EDC Science Weekly, Feb. 10-16, 2022

Post author:HEEDS
Post published:February 16, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Feb. 17: Phthalates and Plasticizers in Fast Food (HEEDS Young EDC Scientists Showcase)

Webinar Feb. 23: How prenatal and postnatal exposure to PFAS affect child cardiometabolic health and inflammatory biomarkers – six European cohorts (EDC Strategies Partnership)

Webinar Feb. 23: Plastics and Climate Change: Consequences of Plastics Production, Use, and Disposal as a Major Contributor to Climate Warming and Harm to Health (CHE-Alaska)

Virtual event Mar. 8: Making TSCA WorkDemystifying the Risk Assessment Process (University of Michigan M-LEEaD Center, go blue!)

Regulations/Policy

Enhancing Scientific Support for the Stockholm Convention’s Implementation: An Analysis of Policy Needs for Scientific Evidence.

Methods/Tools/Screening

Combining ecological, eco-cultural, and environmental justice parameters to create Eco-EJ indicators to monitor cultural and environmental justices for diverse communities around contaminated sites.

Retrospective exposure reconstruction using approximate Bayesian computation: A case study on perfluorooctanoic acid and preeclampsia.

A review of alternative methods to the use of animals in safety evaluation of cosmetics.

MultiConditionRT: Predicting liquid chromatography retention time for emerging contaminants for a wide range of eluent compositions and stationary phases.

Machine Learning for Absolute Quantification of Unidentified Compounds in Non-Targeted LC/HRMS.

Improving the proteome coverage of Daphnia magna – implications for future ecotoxicoproteomics studies.

Global interlaboratory assessments on PCBs, organochlorine pesticides and brominated flame retardants in various environmental matrices 2017/2019.

OBOMod – Integrated modelling framework for residents’ exposure to pesticides.

Quantifying exposure source allocation factors of pesticides in support of regulatory human health risk assessment.

A computational system for Bayesian benchmark dose estimation of genomic data in BBMD.

Mixtures

Imputation of Below Detection Limit Missing Data in Chemical Mixture Analysis with Bayesian Group Index Regression.

Powering Research through Innovative Methods for Mixtures in Epidemiology (PRIME) Program: Novel and Expanded Statistical Methods.

Screening

Quality Control for Single Cell Imaging Analytics Using Endocrine Disruptor-Induced Changes in Estrogen Receptor Expression

Establishment of a developmental toxicity assay based on human iPSC reporter to detect FGF signal disruption.

Transcriptomic and physiological analysis of endocrine disrupting chemicals Impacts on 3D Zebrafish liver cell culture system.

A Multiwell-Based Assay for Screening Thyroid Hormone Signaling Disruptors Using thibz Expression as a Sensitive Endpoint in Xenopus laevis.

Design and fabrication of an integrated 3D dynamic multicellular liver-on-a-chip and its application in hepatotoxicity screening.

Microplastics/Nanomaterials

Micro-Nano Plastic in the Aquatic Environment: Methodological Problems and Challenges.

Collection of Controlled Nanosafety Data-The CoCoN-Database, a Tool to Assess Nanomaterial Hazard.

ASINA Project: Towards a Methodological Data-Driven Sustainable and Safe-by-Design Approach for the Development of Nanomaterials.

Commentaries/Conference Summaries

The determinants of planetary health: an Indigenous consensus perspective.

A long way from Steubenville: Environmental Epidemiology in a rapidly changing world.

Honey Bees and Industrial Agriculture: What Researchers are Missing, and Why it’s a Problem.

Reviews

Numerous Chemicals/Mixtures

Impact of Contaminants on Microbiota: Linking the Gut-Brain Axis with Neurotoxicity.

Impact of environmental pollution on the obesogenic environment.

Endocrine-Disrupting Chemicals and Their Adverse Effects on the Endoplasmic Reticulum.

The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis.

The role of environmental exposures and gene-environment interactions in the etiology of systemic lupus erythematous.

