EDC Science Weekly, Oct. 4 – 20, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

October 26 webinar: Global Cancer Risk From Unregulated Polycyclic Aromatic Hydrocarbons [EDC Strategies Partnership]

Regulations/Policy

Innovation in regulatory approaches for endocrine disrupting chemicals: The journey to risk assessment modernization in Canada.

Methods/Tools/Screening

Developing a screening test for toxicity studies of prenatal development with the use of Hydra attenuata and embryos of zebrafish.

Commentaries/Conference Summaries

Why Is the Biodegradation of Polyfluorinated Compounds So Rare?

Reactive Flame Retardants: Are They Safer Replacements?

Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective.

Issues in the hazard and risk assessment of perfluoroalkyl substance mixtures.

Autism in Three Dimensions: Using Brain Organoids to Study Potential Gene-Environment Interactions. [Science Selection in EHP]

Reviews

Numerous EDCs

Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes.

Environment in Children’s Health: A New Challenge for Risk Assessment.

Contemporary Techniques for Remediating Endocrine-Disrupting Compounds in Various Water Sources: Advances in Treatment Methods and Their Limitations.

The role of adipose tissue analysis on Environmental Pollutants Biomonitoring in women: The European scenario.

The Impact of Early-Life Exposures on Women’s Reproductive Health in Adulthood.

BPA/Phenols

Association of bisphenol A with puberty timing: a meta-analysis.

Recent advances in analysis of bisphenols and their derivatives in biological matrices.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Past, present and future trends of selected pesticidal and industrial POPs in Kuwait.

Potentially Toxic Elements

Lead (Pb) and neurodevelopment: A review on exposure and biomarkers of effect (BDNF, HDL) and susceptibility.

Health Effects Associated With Pre- and Perinatal Exposure to Arsenic.

Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults.

Microplastics

Microplastics in mangroves and coral reef ecosystems: a review.

Microplastics as contaminants in Indian environment: a review.

Dynamics of airborne microplastics, appraisal and distributional behaviour in atmosphere; a review.

Role of Structural Morphology of Commodity Polymers in Microplastics and Nanoplastics Formation: Fragmentation, Effects and Associated Toxicity in the Aquatic Environment.

Pharmaceuticals/Personal Care Products

Are the Effects of DES Over? A Tragic Lesson from the Past.

Abundance, fate, and effects of pharmaceuticals and personal care products in aquatic environments.

Miscellaneous

Upcycling Plastic Waste into High Value-added Carbonaceous Materials.

Human Health Studies

Numerous Chemicals/Mixtures

Relationship between thyroid hormone parameters and exposure to a mixture of organochlorine pesticides, mercury and nutrients in the cord blood of newborns.

BPA/Phenols

Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study.

Phthalates

Association between environmental exposure to phthalates and allergic disorders in Korean children: Korean National Environmental Health Survey (KoNEHS) 2015-2017.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

dipose Tissue Levels of DDT as Risk Factor for Obesity and Type 2 Diabetes Mellitus.

Detection of Persistent Organic Pollutants in Omental Adipose Tissue from Patients with Diffuse-Gastric Cancer: A Pilot Study.

Associations between persistent organic pollutants and endometriosis: A multiblock approach integrating metabolic and cytokine profiling.

Perfluoroalkyl Substances

Cancer incidence in a Swedish cohort with high exposure to perfluoroalkyl substances in drinking water.

Association between the total plasma isomers of per- and polyfluoroalkyl substances and erythrograms in young and middle-aged Taiwanese populations.

Plasma concentrations of perfluoroalkyl substances and risk of inflammatory bowel diseases in women: A nested case control analysis in the Nurses’ Health Study cohorts.

Flame Retardants

Maternal urinary OPE metabolite concentrations and blood pressure during pregnancy: The HOME study.

Pesticides

Association of Pesticides and Kidney Function among Adults in the US Population 2001-2010.

Key Findings of the French BioNutriNet Project on Organic Food-Based Diets: Description, Determinants, and Relationships to Health and the Environment.

Potentially Toxic Elements

Association of albumin to creatinine ratio with urinary arsenic and metal exposure: evidence from NHANES 2015-2016.

Blood Lead Levels and Cardiovascular Disease Risk: Results from the Korean National Health and Nutrition Examination Survey.

Neurological Impacts of Chronic Methylmercury Exposure in Munduruku Indigenous Adults: Somatosensory, Motor, and Cognitive Abnormalities.

An Assessment of Health Outcomes and Methylmercury Exposure in Munduruku Indigenous Women of Childbearing Age and Their Children under 2 Years Old.

Association between the Concentrations of Metallic Elements in Maternal Blood during Pregnancy and Prevalence of Abdominal Congenital Malformations: The Japan Environment and Children’s Study.

Risk of lead exposure, subcortical brain structure, and cognition in a large cohort of 9- to 10-year-old children.

Environmental-level exposure to metals and metal-mixtures associated with spirometry-defined lung disease in American Indian adults: Evidence from the Strong Heart Study.

Prenatal arsenic exposure, arsenic methylation efficiency, and neuropsychological development among preschool children in a Spanish birth cohort.

Pharmaceuticals/Personal Care Products

Prenatal Exposure to Diethylstilbestrol and Multigenerational Psychiatric Disorders: An Informative Family.

Laboratory Studies

BPA/Phenols

Integrating Statistical and Machine-Learning Approach for Meta-Analysis of Bisphenol A-Exposure Datasets Reveals Effects on Mouse Gene Expression within Pathways of Apoptosis and Cell Survival.

Bisphenol A induced apoptosis via oxidative stress generation involved Nrf2/HO-1 pathway and mitochondrial dependent pathways in human retinal pigment epithelium (ARPE-19) cells.

