EDC Science Weekly, May 5 – 11, 2022 – HEEDS

EDC Science Weekly, May 5 – 11, 2022

Post author:HEEDS
Post published:May 11, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar May 12: Personal Care Product Use and Chemical Exposure among Black, Latina, and Vietnamese Women in California: Findings from the CAPABLE Project

Webinar May 19: Obesogens and the Obesity Pandemic: A focus on prevention (EDC Strategies Partnership)

Methods/Tools/Screening

On the Utility of ToxCast-Based Predictive Models to Evaluate Potential Metabolic Disruption by Environmental Chemicals.

Effects of consumer products chemicals ingredients and their mixtures on the estrogen receptor/androgen receptor transcriptional activation.

Assessment of a New Approach Method for Grouped Chemical Hazard Estimation: The Toxicity-Normalized Species Sensitivity Distribution (SSDn).

A microfluidic thyroid-liver platform to assess chemical safety in humans.

The Next Frontier of Environmental Unknowns: Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials (UVCBs).

Harmonization of transcriptomic and methylomic analysis in environmental epidemiology studies for potential application in chemical risk assessment. [case study on arsenic]

Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment – A case study with parabens.

Strengthening Causal Inference in Exposomics Research: Application of Genetic Data and Methods.

TeachOpenCADD 2022: open source and FAIR Python pipelines to assist in structural bioinformatics and cheminformatics research.

A randomization-based causal inference framework for uncovering environmental exposure effects on human gut microbiota. [case study on air pollution and smoking]

Commentaries

Official health communications are failing PFAS-contaminated communities.

I don’t usually include letters or corrections in this summary but these are all relevant:

Comment on “Charting a Path Forward: Assessing the Science of Chemical Risk Evaluations under the Toxic Substances Control Act in the Context of Recent National Academies Recommendations”.

Comment on “Application of an in Vitro Assay to Identify Chemicals That Increase Estradiol and Progesterone Synthesis and Are Potential Breast Cancer Risk Factors” and see the Response.

Comment on “Application of an in Vitro Assay to Identify Chemicals That Increase Estradiol and Progesterone Synthesis and Are Potential Breast Cancer Risk Factors” and see the Response.

Correction: Authors’ rebuttal to Integrated Risk Information System (IRIS) response to “Assessing risk of bias in human environmental epidemiology studies using three tools: different conclusions from different tools”.

Reviews

Numerous Chemicals/Mixtures

Halogenated ingredients of household and personal care products as emerging endocrine disruptors.

What Is “Socioeconomic Position (SEP),” and How Might It Modify Air Pollution-Health Associations? Cohering Findings, Identifying Challenges, and Disentangling Effects of SEP and Race in US City Settings.

Parental Occupational Exposure and Neurodevelopmental Disorders in Offspring: a Systematic Review and Meta-analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Determination of safe levels of persistent organic pollutants in toxicology and epidemiology.

Perfluoroalkyl Substances

The Conundrum of the PFOA human half-life, an international collaboration.

Potentially Toxic Elements

Occupational Exposure to Metal Fumes Among Iranian Welders: Systematic Review and Simulation-Based Health Risk Assessment.

Microplastics/Nanomaterials

Toxicological impacts of micro(nano)plastics in the benthic environment.

Coupled effects of microplastics and heavy metals on plants: Uptake, bioaccumulation, and environmental health perspectives.

Eco-corona formation and associated ecotoxicological impacts of nanoplastics in the environment.

The emerging issue of microplastics in marine environment: A bibliometric analysis from 2004 to 2020.

Air Pollution

Wildfire, Smoke Exposure, Human Health, and Environmental Justice Need to be Integrated into Forest Restoration and Management.

In-utero exposure to air pollution and early-life neural development and cognition.

Pharmaceuticals/Personal Care Products

The potential of algae and aquatic macrophytes in the pharmaceutical and personal care products (PPCPs) environmental removal: a review.

Human Health Studies

Numerous Chemicals/Mixtures

Exposure to phthalates, phenols, and parabens mixture and alterations in sex steroid hormones among adolescents.

Sex-specific associations between maternal exposure to parabens, phenols and phthalates during pregnancy and birth size outcomes in offspring.

BPA/Phenols

Bisphenol A correlates with fewer retrieved oocytes in women with tubal factor infertility.

Phthalates

Urinary phthalate metabolite concentrations during four windows spanning puberty (prepuberty through sexual maturity) and association with semen quality among young Russian men.

Associations between Children’s asthma and allergic symptoms and phthalates in dust in metropolitan Tianjin, China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Thyroid autoimmunity in Greenlandic Inuit.

Perfluoroalkyl Substances

Environmental Exposure to 6:2 Polyfluoroalkyl Phosphate Diester and Impaired Testicular Function in Men.