Endocrine Disruptors and Prostate Cancer.

Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women’s Health.

Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment.

Mediterranean Diet as a Shield against Male Infertility and Cancer Risk Induced by Environmental Pollutants: A Focus on Flavonoids.

Estrogens-Origin of Centrosome Defects in Human Cancer?

Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease.

BPA/Phenols

Bisphenol A and declining semen quality: A systematic review to support the derivation of a reference dose for mixture risk assessments.

Phthalates

Skin models for dermal exposure assessment of phthalates.

Parabens/Triclosan/Antimicrobials

Minireview: Parabens Exposure and Breast Cancer.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants and β-cell toxicity: a comprehensive review. [PCBs, organochlorine and organophosphate pesticides, dioxin, PFAS, flame retardants]

Flame Retardants

PBDEs in the marine environment: Sources, pathways and the role of microplastics.

Pesticides

What can we learn from commercial insecticides? Efficacy, toxicity, environmental impacts, and future developments.

Thiram exposure in environment: A critical review on cytotoxicity.

Analytical Evaluation of Carbamate and Organophosphate Pesticides in Human and Environmental Matrices: A Review.

Potentially Toxic Elements

Mechanisms of Arsenic Exposure-Induced Hypertension and Atherosclerosis: an Updated Overview.

Microplastics/Nanomaterials

The polymers and their additives in particulate plastics: What makes them hazardous to the fauna?

Human health concerns regarding microplastics in the aquatic environment – From marine to food systems.

The impact of nano/micro-plastics toxicity on seafood quality and human health: facts and gaps.

Microplastics as Emerging Food Contaminants: A Challenge for Food Safety.

Effects of Metal Oxide Nanoparticles in Zebrafish.

Air Pollution

Air Pollution and Environmental Justice in Latin America: Where Are We and How Can We Move Forward?

Adverse Effects of fine particulate matter on human kidney functioning: a systematic review.

Ambient air pollution and cardiovascular diseases: An umbrella review of systematic reviews and meta-analyses.

Controlled human exposure to diesel exhaust: results illuminate health effects of traffic-related air pollution and inform future directions.

Air Pollution and Cognitive Impairment across the Life Course in Humans: A Systematic Review with Specific Focus on Income Level of Study Area.

Miscellaneous

Polycyclic aromatic hydrocarbon and its effects on human health: An updated review.

Palladium nanoparticles as emerging pollutants from motor vehicles: An in-depth review on distribution, uptake and toxicological effects in occupational and living environment.

Nanomaterials: Quasi-SMILES as a flexible basis for regulation and environmental risk assessment.

Divergent Evolution of Progesterone and Mineralocorticoid Receptors in Terrestrial Vertebrates and Fish Influences Endocrine Disruption.

Human Health Studies

BPA/Phthalates

Associations between urinary bisphenol A and its analogues and semen quality: A cross-sectional study among Chinese men from an infertility clinic.

Cross-Sectional Association of Urinary Bisphenol A and Vaccine-Induced Immunity against Hepatitis B Virus: Data from the 2003-2014 National Health and Nutrition Examination Survey.

Association between vitamin D and bisphenol A levels in an elderly Italian population: results from the InCHIANTI study.

Environmental Pollution to Blame for Depressive Disorder? [bisphenols and phthalates]

Perfluoroalkyl Substances

Concentrations of per- and polyfluoroalkyl substances (PFAS) in human placental tissues and associations with birth outcomes.

Pesticides

The association between urinary glyphosate and aminomethyl phosphonic acid with biomarkers of oxidative stress among pregnant women in the PROTECT birth cohort study.

Potentially Toxic Elements

Neighborhood Poverty in Combination with Older Housing Is Associated with Adverse Birth Outcomes: A Study on Ubiquitous Lead Risk among 1 Million Births in Texas.

Toenail speciation biomarkers in arsenic-related disease: a feasibility study for investigating the association between arsenic exposure and chronic disease.

Associations and Interactions between Heavy Metals with White Blood Cell and Eosinophil Count.

