EDC Science Weekly, Oct. 28 – Nov. 3, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Nov. 9: Developmental Endocrine Disruption and Neurotoxicity (HEEDS)

Virtual Town Hall Nov. 10: Eat your Peas, not PFAS: A look into the movement to make school lunch plates safe from PFAS (CEH)

Webinar Nov. 11: Protecting Water Quality, Health and the Environment: Urgent Questions Pertaining to PFAS with Dr. Carla Ng (CHE-Alaska)

Webinar Nov. 17: Mechanistic Mediation of Flame Retardants in Preterm Birth (EDC Strategies Partnership)

Regulations/Policy

Opinion on the impact of non-monotonic dose responses on EFSA’s human health risk assessments.

Update of the Blood Lead Reference Value – United States, 2021.

Preventing Parkinson’s Disease: An Environmental Agenda.

Organic foods and contribution to the protection of body cells and molecules (lipids and DNA) from oxidative damage: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.

Methods/Tools/Screening

The Eco-Exposome concept: Supporting an Integrated Assessment of Mixtures of Environmental Chemicals.

Summary of 17 chemicals evaluated by OECD TG229 using Japanese Medaka, Oryzias latipes in EXTEND 2016.

Using High-Throughput Screening to Evaluate Perturbations Potentially Linked to Neurobehavioral Outcomes: A Case Study Using Publicly Available Tools on FDA Batch-Certified Synthetic Food Dyes.

AOP-helpFinder webserver: a tool for comprehensive analysis of the literature to support adverse outcome pathways development.

New approach methods (NAMs) supporting read-across: Two neurotoxicity AOP-based IATA case studies.

A proposed nomenclature for microplastic contaminants.

Quantitative high-throughput phenotypic screening for environmental estrogens using the E-Morph Screening Assay in combination with in silico predictions.

Large-Scale Transcriptional Profiling of Molecular Perturbations Reveals Cell Line Specific Responses and Implications for Environmental Screening.

CRISPR approach in environmental chemical screening focusing on population variability.

Advances in Assessing Hazard and Risk to Emerging Threats and Emergency Response: Comparing and Contrasting Efforts of Three Federal Agencies.

Commentaries/Conference Summaries

Environmental Pollution, Climate Change, and a Critical Role for the Endocrinologist.

Developmental Origins of Health and Disease, resilience and social justice in the COVID era.

#EnvChem2020: Chemistry of the Whole Environment Research.

Reviews

Numerous Chemicals/Mixtures

Adverse Impact of Environmental Chemicals on Developmental Origins of Kidney Disease and Hypertension.

Two decades of Chronic Kidney Disease of Unknown Aetiology research: Existing evidence and persistent gaps from epidemiological studies in Sri Lanka.

Perfluoroalkyl Substances

Perfluoroalkyl substances exposure and immunity, allergic response, infection, and asthma in children: review of epidemiologic studies.

Potentially Toxic Elements

Epigenetic modifications from arsenic exposure: A comprehensive review.

Pharmaceuticals/Personal Care Products

Occurrences and removal of pharmaceutical and personal care products from aquatic systems using advanced treatment- A review.

Phycoremediation integrated approach for the removal of pharmaceuticals and personal care products from wastewater – A review.

Monitoring of emerging contaminants of concern in the aquatic environment: a review of studies showing the application of effect-based measures.

Human Health Studies

Numerous Chemicals/Mixtures

Chemical exposures assessed via silicone wristbands and endogenous plasma metabolomics during pregnancy.

Phthalates

The associations of urinary DEHP metabolite levels, serum thyroid hormones, and thyroid-related genes among the adolescent students from China: a cross-sectional study.

Potentially Toxic Elements

Sex-specific associations of exposure to metal mixtures with telomere length change: Results from an 8-year longitudinal study.

Association Between Prenatal Exposure to Metals and Atopic Dermatitis Among Children Aged 4 Years in Taiwan.

Timing of Toenail Collection and Concentrations of Metals in Pancreatic Cancer. Evidence Against Disease Progression Bias.

Association between Renal Dysfunction Biomarkers and Low Levels of Cadmium Burden in Populations Exposed to Environmental Cadmium.

Metal mixtures are associated with increased anxiety during pregnancy.

The Effects of Lead and Cadmium Co-exposure on Serum Ions in Residents Living Near a Mining and Smelting Area in Northwest China.

