EDC Science Weekly, Nov. 18-23, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events,Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Dec. 1:Potential Endocrine Disrupting Effects of Microplastics in Human Placenta and Aquatic Life(HEEDS Young EDC Scientists Showcase (YESS) webinar series)

Conference (virtual) Jan 10-13:PPTOX VII: International Conference on Prenatal Programming and Toxicity(Abstracts due Nov 29)

For more upcoming events, see the November HEEDS Newsletter.

Regulations/Policy

US EPA’s TSCA risk assessment approach: a case study of asbestos in automotive brakes.

New implication of pesticide regulatory management in soils: Average vs ceiling legal limits.

A regulatory relic: After 60 years of research on cancer risk, the Delaney Clause continues to keep us in the past

Methods/Tools/Screening

Development of a mixed-source, single pesticide database for use in ecological risk assessment: quality control and data standardization practices.

Environmental Health Risk Evaluation Model for Coastal Chemical Industry.

Commentaries/Conference Summaries

Pervasive structural racism in environmental epidemiology.

Pesticide and agro-ecological transition: assessing the environmental and human impacts of pesticides and limiting their use. [intro to special issue of Environ Sci Pollut Res Int that includes papers presented at the 48th and 49th congresses of the French pesticide research group]

Linking Pollutants and Therapeutics to Heart Health: Key Characteristics of Cardiovascular Toxicants. [Science Selection in EHP]

Invited Perspective: Ambient Air Pollution and SARS-CoV-2: Research Challenges and Public Health Implications.

Reviews

Numerous Chemicals/Mixtures

Effects of common environmental endocrine-disrupting chemicals on zebrafish behavior.

Air pollution and endocrine disruptors induce human microbiome imbalances: A systematic review of recent evidence and possible biological mechanisms.

A Review on Epigenetic Inheritance of Experiences in Humans.

Exposure to toxic occupations and their association with Parkinson’s disease: a systematic review with meta-analysis.

Toxic chemicals from uncontrolled e-waste recycling: Exposure, body burden, health impact.

A number of articles in French in La Revue du praticien:

[Endocrine Disruptors: what are we talking about and what new mechanisms of toxicity do they bring into play?].

[Endocrine disruptors: key messages].

[What do we know about effects of the endocrine disruptors on metabolism and obesity?].

[What is known about the action of endocrine disruptors on the immune system?].

[What about the effects of endocrine disruptors on neurodevelopment?].

[Pesticides : what is known or suspected about their harmful effects on health].

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Forty years studies on polychlorinated biphenyls pollution, food safety, health risk, and human health in an e-waste recycling area from Taizhou city, China: a review.

Animal Toxicology Studies on the Male Reproductive Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin: Data Analysis and Health Effects Evaluation.

Perfluoroalkyl Substances

Associations between exposure to perfluoroalkyl substances and birth outcomes: A meta-analysis.

Organotins

The organotin contaminants in food: Sources and methods for detection: A systematic review and meta-analysis.

Pesticides

Environmental Occurrence, Toxicity Concerns, and Degradation of Diazinon Using a Microbial System.

Potentially Toxic Elements

Functional consequences of lead and mercury exposomes in the heart.

The role of heavy metals in thyroid cancer: A meta-analysis.

Microplastics/Nanomaterials

Emerging trends in nanoparticle toxicity and the significance of using Daphnia as a model organism.

Microplastic pollution in wild populations of decapod crustaceans: A review.

Air Pollution

Environmental risk factors of type 2 diabetes-an exposome approach.

PM_2.5 Exposure and Pediatric Health in E-waste Dismantling Areas.

Pharmaceuticals/Personal Care Products

A Systematic Review on Occurrence and Ecotoxicity of Organic UV Filters in Aquatic Organisms.

Miscellaneous

Occurrence and fate of polycyclic aromatic hydrocarbons from electronic waste dismantling activities: A critical review from environmental pollution to human health.

Developmental exposure to phytoestrogens found in soy: New findings and clinical implications.

