EDC Science Weekly, Nov. 24 – Dec. 1, 2021

Post author:HEEDS
Post published:December 1, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Starting soon! Webinar Dec. 1: Potential Endocrine Disrupting Effects of Microplastics in Human Placenta and Aquatic Life (HEEDS Young EDC Scientists Showcase (YESS) webinar series)

Webinar Dec. 15: PFAS Exposure and Epigenetics in the Firefighter Cancer Cohort Study (EDC Strategies Partnership)

Podcast available: Lariah Edwards on hormone-altering chemicals (Agents of Change in Environmental Justice)

Presentation and discussion Dec. 2: Mental health impacts of oil and gas (Halt the Harm, EHN)

Webinar Dec. 8: Microplastics from Food and Water: State of the Science and Potential Impacts on Human Health (the National Academies)

Virtual workshop Dec. 10: Addressing Racism As a Public Health Issue Through the Lens of Environmental Health Disparities and Environmental Justice (NIEHS)

Virtual seminar Dec. 10: The Multifaceted Challenges with Microplastics and Nanoplastics (University of Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)) Go blue!

Virtual conference Jan 10-13: PPTOX VII: International Conference on Prenatal Programming and Toxicity (Abstract deadline extended to Dec. 5)

In-person course: May 25-June 9: Endocrine-Disrupting Chemicals: Hazards and Opportunities (Marine Biological Laboratory at Woods Hole)

In-person Gordon Research Conference and Seminar June 18-24: EDCs and the Environment and Harnessing Interdisciplinary Evidence for Endocrine Disruption to Improve Public Health

Regulations/Policy

Invited Perspective: How Can Studies of Chemical Mixtures and Human Health Guide Interventions and Policy?

Updating the European Union’s regulation on classification, labelling and packaging of substances and mixtures (CLP): A key opportunity for consumers, workers and stakeholders with interests in the legislation and toxicology of hazardous chemicals.

Human Chemical Exposure from Background Emissions in the United States and the Implication for Quantifying Risks from Marginal Emission Increase.

The case for a more precise definition of regulated PFAS.

Methods/Tools/Screening

National Academies of Sciences, Engineering, and Medicine Releases Peer Review Report Commending EPA’s “IRIS Handbook”

Integrating Sex/Gender into Environmental Health Research: Development of a Conceptual Framework.

BIKE: Dietary Exposure Model for Foodborne Microbiological and Chemical Hazards.

Mining Early Life Risk and Resiliency Factors and Their Influences in Human Populations from PubMed: A Machine Learning Approach to Discover DOHaD Evidence.

A Systematic Review of Published Physiologically based Kinetic Models and an Assessment of their Chemical Space Coverage.

The Residential Population Generator (RPGen): Parameterization of Residential, Demographic, and Physiological Data to Model Intraindividual Exposure, Dose, and Risk.

A Fast and Automated Strategy for the Identification and Risk Assessment of Unknown Substances (IAS/NIAS) in Plastic Food Contact Materials by GC-Q-Orbitrap HRMS: Recycled LDPE as a Proof-of-Concept.

Implementing in vitro bioactivity data to modernize priority setting of chemical inventories.

An Introduction to the Benchmarking and Publications for Non-Targeted Analysis Working Group.

Commentaries

Pollution and the developing brain. [letter]

Thinking about infertility from a mixed-methods perspective: the need to look at toxicity in rural India.

Reviews

Numerous Chemicals/Mixtures

In utero exposure to endocrine-disrupting chemicals, maternal factors and alterations in the epigenetic landscape underlying later-life health effects.

Killing two birds with one stone: Pregnancy is a sensitive window for endocrine effects on both the mother and the fetus.

Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity.

Examining hydraulic fracturing chemicals: A temporal and comparative analysis.

Environmental Substances Associated with Alzheimer’s Disease-A Scoping Review.

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering.

Extravillous Trophoblast Migration and Invasion: Impact of Environmental Chemicals and Pharmaceuticals.

