EDC Science Weekly, Feb. 3 – 9, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Feb. 17: Phthalate and Novel Plasticizer Concentrations in Food Items from U.S. Fast Food Chains (Healthy Environment and Endocrine Disruptor Strategies (HEEDS) Young EDC Scientists Showcase (YESS))

Webinar Feb. 23: How prenatal and postnatal exposure to PFAS affect child cardiometabolic health and inflammatory biomarkers – six European cohorts (EDC Strategies Partnership)

Webinar Feb 23: Plastics and Climate Change: Consequences of Plastics Production, Use, and Disposal as a Major Contributor to Climate Warming and Harm to Health (CHE-Alaska)

Regulations/Policy

Twenty-five years beyond “Our Stolen Future”: How did we progress as an international society on screening and regulating Endocrine Disrupting Chemicals (EDCs)?

The EU chemicals strategy for sustainability: critical reflections on proposed regulatory changes for endocrine disruptors and mixture toxicity.

Methods/Tools/Screening

A Data Mining Approach Reveals Chemicals Detected at Higher Levels in Non-Hispanic Black Women Target Preterm Birth Genes and Pathways.

A permutation-based approach to inference for weighted sum regression with correlated chemical mixtures.

Use of Reporter Genes to Analyze Estrogen Response: The Transgenic Zebrafish Model.

Frameworks for Screening and Risk Management of Chemicals and Advanced Materials: A Critical Review.

Molecular Gatekeeper Discovery: Workflow for Linking Multiple Exposure Biomarkers to Metabolomics. [PFAS and metals]

Integrating publicly available information to screen potential candidates for chemical prioritization under the Toxic Substances Control Act: A proof of concept case study using genotoxicity and carcinogenicity.

What to Expect When Expecting in Lab: A Review of Unique Risks and Resources for Pregnant Researchers in the Chemical Laboratory.

Rise of the preprint: how rapid data sharing during COVID-19 has changed science forever. [not EDCs but interesting]

Commentaries

Show Your Work: Increasing Engagement through Personalized Participant Report-Back. [Science Selection in EHP]

Reviews

Numerous Chemicals/Mixtures

Nutritional interventions to ameliorate the effect of endocrine disruptors on human reproductive health: A semi-structured review from FIGO.

Gut Microbiota: A Key Regulator in the Effects of Environmental Hazards on Modulates Insulin Resistance.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Agent Orange and dioxin-induced myeloid leukemia: a weaponized vehicle of leukemogenesis.

Sex differences in the association of measures of sexual maturation to common toxicants: Lead, dichloro-diphenyl-trichloroethane (DDT), dichloro-diphenyl-dichloroethylene (DDE), and polychlorinated biphenyls (PCBs).

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substances in the environment.

Human exposure to F-53B in China and the evaluation of its potential toxicity: An overview.

Nano-enabled sensing of per-/poly-fluoroalkyl substances (PFAS) from aqueous systems – A review.

Recent advances in mass spectrometry analytical techniques for per- and polyfluoroalkyl substances (PFAS).

Pesticides

Pesticide-induced disturbances of bee gut microbiotas.

Microplastics

Microbiome: A forgotten target of environmental micro(nano)plastics?

Human Health Studies

Numerous Chemicals/Mixtures

Associations between exposure to a mixture of phenols, parabens, and phthalates and sex steroid hormones in children 6-19 years from NHANES, 2013-2016.

BPA/Phthalates

Interrelationships among growth hormone, thyroid function, and endocrine-disrupting chemicals on the susceptibility to attention-deficit/hyperactivity disorder. [BPA and phthalates]

Flame Retardants

Associations between plasma levels of brominated flame retardants and methylation of DNA from peripheral blood: A cross-sectional study in a cohort of French women.

Pesticides

Pesticide use and risk of systemic autoimmune diseases in the Agricultural Health Study.

Investigation of Prenatal Pesticide Exposure and Neurodevelopmental Deficits in Northern Thailand: Protocol for a Longitudinal Birth Cohort Study.

Farmland transfer and esophageal cancer incidence rate: mediation of pollution-related agricultural input intensity.

Potentially Toxic Elements

Sexually dimorphic associations between prenatal blood lead exposure and performance on a behavioral testing battery in children.

Mixed metals exposure and cognitive function in Bangladeshi adolescents.

Association between urinary cadmium concentrations and liver function in adolescents.

Long-term cadmium exposure and fractures, cardiovascular disease, and mortality in a prospective cohort of women.

Maternal blood metal concentrations are associated with matrix metalloproteinases (MMPs) among pregnant women in Puerto Rico.

Exposure Levels and Contributing Factors of Various Arsenic Species and Their Health Effects on Korean Adults.