Research into the Association of Cadmium and Manganese Excretion with Thyroid Function and Behavioral Areas in Adolescents with Autism Spectrum Disorders

Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa.

Air Pollution

Omega-3 fatty acids attenuate cardiovascular effects of short-term exposure to ambient air pollution.

Neighborhood environmental exposures and incidence of attention deficit/hyperactivity disorder: A population-based cohort study.

Air quality improvement and incident dementia: Effects of observed and hypothetical reductions in air pollutant using parametric g-computation.

Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood.

Laboratory Studies

Numerous Chemicals/Mixtures

Effects of Pubertal Exposure to Butyl Benzyl Phthalate, Perfluorooctanoic Acid, and Zeranol on Mammary Gland Development and Tumorigenesis in Rats.

Linking biochemical and individual-level effects of chlorpyrifos, triphenyl phosphate, and bisphenol A on sea urchin (Paracentrotus lividus) larvae.

Pregnant Women and Endocrine Disruptors: Role of P2X7 Receptor and Mitochondrial Alterations in Placental Cell Disorders.

EDCs trigger immune-neurotransmitter related gene expression, and cause histological damage in sensitive mud crab Macrophthalmus japonicus gills and hepatopancreas. [BPA and DEHP]

BPA/Phenols

Chlorobisphenol A activated kisspeptin/GPR54-GnRH neuroendocrine signals through ERα and GPER pathway in neuronal GT1-7 cells.

Estrogenic Activity of Tetrazole Derivatives Bearing Bisphenol Structures: Computational Studies, Synthesis, and In Vitro Assessment.

Intergenerational toxic effects of parental exposure to bisphenol AF on offspring and epigenetic modulations in zebrafish.

Toxicity screening of bisphenol A replacement compounds: cytotoxicity and mRNA expression in LMH 3D spheroids.

Photoaging of Baby Bottle-Derived Polyethersulfone and Polyphenylsulfone Microplastics and the Resulting Bisphenol S Release.

Analysis of Indirect Biomarkers of Effect after Exposure to Low Doses of Bisphenol A in a Study of Successive Generations of Mice.

In Silico Study to Predict the Structural and Functional Consequences of SNPs on Biomarkers of Ovarian Cancer (OC) and BPA Exposure-Associated OC.

Phthalates

MEHP promotes liver fibrosis by down-regulating STAT5A in BRL-3A hepatocytes.

A Chronic-Low-Dose Exposing of DEHP with OECD TG 443 Altered the Histological Characteristics and Steroidogeic Gene Expression of Adrenal Gland in Female Mice.

The Impairment of Thyroid Hormones Homeostasis after Short-Term Exposure to Di(2-ethylhexyl)phthalate in Adolescent Male Rats.

The Association of Certain Seminal Phthalate Metabolites on Spermatozoa Apoptosis: An Exploratory Mediation Analysis via sperm protamine.

Parabens/Triclosan/Antimicrobials

Characterization of the effects of triclosan on sperm and embryos of Mytilus and Perna mussel species.

Oxysterols Profile in Zebrafish Embryos Exposed to Triclocarban and Propylparaben-A Preliminary Study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

In vitro effects of polychlorinated biphenyls and their hydroxylated metabolites on the synthesis and metabolism of iodothyronines in the chicken (Gallus domesticus) thyroid gland.

Metabolomics and lipidomics to identify biomarkers of effect related to exposure to NON-dioxin-like polychlorinated biphenyls in pigs.

Early life PCB138 exposure induces kidney injury secondary to hyperuricemia in male mice.

Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver.

Accumulation and decontamination kinetics of PCBs and PCDD/Fs from grass silage and soil in a transgenerational cow-calf setting.

Perfluoroalkyl Substances

Fecal transplantation from young zebrafish donors efficiently ameliorates the lipid metabolism disorder of aged recipients exposed to perfluorobutanesulfonate.

