A randomization-based causal inference framework for uncovering environmental exposure effects on human gut microbiota. [case study on air pollution and smoking]

Commentaries

Official health communications are failing PFAS-contaminated communities.

I don’t usually include letters or corrections in this summary but these are all relevant:

Comment on “Charting a Path Forward: Assessing the Science of Chemical Risk Evaluations under the Toxic Substances Control Act in the Context of Recent National Academies Recommendations”.

Comment on “Application of an in Vitro Assay to Identify Chemicals That Increase Estradiol and Progesterone Synthesis and Are Potential Breast Cancer Risk Factors” and see the Response.

Comment on “Application of an in Vitro Assay to Identify Chemicals That Increase Estradiol and Progesterone Synthesis and Are Potential Breast Cancer Risk Factors” and see the Response.

Correction: Authors’ rebuttal to Integrated Risk Information System (IRIS) response to “Assessing risk of bias in human environmental epidemiology studies using three tools: different conclusions from different tools”.

Reviews

Numerous Chemicals/Mixtures

Halogenated ingredients of household and personal care products as emerging endocrine disruptors.

What Is “Socioeconomic Position (SEP),” and How Might It Modify Air Pollution-Health Associations? Cohering Findings, Identifying Challenges, and Disentangling Effects of SEP and Race in US City Settings.

Parental Occupational Exposure and Neurodevelopmental Disorders in Offspring: a Systematic Review and Meta-analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Determination of safe levels of persistent organic pollutants in toxicology and epidemiology.

Perfluoroalkyl Substances

The Conundrum of the PFOA human half-life, an international collaboration.

Potentially Toxic Elements

Occupational Exposure to Metal Fumes Among Iranian Welders: Systematic Review and Simulation-Based Health Risk Assessment.

Microplastics/Nanomaterials

Toxicological impacts of micro(nano)plastics in the benthic environment.

Coupled effects of microplastics and heavy metals on plants: Uptake, bioaccumulation, and environmental health perspectives.

Eco-corona formation and associated ecotoxicological impacts of nanoplastics in the environment.

The emerging issue of microplastics in marine environment: A bibliometric analysis from 2004 to 2020.

Air Pollution

Wildfire, Smoke Exposure, Human Health, and Environmental Justice Need to be Integrated into Forest Restoration and Management.

In-utero exposure to air pollution and early-life neural development and cognition.

Pharmaceuticals/Personal Care Products

The potential of algae and aquatic macrophytes in the pharmaceutical and personal care products (PPCPs) environmental removal: a review.

Human Health Studies

Numerous Chemicals/Mixtures

Exposure to phthalates, phenols, and parabens mixture and alterations in sex steroid hormones among adolescents.

Sex-specific associations between maternal exposure to parabens, phenols and phthalates during pregnancy and birth size outcomes in offspring.

BPA/Phenols

Bisphenol A correlates with fewer retrieved oocytes in women with tubal factor infertility.

Phthalates

Urinary phthalate metabolite concentrations during four windows spanning puberty (prepuberty through sexual maturity) and association with semen quality among young Russian men.

Associations between Children’s asthma and allergic symptoms and phthalates in dust in metropolitan Tianjin, China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Thyroid autoimmunity in Greenlandic Inuit.

Perfluoroalkyl Substances

Environmental Exposure to 6:2 Polyfluoroalkyl Phosphate Diester and Impaired Testicular Function in Men.

Serum PFAS and Urinary Phthalate Biomarker Concentrations and Bone Mineral Density in 12-19 Year Olds: 2011-2016 NHANES.

Flame Retardants

Infants’ diminished response to DTaP vaccine is associated with exposure to organophosphate esters.

Associations between organophosphate esters metabolites and sleep disorder and trouble sleeping in adults: a machine-learning approach.

Pesticides

Occupational risk assessment of organophosphates with an emphasis on psychological and oxidative stress factors.

Association between maternal exposure to chemical fertilizer and the risk of birth defects in a rural population in northern China: a population-based study.

