EDC Science Weekly, Nov. 11 – 17, 2021

Post author:HEEDS
Post published:November 17, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events,Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Nov. 17 starting soon: Mechanistic Mediation of Flame Retardants in Preterm Birth (EDC Strategies Partnership)

Webinar Dec. 1: Potential Endocrine Disrupting Effects of Microplastics in Human Placenta and Aquatic Life (HEEDS Young EDC Scientists Showcase (YESS) webinar series)

Conference (virtual) Jan 10-13: PPTOX VII: International Conference on Prenatal Programming and Toxicity (Abstracts due Nov 29)

Course (in person) May 25 – June 9: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) (Marine Biological Laboratory, Woods Hole)

Regulations/Policy

Role of epidemiology in risk assessment: a case study of five ortho-phthalates. [see related article in Environmental Health News, Phthalates’ regulatory standards may not protect people’s health, new study]

Per- and Polyfluoroalkyl Substances (PFAS): Significance and Considerations within the Regulatory Framework of the USA.

Emerging technologies and their impact on regulatory science.

Three reasons why the Water Framework Directive (WFD) fails to identify pesticide risks.

Methods/Tools/Screening

Coral Ecotoxicological Data Evaluation for the Environmental Safety Assessment of Ultraviolet Filters.

Threshold of Toxicological Concern: Extending the chemical space by inclusion of a highly curated dataset for organosilicon compounds.

Special issue: Advances in methodology and applications of non-targeted analysis in environmental monitoring.

Outcomes from Returning Individual versus Only Study-Wide Biomonitoring Results in an Environmental Exposure Study Using the Digital Exposure Report-Back Interface (DERBI).

Commentaries/Conference Summaries

Per- and Polyfluorinated Substances: An Environmental Update.

New WHO global air quality guidelines: more pressure on nations to reduce air pollution levels.

Invited Perspective: Assessing the Contaminant Exposure Risks of Urban Gardening: Call for Updated Health Guidelines.

World scientists’ warnings into action, local to global.

Reviews

Numerous Chemicals/Mixtures

Exposure to environmental chemicals and perinatal psychopathology.

New evidence for deleterious effects of environmental contaminants on the male gamete.

Endocrine disruptor chemicals. A review of their effects on male reproduction and antioxidants as a strategy to counter it.

Environmental Risk Factors for Endometriosis: An Umbrella Review of a Meta-Analysis of 354 Observational Studies With Over 5 Million Populations.

Environmental Factors and Endometriosis.

Childhood obesity: an ecological perspective.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies. [PCBs, PFAS, PBDEs, OCPs, HCB]

Human Exposure to Polychlorinated Biphenyls (PCBs) and The Risk of Endometriosis: A Systematic Review and Meta-Analysis Protocol.

Perfluoroalkyl Substances

Per- and Poly-fluoroalkyl Substances (PFAS) and Female Reproductive Outcomes: PFAS Elimination, Endocrine-Mediated Effects, and Disease.

Immunotoxicity mechanisms of perfluorinated compounds PFOA and PFOS.

Global occurrence and probabilistic environmental health hazard assessment of per- and polyfluoroalkyl substances (PFASs) in groundwater and surface waters.

Biodegradation of per- and polyfluoroalkyl substances (PFAS): A review.

Pesticides

Environmental and occupational pesticide exposure and human sperm parameters: a Navigation Guide review.

Potentially Toxic Elements

The Role of Micronutrients and Toxic Metals in the Management of Epidemics in Cambodia.

Pathophysiological effects of cadmium(II) on human health-a critical review.

Microplastics

Updated review on microplastics in water, their environmental pollution, and the need for regulatory standards.

Extraction and detection methods of microplastics in food and marine systems: A critical review.

Ecotoxicity of microplastics to freshwater biota: Considering exposure and hazard across trophic levels.

Critical steps for microplastics characterization from the atmosphere.

Effects of nanoplastics on microalgae and their trophic transfer along the food chain: recent advances and perspectives.

Air Pollution

Environmental factors and risks of cognitive impairment and dementia: A systematic review and meta-analysis.

Association between long-term exposure to PM_2.5 and hypertension: A systematic review and meta-analysis of observational studies.

Formation and growth mechanisms of polycyclic aromatic hydrocarbons: A mini-review.

Particulate Air Pollution and Risk of Neuropsychiatric Outcomes. What We Breathe, Swallow, and Put on Our Skin Matters.

