EDC Science Weekly, Apr. 28 – May 4, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar May 5: How plastics poison the circular economy: Data from China, Indonesia, Russia and countries reveal plastics’ public health threats

Webinar May 12: Personal Care Product Use and Chemical Exposure among Black, Latina, and Vietnamese Women in California: Findings from the CAPABLE Project

Webinar May 19: Obesogens and the Obesity Pandemic: A focus on prevention (EDC Strategies Partnership)

Regulations/Policy

Current and future federal and state sampling guidance for per- and polyfluoroalkyl substances in environmental matrices.

Methods/Tools/Screening

Preself-Feeding Medaka Fry Provides a Suitable Screening System for in Vivo Assessment of Thyroid Hormone-Disrupting Potential.

Development of a PFAS reaction library: identifying plausible transformation pathways in environmental and biological systems.

Identification of Branched and Linear Forms of PFOA and Potential Precursors: A User-Friendly SMILES Structure-based Approach.

Translatability and transferability of in silico models: Context of use switching to predict the effects of environmental chemicals on the immune system. [case study on PFAS]

Gsdf expression may be useful to predict EDC effects.

Graph Attention Network Model with Defined Applicability Domains for Screening PBT Chemicals.

Combining urinary biomarker data from studies with different measures of urinary dilution. [case study on phthalates]

Commentaries

Marks and Mechanisms: Unraveling Potential Health Impacts of PFAS via DNA Methylation. [Science Selection in EHP]

Perspective of the Induction of Liver Microsomal P450s by Chemical Compounds.

Reviews

Numerous Chemicals/Mixtures

Interventions on Reducing Exposure to Endocrine Disrupting Chemicals in Human Health Care Context: A Scoping Review.

The Placental Epigenome as a Molecular Link Between Prenatal Exposures and Fetal Health Outcomes Through the DOHaD Hypothesis.

The effects of polycyclic aromatic compounds (PACs) on mammalian ovarian function.

Endocrine disruptor chemicals, adipokines and reproductive functions.

BPA/Phenols

Molecular dissection of cellular response of pancreatic islet cells to Bisphenol-A (BPA): a comprehensive review.

Genotoxic potential of bisphenol A: A review.

[The association between bisphenol A exposure and obesity/overweight in children and adolescents: dose-response Meta analysis]. [in Chinese]

Perfluoroalkyl Substances

Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis. [see related commentary, Invited Perspective: PFAS and Liver Disease: Bringing All the Evidence Together.]

A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior.

PFAS risk propagation terminology in spatial and temporal scales: Risk intensification, risk attenuation, and risk amplification.

Pesticides

Pesticide pollutants in the environment – A critical review on remediation techniques, mechanism and toxicological impact.

Microplastics/Nanomaterials

Nano-pollution: Why it should worry us.

Pharmaceuticals/Personal Care Products

Maternal Paracetamol Intake During Pregnancy-Impacts on Offspring Reproductive Development.

Miscellaneous

Robust strategies to eliminate endocrine disruptive estrogens in water resources.

17α-Ethinylestradiol (EE2): concentrations in the environment and methods for wastewater treatment – an update.

A review toward contaminants of emerging concern in Brazil: Occurrence, impact and their degradation by advanced oxidation process in aquatic matrices.

Human Health Studies

Phthalates

Dibutyl phthalate exposure alters T-cell subsets in blood from allergen-sensitized volunteers.

Indoor exposure to phthalates and its burden of disease in China.

Phthalate exposure enhances incidence of urinary incontinence: US NHANES, 2003-2004 and 2005-2006.

Levels and health risks of urinary phthalate metabolites and the association between phthalate exposure and unexplained recurrent spontaneous abortion: a large case-control study from China.

Parabens/Triclosan/Antimicrobials

Environmental Exposure to Triclosan and Male Fecundity: A Prospective Study in China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association of prenatal exposure to dioxin-like compounds, polychlorinated biphenyl, and methylmercury with event-related brain potentials in school-aged children: the Hokkaido study.

A nested case-control study of serum polychlorinated biphenyls and papillary thyroid cancer risk among U.S. military service members.

Flame Retardants

Metabolomics insights into the prenatal exposure effects of polybrominated diphenyl ethers on neonatal birth outcomes.

Pesticides

Prenatal exposure to organophosphate pesticides and autism spectrum disorders in 11-year-old children in the French PELAGIE cohort.

Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins.

Potentially Toxic Elements

Combined exposure to multiple metals on serum uric acid in NHANES under three statistical models.

Pregnancy Outcome in Women Exposed to Metal Fume in Welding: A Canadian Cohort Study.

Trimester-specific prenatal heavy metal exposures and sex-specific postpartum size and growth.

Associations of maternal blood mercury with preeclampsia and birth outcomes.

The benefits of fish intake: results concerning prenatal mercury exposure and child outcomes from the ALSPAC prebirth cohort.

Gender differences in trace element exposures with cognitive abilities of school-aged children: a cohort study in Wujiang city, China.

Biochemical and reproductive biomarker analysis to study the consequences of heavy metal burden on health profile of male brick kiln workers.

Laboratory Studies

BPA/Phenols

Chronic exposure of bisphenol-A impairs cognitive function and disrupts hippocampal insulin signaling pathway in male mice.

Effects of tetramethyl bisphenol F on thyroid and growth hormone-related endocrine systems in zebrafish larvae.

Transcriptome alterations in spermatogonial stem cells exposed to bisphenol A.

Cineole alleviates the BPA-inhibited NETs formation by regulating the p38 pathway-mediated programmed cell death.

Sex-specific extracellular matrix remodeling during early adipogenic differentiation by gestational bisphenol A exposure.