Urinary Pesticide Residual Levels and Acute Respiratory Infections in Children Under 5 Years of Age: Findings From the Offinso North Farm Health Study.

DNA damage in a Chilean population exposed to pesticides and its association with PON1 (Q192R and L55M) susceptibility biomarker.

Potentially Toxic Elements

Associations of exposure to metal and metal mixtures with thyroid hormones: Results from the NHANES 2007-2012.

Co-exposure to priority-controlled metals mixture and blood pressure in Chinese children from two panel studies.

Mediating effect of telomere length in a hypertension population exposed to cadmium: a case-control study.

Air Pollution

Both parents matter: a national-scale analysis of parental race/ethnicity, disparities in prenatal PM_2.5 exposures and related impacts on birth outcomes.

Associations between estimates of perinatal industrial pollution exposures and intellectual disability in Utah children.

Pharmaceuticals/Personal Care Products

Association of In Utero Exposures With Risk of Early Natural Menopause. [DES]

Laboratory Studies

Numerous Chemicals/Mixtures

Observed and predicted embryotoxic and teratogenic effects of organic and inorganic environmental pollutants and their mixtures in zebrafish (Danio rerio).

Effect-directed analysis of estrogenic chemicals in sediments from an electronic-waste recycling area.

BPA/Phenols

Bisphenol A Exposure Induces Sensory Processing Deficits in Larval Zebrafish During Neurodevelopment.

Bisphenol A attenuates the therapeutic effect of the selective G protein-coupled estrogen receptor agonist G-1 on allergic rhinitis inflammation in mice.

Phthalates

High-fat diet aggravates prenatal low-dose DEHP exposure induced spermatogenesis disorder: Characterization of testicular metabolic patterns in mouse offspring.

The protective effects of thymol and carvacrol against di (2-ethylhexyl) phthalate-induced cytotoxicity in HEK-293 cells.

Nongenomic effects and mechanistic study of butyl benzyl phthalate-induced thyroid disruption: Based on integrated in vitro, in silico assays and proteome analysis.

Di-2-ethylhexyl phthalate (DEHP) induced lipid metabolism disorder in liver via activating the LXR/SREBP-1c/PPARα/γ and NF-κB signaling pathway.

Complexes of ortho-Phthalic Acid in Spontaneous Animal Tumors.

Parabens/Triclosan/Antimicrobials

Comparison of toxicological effects and exposure levels between triclosan and its structurally similar chemicals using in vitro tests for read-across case study.

Flame Retardants

Effects of Developmental Exposure to FireMaster® 550 (FM 550) on Microglia Density, Reactivity and Morphology in a Prosocial Animal Model.

TBBPA downregulates thyroid receptor and estrogen receptor mRNA levels in goldfish gonadal tissue.

Synthesis and evaluation of hydroxy‑ and dihydroxy brominated benzenes, methyl- and ethylbenzenes: Potential metabolites of current-use brominated flame retardants.

Organotins

Prolonged exposure of azocyclotin induced inter- and transgenerational endocrine disruption on Danio rerio linked to transcriptomic and DNA methylomic alterations.

Pesticides

Combined effects of S-metolachlor and benoxacor on embryo development in zebrafish (Danio rerio).

Structure identification and toxicity evaluation of one newly-discovered dechlorinated photoproducts of chlorpyrifos.

Selenium Heals the Chlorpyrifos-Induced Oxidative Damage and Antioxidant Enzyme Levels in the Rat Tissues.

Melatonin improves meiosis maturation against diazinon exposure in mouse oocytes.

Quizalofop-P-ethyl induced developmental toxicity and cardiotoxicity in early life stage of zebraﬁsh (Danio rerio).

Sub-lethal doses of sulfoxaflor impair honey bee homing ability.

Potentially Toxic Elements

Nrf2 activation contributes to hepatic tumor-augmenting effects of developmental arsenic exposure.

Microplastics

Polystyrene Nanoplastics Toxicity to Zebrafish: Dysregulation of the Brain-Intestine-Microbiota Axis.