Pharmaceuticals/Personal Care Products

Occurrence, Fate, Effects, and Risks of Dexamethasone: Ecological Implications Post-COVID-19.

Miscellaneous

Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects.

Human Health Studies

Numerous Chemicals/Mixtures

Machine Learning for Investigation on Endocrine-Disrupting Chemicals with Gestational Age and Delivery Time in a Longitudinal Cohort.

Exposure to common-use pesticides, manganese, lead, and thyroid function among pregnant women from the Infants’ Environmental Health (ISA) study, Costa Rica.

Aguascalientes: one of the hottest chronic kidney disease (CKD) hotspots in Mexico and a CKD of unknown aetiology mystery to be solved.

BPA/Phenols

Prenatal exposure to bisphenols and risk of preterm birth: Findings from Guangxi Zhuang birth cohort in China.

Prenatal exposure to bisphenols, immune responses in cord blood and infantile eczema: A nested prospective cohort study in China.

The association between urinary bisphenol A levels and nonalcoholic fatty liver disease in Korean adults: Korean National Environmental Health Survey (KoNEHS) 2015-2017.

Phthalates

Association of phthalates and early menarche in Korean adolescent girls from Korean National Environmental Health Survey (KoNEHS) 2015-2017.

Phthalate and DINCH urinary concentrations across pregnancy and risk of preterm birth.

Parabens/Triclosan/Antimicrobials

Increased Prevalence of Atopic Dermatitis in Children Aged 0-3 Years Highly Exposed to Parabens.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants-environmental risk factors for diabetes mellitus? – A population-based study.

2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin potential impacts on peripheral blood mononuclear cells of endometriosis women.

Flame Retardants

Analysis of Polybrominated Diphenyl Ethers and Lipid Composition in Human Breast Milk and Their Correlation with Infant Neurodevelopment.

Pesticides

Parkinson’s disease in a worker exposed to insecticides at a greenhouse.

Potentially Toxic Elements

Correlation between urinary contents of some metals and fasting plasma glucose levels: A cross-sectional study in China.

Exploring the relationship between metal exposure, BDNF, and behavior in adolescent males.

Fluoride exposure during early adolescence and its association with internalizing symptoms.

Biomarkers of cadmium exposure and renal function in estuarine adult villagers.

Prenatal and Early Childhood Exposure to Lead and Repeated Measures of Metabolic Syndrome Risk Indicators From Childhood to Preadolescence.

Pharmaceuticals/Personal Care Products

In utero exposure to 17α-hydroxyprogesterone caproate and risk of cancer in offspring.

Laboratory Studies

Numerous Chemicals/Mixtures

Unexpected Interacting Effects of Physical (Radiation) and Chemical (Bisphenol A) Treatments on Male Reproductive Functions in Mice.

BPA/Phenols

Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1).

In vivo and in vitro short-term bisphenol A exposures disrupt testicular energy metabolism and negatively impact spermatogenesis in zebrafish.

Effects of bisphenol a on hematological, serum biochemical, and histopathological biomarkers in bighead carp (Aristichthys nobilis) under long-term exposure.

Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression.

Buckwheat-enriched diet alleviates bisphenol A mediated oxidative stress via modulation of sirtuin 1 and antioxidant status in experimental rats.

Toxicological profile of bisphenol F via comprehensive and extensive toxicity evaluations following dermal exposure.

Transcriptomics integrated with metabolomics reveals the effect of Bisphenol F (BPF) exposure on intestinal inflammation.

Effects of the endocrine disruptor 4-nonylphenol on the demography of rotifers Plationus patulus and Brachionus havanaensis: a multigenerational study.

Phthalates

Prenatal exposure to di (2-ethylhexyl) phthalate causes autism-like behavior through inducing Nischarin expression in the mouse offspring.

Combined effects of obesity and di-(2-ethylhexyl) phthalate on testosterone levels and kisspeptin/GPR54 expression in hypothalamus and testes of male mice.

Di-butyl phthalate (DBP) induces defects during embryonic eye development in zebrafish.

Mechanisms of MEHP Inhibitory Action and Analysis of Potential Replacement Plasticizers on Leydig Cell Steroidogenesis.

Maternal high-fat diet during pregnancy with concurrent phthalate exposure leads to abnormal placentation.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Peripherally Administered Persistent Organic Pollutants Distribute to the Brain of Developing Chicken Embryo in Concentrations Relevant for Human Exposure.