Air Pollution

Air quality improvement and cognitive decline in community-dwelling older women in the United States: A longitudinal cohort study.

Randomized trial of a portable HEPA air cleaner intervention to reduce asthma morbidity among Latino children in an agricultural community.

Metals, Nanoparticles, Particulate Matter, and Cognitive Decline.

Associations between PM_2.5 exposure and infant growth: A mediation analysis of oral microbiota.

Associations of PM_2.5 exposure with blood glucose impairment in early pregnancy and gestational diabetes mellitus.

Long-term residential exposure to air pollution and risk of testicular cancer in Denmark: A population-based case-control study.

Miscellaneous

Prenatal Androgen Exposure and Traits of Autism Spectrum Disorder in the Offspring: Odense Child Cohort.

Laboratory Studies

Numerous Chemicals/Mixtures

Differential effects of two prevalent environmental pollutants on host-pathogen dynamics. [microplastics and Roundup]

Bisphenols/Phthalates

Thyroid endocrine disruption and hepatotoxicity induced by bisphenol AF: Integrated zebrafish embryotoxicity test and deep learning.

The bisphenol A metabolite MBP causes proteome alterations in male Cyprinodon variegatus fish characteristic of estrogenic endocrine disruption.

Bisphenol A Induces Histopathological, Hematobiochemical Alterations, Oxidative Stress, and Genotoxicity in Common Carp (Cyprinus carpio L.).

Effects of bone marrow-derived mesenchymal stem cells exposed to endocrine-disrupting chemicals on the differentiation of umbilical cord blood hematopoietic stem cells. [BPA and DEHP]

Toxicity of di-2-ethylhexyl phthalate and tris (2-butoxyethyl) phosphate to a tropical micro-crustacean (Ceriodaphnia cornuta) is higher in Mekong River water than in standard laboratory medium.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Quercetin protects human liver cells from o,p’-DDT-induced toxicity by suppressing Nrf2 and NADPH oxidase-regulated ROS production.

Reduced Colonic Mucosal Injury in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Poly ADP-Ribose Polymerase (TIPARP/PARP7)-Deficient Mice.

Perfluoroalkyl Substances

Perfluorohexanoic acid caused disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae.

Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication.

The impact of legacy and novel perfluoroalkyl substances on human cytochrome P450: An in vitro study on the inhibitory potential and underlying mechanisms.

Insights into the effects of salinity on the sorption and desorption of legacy and emerging per-and polyfluoroalkyl substances (PFASs) on marine sediments.

Flame Retardants

Effects of nano-TiO₂ on the bioavailability and toxicity of bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH) in developing zebrafish.

Melatonin relieves 2,2,4,4-tetrabromodiphenyl ether (BDE-47)-induced apoptosis and mitochondrial dysfunction through the AMPK-Sirt1-PGC-1α axis in fish kidney cells (CIK).

Pesticides

New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish.

Protective effects of Folic acid against reproductive, hematological, hepatic, and renal toxicity induced by Acetamiprid in male Albino rats.

Alterations at biochemical, proteomic and transcriptomic levels in liver of tilapia (Oreochromis niloticus) under chronic exposure to environmentally relevant level of glyphosate.

Cytotoxic and genotoxic effects induced by associated commercial glyphosate and 2,4-D formulations using the Allium cepa bioassay.

Transcriptomic and targeted metabolomic analysis revealed the toxic effects of prochloraz on larval zebrafish.

Effects of subchronic exposure to environmentally relevant concentrations of a commercial fluridone formulation on fathead minnows (Pimephales promelas).

Nicosulfuron, a sulfonylurea herbicide, alters embryonic development and oxidative status of hatchlings at environmental concentrations in an amphibian species.

Behavioural impairment and oxidative stress by acute exposure of zebrafish to a commercial formulation of tebuconazole.

Multiple factors mediate insecticide toxicity to a key predator for cotton insect pest management.

Enantioselective acute toxicity, oxidative stress effects, neurotoxicity, and thyroid disruption of uniconazole in zebrafish (Danio rerio).

Parental diuron exposure causes lower hatchability and abnormal ovarian development in offspring of medaka (Oryzias melastigma).

Acute oral toxicity and risks of four classes of systemic insecticide to the Common Eastern Bumblebee (Bombus impatiens).

Potentially Toxic Elements

Noninvasive Dual-Modality Photoacoustic-Ultrasonic Imaging to Detect Mammalian Embryo Abnormalities after Prenatal Exposure to Methylmercury Chloride (MMC): A Mouse Study.

Interference with zinc homeostasis and oxidative stress induction as probable mechanisms for cadmium-induced embryo-toxicity in zebrafish.

Dietary cadmium induced declined locomotory and reproductive fitness with altered homeostasis of essential elements in Drosophila melanogaster.