Perfluorooctane sulfonate induces suppression of testosterone biosynthesis via Sertoli cell-derived exosomal/miR-9-3p downregulating StAR expression in Leydig cells.

Effect of Enterohepatic Circulation on the Accumulation of Per- and Polyfluoroalkyl Substances: Evidence from Experimental and Computational Studies.

Effects of perfluoroundecanoic acid on the function of Leydig cells in adult male rats.

Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity.

Oral exposure to a hexafluoropropylene oxide trimer acid (HFPO-TA) disrupts mitochondrial function and biogenesis in mice.

Flame Retardants

Brominated flame retardants effect in MCF-7 cells: Impact on vitamin D pathway.

Tetrabromobisphenol A Disturbs Brain Development in Both Thyroid Hormone-Dependent and -Independent Manners in Xenopus laevis.

Interaction of tetrabromobisphenol A (TBBPA) with microplastics-sediment (MPs-S) complexes: A comparison between binary and simple systems.

Pesticides

Perinatal exposure to pesticides alters synaptic plasticity signaling and induces behavioral deficits associated with neurodevelopmental disorders.

The Effect of Synergistic Compounds on the Susceptibility of Euschistus heros (Hemiptera: Pentatomidae) and Chrysodeixis includens (Lepidoptera: Noctuidae) to Pyrethroids.

Effects of chlorpyrifos on non-cholinergic toxicity endpoints in immortalized and primary rat hepatocytes under normal and hepatosteatotic conditions.

Temperature affects the toxicity of pesticides to cercariae of the trematode Echinostoma trivolvis.

Reproductive effects of sulfoxaflor in male Sprague Dawley rats.

Protective effects of N-acetylcysteine niosome nanoparticles on paraquat-induced nephrotoxicity in male rats.

Honey Bees (Hymenoptera: Apidae) Decrease Foraging But Not Recruitment After Neonicotinoid Exposure.

Potentially Toxic Elements

Long-term exposure of the binary mixture of cadmium and mercury damages the developed ovary of adult zebrafish.

Inorganic arsenic promotes apoptosis of human immortal keratinocytes through the TGF-β1/ERK signaling pathway.

Combined toxicity of microplastic and lead on submerged macrophytes.

Polyphenolics with Strong Antioxidant Activity from Acacia nilotica Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice.

Is Cadmium Toxicity Tissue-Specific? Toxicogenomics Studies Reveal Common and Specific Pathways in Pulmonary, Hepatic, and Neuronal Cell Models.

New Eco-Sustainable Feed in Aquaculture: Influence of Insect-Based Diets on the Content of Potentially Toxic Elements in the Experimental Model Zebrafish (Danio rerio).

Microplastics/Nanoplastics

Polystyrene micro-/nanoplastics induced hematopoietic damages via the crosstalk of gut microbiota, metabolites, and cytokines.

Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice.

Effect of polystyrene nanoplastics and their degraded forms on stem cell fate.

Soil Invertebrates Generate Microplastics From Polystyrene Foam Debris.

Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.

Microplastics (Polystyrene) Exposure Induces Metabolic Changes in the Liver of Rare Minnow (Gobiocypris rarus).

Nanoplastics Increase Fish Susceptibility to Nodavirus Infection and Reduce Antiviral Immune Responses.

Toxicity Study and Quantitative Evaluation of Polyethylene Microplastics in ICR Mice.

The underestimated toxic effects of nanoplastics coming from marine sources: A demonstration on oysters (Isognomon alatus).

Pharmaceuticals/Personal Care Products

Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents.

Evaluation of toxicological aspects of three new benzoxazole compounds with sunscreen photophysical properties using in silico and in vitro methods.

Epigenetic mechanisms of DNA methylation in the transgenerational effect of ethylhexyl salicylate on zebrafish.

Accumulation of chiral pharmaceuticals (ofloxacin or levofloxacin) onto polyethylene microplastics from aqueous solutions.

Toxicity assessment and microbial response to soil antibiotic exposure: differences between individual and mixed antibiotics.