Using In Vitro and Machine Learning Approaches to Determine Species-Specific Dioxin-like Potency and Congener-Specific Relative Sensitivity among Birds for Brominated Dioxin Analogues.

Effects of Acute 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Exposure on the Circulating and Cecal Metabolome Profile.

Perfluoroalkyl Substances

Transcriptome analysis of 3D primary mouse liver spheroids shows that long-term exposure to hexafluoropropylene oxide trimer acid disrupts hepatic bile acid metabolism.

Perfluorooctane sulfonate (PFOS) exposure of bovine oocytes affects early embryonic development at human-relevant levels in an in vitro model.

Low-dose perfluorooctanoic acid stimulates steroid hormone synthesis in Leydig cells: Integrated proteomics and metabolomics evidence.

Hexafluoropropylene oxide dimer acid (GenX) exposure induces apoptosis in HepG2 cells.

Perfluorooctane sulfonate (PFOS) induces several behavioural defects in Caenorhabditis elegans that can also be transferred to the next generations.

Impairment of human dopaminergic neurons at different developmental stages by perfluoro-octanoic acid (PFOA) and differential human brain areas accumulation of perfluoroalkyl chemicals.

Pesticides

Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring.

Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells.

A common fungicide tebuconazole promotes colitis in mice via regulating gut microbiota.

The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.

Acute exposure to paraquat affects the phenotypic differentiation of substantia nigra microglia in rats.

Embryonic exposure to fenbuconazole inhibits gametogenesis in adult zebrafish by targeting gonads not brain.

Characterizing the potentially neuronal acetylcholinesterase reactivity toward chiral pyraclofos: Enantioselective insights from spectroscopy, in silico docking, molecular dynamics simulation and per-residue energy decomposition studies.

The protective effects of erdosteine on subacute diazinon-induced oxidative stress and inflammation in rats.

Morphometric Evaluation of the Recurrent Laryngeal Nerve of Wistar Rats Exposed to Pesticides.

Potentially Toxic Elements

Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice.

AMPK pathway is implicated in low level lead-induced pubertal testicular damage via disordered glycolysis.

Progesterone modulates cadmium-induced oxidative stress and inflammation in hepatic tissues of Wistar rats.

Molecular Studies on the Nephroprotective Potential of Celastrus paniculatus against Lead-Acetate-Induced Nephrotoxicity in Experimental Rats: Role of the PI3K/AKT Signaling Pathway.

3,4-Dihydroxybenzaldehyde mitigates fluoride-induced cytotoxicity and oxidative damage in human RBC.

Identification of epigenetic modifications mediating the antagonistic effect of selenium against cadmium-induced breast carcinogenesis.

Prenatal cadmium exposure does not induce greater incidence or earlier onset of autoimmunity in the offspring.

Effects of the Toxic Metals Arsenite and Cadmium on α-Synuclein Aggregation In Vitro and in Cells.

Direct cardiotoxicity of lead.

Sexual dimorphism in inorganic mercury toxicokinetics and the attendant lipotoxic and non-lipotoxic dyslipidemia in the rat.

Arsenite exposure inhibits the erythroid differentiation of human hematopoietic progenitor CD34⁺ cells and causes decreased levels of hemoglobin.

Microplastics

Polystyrene nanoplastics potentiate the development of hepatic fibrosis in high fat diet fed mice.

Histopathological damage and stress- and immune-related genes’ expression in the intestine of common carp, Cyprinus carpio exposed to copper and polyvinyl chloride microparticle.

Individual and combined multigenerational effects induced by polystyrene nanoplastic and glyphosate in Daphnia magna (Strauss, 1820).

Non-targeted analysis for organic components of microplastic leachates.

Rethinking the relevance of microplastics as vector for anthropogenic contaminants: Adsorption of toxicants to microplastics during exposure in a highly polluted stream – Analytical quantification and assessment of toxic effects in zebrafish (Danio rerio).

Acute and subacute repeated oral toxicity study of fragmented microplastics in Sprague-Dawley rats.

Polycyclic Aromatic Hydrocarbons

Phenanthrene disrupting effects on the thyroid system of Arabian seabream, Acanthopagrus arabicus: In situ and in vivo study.

3-Bromofluoranthene-induced cardiotoxicity of zebrafish and apoptosis in the vascular endothelial cells via intrinsic and extrinsic caspase-dependent pathways.