Serum PFAS and Urinary Phthalate Biomarker Concentrations and Bone Mineral Density in 12-19 Year Olds: 2011-2016 NHANES.

Flame Retardants

Infants’ diminished response to DTaP vaccine is associated with exposure to organophosphate esters.

Associations between organophosphate esters metabolites and sleep disorder and trouble sleeping in adults: a machine-learning approach.

Pesticides

Occupational risk assessment of organophosphates with an emphasis on psychological and oxidative stress factors.

Association between maternal exposure to chemical fertilizer and the risk of birth defects in a rural population in northern China: a population-based study.

Urinary Pesticide Residual Levels and Acute Respiratory Infections in Children Under 5 Years of Age: Findings From the Offinso North Farm Health Study.

DNA damage in a Chilean population exposed to pesticides and its association with PON1 (Q192R and L55M) susceptibility biomarker.

Potentially Toxic Elements

Associations of exposure to metal and metal mixtures with thyroid hormones: Results from the NHANES 2007-2012.

Co-exposure to priority-controlled metals mixture and blood pressure in Chinese children from two panel studies.

Mediating effect of telomere length in a hypertension population exposed to cadmium: a case-control study.

Air Pollution

Both parents matter: a national-scale analysis of parental race/ethnicity, disparities in prenatal PM_2.5 exposures and related impacts on birth outcomes.

Associations between estimates of perinatal industrial pollution exposures and intellectual disability in Utah children.

Pharmaceuticals/Personal Care Products

Association of In Utero Exposures With Risk of Early Natural Menopause. [DES]

Laboratory Studies

Numerous Chemicals/Mixtures

Observed and predicted embryotoxic and teratogenic effects of organic and inorganic environmental pollutants and their mixtures in zebrafish (Danio rerio).

Effect-directed analysis of estrogenic chemicals in sediments from an electronic-waste recycling area.

BPA/Phenols

Bisphenol A Exposure Induces Sensory Processing Deficits in Larval Zebrafish During Neurodevelopment.

Bisphenol A attenuates the therapeutic effect of the selective G protein-coupled estrogen receptor agonist G-1 on allergic rhinitis inflammation in mice.

Phthalates

High-fat diet aggravates prenatal low-dose DEHP exposure induced spermatogenesis disorder: Characterization of testicular metabolic patterns in mouse offspring.

The protective effects of thymol and carvacrol against di (2-ethylhexyl) phthalate-induced cytotoxicity in HEK-293 cells.

Nongenomic effects and mechanistic study of butyl benzyl phthalate-induced thyroid disruption: Based on integrated in vitro, in silico assays and proteome analysis.

Di-2-ethylhexyl phthalate (DEHP) induced lipid metabolism disorder in liver via activating the LXR/SREBP-1c/PPARα/γ and NF-κB signaling pathway.

Complexes of ortho-Phthalic Acid in Spontaneous Animal Tumors.

Parabens/Triclosan/Antimicrobials

Comparison of toxicological effects and exposure levels between triclosan and its structurally similar chemicals using in vitro tests for read-across case study.

Flame Retardants

Effects of Developmental Exposure to FireMaster® 550 (FM 550) on Microglia Density, Reactivity and Morphology in a Prosocial Animal Model.

TBBPA downregulates thyroid receptor and estrogen receptor mRNA levels in goldfish gonadal tissue.

Synthesis and evaluation of hydroxy‑ and dihydroxy brominated benzenes, methyl- and ethylbenzenes: Potential metabolites of current-use brominated flame retardants.

Organotins

Prolonged exposure of azocyclotin induced inter- and transgenerational endocrine disruption on Danio rerio linked to transcriptomic and DNA methylomic alterations.

Pesticides

Combined effects of S-metolachlor and benoxacor on embryo development in zebrafish (Danio rerio).

Structure identification and toxicity evaluation of one newly-discovered dechlorinated photoproducts of chlorpyrifos.

Selenium Heals the Chlorpyrifos-Induced Oxidative Damage and Antioxidant Enzyme Levels in the Rat Tissues.

Melatonin improves meiosis maturation against diazinon exposure in mouse oocytes.

Quizalofop-P-ethyl induced developmental toxicity and cardiotoxicity in early life stage of zebraﬁsh (Danio rerio).

Sub-lethal doses of sulfoxaflor impair honey bee homing ability.

Potentially Toxic Elements

Nrf2 activation contributes to hepatic tumor-augmenting effects of developmental arsenic exposure.

Microplastics

Polystyrene Nanoplastics Toxicity to Zebrafish: Dysregulation of the Brain-Intestine-Microbiota Axis.