Could Contamination Avoidance Be an Endpoint That Protects the Environment? An Overview on How Species Respond to Copper, Glyphosate, and Silver Nanoparticles.

BPA/Phenols

Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review.

Phthalates

Phthalate hydrolase: distribution, diversity and molecular evolution.

Flame Retardants

Organophosphate Esters in China: Fate, Occurrence, and Human Exposure.

Pesticides

Review: Mechanisms of Glyphosate and Glyphosate-Based Herbicides Action in Female and Male Fertility in Humans and Animal Models.

Glyphosate Use, Toxicity and Occurrence in Food.

Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development.

A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico.

Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture.

Exposure to non-persistent pesticides in the Spanish population using biomonitoring: A review.

SDHI Fungicide Toxicity and Associated Adverse Outcome Pathways: What Can Zebrafish Tell Us?

Highly hazardous pesticides and related pollutants: Toxicological, regulatory, and analytical aspects.

Oxidative stress as a molecular mechanism of exposure to organophosphorus pesticides. A Review.

Potentially Toxic Elements

Association between occupational lead exposure and immunotoxicity markers: A systematic review and meta-analysis.

Microplastics/Nanomaterials

Aggregate exposure pathways for microplastics (mpAEP): An evidence-based framework to identify research and regulatory needs.

On Placental Toxicology Studies and Cerium Dioxide Nanoparticles.

Concentration of microplastics in bivalves of the environment: a systematic review.

Uptake and Accumulation of Nano/Microplastics in Plants: A Critical Review.

Aquatic Environment Exposure and Toxicity of Engineered Nanomaterials Released from Nano-Enabled Products: Current Status and Data Needs.

In Vitro and In Vivo Models to Assess the Immune-Related Effects of Nanomaterials.

Occurrence, human exposure, and risk of microplastics in the indoor environment.

Air Pollution

Prenatal Air Pollution Exposure and Placental DNA Methylation Changes: Implications on Fetal Development and Future Disease Susceptibility.

Pharmaceuticals/Personal Care Products

Nanohybrids-assisted photocatalytic removal of pharmaceutical pollutants to abate their toxicological effects – A review.

An Overview of Antibiotics as Emerging Contaminants: Occurrence in Bivalves as Biomonitoring Organisms.

Miscellaneous

Environmental factors modulating protein conformations and their role in protein aggregation diseases.

Lung cancer risk in never-smokers: An overview of environmental and genetic factors.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal Exposure to Nonpersistent Chemical Mixtures and Fetal Growth: A Population-Based Study.

Female Reproductive Health and Exposure to Phthalates and Bisphenol A: A Cross Sectional Study.

Prenatal Exposure to Chemical Mixtures and Inhibition among Adolescents.

Prenatal exposure to chemical mixtures and working memory among adolescents.

BPA/Phenols

Associations of bisphenol exposure with the risk of gestational diabetes mellitus: a nested case-control study in Guangxi, China.

The Effect of Bisphenol A on the IVF Outcomes Depending on the Polymorphism of the Detoxification System Genes.

Association of Urinary Bisphenols Concentration with Asthma in Korean Adolescents: Data from the Third Korean National Environmental Health Survey.

Comprehensive analysis based in silico study of alternative bisphenols – Environmental explanation of prostate cancer progression.

Phthalates

Urinary levels of Phthalate metabolite mixtures and pulmonary function in adolescents.

Parabens/Triclosan/Antimicrobials

Association between exposure to parabens and total mortality in US adults.

Perfluoroalkyl Substances

Prenatal exposure to poly-/per-fluoroalkyl substances is associated with alteration of lipid profiles in cord-blood.

Pesticides

Proximity to endocrine-disrupting pesticides and risk of testicular germ cell tumors (TGCT) among adolescents: A population-based case-control study in California.

The association between 2,4-D and serum testosterone levels: NHANES 2013-2014.

Environmental Pyrethroid Exposure and Cognitive Dysfunction in U.S. Older Adults: The NHANES 2001-2002.