Laboratory Studies

Numerous Chemicals/Mixtures

Endocrine disrupting chemicals differentially alter intranuclear dynamics and transcriptional activation of estrogen receptor-α.

BPA/Phenols

Systems toxicology approach explores target-pathway relationship and adverse health impacts of ubiquitous environmental pollutant bisphenol A.

Comparison of the renal effects of bisphenol A in mice with and without experimental diabetes. Role of sexual dimorphism.

Estrogen Receptor β as a Possible Double-Edged Sword Molecule in Breast Cancer: A Mechanism of Alteration of Its Role by Exposure to Endocrine-Disrupting Chemicals.

Vitamin D mitigates adult onset diseases in male and female mice induced by early-life exposure to endocrine disruptor BPA.

The Influence of Bisphenol A (BPA) on the Occurrence of Selected Active Substances in Neuregulin 1 (NRG1)-Positive Enteric Neurons in the Porcine Large Intestine.

Degradation of the endocrine-disrupting 4-nonylphenol by ferrate(VI): biodegradability and toxicity evaluation.

Phthalates

Prenatal exposure to a mixture of phthalates accelerates the age-related decline in reproductive capacity but may not affect direct biomarkers of ovarian aging in the F1 generation of female mice.

Regulation of TRAF6 by MicroRNA-146a in Zebrafish Embryos after Exposure to Di(2-Ethylhexyl) Phthalate at Different Concentrations.

Parabens/Triclosan/Antimicrobials

Developmental and Reproductive Outcomes in Male Rats Exposed to Triclosan: Two-Generation Study.

Effects of Long-Term Triclosan Exposure on Microbiota in Zebrafish.

Impact of chronic sub-lethal methylparaben exposure on cardiac hypoxia and alterations in neuroendocrine factors in zebrafish model.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Negative Feedback Loop and Transcription Factor Cooperation Regulate Zonal Gene Induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-Dioxin in the Mouse Liver.

Perfluoroalkyl Substances

Bayesian Refinement of the Permeability-Limited Physiologically Based Pharmacokinetic Model for Perfluorooctanoic Acid in Male Rats.

Chronic exposure to perfluorohexane sulfonate leads to a reproduction deficit by suppressing hypothalamic kisspeptin expression in mice.

Flame Retardants

Biotransformation of 2,4,6-tris(2,4,6-tribromophenoxy)-1,3,5-triazine (TTBP-TAZ) can contribute to high levels of 2,4,6-tribromophenol (2,4,6-TBP) in humans.

Structural binding perspectives of common plasticizers and a flame retardant, BDE-153, against thyroxine-binding globulin: potential for endocrine disruption.

Decabromodiphenyl ether induces male reproductive toxicity by activating mitochondrial apoptotic pathway through glycolipid metabolism dysbiosis.

Pesticides

Oxidative stress is involved in the activation of NF-κB signal pathway and immune inflammatory response in grass carp gill induced by cypermethrin and/or sulfamethoxazole.

Propolis nanoparticles relieved the impacts of glyphosate-induced oxidative stress and immunosuppression in Nile tilapia.

Long-term exposure to cyprodinil causes abnormal zebrafish aggressive and antipredator behavior through the hypothalamic-pituitary-interrenal axis.

The effect and mechanism of cypermethrin-induced hippocampal neurotoxicity as determined by network pharmacology analysis and experimental validation.

Identification of CYP Isozymes Involved in Enantioselective Metabolism of Fipronil in Fish Liver: In Vitro Metabolic Kinetics and Molecular Modeling.

Potentially Toxic Elements

Influence of salinity on the toxicity of copper and cadmium to Zebrafish embryos.

Cadmium inhibits signal transducer and activator of transcription 6 leading to pancreatic β cell apoptosis.

Distribution of arsenic species and pathological characteristics of tissues of the mice fed with arsenic-supplemented food simulating rice.

Therapeutic Effects of Ethanolic Extract of Polygonum limbatum meism Against Reproductive Toxicity Induced by Cadmium in Male Guinea Pigs (Cavia porcellus).

Microplastics

Combined toxicity of polystyrene microplastics and sulfamethoxazole on zebrafish embryos.

Pharmaceutical Products and Pesticides Toxicity Associated with Microplastics (Polyvinyl Chloride) in Artemia salina.

Pharmaceuticals/Personal Care Products

Maternal Benzophenone Exposure Impairs Hippocampus Development and Cognitive Function in Mouse Offspring.

