EDC Science Weekly, Feb. 17 – 21, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week. I’m posting this early due to vacation this week!

Contents: Events, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Feb. 23: How prenatal and postnatal exposure to PFAS affect child cardiometabolic health and inflammatory biomarkers – six European cohorts (EDC Strategies Partnership)

Webinar Feb. 23: Plastics and Climate Change: Consequences of Plastics Production, Use, and Disposal as a Major Contributor to Climate Warming and Harm to Health (CHE-Alaska)

Virtual event Mar. 8: Making TSCA WorkDemystifying the Risk Assessment Process (University of Michigan M-LEEaD Center)

Methods/Tools/Screening

Chemical Screening in an Estrogen Receptor Transactivation Assay with Metabolic Competence.

Integrating data from in vitro New Approach Methodologies for Developmental Neurotoxicity.

Early environmental quality and life-course mental health effects: The Equal-Life project.

Chemical Characterization and Non-targeted Analysis of Medical Device Extracts: A Review of Current Approaches, Gaps, and Emerging Practices.

Predicting nonlinear relationships between external and internal concentrations with physiologically based pharmacokinetic modeling.

An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat.

Evaluation and validation of methodologies for the extraction of per- and polyfluoroalkyl substances (PFASs) in serum of birds and mammals.

European interlaboratory comparison investigations (ICI) and external quality assurance schemes (EQUAS) for the analysis of bisphenol A, S and F in human urine: Results from the HBM4EU project.

Evaluation of the binding performance of flavonoids to estrogen receptor alpha by Autodock, Autodock Vina and Surflex-Dock.

Commentaries/Conference Summaries

Human health effects of chemical mixtures. Comment in Science on article also listed below to make sure you don’t miss it: From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures.

The Interplay of Environmental Exposures and Mental Health: Setting an Agenda.

Filling in the Blanks: A New Tool to Predict Chemical Pathways from Production to Exposure. [Science Selection in EHP]

Europe proposes drastic cut of endocrine disruptor in plastic. [News item in Science]

A tipping point in cancer epidemiology: embracing a life course exposomic framework.

Reviews

Numerous Chemicals/Mixtures

Persistent, bioaccumulative, and toxic chemicals in insects: Current state of research and where to from here?

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Influence of climate change on persistent organic pollutants and chemicals of emerging concern in the Arctic: state of knowledge and recommendations for future research. [intro to a themed issue of Environmental Science: Processes & Impacts on this topic]

The influence of global climate change on accumulation and toxicity of persistent organic pollutants and chemicals of emerging concern in Arctic food webs.

Interlinkage Between Persistent Organic Pollutants and Plastic in the Waste Management System of India: An Overview.

Potentially Toxic Elements

Environmental and health risks posed to children by artisanal gold mining: A systematic review.

Interactions of antimony with biomolecules and its effects on human health.

Mitigation of potentially toxic elements in food products by probiotic bacteria: A comprehensive review.

Microplastics

The emerging risk of microplastics and nanoplastics on the microstructure and function of reproductive organs in mammals: A systematic review of preclinical evidence.

Microplastics contamination of groundwater: Current evidence and future perspectives. A review.

Microplastics in Latin America and the Caribbean: A review on current status and perspectives.

Miscellaneous

One Health, One Hive: A scoping review of honey bees, climate change, pollutants, and antimicrobial resistance.

Human Health Studies

Numerous Chemicals/Mixtures

From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures.

Endocrine Disrupting Chemicals and Premenstrual Syndrome in Female College Students in East Asia: A Multi-Country Study.

BPA/Phenols

Associations of mid-childhood bisphenol A and bisphenol S exposure with mid-childhood and adolescent obesity.

Phthalates

Medication-Associated Phthalate Exposure and Childhood Cancer Incidence.

Chronic inflammation as a potential mediator between phthalate exposure and depressive symptoms.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Relationship between dioxins and steroid hormone in 6-year-olds: A follow-up study in an e-waste region of China.

Perfluoroalkyl Substances

Association between maternal per- and polyfluoroalkyl substance exposure and newborn telomere length: Effect modification by birth seasons.

Serum concentrations of per-/polyfluoroalkyl substances and its association with renal function parameters among teenagers near a Chinese fluorochemical industrial plant: A cross-sectional study.

Flame Retardants

Associations between polybrominated diphenyl ethers (PBDEs) levels in adipose tissues and female menstrual cycle and menstrual bleeding duration in Shantou, China.

Potentially Toxic Elements

Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study.

The associations of serum metals concentrations with the intermediate and pregnancy outcomes in women undergoing in vitro fertilization (IVF).

Association between blood metals mixtures concentrations and cognitive performance, and effect modification by diet in older US adults.

Are ethnic differences, urinary iodine status, lead and cadmium exposure associated with thyroid autoimmunity and hypothyroid status? A cross-sectional study.

Urinary Metals, Arsenic, and Polycyclic Aromatic Hydrocarbon Exposure and Risk of Self-reported Emphysema in the US Adult Population.