Association between organophosphate insecticide exposure and dyslexia among children from three cities of China: The READ program.

Effect of organophosphorus pesticide exposure on the immune cell phenotypes among farm women and their children.

Association of occupational exposure to pesticides with overweight and abdominal obesity in family farmers in southern Brazil.

Potentially Toxic Elements

Is living in a region with high groundwater arsenic contamination associated with adverse reproductive health outcomes? An analysis using nationally representative data from India.

Plasma Vitamin B₁₂ and Folate Alter the Association of Blood Lead and Cadmium and Total Urinary Arsenic Levels with Chronic Kidney Disease in a Taiwanese Population.

Prenatal Exposure to Heavy Metals Affects Gestational Age by Altering DNA Methylation Patterns.

Association of Seafood Consumption and Mercury Exposure With Cardiovascular and All-Cause Mortality Among US Adults.

Exposure to airborne cadmium and breast cancer stage, grade and histology at diagnosis: findings from the E3N cohort study.

Pharmaceuticals/Personal Care Products

The association of prenatal exposure to benzophenones with gestational age and offspring size at birth.

Association between Maternal Exposure to Chemicals during Pregnancy and the Risk of Foetal Death: The Japan Environment and Children’s Study.

Prenatal and Postnatal Household Air Pollution Exposure and Infant Growth Trajectories: Evidence from a Rural Ghanaian Pregnancy Cohort.

Miscellaneous

Association of chronic kidney disease with exposure to polycyclic aromatic hydrocarbons in the US population.

Prenatal Exposure to Disinfection Byproducts and Intrauterine Growth in a Chinese Cohort.

Laboratory Studies

Numerous Chemicals/Mixtures

Interspecies Differences in Activation of Peroxisome Proliferator-Activated Receptor γ by Pharmaceutical and Environmental Chemicals.

Effects of single and combined exposure to BDE-47 and PFOA on distribution, bioaccumulation, and toxicity in blue mussel (Mytilus galloprovincialis).

Estrogenic mixtures induce alterations in lipidomic profiles in the gonads of female oysters.

BPA/Phenols

MicroRNA changes in the mouse placenta due to bisphenol A exposure.

Bisphenol-A exposure leads to neurotoxicity through upregulating the expression of histone deacetylase 2 in vivo and in vitro.

Low-dose bisphenol S exposure induces hypospermatogenesis and mitochondrial dysfunction in rats: A possible implication of StAR protein.

Protective effect of the association of curcumin with piperine on prostatic lesions: New perspectives on BPA-induced carcinogenesis.

Assessing the toxic effects of bisphenol A in consumed crayfish Astacus leptodactylus using multi biochemical markers.

Bisphenol A Analogues Suppress Spheroid Attachment on Human Endometrial Epithelial Cells through Modulation of Steroid Hormone Receptors Signaling Pathway

Does Bisphenol A bioaccumulate on zebrafish, determination of tissue Bisphenol A level.

Gestational and lactational exposure to BPA, but not BPS, negatively impacts trabecular microarchitecture and cortical geometry in adult male offspring.

Effects of melatonin on the Bisphenol-A- induced cytotoxicity and genetic toxicity in colon cancer cell lines, normal gingival cell lines, and bone marrow stem cell lines.

Chronic exposure to nonylphenol induces oxidative stress and liver damage in male zebrafish (Danio rerio): Mechanistic insight into cellular energy sensors, lipid accumulation and immune modulation.

Phthalates

Toxicokinetics of mono-(2-ethylhexyl) phthalate with low-dose exposure applying fluorescence tracing technique.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Dose-Dependently Shifts the Gut Microbiome Consistent with the Progression of Non-Alcoholic Fatty Liver Disease.

Perfluoroalkyl Substances

Elucidation of specific binding sites and extraction of toxic Gen X from HSA employing cyclodextrin.

Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression.

Lipid metabolism disorders effects of 6:2 chlorinated polyfluorinated ether sulfonate through Hsa-miRNA-532-3p/Acyl-CoA oxidase 1(ACOX1) pathway.