Low-dose cadmium affects the enantioselective bioaccumulation and dissipation of chiral penflufen in zebrafish (Danio rerio).

CORO1A regulates lipoprotein uptake in Leydig cells exposed to cadmium.

Long-isoform NFE2L1 silencing inhibits acquisition of malignant phenotypes induced by arsenite in human bronchial epithelial cells.

Cd exposure-triggered metabolic disruption increases the susceptibility of Lymantria dispar (Lepidoptera: Erebidae) larvae to Mamestra brassicae nuclear polyhedrosis virus: A multi-omics study.

Urolithin A attenuates arsenic-induced gut barrier dysfunction.

Microplastics

Diet preference of zebrafish (Danio rerio) for bio-based polylactic acid microplastics and induced intestinal damage and microbiota dysbiosis.

Air Pollution

Repeated short-term exposure to diesel exhaust reduces honey bee colony fitness.

Pharmaceuticals/Personal Care Products

Effect of cashew (Anacardium occidentale L.) nut-supplemented diet on steroidogenic enzymes, hormonal and oxidative imbalances, and sperm parameters in cisplatin-induced reproductive toxicity in male rats.

Macrophage polarization induced by quinolone antibiotics at environmental residue level.

Sorafenib is an antagonist of the aryl hydrocarbon receptor.

Neuroendocrine pathways at risk? Simvastatin induces inter and transgenerational disruption in the keystone amphipod Gammarus locusta.

Miscellaneous

Sexual dimorphism in testosterone programming of cardiomyocyte development in sheep.

Methyl tert-butyl ether inhibits pubertal development of Leydig cells in male rats by inducing mitophagy and apoptosis.

Exposure/Environment Studies

Bisphenols/Phthalates

A new approach for reducing pollutants level: a longitudinal cohort study of physical exercises in young people. [BPA, dimethoate, BaP]

Within- and between-person variability of urinary phthalate metabolites and bisphenol analogues over seven days: Considerations of biomonitoring study design.

Concentrations of bisphenol a (BPA) in fresh pork loin meat under standard stock-farming conditions and after oral exposure – A preliminary study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Biomonitoring of Polybrominated Dioxins & Furans, Polychlorinated Dioxins & Furans, and Dioxin Like Polychlorinated Biphenyls in Vietnamese Female Electronic Waste Recyclers.

Hydroxylated Polychlorinated Biphenyls Are Emerging Legacy Pollutants in Contaminated Sediments.

Survey of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and non-ortho-polychlorinated biphenyls in U.S. meat, poultry, and siluriform fish from 2018-2019: toxic equivalency levels, temporal trends, and implications.

Occurrence and Distribution of Persistent Organic Pollutants (POPs) in Amphibian Species: Implications from Biomagnification Factors Based on Quantitative Fatty Acid Signature Analysis.

Perfluoroalkyl Substances

Simultaneous determination of perfluorooctanoic acid and perfluorooctanesulfonic acid in Korean sera using LC-MS/MS.

Perfluoroalkyl and Polyfluoroalkyl Substances in Groundwater Used as a Source of Drinking Water in the Eastern United States.

Method development and evaluation for the determination of perfluoroalkyl and polyfluoroalkyl substances in multiple food matrices.

Spatiotemporal distribution, partitioning behavior and flux of per- and polyfluoroalkyl substances in surface water and sediment from Poyang Lake, China.

A regional numerical environmental multimedia modeling approach to assess spatial Eco-Environmental exposure risk of perfluorooctane sulfonate (PFOS) in the Pearl river basin.

Flame Retardants

Effect of Affinity between Dechlorane Plus and Human Serum Albumin on Its Serum Concentration in a General Population.

Assessment of polybrominated diphenyl ether contamination and associated human exposure risk at municipal waste dumping sites.

Pesticides

Data on estimation of health hazards associated with pesticide residues in drinking water.

The impact of imidacloprid and thiacloprid on the mean species abundance in aquatic ecosystems.

Determination of glyphosate exposure in the Iberian hare: A potential focal species associated to agrosystems.

Potentially Toxic Elements

Metals dust in workers’ homes and potential for take home in the Greater Boston area: Pilot study.

A U-Turn for Mercury Concentrations over 20 Years: How Do Environmental Conditions Affect Exposure in Arctic Seabirds?

Wildlife hair as bioindicators of metal exposure.

Microplastics

Macro- and microplastic accumulation in soil after 32 years of plastic film mulching.

Pharmaceuticals/Personal Care Products

Residues of Cardiovascular and Lipid-Lowering Drugs Pose a Risk to the Aquatic Ecosystem despite a High Wastewater Treatment Ratio in the Megacity Shanghai, China.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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