Human Health Studies

Numerous Chemicals/Mixtures

Urinary levels of phthalate, bisphenol, and paraben and allergic outcomes in children: Korean National Environmental Health Survey 2015-2017.

BPA/Phenols

BDNF as a potential mediator between childhood BPA exposure and behavioral function in adolescent boys from the INMA-Granada cohort.

Phthalates

Assessment of metabolic perturbations associated with exposure to phthalates among pregnant African American women.

DEHP mediates drug resistance by directly targeting AhR in human breast cancer.

Associations between maternal mono-(2-ethylhexyl) phthalate levels, nuclear receptor gene polymorphisms, and fatty acid levels in pregnant Japanese women in the Hokkaido study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Emissions of dioxins and dioxin-like compounds and incidence of hepatocellular carcinoma in the United States.

Perfluoroalkyl Substances

Impaired gross motor development in infants with higher PFAS concentrations.

Potentially Toxic Elements

Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals.

Exposure to metal mixture and growth indicators at 4-5 years. A study in the INMA-Asturias cohort.

Prenatal Metal Mixture Concentrations and Reward Motivation in Children.

Prenatal serum thallium exposure and cognitive development among preschool-aged children: A prospective cohort study in China.

Non-linear associations between metabolic syndrome and four typical heavy metals: Data from NHANES 2011-2018.

Prospective Associations of Early Pregnancy Metal Mixtures with Mitochondria DNA Copy Number and Telomere Length in Maternal and Cord Blood.

Air Pollution

Ambient Air Pollution in Relation to SARS-CoV-2 Infection, Antibody Response, and COVID-19 Disease: A Cohort Study in Catalonia, Spain (COVICAT Study).

Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry.

Prenatal exposure to air pollution and neurodevelopmental delay in children: A birth cohort study in Foshan, China.

PM_2.5 exposure increases the risk of preterm birth in pre-pregnancy impaired fasting glucose women: A cohort study in a Southern province of China.

Pharmaceuticals/Personal Care Products

Personal care products: Demographic characteristics and maternal hormones in pregnant women from Puerto Rico.

Miscellaneous

Prenatal exposure to polycyclic aromatic hydrocarbons could increase the risk of low birth weight by affecting the DNA methylation states in a Chinese cohort.

Laboratory Studies

Numerous Chemicals/Mixtures

Use of Mixture Dosing and Nonlinear Mixed Effect Modeling of Eight Environmental Contaminants in Rabbits to Improve Extrapolation Value of Toxicokinetic Data.

Integrating in silico with in vivo approach to investigate phthalate and bisphenol A mixture-linked asthma development: Positive probiotic intervention.

Evaluation of single and joint toxicity of perfluorooctanoic acid and arsenite to earthworm (Eisenia fetida): A multi-biomarker approach.

The effect of endocrine disrupting chemicals on the vitronectin-receptor (integrin α_vβ₃)-mediated cell adhesion of human umbilical vein endothelial cells.

Endrin potentiates early-stage adipogenesis in 3T3-L1 cells by activating the mammalian target of rapamycin.

BPA/Phenols

Exposure to a “safe” dose of environmental pollutant bisphenol A elevates oxidative stress and modulates vasoactive system in hypertensive rats.

Combinational exposure to Bisphenol A and a high-fat diet causes trans-generational Malfunction of the female reproductive system in mice.

Effects of Bisphenol A and Its Alternatives, Bisphenol F and Tetramethyl Bisphenol F on Osteoclast Differentiation.

Three-Generation Study of Male Rats Gestationally Exposed to High Butterfat and Bisphenol A: Impaired Spermatogenesis, Penetrance with Reduced Severity.

Chemical Exposure-Induced Developmental Neurotoxicity in Head-Regenerating Schmidtea Mediterranea.

A systematic comparison of the developmental vascular toxicity of bisphenol A and its alternatives in vivo and in vitro.

Bisphenol AF exposure causes fasting hyperglycemia in zebrafish (Danio rerio) by interfering with glycometabolic networks.