Renal tubular dysfunction and cancer mortality in the Japanese general population living in cadmium non-contaminated areas.

Air Pollution

Association of Exposure to Particulate Matter Air Pollution With Semen Quality Among Men in China.

Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project.

Pharmaceuticals/Personal Care Products

Environmental antibiotics exposure in school-age children in Shanghai and health risk assessment: A population-based representative investigation.

Miscellaneous

Drinking water, fracking, and infant health.

Laboratory Studies

BPA/Phenols

Sex-dependent and long-lasting effects of bisphenol AF exposure on emotional behaviors in mice.

Phthalates

Black coffee mitigates diethyl phthalate disrupted folliculogenesis, reduced gonadotropins, and ovarian lesions in female albino mice.

Associating diethylhexyl phthalate to gestational diabetes mellitus via adverse outcome pathways using a network-based approach.

Parabens/Triclosan/Antimicrobials

The potential implications of estrogenic and antioxidant-dependent activities of high doses of methyl paraben on MCF7 breast cancer cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated biphenyl quinone induces immunotoxicity via lymphocytes apoptosis and Th1-Th2 cell imbalance in C57BL/6 mice.

Dioxin Disrupts Thyroid Hormone and Glucocorticoid Induction of klf9, a Master Regulator of Frog Metamorphosis.

Endocrine disruptor hexachlorobenzene induces cell migration and invasion, and enhances aromatase expression levels in human endometrial stromal cells.

Multi-walled carbon nanotubes inhibit potential detoxification of dioxin-mediated toxicity by blocking the nuclear translocation of aryl hydrocarbon receptor.

Evaluation of dioxin induced transcriptomic responses in a 3D human liver microtissue model.

Perfluoroalkyl Substances

Effect of thyroid hormone-disrupting chemicals on swim bladder inflation and thyroid hormone-related gene expression in Japanese medaka and zebrafish. [PFBA and TDCPP]

Flame Retardants

Gestational exposure to BDE-209 induces placental injury via the endoplasmic reticulum stress-mediated PERK/ATF4/CHOP signaling pathway.

Transcriptomic investigation of the effects of TDCPP on PC12 and GC2 cells with experimental validation.

Pesticides

Exploration of structural requirements for azole chemicals towards human aromatase CYP19A1 activity: Classification modeling, structure-activity relationships and read-across study.

Ameliorative effect of N-acetylcysteine on the testicular tissue of adult male albino rats after glyphosate-based herbicide exposure.

Effect of daily co-exposure to inulin and chlorpyrifos on selected microbiota endpoints in the SHIME® model.

Potentially Toxic Elements

Cadmium perturbed metabolomic signature in pancreatic beta cells c orrelates with disturbed metabolite profile in human urine.

Cadmium exposure suppresses insulin secretion through mtROS-mediated mitochondrial dysfunction and inflammatory response in pancreatic beta cells.

Identification of miRNAs Involved in Liver Injury Induced by Chronic Exposure to Cadmium.

Chronic exposure to low-dose cadmium facilitated nonalcoholic steatohepatitis in mice by suppressing fatty acid desaturation.

Arsenic Induces Differential Neurotoxicity in Male, Female, and E2-Deficient Females: Comparative Effects on Hippocampal Neurons and Cognition in Adult Rats.

Microplastics

Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway.

Biomarker responses in zebrafish (Danio rerio) following long-term exposure to microplastic-associated chlorpyrifos and benzo(k)fluoranthene.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Estrogenic activity and ecological risk of steroids, bisphenol A and phthalates after secondary and tertiary sewage treatment processes.

Parabens/Triclosan/Antimicrobials

Parabens and antimicrobial compounds in conventional and “green” personal care products.

Perfluoroalkyl Substances

Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances (PFAS).

Flame Retardants

Novel Brominated Flame Retardants (NBFRs) in a Tropical Marine Food Web from the South China Sea: The Influence of Hydrophobicity and Biotransformation on Structure-Related Trophodynamics.

Brominated flame retardants (BFRs) in sediment from a typical e-waste dismantling region in Southern China: Occurrence, spatial distribution, composition profiles, and ecological risks.

Inter-annual variation and comprehensive evaluation of organophosphate esters (OPEs) in the Yellow Sea, China.

Organotins

A reassessment of TBT action levels for determining the fate of dredged sediments in the United Kingdom.

Pesticides

Levels and Health Risk of Pesticide Residues in Chinese Herbal Medicines.

Mapping agricultural use of pesticides to enable research and environmental health actions in Belgium.

Microplastics

Extraction, identification, and environmental risk assessment of microplastics in commercial toothpaste.

Pharmaceuticals/Personal Care Products

Emerging pharma residue contaminants: Occurrence, monitoring, risk and fate assessment – A challenge to water resource management.

Miscellaneous

Urinary levels of monohydroxylated polycyclic aromatic hydrocarbons in Brazilian children and health risk assessment: a human biomonitoring-based study.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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