Sex-specific effects of PET-MPs on Drosophila lifespan.

Effects of polystyrene micro/nanoplastics on liver cells based on particle size, surface functionalization, concentration and exposure period.

Excretion characteristics of nylon microplastics and absorption risk of nanoplastics in rats.

Microplastics released from food containers can suppress lysosomal activity in mouse macrophages.

Seeping plastics: Potentially harmful molecular fragments leaching out from microplastics during accelerated ageing in seawater.

Disturbed Gut-Liver axis indicating oral exposure to polystyrene microplastic potentially increases the risk of insulin resistance.

Miscellaneous

Widespread alterations upon exposure to the estrogenic endocrine disruptor ethinyl estradiol in the liver proteome of the marine male fish Cyprinodon variegatus.

Inhibition of human androgen receptor by delta 9-tetrahydro-cannabinol and cannabidiol related to reproductive dysfunction: A computational study.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Exposure to Contemporary and Emerging Chemicals in Commerce among Pregnant Women in the United States: The Environmental influences on Child Health Outcome (ECHO) Program.

Suspect Screening and Chemical Profile Analysis of Stormwater Runoff Following 2017 Wildfires in Northern California.

BPA/Phenols

Higher levels of nonylphenol were found in human urine and drinking water from rural areas as compared to metropolitan regions of Wuhan, China.

Phthalates

Pollution Characteristics and Health Risk Assessment of Phthalate Esters in PSW Recycling Sites: A Typical Case Study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Franciscana dolphins, Pontoporia blainvillei, as environmental sentinels of the world’s largest mining disaster: Temporal trends for organohalogen compounds and their consequences for an endangered population.

Concentration levels and an assessment of human health risk of polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) in honey and pollen.

The evaluation of Hudson River sediment as a growth substrate – Microbial activity, PCB-degradation potential and risk assessment.

Perfluoroalkyl Substances

Poly- and perfluoroalkyl substances (PFAS) exposure through infant feeding in early life.

How Well Do Product Labels Indicate the Presence of PFAS in Consumer Items Used by Children and Adolescents?

Ultra-Short-Chain PFASs in the Sources of German Drinking Water: Prevalent, Overlooked, Difficult to Remove, and Unregulated.

Fluorine mass balance analysis and per- and polyfluoroalkyl substances in the atmosphere.

Flame Retardants

The first detection of organophosphate esters (OPEs) of a high altitude fresh snowfall in the northeastern Tibetan Plateau.

Insights into the long-term fates and impacts of polybrominated diphenyl ethers in sediment samples in Taiwan: The national project for background monitoring of the environmental distribution of chemical substances (BMECs).

Legacy and emerging flame retardants in indoor and outdoor dust from Indo-Gangetic Region (Patna) of India: implication for source apportionment and health risk exposure.

Tetrabromobisphenol A and hexabromocyclododecanes in sediments from fishing ports along the coast of South China: Occurrence, distribution and ecological risk.

Potentially Toxic Elements

Anthropogenic trace elements (Bi, Cd, Cr, Pb) concentrations in a West Antarctic ice core.

Microplastics

Assessing exposure of the Australian population to microplastics through bottled water consumption.

Microplastic presence in the pelagic fish, Seriola dumerili, from Balearic Islands (Western Mediterranean), and assessment of oxidative stress and detoxification biomarkers in liver.

Microplastic bioaccumulation in estuary-caught fishery resource.

Pharmaceuticals/Personal Care Products

Acetaminophen Levels Found in Recycled Wastewater Alter Soil Microbial Community Structure and Functional Diversity.

Risk assessment of selected pharmaceuticals on wildlife with nanomaterials based aptasensors.

Occurrence, distribution and risk of pharmaceutical and personal care products in the Haihe River sediments, China.

Miscellaneous

Global Historical Production, Use, In-Use Stocks, and Emissions of Short-, Medium-, and Long-Chain Chlorinated Paraffins.

[May no one say “I will never drink of this water”: agricultural production and water pollution in western Santa Catarina State, Brazil]. [in Portuguese]

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."
Pesticide use linked to increased prostate cancer risk
by EHN Curators on November 18, 2024 at 11:22 am
A study finds 22 pesticides associated with prostate cancer risk in the U.S., with four also tied to higher death rates. Andrea Tamayo reports for Science News.
PFAS levels increase throughout pregnancy, study finds
by Katherine McMahon,Sarah Howard on November 15, 2024 at 9:32 pm
A recent study published in Environmental Health Perspectives examines trends in PFAS exposure in pregnant Black women and their newborns in Atlanta. “Investigating the changes in PFAS exposure levels throughout pregnancy… is crucial for identifying critical exposure periods and guiding public health policies to reduce PFAS exposure.”

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.