Neonatal Exposure of Bisphenol A Led to Increased Lipolysis of Visceral Adipose Tissue in Adult Rats with DNA Hypomethylation of Atgl Being One of the Possible Underlying Mechanisms.

Testicular toxicity of bisphenol compounds: Homeostasis disruption of cholesterol/testosterone via PPARα activation.

Phthalates

Antioxidant defense system responses, lysosomal membrane stability and DNA damage in earthworms (Eisenia fetida) exposed to perfluorooctanoic acid: an integrated biomarker approach to evaluating toxicity.

Hindbrain defects induced by Di-butyl phthalate (DBP) in developing zebrafish embryos.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of 1,3,7-tribromodibenzo-p-dioxin, a natural dioxin on chicken embryos: Comparison with effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Perfluoroalkyl Substances

Acute Toxicity of Eight Aqueous Film-Forming Foams to 14 Aquatic Species.

Flame Retardants

Screening of Organophosphate Flame Retardants with Placentation-Disrupting Effects in Human Trophoblast Organoid Model and Characterization of Adverse Pregnancy Outcomes in Mice.

Genotoxic Mechanism of Action of TBBPA, TBBPS and Selected Bromophenols in Human Peripheral Blood Mononuclear Cells.

Tetramethyl bisphenol a inhibits leydig cell function in late puberty by inducing ferroptosis.

Organotins

Triphenyltin disrupts the testicular microenvironment and reduces sperm quality in adult male rats.

Pesticides

Toxic effects of glyphosate on the intestine, liver, brain of carp and on epithelioma papulosum cyprinid cells: Evidence from in vivo and in vitro research.

Hematological effects of glyphosate in mice revealed by traditional toxicology and transcriptome sequencing.

Glyphosate-based herbicide induces long-lasting impairment in neuronal and glial differentiation.

Assessing the health hazard originated via pesticide chemicals in human through rabbit model in agricultural production system in Bangladesh.

Lupeol inhibits pesticides induced hepatotoxicity via reducing oxidative stress and inflammatory markers in the rats.

Investigating mitochondria-immune responses in zebrafish, Danio rerio (Hamilton, 1822): A case study with the herbicide dinoseb.

Acute toxicity and teratogenicity of carbaryl (carbamates), tebufenpyrad (pyrazoles), cypermethrin and permethrin (pyrethroids) on the European sea bass (Dicentrarchus labrax L, 1758) early life stages.

Sublethal pesticide exposure influences behaviour, but not condition in a widespread Australian lizard.

Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior.

Developmental and behavioral toxicity assessment of glyphosate and its main metabolite aminomethylphosphonic acid (AMPA) in zebrafish embryos/larvae.

Pre-imaginal exposure to mancozeb induces morphological and behavioral deficits and oxidative damage in Drosophila melanogaster.

Microplastics/Nanomaterials

Polystyrene microplastics induce mitochondrial damage in mouse GC-2 cells.

Molecular, biochemical and behavioral responses of Daphnia magna under long-term exposure to polystyrene nanoplastics.

Microplastics exposure affects neural development of human pluripotent stem cell-derived cortical spheroids.

Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells.

Polystyrene nanoplastics induced cardiomyocyte apoptosis and myocardial inflammation in carp by promoting ROS production.

Pharmaceuticals/Personal Care Products

Exposure to enrofloxacin and depuration: Endocrine disrupting effect in juvenile grass carp (Ctenopharyngodon idella).

Effects of benzotriazole UV stabilizers, UV-PS and UV-P, on the differentiation of splenic regulatory T cells via aryl hydrocarbon receptor.

4-hydroxybenzophenone exposure inhibits mouse hippocampal neural stem cell proliferation in vitro by upregulating Cxcl1.

Miscellaneous

Integration of in silico methods to determine endocrine-disrupting tobacco pollutants binding potency with steroidogenic genes: comprehensive QSAR modeling and ensemble docking strategies.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

A risk based assessment approach for chemical mixtures from wastewater treatment plant effluents.

Evaluating risk, exposure, and detection capabilities for chemical threats in water.

BPA/Phenols

Bisphenol-diglycidyl ethers in paired urine and serum samples from children and adolescents: Partitioning, clearance and exposure assessment.

Phthalates

Evaluation of transdermal exposure of phthalates in children’s products.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

PCB Sulfates in Serum from Mothers and Children in Urban and Rural U.S. Communities.

Occurrence, partitioning, and bioaccumulation of an emerging class of PBT substances (polychlorinated diphenyl sulfides) in Chaohu Lake, Southeast China.

Concentration dynamics of polychlorinated biphenyls and organochlorine pesticides in blood of growing Grey heron (Ardea cinerea) chicks in the wild.

Perfluoroalkyl Substances

Spatial distribution and mass transport of Perfluoroalkyl Substances (PFAS) in surface water: A statewide evaluation of PFAS occurrence and fate in Alabama.

A new on-line SPE LC-HRMS method for the analysis of Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) in PM_2.5 and its application for screening atmospheric particulates from Dublin and Enniscorthy, Ireland.

Pesticides

Precision farming and environmental pesticide regulation in the EU – how does it fit together?

Pesticide risk to managed bees during blueberry pollination is primarily driven by off-farm exposures.

First national survey of residues of active substances in honeybee apiaries across Spain between 2012 and 2016.

Potentially Toxic Elements

Human adaptation to arsenic in Bolivians living in the Andes.

Pharmaceuticals/Personal Care Products

Pharmaceuticals and personal care products (PPCPs) in water, sediment and freshwater mollusks of the Dongting Lake downstream the Three Gorges Dam.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS.

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