Phthalates

Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exploring the binding mechanism and adverse toxic effects of persistent organic pollutant (dicofol) to human serum albumin: A biophysical, biochemical and computational approach.

Perfluoroalkyl Substances

Lipidomic Analyses Reveal Modulation of Lipid Metabolism by the PFAS Perfluoroundecanoic Acid (PFUnDA) in Non-Obese Diabetic Mice.

Flame Retardants

Leaching of PBDEs from microplastics under simulated gut conditions: Chemical diffusion and bioaccumulation.

Pesticides

Identifying potential thyroid hormone disrupting effects among diphenyl ether structure pesticides and their metabolites in silico.

Whole-body bioconcentration and biochemical and morphological responses of gills of the neotropical fish Prochilodus lineatus exposed to 2,4-dichlorophenoxyacetic acid or fipronil individually or in a mixture.

Cytotoxicity of mancozeb on Sertoli-germ cell co-culture system: Role of MAPK signaling pathway.

Renal and hepatic changes in the offspring of rats that received biological insecticides during pregnancy and lactation.

Naringenin alleviates paraquat-induced dopaminergic neuronal loss in SH-SY5Y cells and a rat model of Parkinson’s disease.

Potentially Toxic Elements

Contributing to Understand the Crosstalk between Brain and Periphery in Methylmercury Intoxication: Neurotoxicity and Extracellular Vesicles.

Insights into Cadmium-Induced Carcinogenesis through an In Vitro Study Using C3H10T1/2Cl8 Cells: The Multifaceted Role of Mitochondria.

Subacute cadmium exposure modulates Th1 polarization to trigger ER stress-induced porcine hepatocyte apoptosis via regulation of miR-369-TNFα axis.

Phycobiliproteins extract from Spirulina protects against single-dose cadmium-induced reproductive toxicity in male mice.

Microplastics

Warming, temperature fluctuations and thermal evolution change the effects of microplastics at an environmentally relevant concentration.

Microcystis aeruginosa’s exposure to an antagonism of nanoplastics and MWCNTs: The disorders in cellular and metabolic processes.

Polyamide microplastics in wastewater as vectors of cationic pharmaceutical drugs.

Polyethylene microplastics cooperate with Helicobacter pylori to promote gastric injury and inflammation in mice.

Photo-transformation of microplastics and its toxicity to Caco-2 cells.

Environmental effects of nanoparticles on the ecological succession of gut microbiota across zebrafish development.

Pharmaceuticals/Personal Care Products

Induction of apoptosis in the gonads of Mytilus edulis by metformin and increased temperature, via regulation of HSP70, CASP8, BCL2 and FAS.

Benzophenone-1 induced aberrant proliferation and metastasis of ovarian cancer cells via activated ERα and Wnt/β-catenin signaling pathways.

17β-Trenbolone binds to androgen receptor, decreases number of primordial germ cells, modulates expression of genes related to sexual differentiation, and affects sexual differentiation in zebrafish (Danio rerio).

Miscellaneous

Neuromotor activity inhibition in zebrafish early-life stages after exposure to environmental relevant concentrations of caffeine.

Exposure/Environment Studies

Numerous Chemicals

Firefighter exposures to potential endocrine disrupting chemicals measured by military-style silicone dog tags.

Ecological and spatial variations of legacy and emerging contaminants in white-tailed sea eagles from Germany: Implications for prioritisation and future risk management.

BPA/Phenols

Release of Bisphenol A from Milled and 3D-Printed Dental Polycarbonate Materials.

Phthalates

Exposure of childbearing-aged female to phthalates through the use of personal care products in China: An assessment of absorption via dermal and its risk characterization.

Occurrence of Phthalates in Bottled Drinks in the Chinese Market and Its Implications for Dietary Exposure.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A complete check-up of European eel after eight years of restocking in an upland river: Trends in growth, lipid content, sex ratio and health status.

Perfluoroalkyl Substances

Analytical uncertainties in a longitudinal study – A case study assessing serum levels of per- and poly-fluoroalkyl substances (PFAS).

Insight into the defluorination ability of per- and polyfluoroalkyl substances based on machine learning and quantum chemical computations.

Postflood Monitoring in a Subtropical Estuary and Benchmarking with PFASs Allows Measurement of Chemical Persistence on the Scale of Months.

Release of Per- and Polyfluoroalkyl Substances from Aqueous Film-Forming Foam Impacted Soils.

Flame Retardants

Organophosphate ester plasticizers in edible fish from the Mediterranean Sea: Marine pollution and human exposure.

Organophosphate esters in Great Lakes fish: An improved analysis to assess concentrations and human exposure via consumption.

Pesticides

Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages.

Excretion of Heavy Metals and Glyphosate in Urine and Hair Before and After Long-Term Fasting in Humans.

Rethinking the term “glyphosate effect” through the evaluation of different glyphosate-based herbicide effects over aquatic microbial communities.

Potentially Toxic Elements

Health effects of selected trace elements in hairdressing cosmetics on hairdressers in Enugu, Nigeria.

Sources, fate and distribution of inorganic contaminants in the Svalbard area, representative of a typical Arctic critical environment-a review.

Microplastics

Microplastic occurrence in settled indoor dust in schools.

Pharmaceuticals/Personal Care Products

Occurrence, source apportionment and potential risks of selected PPCPs in groundwater used as a source of drinking water from key urban-rural settings of Pakistan.

Miscellaneous

Community-Level Analysis of Drinking Water Data Highlights the Importance of Drinking Water Metrics for the State, Federal Environmental Health Justice Priorities in the United States.

A review on occurrence of emerging pollutants in waters of the MENA region.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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