Miscellaneous

A biologically based model to quantitatively assess the role of the nuclear receptors liver X (LXR), and pregnane X (PXR) on chemically induced hepatic steatosis.

Effects of sodium perchlorate and 6-propylthiouracil on metamorphosis and thyroid gland histopathology in the European common frog (Rana temporaria)

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Occupational Exposure of Canadian Nail Salon Workers to Plasticizers Including Phthalates and Organophosphate Esters.

Investigating a broad range of emerging contaminants in a set of anthropogenically impacted environmental compartments.

Survey on endocrine-disrupting chemicals in seafood: Occurrence and distribution.

Wastewater treatment and emerging contaminants: Bibliometric analysis.

BPA/Phenols

Nonylphenol exposure in 7-year-old Japanese children between 2012 and 2017- Estimation of daily intakes based on novel urinary metabolites.

Phthalates

Phthalate metabolites in paired human serum and whole blood.

Phthalate exposure among U.S. college-aged women: Biomonitoring in an undergraduate student cohort (2016-2017) and trends from the National Health and Examination Survey (NHANES, 2005-2016).

Rapid Analysis of Trace Phthalates by Spray-Inlet Microwave Plasma Torch Ionization Tandem Mass Spectrometry in Commercial Perfumes.

Evaluation of occurrence, fate and removal of priority phthalate esters (PAEs) in wastewater and sewage sludge by advanced biological treatment, waste stabilization pond and constructed wetland.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Geographic and Ethnic Variations in Serum Concentrations of Legacy Persistent Organic Pollutants among Men in the Nenets Autonomous Okrug, Arctic Russia.

Perfluoroalkyl Substances

Spatial distribution and load of per- and polyfluoroalkyl substances (PFAS) in background soils in Sweden.

Neutral and ionizable per-and polyfluoroalkyl substances in the urban atmosphere: Occurrence, sources and transport.

Microbial biotransformation of aqueous film-forming foam derived polyfluoroalkyl substances.

Noise-Reduced Quantitative Fluorine NMR Spectroscopy Reveals the Presence of Additional Per- and Polyfluorinated Alkyl Substances in Environmental and Biological Samples When Compared with Routine Mass Spectrometry Methods.

Flame Retardants

Occurrence and levels of polybrominated diphenyl ethers (PBDEs) in deep-sea sharks from Suruga Bay, Japan.

Habitat-dependent trophic transfer of legacy and emerging halogenated flame retardants in estuarine and coastal food webs near a source region.

Occurrence and Risk Assessment of Polybrominated Diphenyl Ethers in Surface Water and Sediment of Nahoon River Estuary, South Africa.

Pesticides

Risk Assessment of the Chiral Fungicide Triticonazole: Enantioselective Effects, Toxicity, and Fate.

Peer review of the pesticide risk assessment for the active substance propyzamide in light of confirmatory data submitted. [EFSA]

Health Impact Associated with Pesticides Use among Vegetables Farmers in Nepal: A Secondary Analysis.

Association between increasing agricultural use of 2,4-D and population biomarkers of exposure: findings from the National Health and Nutrition Examination Survey, 2001-2014.

Potentially Toxic Elements

Racial Disparities in the Heavy Metal Contamination of Urban Soil in the Southeastern United States.

Does environmental metal pollution affect bird morphometry? A case study on the tree sparrow Passer montanus.

Climate change and mercury in the Arctic: Abiotic interactions.

Microplastics

Covid-19-derived plastic debris contaminating marine ecosystem: Alert from a sea turtle.

Spatial variability of microplastic pollution on surface of rivers in a mountain-plain transitional area: A case study in the Chin Ling-Wei River Plain, China.

Airborne and marine microplastics from an oceanographic survey at the Baltic Sea: An emerging role of air-sea interaction?

Pharmaceuticals/Personal Care Products

Pharmaceutical pollution of the world’s rivers.

From the pills to environment – Prediction and tracking of non-steroidal anti-inflammatory drug concentrations in wastewater.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.