Phthalates

Phthalates and Alternative Plasticizers Differentially affect Phenotypic Parameters in Gonadal Somatic and Germ Cell Lines.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Insights into the toxicokinetic, tissue distribution and maternal transfer of polychlorinated dibenzo-p-dioxins/dibenzofurans in laying hens fed with dioxin-associated dietary.

Larval Exposure to Polychlorinated Biphenyl-126 Led to a Long-Lasting Decrease in Immune Function in Post-Metamorphic Juvenile Northern Leopard Frogs, Lithobates pipiens.

Perfluoroalkyl Substances

Tissue distribution study of perfluorooctanoic acid in exposed zebrafish using MALDI mass spectrometry imaging.

Metabolomic profiles in zebrafish larvae following probiotic and perfluorobutanesulfonate coexposure.

Perfluorooctanesulfonic acid modulates barrier function and systemic T cell homeostasis during intestinal inflammation.

Per- and polyfluoroalkyl substances (PFAS) augment adipogenesis and shift the proteome in murine 3T3-L1 adipocytes.

Perfluorooctane sulfonic acid (PFOS) inhibits vessel formation in a human 3D co-culture angiogenesis model (NCFs/HUVECs).

Species- and Tissue-Specific Chronic Toxicity Values for Northern Bobwhite Quail (Colinus virginianus) Exposed to PFHxA and a Binary Mixture of PFOS and PFHxA.

Flame Retardants

Brominated flame retardant TBPH induced oxidative damage and reduced the expression of memory-related proteins in mice, with no discernable impairment of learning and memory.

Using recombinant adhesive proteins as durable and green flame-retardant coatings.

Microplastics habituated with biofilm change decabrominated diphenyl ether degradation products and thyroid endocrine toxicity.

Triphenyl phosphate-induced pericardial edema is associated with elevated epidermal ionocytes within zebrafish embryos.

Pesticides

Exposure to acetochlor impairs swim bladder formation, induces heat shock protein expression, and promotes locomotor activity in zebrafish (Danio rerio) larvae.

Behavioral and developmental toxicity assessment of the strobilurin fungicide fenamidone in zebrafish embryos/larvae (Danio rerio).

Acute Exposure to the Penconazole-Containing Fungicide Topas Induces Metabolic Stress in Goldfish.

Assessment of pesticide induced inhibition of Apis mellifera (honeybee) acetylcholinesterase by means of N-doped carbon dots/BSA nanocomposite modified electrochemical biosensor.

Atrazine exposure and recovery alter the intestinal structure, bacterial composition and intestinal metabolites of male Pelophylax nigromaculatus.

Antioxidant, anti-inflammatory and protective potential of gallic acid against paraquat-induced liver toxicity in male rats.

Potentially Toxic Elements

Selenomethionine alleviated fluoride-induced toxicity in zebrafish (Danio rerio) embryos by restoring oxidative balance and rebuilding inflammation homeostasis.

CO₂-driven seawater acidification increases cadmium toxicity in a marine copepod.

Toxicological effects of cadmium on the immune response and biomineralization of larval flounder Paralichthys olivaceus under seawater acidification.

Dual role of cadmium in rat liver: inducing liver injury and inhibiting the progression of early liver cancer.

Caffeic acid phenethyl ester mitigates infertility: A crucial role of metalloproteinase and angiogenic factor in cadmium-induced testicular damage.

Protective Effect of an Exopolysaccharide Produced by Lactiplantibacillus plantarum BGAN8 Against Cadmium-Induced Toxicity in Caco-2 Cells.

Changes in metabolomics and lipidomics in brain tissue and their correlations with the gut microbiome after chronic food-derived arsenic exposure in mice.

Potential protective role of curcumin powder to regulate arsenic-induced hepatorenal toxicity and hyperlipidemic metabolic dysfunction in rat model.

Novelkaraya gum micro-particles loaded Ganoderma lucidum polysaccharide regulate sex hormones, oxidative stress and inflammatory cytokine levels in cadmium induced testicular toxicity in experimental animals.

Microplastics

Polystyrene microplastic particles induce endothelial activation.

