EDC Science Weekly, Nov. 4-10, 2021

Post author:HEEDS
Post published:November 10, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Nov. 11: Protecting Water Quality, Health and the Environment: Urgent Questions Pertaining to PFAS with Dr. Carla Ng (CHE-Alaska)

Online conference Nov. 11: Moving Towards Beauty Justice: Conversations for Change (NIEHS)

Webinar Nov. 17: Mechanistic Mediation of Flame Retardants in Preterm Birth (EDC Strategies Partnership)

Webinar Dec. 1: Potential Endocrine Disrupting Effects of Microplastics in Human Placenta and Aquatic Life (HEEDS Young EDC Scientists Showcase (YESS) webinar series)

Methods/Tools/Screening

CEBS update: curated toxicology database with enhanced tools for data integration.

Towards further harmonization of a glossary for exposure science-an ISES Europe statement.

Endogenous Lifecycle Models for Chemical Risk Assessment.

Incorporating human exposure information in a weight of evidence approach to inform design of repeated dose animal studies.

Exposome in human health: Utopia or wonderland?

Commentaries/Conference Summaries

Endocrine disruptors-the lessons (not) learned.

PFAS: here today-here tomorrow.

A New OECD Definition for Per- and Polyfluoroalkyl Substances.

Can Environmental Pollutants Be a Factor Linking Obesity and COVID-19?

Editorial: Developmental Programming of Metabolic Diseases. [intro to a special issue in Frontiers in Endocrinology]

The 2021 report of the Lancet Countdown on health and climate change: code red for a healthy future

Reviews

Numerous Chemicals/Mixtures

Endocrine-Disrupting Chemicals and Vitamin D Deficiency in the Pathogenesis of Uterine Fibroids.

BPA/Phenols

The association between bisphenol A exposure and oxidative damage in rats/mice: A systematic review and meta-analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Guide and advances on childhood obesity determinants: Setting the research agenda.

Where the Aryl Hydrocarbon Receptor Meets the microRNAs: Literature Review of the Last 10 Years.

Pesticides

A meta-analytic review of fish antioxidant defense and biotransformation systems following pesticide exposure.

A global systematic review of the concentrations of Malathion in water matrices: Meta-analysis, and probabilistic risk assessment.

Systematic review of human biomonitoring studies of ethylenethiourea, a urinary biomarker for exposure to dithiocarbamate fungicides.

Potentially Toxic Elements

Blood lead concentrations in children with iron deficiency anemia: a systematic review and meta-analysis.

Heavy metals contamination and associated health risks in food webs-a review focuses on food safety and environmental sustainability in Bangladesh.

Environmental and health risk assessment of potentially toxic trace elements in soils near uranium (U) mines: A global meta-analysis.

Microplastics

Seeking for a perfect (non-spherical) microplastic particle – The most comprehensive review on microplastic laboratory research.

Effects of microplastics on soil properties: Current knowledge and future perspectives.

Interaction of Microplastics with Antibiotics in Aquatic Environment: Distribution, Adsorption, and Toxicity.

Birds and plastic pollution: recent advances.

Phytotoxic effects of plastic pollution in crops: what is the size of the problem?

Research progress of microplastics in soil-plant system: Ecological effects and potential risks.

On the degradation of (micro)plastics: Degradation methods, influencing factors, environmental impacts.

Global meta-analysis of microplastic contamination in reservoirs with a novel framework.

Air Pollution

Safe in the womb? Effects of air pollution to the unborn child and neonates.

The impact of environmental injustice and social determinants of health on the role of air pollution in asthma and allergic disease in the United States.

Pharmaceuticals/Personal Care Products

Environmental pollution with psychiatric drugs.

Miscellaneous

Role of environmentally induced epigenetic transgenerational inheritance in evolutionary biology: Unified Evolution Theory.

The Impact of Environmental Pollutants on Barrier Dysfunction in Respiratory Disease.

Disinfectant-induced hormesis: An unknown environmental threat of the application of disinfectants to prevent SARS-CoV-2 infection during the COVID-19 pandemic?

Extracellular Vesicles: Footprints of environmental exposures in the aging process?

Human Health Studies

Numerous Chemicals/Mixtures

Maternal occupational exposure to endocrine-disrupting chemicals and urogenital anomalies in the offspring.