Tumorigenic activity of alternative per- and polyfluoroalkyl substances (PFAS): Mechanistic in vitro studies.

Flame Retardants

Combining Network Pharmacology with Molecular Docking for Mechanistic Research on Thyroid Dysfunction Caused by Polybrominated Diphenyl Ethers and Their Metabolites.

Dose-Dependent Molecular Responses of Labeo rohita to Triphenyl Phosphate.

Pesticides

Paraquat exposure impairs porcine oocyte meiotic maturation.

Ellagic acid ameliorates paraquat-induced liver injury associated with improved gut microbial profile.

Transcriptome-Based Identification of Genes Responding to the Organophosphate Pesticide Phosmet in Danio rerio.

Low-Dose Pesticides Alter Primary Human Bone Marrow Mesenchymal Stem/Stromal Cells through ALDH2 Inhibition.

Enantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (Danio rerio).

No evidence of effects or interaction between the widely used herbicide, glyphosate, and a common parasite in bumble bees.

An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila.

Effects of a 28-day early life stage exposure to carbaryl on fathead minnow long-term growth and reproduction.

Genomic comparisons between hepatocarcinogenic and non-hepatocarcinogenic organophosphate insecticides in the mouse liver.

Disruption of developmental programming with long-term consequences after exposure to a glyphosate-based herbicide in a rat model.

Assessing sub-lethal effects of the dinitroaniline herbicide pendimethalin in zebrafish embryos/larvae (Danio rerio).

A QSTR model for toxicity prediction of pesticides towards Daphnia magna.

Ethoprophos induces cardiac toxicity in zebrafish embryos.

Potentially Toxic Elements

Developmental Toxicology of Metal Mixtures in Drosophila: Unique Properties of Potency and Interactions of Mercury Isoforms.

Intra- and interspecific toxicity testing methods and data for nematodes exposed to metals.

Protecting Effects of N-acetyl Cysteine Supplementation Against Lead and Cadmium-Induced Brain Toxicity in Rat Models.

SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.

Oral Subacute Exposure to Cadmium LOAEL Dose Induces Insulin Resistance and Impairment of the Hormonal and Metabolic Liver-Adipose Axis in Wistar Rats.

Microplastics

Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny.

Microplastics increase the accumulation of phenanthrene in the ovaries of marine medaka (Oryzias melastigma) and its transgenerational toxicity.

Effects of different types of primary microplastics on early life stages of rainbow trout (Oncorhynchus mykiss).

Aquatic Toxicity Effects and Risk Assessment of ‘Form Specific’ Product-Released Engineered Nanomaterials.

Variable Fitness Response of Two Rotifer Species Exposed to Microplastics Particles: The Role of Food Quantity and Quality.

Inflammatory response in the mid colon of ICR mice treated with polystyrene microplastics for two weeks.

Time-dependent immune response in Porcellio scaber following exposure to microplastics and natural particles.

Do microplastics mediate the effects of chemicals on aquatic organisms?

The presence of polystyrene nanoplastics enhances the MCLR uptake in zebrafish leading to the exacerbation of oxidative liver damage.

Pharmaceuticals/Personal Care Products

The first comprehensive study evaluating the ecotoxicity and biodegradability of water-soluble polymers used in personal care products and cosmetics.

Miscellaneous

Estrogens as immunotoxicants: 17α-ethinylestradiol exposure retards thymus development in zebrafish (Danio rerio).

Effects of perchlorate and exogenous T4 exposures on development, metamorphosis and endochondral ossification in Bufo gargarizans larvae.

In vitro profiling of toxic effects of environmental polycyclic aromatic hydrocarbons on nuclear receptor signaling, disruption of endogenous metabolism and induction of cellular stress.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Variability of Urinary Concentrations of Phenols, Parabens, and Triclocarban during Pregnancy in First Morning Voids and Pooled Samples.

Occurrence of Pharmaceuticals and Endocrine Disrupting Compounds in Brazilian Water and the Risks They May Represent to Human Health.