Microplastics influence physiological processes, growth and reproduction in the Manila clam, Ruditapes philippinarum.

Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice.

The effects of two sized polystyrene nanoplastics on the growth, physiological functions, and toxin production of Alexandrium tamarense.

Microplastics increase susceptibility of amphibian larvae to the chytrid fungus Batrachochytrium dendrobatidis.

Polystyrene nanoplastics and microplastics can act as Trojan horse carriers of benzo(a)pyrene to mussel hemocytes in vitro.

The toxicity analysis of PVP, PVA and PEG surface functionalized ZnO nanoparticles on embryonic as well as adult Danio rerio.

Evaluation of antioxidant response and Na⁺-K⁺-ATPase activity in zebrafish exposed to polyethylene microplastics: Shedding light on a physiological adaptation.

Vertical distribution of microplastics in water bodies causes sublethal effects and changes in Daphnia magna swimming behaviour.

Polystyrene nanoplastics diminish the toxic effects of Nano-TiO₂ in marine algae Chlorella sp.

Effects of polystyrene microplastics on copper toxicity to the protozoan Euglena gracilis: emphasis on different evaluation methods, photosynthesis, and metal accumulation.

Plastic nanoparticles cause mild inflammation, disrupt metabolic pathways, change the gut microbiota and affect reproduction in zebrafish: A full generation multi-omics study.

Pharmaceuticals/Personal Care Products

Exposed to Sulfamethoxazole induced hepatic lipid metabolism disorder and intestinal microbiota changes on zebrafish (Danio rerio).

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Chemicals of concern in building materials: A high-throughput screening.

Long-Term Exposure to the Water of Wadi El-Rayan Lakes Induced Testicular Damage and Endocrine Disruption in Mugil cephalus.

BPA/Phenols

Urinary concentrations of bisphenol analogues in the south of China population and their contribution to the per capital mass loads in wastewater.

Bisphenol A Release from Short-Term Degraded Resin-Based Dental Materials

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Bioaccumulation of PCBs and their hydroxy and sulfonated metabolites in earthworms: Comparing lab and field results.

Organochlorine Pesticides and Polychlorinated Biphenyls in Sediment Impacted by Cage Aquaculture in the Volta Basin of Ghana.

Perfluoroalkyl Substances

Poly- and Perfluorinated Alkyl Substances in Air and Water from Dhaka, Bangladesh.

Distribution, source identification and health risk assessment of PFASs in groundwater from Jiangxi Province, China.

Flame Retardants

Temporal and spatial trends of chlorinated paraffins and organophosphate flame retardants in black-tailed gull (Larus crassirostris) eggs.

Pesticides

Insecticide-contaminated honeydew: risks for beneficial insects.

Reducing environmental risks of chlorpyrifos application in typical soils by adding appropriate exogenous organic matter: Evidence from a simulated paddy field experiment.

The Longitudinal Profile of a Stream Contaminated With 2,4-D and its Effects on Non-Target Species.

First Evidence of Glyphosate in American Horseshoe Crab from the Yucatan Peninsula in Mexico.

Potentially Toxic Elements

An assessment of uranium in groundwater in the Grand Canyon region.

Quantification of Spatial and Temporal Trends in Atmospheric Mercury Deposition across Canada over the Past 30 Years.

Heavy Metal Concentrations in Fish from River Tano in Ghana and the Health Risks Posed to Consumers.

Selecting the best non-invasive matrix to measure mercury exposure in human biomonitoring surveys.

Identification of mercury-containing nanoparticles in the liver and muscle of cetaceans.

Microplastics

Accumulation of microplastics in tadpoles from different functional zones in Hangzhou Great Bay Area, China: Relation to growth stage and feeding habits.

Air Pollution

Does the EU emissions trading system help reduce PM_2.5 damage? A research based on PSM-DID method.

Pharmaceuticals/Personal Care Products

Judging Pharmaceutical Environmental Risk by its Cover? The Effects of Prescription Medication and Disease Severity on Environmental Risk Perception.

Miscellaneous

An atlas of fragrance chemicals in children’s products.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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