Mixtures modeling identifies heavy metals and pyrethroid insecticide metabolites associated with obesity.

BPA/Phenols

Environmental exposure to bisphenol analogues and unexplained recurrent miscarriage: A case-control study.

Human Metabolism and Urinary Excretion Kinetics of Nonylphenol in Three Volunteers after a Single Oral Dose.

Phthalates

Phasing out DEHP from plastic indwelling medical devices used for intensive care: Does it reduce the long-term attention deficit of critically ill children?

Associations of pregnancy phthalate concentrations and their mixture with early adolescent bone mineral content and density: The Health Outcomes and Measures of the Environment (HOME) study.

Association of Phthalate Exposure with Thyroid Function and Thyroid Homeostasis Parameters in Type 2 Diabetes.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

t(14;18) Translocations in Dioxin-Exposed Workers.

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substance (PFAS) exposure, maternal metabolomic perturbation, and fetal growth in African American women: A meet-in-the-middle approach.

Association of maternal exposure to perfluoroalkyl and polyfluroalkyl substances with infant growth from birth to 12 months: A prospective cohort study.

Pesticides

Time after a peak-pesticide use period and neurobehavior among ecuadorian children and adolescents: The ESPINA study.

Reported organic food consumption and metabolic syndrome in older adults: cross-sectional and longitudinal analyses.

Potentially Toxic Elements

Identifying periods of heightened susceptibility to lead exposure in relation to behavioral problems.

Polymorphisms of the AS3MT gene are associated with arsenic methylation capacity and damage to the P21 gene in arsenic trioxide plant workers.

Associations between hair levels of trace elements and the risk of preterm birth among pregnant women: A prospective nested case-control study in Beijing Birth Cohort (BBC), China.

The Associations between Blood and Urinary Concentrations of Metal Metabolites, Obesity, Hypertension, Type 2 Diabetes, and Dyslipidemia among US Adults: NHANES 1999-2016.

Multiple plasma metals, genetic risk and serum complement C3, C4: A gene-metal interaction study.

Arsenic and fluoride co-exposure through drinking water and their impacts on intelligence and oxidative stress among rural school-aged children of Lahore and Kasur districts, Pakistan.

Air Pollution

Association between prenatal exposure to indoor air pollution and autistic-like behaviors among preschool children.

Laboratory Studies

Numerous Chemicals/Mixtures

Exposure to a mixture of benzo[a]pyrene and triclosan induces multi-and transgenerational metabolic disorders associated with decreased female investment in reproduction in Silurana (Xenopus) tropicalis.

BPA/Phenols

CLARITY-BPA Research Program. 2021. NTP research report on the consortium linking academic and regulatory insights on bisphenol A toxicity (CLARITY-BPA): a compendium of published findings. Research Triangle Park, NC: National Toxicology Program. Research Report 18.

Effects of bisphenol A on the proliferation, migration, and tumor growth of colon cancer cells: In vitro and in vivo evaluation with mechanistic insights related to ERK and 5-HT3.

A mutispectroscopic study on the structure-affinity relationship of the interactions of bisphenol analogues with bovine serum albumin.

Graphene oxide enhanced the endocrine disrupting effects of bisphenol A in adult male zebrafish: Integrated deep learning and metabolomics studies.

A low dose of bisphenol A stimulates estradiol production by regulating β-catenin-FOXL2-CYP19A1 pathway in human ovarian granulosa cells

Co-occurring Environmental Stressors have Emerging Impacts on Sensory-Motor Behavior. [BPA]

[Effects of interleukin-17 antibody on polarization of macrophages in adipose tissue of high-fat diet fed mice exposed to bisphenol A]. [in Chinese]

Phthalates

Perinatal DEHP exposure modulates pituitary estrogen receptor α and β expression altering lactotroph and somatotroph cell growth in prepuberal and adult male rats.

Parabens/Triclosan/Antimicrobials

Toxic effects of triclocarban on larval zebrafish: A focus on visual dysfunction.

Effects of chronic triclosan exposure on social behaviors in adult mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated biphenyl quinone exposure promotes breast cancer aerobic glycolysis: An in vitro and in vivo examination.

Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure.

Suppression of apoptotic signaling in rat hepatocytes by non-dioxin-like polychlorinated biphenyls depends on the receptors CAR and PXR.

