EDC Science Weekly, Sept. 30- Oct. 6, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events,Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Thurs. Oct 14 is Children’s Environmental Health Day

Jan 10-13 online conference PPTox VII: International Conference on Prenatal Programming and Toxicity [registration is open; abstracts due Nov 29]

June 19-24 in-person conference Gordon Research Conference: Environmental Endocrine Disruptors [registration is open]

Regulations/Policy

Information Requirements under the Essential-Use Concept: PFAS Case Studies.

Methods/Tools/Screening

Method Development for a Short-Term 7-d Toxicity Test with Unionid Mussels.

Commentaries/Conference Summaries

Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders.

Taxonomic Chauvinism in Pesticide Ecotoxicology.

Moving toward the Real World: Zebrafish Transcript Map Predicts Mixture Effects Using Single-Compound Data. [Science Selection in EHP]

Reviews

Numerous EDCs

Maternal exposure to endocrine disrupting chemicals (EDCs) and preterm birth: A systematic review, meta-analysis, and meta-regression analysis.

The Male Reproductive System and Endocrine Disruptors.

Endocrine Disrupting Chemicals: Friend or Foe to Brown and Beige Adipose Tissue?

BPA/Phenols

Bisphenol A exposure and abnormal glucose tolerance during pregnancy: systematic review and meta-analysis.

Phthalates

Human health impacts of exposure to phthalate plasticizers: An overview of reviews.

Health effects associated with phthalate activity on nuclear receptors.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT) and 1,1-Dichloro-2,2-bis (p, p’-chlorophenyl) ethylene (DDE) as endocrine disruptors in human and wildlife: A possible implication of mitochondria.

Perfluoroalkyl Substances

Exposure routes, bioaccumulation and toxic effects of per- and polyfluoroalkyl substances (PFASs) on plants: A critical review.

GenX is not always a better fluorinated organic compound than PFOA: A critical review on aqueous phase treatability by adsorption and its associated cost.

Critical review on PFOA, kidney cancer, and testicular cancer.

Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation.

Occurrence, profiles, and ecotoxicity of poly- and perfluoroalkyl substances and their alternatives in global apex predators: A critical review.

Flame Retardants

Toxic Effects of Tetrabromobisphenol A: Focus on Endocrine Disruption.

Potentially Toxic Elements

Arsenic exposure and non-carcinogenic health effects.

Heavy metal pollution in coastal wetlands: A systematic review of studies globally over the past three decades.

Urinary cadmium in relation to bone damage: Cadmium exposure threshold dose and health-based guidance value estimation.

Microplastics

Critical review of environmental impacts of microfibers in different environmental matrices.

Potential microplastics impacts on African fishing resources.

Air Pollution

Environmental risk factors and cardiovascular diseases: a comprehensive review.

Pharmaceuticals/Personal Care Products

Human health and ecological risk assessment of 98 pharmaceuticals and personal care products (PPCPs) detected in Indian surface and wastewaters.

Miscellaneous

Chemical contaminants in canned food and can-packaged food: a review.

Identification of organic pollutants with potential ecological and health risks in aquatic environments: Progress and challenges.

Environmental estrogens in surface water and their interaction with microalgae: A review.

Human Health Studies

Numerous Chemicals

Identifying the link between chemical exposures and breast cancer in African American women via integrated in vitro and exposure biomarker data.

Cosmetic use and serum level of lead (not cadmium) affect bone mineral density among young Iranian women.

FLEXiGUT: Rationale for exposomics associations with chronic low-grade gut inflammation.

Phthalates

Sex-specific mediation of placental inflammatory biomarkers in the effects of prenatal phthalate coexposure on preschooler cognitive development.

Urinary Phthalate Biomarkers and Bone Mineral Density in Postmenopausal Women.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Longitudinal changes in concentrations of persistent organic pollutants (1986-2016) and their associations with type 2 diabetes mellitus.

Pre- and postnatal polychlorinated biphenyl exposure and cognitive and behavioral development at age 45 Months in a cohort of Slovak children.

Maternal and Newborn Thyroid Hormone, and the Association With Polychlorinated Biphenyls (PCBs) Burden: The EHF (Environmental Health Fund) Birth Cohort.

Perfluoroalkyl Substances

Associations of Maternal Serum Perfluoroalkyl Substances Concentrations with Early Adolescent Bone Mineral Content and Density: The Health Outcomes and Measures of the Environment (HOME) Study.

The effects of Cl-PFESAs exposure on blood lipids – A community-based large population study in Guangzhou.

Pesticides

Recent pesticide exposure affects sleep: A cross-sectional study among smallholder farmers in Uganda.