Sex-specific effects of PET-MPs on Drosophila lifespan.

Effects of polystyrene micro/nanoplastics on liver cells based on particle size, surface functionalization, concentration and exposure period.

Excretion characteristics of nylon microplastics and absorption risk of nanoplastics in rats.

Microplastics released from food containers can suppress lysosomal activity in mouse macrophages.

Seeping plastics: Potentially harmful molecular fragments leaching out from microplastics during accelerated ageing in seawater.

Disturbed Gut-Liver axis indicating oral exposure to polystyrene microplastic potentially increases the risk of insulin resistance.

Miscellaneous

Widespread alterations upon exposure to the estrogenic endocrine disruptor ethinyl estradiol in the liver proteome of the marine male fish Cyprinodon variegatus.

Inhibition of human androgen receptor by delta 9-tetrahydro-cannabinol and cannabidiol related to reproductive dysfunction: A computational study.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Exposure to Contemporary and Emerging Chemicals in Commerce among Pregnant Women in the United States: The Environmental influences on Child Health Outcome (ECHO) Program.

Suspect Screening and Chemical Profile Analysis of Stormwater Runoff Following 2017 Wildfires in Northern California.

BPA/Phenols

Higher levels of nonylphenol were found in human urine and drinking water from rural areas as compared to metropolitan regions of Wuhan, China.

Phthalates

Pollution Characteristics and Health Risk Assessment of Phthalate Esters in PSW Recycling Sites: A Typical Case Study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Franciscana dolphins, Pontoporia blainvillei, as environmental sentinels of the world’s largest mining disaster: Temporal trends for organohalogen compounds and their consequences for an endangered population.

Concentration levels and an assessment of human health risk of polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) in honey and pollen.

The evaluation of Hudson River sediment as a growth substrate – Microbial activity, PCB-degradation potential and risk assessment.

Perfluoroalkyl Substances

Poly- and perfluoroalkyl substances (PFAS) exposure through infant feeding in early life.

How Well Do Product Labels Indicate the Presence of PFAS in Consumer Items Used by Children and Adolescents?

Ultra-Short-Chain PFASs in the Sources of German Drinking Water: Prevalent, Overlooked, Difficult to Remove, and Unregulated.

Fluorine mass balance analysis and per- and polyfluoroalkyl substances in the atmosphere.

Flame Retardants

The first detection of organophosphate esters (OPEs) of a high altitude fresh snowfall in the northeastern Tibetan Plateau.

Insights into the long-term fates and impacts of polybrominated diphenyl ethers in sediment samples in Taiwan: The national project for background monitoring of the environmental distribution of chemical substances (BMECs).

Legacy and emerging flame retardants in indoor and outdoor dust from Indo-Gangetic Region (Patna) of India: implication for source apportionment and health risk exposure.

Tetrabromobisphenol A and hexabromocyclododecanes in sediments from fishing ports along the coast of South China: Occurrence, distribution and ecological risk.

Potentially Toxic Elements

Anthropogenic trace elements (Bi, Cd, Cr, Pb) concentrations in a West Antarctic ice core.

Microplastics

Assessing exposure of the Australian population to microplastics through bottled water consumption.

Microplastic presence in the pelagic fish, Seriola dumerili, from Balearic Islands (Western Mediterranean), and assessment of oxidative stress and detoxification biomarkers in liver.

Microplastic bioaccumulation in estuary-caught fishery resource.

Pharmaceuticals/Personal Care Products

Acetaminophen Levels Found in Recycled Wastewater Alter Soil Microbial Community Structure and Functional Diversity.

Risk assessment of selected pharmaceuticals on wildlife with nanomaterials based aptasensors.

Occurrence, distribution and risk of pharmaceutical and personal care products in the Haihe River sediments, China.

Miscellaneous

Global Historical Production, Use, In-Use Stocks, and Emissions of Short-, Medium-, and Long-Chain Chlorinated Paraffins.

[May no one say “I will never drink of this water”: agricultural production and water pollution in western Santa Catarina State, Brazil]. [in Portuguese]

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.