Perfluoroalkyl Substances

Short-term exposure to perfluorotetradecanoic acid affects the late-stage regeneration of Leydig cells in adult male rats.

New insight into PFOS transformation pathways and the associated competitive inhibition with other perfluoroalkyl acids via photoelectrochemical processes using GOTiO₂ film photoelectrodes.

Stability of Per- and Polyfluoroalkyl Substances in Solvents Relevant to Environmental and Toxicological Analysis.

Perfluorooctane sulfonate (PFOS) triggers migration and invasion of esophageal squamous cell carcinoma cells via regulation of Zeb1.

Perfluoroalkyl Carboxylic Acids Interact with the Human Bile Acid Transporter NTCP.

Predicting the Effects of Per- and Polyfluoroalkyl Substance Mixtures on Peroxisome Proliferator-Activated Receptor Alpha Activity in Vitro.

In Vivo Transformation of a Novel Polyfluoroether Surfactant.

Computational Analysis of the Binding Mechanism of GenX and HSA.

Flame Retardants

Human CYP enzyme-activated genotoxicity of 2,2′,4,4′-tetrabromobiphenyl ether in mammalian cells.

Pesticides

A Typical Fungicide and Its Main Metabolite Promote Liver Damage in Mice through Impacting Gut Microbiota and Intestinal Barrier Function.

Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase.

Metabolomics insight into the influence of environmental factors in responses of freshwater biofilms to the model herbicide diuron.

Ecotoxicological effects of commercial herbicides on the reproductive system of aquatic arthropod Limnocoris submontandoni (Hemiptera: Naucoridae).

Toxicity and biochemical responses induced by phosmet in rainbow trout (Oncorhynchus mykiss).

Benchmark dose and the adverse effects of exposure to pendimethalin at low dose in female rats.

Comprehensive analysis of differences of N⁶-methyladenosine of lncRNAs between atrazine-induced and normal Xenopus laevis testis.

Acute exposure of embryo, larvae and adults of Danio rerio to fipronil commercial formulation reveals effects on development and motor control.

Reproductive toxicological changes in avian embryos due to a pesticide and an environmental contaminant.

Potentially Toxic Elements

Protective effect of melatonin against chronic cadmium-induced hepatotoxicity by suppressing oxidative stress, inflammation, and apoptosis in mice.

Effects of long-term cadmium exposure on growth, antioxidant defense and DNA methylation in juvenile Nile tilapia (Oreochromis niloticus).

Lead and lead-arsenic combined exposure induces mortality and developmental impairments in zebrafish embryos: a study using wild-caught zebrafish from Bangladesh.

MiR-182-5p/TLR4/NF-κB axis contributes to the protective effect of caffeic acid phenethyl ester against cadmium-induced spleen toxicity and associated damage in mice.

Transcriptomic analysis of Neocaridina denticulate sinensis hepatopancreas indicates immune changes after copper exposure.

The role of regulatory T cells on the activation of astrocytes in the brain of high-fat diet mice following lead exposure.

Common mechanisms cannot explain time- and dose-dependent DNA methylation changes in earthworms exposed to cadmium.

Arctigenin alleviates cadmium-induced nephrotoxicity: Targeting endoplasmic reticulum stress, Nrf2 signaling, and the associated inflammatory response

Developmental exposure to environmental levels of cadmium induces neurotoxicity and activates microglia in zebrafish larvae: From the perspectives of neurobehavior and neuroimaging.

Microplastics

In vivo impact assessment of orally administered polystyrene nanoplastics: biodistribution, toxicity, and inflammatory response in mice.

Interactive effects of environmental microplastics and 2,4-dichlorophenoxyacetic acid (2,4-D) on the earthworm Eisenia andrei.

Cloning and characterization of AMP-activated protein kinase genes in Daphnia pulex: Modulation of AMPK gene expression in response to polystyrene nanoparticles.

Polystyrene microplastics induced female reproductive toxicity in mice.

A multifaceted assessment of the effects of polyethylene microplastics on juvenile gilthead seabreams (Sparus aurata).

Particles rather than released Zn²⁺ from ZnO nanoparticles aggravate microplastics toxicity in early stages of exposed zebrafish and their unexposed offspring.

Physiological and transcriptional responses of Dictyosphaerium sp. under co-exposure of a typical microplastic and nonylphenol.