Pesticides use and health impacts on farmers in Thailand, Vietnam, and Lao PDR: Protocol for a survey of knowledge, behaviours and blood acetyl cholinesterase concentrations.

Potentially Toxic Elements

The associations between urinary metals and metal mixtures and kidney function in Chinese community-dwelling older adults with diabetes mellitus.

Assessment of biomarkers of early kidney damage and exposure to pollutants in artisanal mercury mining workers from Mexico.

Air Pollution

Cohort Profile: The Environmental-Pollution-Induced Neurological EFfects (EPINEF) study, a multicenter cohort study of Korean adults.

Fine Particulate Air Pollution, Early Life Stress, and Their Interactive Effects on Adolescent Structural Brain Development: A Longitudinal Tensor-Based Morphometry Study.

Miscellaneous

Drinking Water Disinfection by-Products and Congenital Malformations: A Nationwide Register-Based Prospective Study.

Spatial interaction between breast cancer and environmental pollution in the Monterrey Metropolitan Area.

Global Cancer Risk From Unregulated Polycyclic Aromatic Hydrocarbons.

Laboratory Studies

BPA/Phenols

Dose-response metabolomics and pathway sensitivity to map molecular cartography of bisphenol A exposure.

Examining the Developmental Trajectory of an in Vitro Model of Mouse Primordial Germ Cells following Exposure to Environmentally Relevant Bisphenol A Levels.

Biomarker-assisted assessment of aquatic health using the cosmopolitan common carp, Cyprinus carpio (L): a case study of bisphenol-A exposures.

Pubertal exposure to bisphenol-A affects social recognition and arginine vasopressin in the brain of male mice.

Developmental toxicity of bisphenol S in Caenorhabditis elegans and NODEF mice.

Hormone receptor expression in aging mammary tissue and carcinoma from a rodent model after xenoestrogen disruption.

Potential role of green tea extract and epigallocatechin gallate in preventing bisphenol A-induced metabolic disorders in rats: Biochemical and molecular evidence.

Gastrointestinal tract and skin permeability of chemicals in consumer products using parallel artificial membrane permeability assay (PAMPA). [bisphenols, phthalates, parabens]

Phthalates

Long-term chronic exposure to di-(2-ethylhexyl)-phthalate induces obesity via disruption of host lipid metabolism and gut microbiota in mice.

Perinatal phthalate exposure increases developmental apoptosis in the rat medial prefrontal cortex.

Prenatal exposure to an environmentally relevant phthalate mixture alters ovarian steroidogenesis and folliculogenesis in the F1 generation of adult female mice.

Multiple transcriptomic profiling: potential novel metabolism-related genes predict prepubertal testis damage caused by DEHP exposure.

Parabens/Triclosan/Antimicrobials

Parabens disrupt non-canonical inflammasome activation.

Placental transport of parabens studied using an ex-vivo human perfusion model.

Dataset on transcriptomic profiling of cholestatic liver injury induced by food additives and a cosmetic ingredient.

Methylparaben-induced regulation of estrogenic signaling in human neutrophils.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

PCB cause global DNA hypomethylation of human peripheral blood monocytes in vitro.

Assessment of binding potencies of polychlorinated biphenyls and polybrominated diphenyl ethers with Baikal seal and mouse constitutive androstane receptors: Comparisons across species and congeners.

A human relevant mixture of persistent organic pollutants induces reactive oxygen species formation in isolated human leucocytes: Involvement of the β2-adrenergic receptor.

Interlaboratory assessments for dioxin-like POPs (2016/2017 and 2018/2019).

Perfluoroalkyl Substances

Epigenetic toxicity and cytotoxicity of perfluorooctanoic acid and its effects on gene expression in embryonic mouse hypothalamus cells.

Evaluation of the acute toxicity and neurodevelopmental inhibition of perfluorohexanoic acid (PFHxA) in zebrafish embryos.

Flame Retardants

Toxicity pathways of lipid metabolic disorders induced by typical replacement flame retardants via data-driven analysis, in silico and in vitro approaches.

Maize plant (Zea mays) uptake of organophosphorus and novel brominated flame retardants from hydroponic cultures.

Pesticides

Transcriptome analysis reveals the molecular mechanism of long-term exposure of Eriocheir sinensis to low concentration of trichlorfon.

Exposure to Atrazine through gestation and lactation period led to impaired sexual maturation and subfertility in F1 male rats with congenital deformities in F2 progeny.

Effects of glufosinate-ammonium on male reproductive health: Focus on epigenome and transcriptome in mouse sperm.

Cardiac developmental toxicity and transcriptome analyses of zebrafish (Danio rerio) embryos exposed to Mancozeb.