Miscellaneous

Exposure to the synthetic phenolic antioxidant 4,4′-thiobis(6-t-butyl-m-cresol) disrupts early development in the frog Silurana tropicalis.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Estimation of parabens and bisphenols in maternal products and urinary concentrations in Indian pregnant women: daily intake and health risk assessment.

Co-exposure and health risks of several typical endocrine disrupting chemicals in general population in eastern China.

Bio-surveillance of environmental pollutants in the population of Kinshasa, Democratic Republic of Congo (DRC): a small pilot study.

Microplastics, bisphenols, phthalates and pesticides in odontocete species in the Macaronesian Region (Eastern North Atlantic).

Legacy and emerging organohalogenated compounds in feathers of Eurasian eagle-owls (Bubo bubo) in Norway: Spatiotemporal variations and associations with dietary proxies (δ¹³C and δ¹⁵N).

Uptake of perfluoroalkyl substances, pharmaceuticals, and parabens by oyster mushrooms (Pleurotus ostreatus) and exposure risk in human consumption.

BPA/Phenols

Exposure assessment of bisphenol A by drinking coffee from plastic cups.

Parabens/Triclosan/Antimicrobials

Research on freshwater water quality criteria, sediment quality criteria and ecological risk assessment of triclosan in China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent Organic Pollutants in Human Milk: Exposure Levels and Determinants among Lactating mothers in Lebanon.

Exposure of infants to organochlorine pesticides from breast milk consumption in southwestern Ethiopia.

Intracity occurrence and distribution of airborne PCB congeners in Chicago.

Legacy organochlorines in estuarine sediment in relation to socioeconomic pattern in multi-coastal watersheds.

Perfluoroalkyl Substances

Serum concentrations of legacy and emerging per- and polyfluoroalkyl substances in the Anniston Community Health Surveys (ACHS I and ACHS II).

Elevated levels of per- and polyfluoroalkyl substances (PFAS) in freshwater benthic macroinvertebrates from the Hudson River Watershed.

Novel and legacy per- and polyfluoroalkyl substances (PFAS) in freshwater sporting fish from background and firefighting foam impacted ecosystems in Eastern Canada.

Occurrence, partitioning behavior and risk assessments of per- and polyfluoroalkyl substances in water, sediment and biota from the Dongshan Bay, China.

The driving factors of per- and polyfluorinated alkyl substance (PFAS) accumulation in selected fish species: The influence of position in river continuum, fish feed composition, and pollutant properties.

Levels and Seasonal Trends of C₁-C₄ Perfluoroalkyl Acids and the Discovery of Trifluoromethane Sulfonic Acid in Surface Snow in the Arctic.

Pesticides

Seasonal Urinary Levels of Glyphosate in Children From Agricultural Communities.

Pesticide exposure of workers in apple growing in France.

A comparative evaluation of dietary exposure to glyphosate resulting from recommended U.S. diets.

High nutritional status promotes vitality of honey bees and mitigates negative effects of pesticides.

A spatially explicit model for estimating risks of pesticide exposure to bird populations.

Ecological risk assessment of pesticides in urban streams of the Brazilian Amazon.

Endocrine disruptors on and in fruits and vegetables: Estimation of the potential exposure of the French population.

Field evidence of UK wild bird exposure to fludioxonil and extrapolation to other pesticides used as seed treatments.

Climate change aggravates non-target effects of pesticides on dragonflies at macroecological scales.

Potentially Toxic Elements

Mercury Exposure in Artisanal Mining: Assessing the Effect of Occupational Activities on Blood Mercury Levels Among Artisanal and Small-Scale Goldminers in Ghana.

Mercury exposure of tidal marsh songbirds in the northeastern United States and its association with nest survival.

Incorporating bioaccessibility and source apportionment into human health risk assessment of heavy metals in urban dust of Xiamen, China.

Road dust-driven elemental distribution in megacity Dhaka, Bangladesh: environmental, ecological, and human health risks assessment.

Microplastics

Wet wipes and disposable surgical masks are becoming new sources of fiber microplastic pollution during global COVID-19.

A microplastic size classification scheme aligned with universal plankton survey methods.

Microplastics in the environment and in commercially significant fishes of mud banks, an ephemeral ecosystem formed along the southwest coast of India.

Fourier transform infrared (FTIR) analysis identifies microplastics in stranded common dolphins (Delphinus delphis) from New Zealand waters.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.