The potential effects of microplastic pollution on human digestive tract cells.

Neuromuscular, retinal, and reproductive impact of low-dose polystyrene microplastics on Drosophila.

Microplastics reduce the bioaccumulation and oxidative stress damage of triazole fungicides in fish.

Understanding the hazards induced by microplastics in different environmental conditions.

Direct reuse of electronic plastic scraps from computer monitor and keyboard to direct stem cell growth and differentiation.

Pharmaceuticals/Personal Care Products

Physiological and transcriptomic analyses reveal the toxicological mechanism and risk assessment of environmentally-relevant waterborne tetracycline exposure on the gills of tilapia (Oreochromis niloticus).

Mice Uterine Stem Cells are Affected by Neonatal Endocrine Disruption & Initiate Uteropathies in Adult Life Independent of Circulatory Ovarian Hormones.

PAHs

Polycyclic Aromatic Hydrocarbons and Mammary Cancer Risk: Does Obesity Matter too?

Substituted Two- to Five-Ring Polycyclic Aromatic Compounds Are Potent Agonists of Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a.

Miscellaneous

Prenatal androgenization causes expression changes of progesterone and androgen receptor mRNAs in the arcuate nucleus of female mice across development.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Combining short-term bioassays using fish and crustacean model organisms with ToxCast in vitro data and broad-spectrum chemical analysis for environmental risk assessment of the river water (Sava, Croatia).

BPA/Phenols

First report on occurrence of bisphenol A isomers in human serum and whole blood.

Enzymatic probe sonication for quick extraction of total bisphenols from animal-derived foods: Applicability to occurrence and exposure assessment.

Phthalates

Phthalates in the environment: characteristics, fate and transport, and advanced wastewater treatment technologies.

Release of phthalate esters from a local landfill in the Tibetan Plateau: Importance of soil particle-size specific association.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The influence of different production systems on dioxin and PCB levels in chicken eggs from Emilia-Romagna and Lombardy regions (Italy) over 2017-2019 and consequent dietary exposure assessment.

Organochlorine pesticides in immature scalloped hammerheads Sphyrna lewini from the western coast of the Gulf of California, Mexico: Bioaccumulation patterns and human exposure.

Perfluoroalkyl Substances

Biomonitoring of per- and polyfluoroalkyl substances in minority angler communities in central New York State.

Brazilian overview of per- and polyfluoroalkyl substances listed as persistent organic pollutants in the stockholm convention.

Air-water interfacial areas relevant for transport of per and poly-fluoroalkyl substances.

Stability of Per- and Polyfluoroalkyl Substances in Solvents Relevant to Environmental and Toxicological Analysis.

Half-lives of several polyfluoroalkyl substances (PFAS) in cattle serum and tissues.

Simulating Impacts of Biosparging on Release and Transformation of Poly- and Perfluorinated Alkyl Substances from Aqueous Film-Forming Foam-Impacted Soil.

Investigation of levels of perfluoroalkyl substances in freshwater fishes collected in a contaminated area of Veneto Region, Italy.

Flame Retardants

Occurrence and Dietary Intake of Organophosphate Esters via Animal-Origin Food Consumption in China: Results of a Chinese Total Diet Study.

Occurrence, potential sources and risks of organophosphate esters in the high-elevation region, Tibet, China.

First report on hydroxylated and methoxylated polybrominated diphenyl ethers in terrestrial environment from the Arctic and Antarctica.

Potentially Toxic Elements

Non-point source arsenic contamination of soil and groundwater from legacy pesticides.

Atmospheric mercury sources in a coastal-urban environment: a case study in Boston, Massachusetts, USA.

Leaching and In Vivo Bioavailability of Antimony in PET Bottled Beverages.

Microplastics

Characteristics of nano-plastics in bottled drinking water.

Characteristics and influencing factors of airborne microplastics in nail salons.

Accumulation of chemical elements and occurrence of microplastics in small pelagic fish from a neritic environment.

Pharmaceuticals/Personal Care Products

Impacts of COVID-19 pandemic on the aquatic environment associated with disinfection byproducts and pharmaceuticals.

Miscellaneous

Dissolved polycyclic aromatic hydrocarbons from the Northwestern Pacific to the Southern Ocean: Surface seawater distribution, source apportionment, and air-seawater exchange.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.