Miscellaneous

Tartrazine exposure results in histological damage, oxidative stress, immune disorders and gut microbiota dysbiosis in juvenile crucian carp (Carassius carassius).

Atlantic cod (Gadus morhua) embryos are highly sensitive to short-term 3,4-dichloroaniline exposure.

Developmental Programming: Prenatal Testosterone Excess on Liver and Muscle Coding and Non-Coding RNA in Female Sheep.

Effect of vinyl chloride exposure on cardiometabolic toxicity.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Pesticides, nonylphenols and polybrominated diphenyl ethers in marine bivalves from France: A pilot study.

Phthalates

Phthalate and novel plasticizer concentrations in food items from U.S. fast food chains: a preliminary analysis.

Potential environmental risk assessment of di-2-ethylhexyl phthalate emissions from a municipal solid waste landfill leachate.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Plasma levels of unintentionally produced non-Aroclor polychlorinated biphenyl (PCB) congeners in workers from the silicone rubber industry.

Occurrence and spatial characteristics of polychlorinated biphenyls (PCBs) in sediments from rivers in the western Niger delta of Nigeria impacted by urban and industrial activities.

Long-Term Consequences of High Polychlorinated Biphenyl Exposure: Projected Decline of Delphinid Populations in a Hotspot for Chemical Pollution.

Agent Orange: Haft-Century Effects On The Vietnamese Wildlife Have Been Ignored.

Perfluoroalkyl Substances

Exposure to perfluoroalkyl substances in waste recycling workers: Distributions in paired human serum and urine.

Ultratrace analysis of per- and polyfluoroalkyl substances in drinking water using ice concentration linked with extractive stirrer and high performance liquid chromatography – tandem mass spectrometry.

Engineering human liver fatty acid binding protein for detection of poly- and perfluoroalkyl substances.

Distribution of perfluoroalkyl acids in fish species from the Baltic Sea and freshwaters in Finland.

A novel fate and transport model for evaluating the presence and environmental risk of per-/poly-fluoroalkyl substances (PFASs) among multi-media in Lingang hybrid constructed wetland, Tianjin, China.

Systematic Study on the Removal of Per- and Polyfluoroalkyl Substances from Contaminated Groundwater Using Metal-Organic Frameworks.

Flame Retardants

Effects of temperature and relative humidity on soil-air partition coefficients of organophosphate flame retardants and polybrominated diphenyl ethers.

Approach to Predicting the Size-Dependent Inhalation Intake of Particulate Novel Brominated Flame Retardants.

Pesticides

Diet and food type affect urinary pesticide residue excretion profiles in healthy individuals: results of a randomized controlled dietary intervention trial.

Peer review of the pesticide risk assessment of the active substance Spodoptera exigua multicapsid nucleopolyhedrovirus (SeMNPV).

Probabilistic public health risks associated with pesticides and heavy metal exposure through consumption of common dried fish in coastal regions of Bangladesh.

Potentially Toxic Elements

Cake Decorating Luster Dust Associated with Toxic Metal Poisonings – Rhode Island and Missouri, 2018-2019.

Metals in Cannabis Vaporizer Aerosols: Sources, Possible Mechanisms, and Exposure Profiles.

Assessment of heavy metals in wild and farmed tilapia (Oreochromis niloticus) on Lake Kariba, Zambia: implications for human and fish health.

Multilaboratory Collaborative Study of a Nontarget Data Acquisition for Target Analysis (nDATA) Workflow Using Liquid Chromatography-High-Resolution Accurate Mass Spectrometry for Pesticide Screening in Fruits and Vegetables.

Lead, cadmium, and aluminum in raw bovine milk: Residue level, estimated intake, and fate during artisanal dairy manufacture.

Legacy of anthropogenic lead in urban soils: Co-occurrence with metal(loid)s and fallout radionuclides, isotopic fingerprinting, and in vitro bioaccessibility.

Arsenic biotransformation and mobilization: the role of bacterial strains and other environmental variables.

Lead in Archeological Human Bones Reflecting Historical Changes in Lead Production.

Dietary Heavy Metal Exposure among Finnish Adults in 2007 and in 2012.

Microplastics

Reef-building corals act as long-term sink for microplastic.

Miscellaneous

Evaluation of an Ozone Chamber as a Routine Method to Decontaminate Firefighters’ PPE. [doesn’t work, re PAHs]

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.