Occurrence and sorption behaviour of bisphenols and benzophenone UV-filters in e-waste plastic and vehicle fluff.

Monitoring metallothionein-like protein concentrations and cholinesterase activity in tropical cup oysters as biomarkers of exposure to metals and pesticides in the southern Caribbean, Colombia.

BPA/Phenols

Italian Children Exposure to Bisphenol A: Biomonitoring Data from the LIFE PERSUADED Project.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Bioaccumulation and maternal transfer of two understudied DDT metabolites in wild fish species.

Model framework to quantify the effectiveness of garbage classification in reducing dioxin emissions.

Spatial distribution, source identification and ecological risk assessment of POPs and heavy metals in lake sediments of Istanbul, Turkey.

Perfluoroalkyl Substances

Perfluoroalkyl substances in circum-ArcticRangifer: caribou and reindeer.

Spatial and temporal trends of perfluoroalkyl acids in water bodies: A case study in Taihu Lake, China (2009-2021).

Predicting the impact of salt mixtures on the air-water interfacial behavior of PFAS.

Flame Retardants

Tris(1,3-dichloro-2-propyl)phosphate Induces Mass Mortality of Crucian Carp (Carassius carassius) Embryos in Taihu Lake.

The exposure of OPFRs in fish from aquaculture area: Backward tracing of the ecological risk regulation.

Short- and long-term effects of decabromodiphenyl ether (BDE-209) on sediment denitrification using a semi-continuous microcosm.

Pesticides

Use of the Species Sensitivity Distribution Approach to Derive Ecological Threshold of Toxicological Concern (eco-TTC) for Pesticides.

Host Plant Species Mediates Impact of Neonicotinoid Exposure to Monarch Butterflies.

Past insecticide exposure reduces bee reproduction and population growth rate.

Continuous high-frequency pesticide monitoring to observe the unexpected and the overlooked.

Non-Invasively Collected Fecal Samples as Indicator of Multiple Pesticide Exposure in Wild Birds.

Potentially Toxic Elements

Dietary Exposure of the Taiwan Population to Mercury Content in Various Seafood Assessed by a Total Diet Study.

Arsenic exposure from drinking water and staple food (rice): A field scale study in rural Bengal for assessment of human health risk.

Source identification of pollution and health risks to metals in household indoor and outdoor dust: A cross-sectional study in a typical mining town, China.

Heavy Metal Pollution in Aquaculture: Sources, Impacts and Mitigation Techniques.

Heavy metal contamination in Peru: implications on children’s health.

Heavy metals and Pb isotopes in a marine sediment core record environmental changes and anthropogenic activities in the Pearl River Delta over a century.

Geogenic and anthropogenic sources identification and ecological risk assessment of heavy metals in the urban soil of Yazd, central Iran.

Potential Health Risks Associated with the Heavy Metal Content in Commonly Consumed Food from Prakasam District of Andhra Pradesh, India.

Microplastics

Microplastic-oil-dispersant agglomerates in the marine environment: Formation mechanism and impact on oil dispersion.

Assessing microplastic exposure of large marine filter-feeders.

Different patterns of hypoxia aggravate the toxicity of polystyrene nanoplastics in the mussels Mytilus galloprovincialis: Environmental risk assessment of plastics under global climate change.

Microplastics in the Weddell Sea (Antarctica): A Forensic Approach for Discrimination between Environmental and Vessel-Induced Microplastics.

Evaluation of microplastic and marine debris on the beaches of Niterói Oceanic Region, Rio De Janeiro, Brazil.

Pharmaceuticals/Personal Care Products

Suspect, non-target and target screening of pharmaceuticals and personal care products (PPCPs) in a drinking water system.

Miscellaneous

Polycyclic aromatic hydrocarbons (PAHs) in the upstream rivers of Taihu Lake Basin, China: spatial distribution, sources and environmental risk.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

If you enjoy this newsletter, please feel free to donate here! Thank you!

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.