The enantioselective toxicity and oxidative stress of dinotefuran on zebrafish (Danio rerio).

The effect of Roundup on embryonic development, early foxr1 and hsp70 gene expression and hatching of common carp (Cyprinus carpio L.).

The active ingredients of a mitotoxic fungicide negatively affect pollen consumption and worker survival in laboratory-reared honey bees (Apis mellifera).

Toxicological assessment of agrochemicals in bees using machine learning tools.

Microplastics/Nanomaterials

Response process and adaptation mechanism of estuarine benthic microbiota to polyvinyl chloride microplastics with and without phthalates.

Contribution of aged polystyrene microplastics to the bioaccumulation of pharmaceuticals in marine organisms using experimental and model analysis.

Assessing the role of polyethylene microplastics as a vector for organic pollutants in soil: Ecotoxicological and molecular approaches.

Micro- and nanoplastic transfer in freezing saltwater: implications for their fate in polar waters.

TiO₂ NPs induce the reproductive toxicity in mice with gestational diabetes mellitus through the effects on the endoplasmic reticulum stress signaling pathway.

Pharmaceuticals/Personal Care Products

Avobenzone and nanoplastics affect the development of zebrafish nervous system and retinal system and inhibit their locomotor behavior.

Towards standard methods for the classification of aquatic toxicity for biologically active household chemicals (BAHC) present in plastics, pharmaceuticals, and cosmetic products.

Delayed toxicity of three fluoroquinolones and their mixtures after neonatal or embryonic exposure, in Daphnia magna.

Mixtures

Biomarker responses in perch (Perca fluviatilis) under multiple stress: Parasite co-infection and multicomponent metal mixture exposure.

Miscellaneous

Mechanism of subchronic vinyl chloride exposure combined with a high-fat diet on hepatic steatosis.

New insights into benzo[⍺]pyrene osteotoxicity in zebrafish.

Bioplastics and Carbon-Based Sustainable Materials, Components, and Devices: Toward Green Electronics.

Exposure/Environment Studies

Numerous Chemicals

Identification of known and novel nonpolar endocrine disruptors in human amniotic fluid.

Pharmaceuticals, hormones, plasticizers, and pesticides in drinking water.

Spatial and seasonal variations of endocrine disrupting compounds in water and sediment samples of Markman Canal and Swartkops River Estuary, South Africa and their ecological risk assessment.

BPA/Phenols

Associations between pediatric intensive care procedures and urinary free-BPA levels.

Phthalates

Identifying Citric Acid Esters, a Class of Phthalate Substitute Plasticizers, in Indoor Dust via an Integrated Target, Suspect, and Characteristic Fragment-Dependent Screening Strategy.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Correlates of Persistent Endocrine-Disrupting Chemical Mixtures among Reproductive-Aged Black Women. [PCBs, OCPs, PFAS, PBDEs]

Atmospheric emissions of PCDDs and PCDFs in China from 1960 to 2014.

Assessment of concentration and distribution of total mercury and polychlorinated biphenyls in Green Bay, Wisconsin, USA.

Concentrations of halogenated flame retardants and polychlorinated biphenyls in house dust from Lagos, Nigeria.

Perfluoroalkyl Substances

Perfluoroalkyl acids in dust on residential indoor/outdoor window glass in Chinese cities: occurrence, composition, and toddler exposure.

Occurrence of selected per- and polyfluorinated alkyl substances (PFASs) in food available on the European market – A review on levels and human exposure assessment.

Per- and polyfluoroalkyl substances (PFAS), trace elements and life history parameters of mass-stranded common dolphins (Delphinus delphis) in New Zealand.

Occurrence of legacy and emerging poly- and perfluoroalkyl substances in water: A case study in Tianjin (China).

Per- and polyfluoroalkyl substances in the atmospheric total suspended particles in Karachi, Pakistan: Profiles, potential sources, and daily intake estimates.

Per- and Polyfluoroalkyl Substances (PFAS) in Street Sweepings.

Flame Retardants

Flame retardants and their associations with thyroid hormone-related variables in northern fulmars from the Faroe Islands.

Halogenated flame retardants in wild, prey-sized mud carp from an e-waste recycling site in South China, 2006-2016: Residue dynamics and ecological risk assessment.

Novel brominated flame retardants (NBFRs) in soil and moss in Mt. Shergyla, southeast Tibetan Plateau: Occurrence, distribution and influencing factors.

Occurrence and distribution of organophosphate flame retardants in the typical soil profiles of the Tibetan Plateau, China.

Spatial monitoring and health risk assessment of polybrominated diphenyl ethers in environmental matrices from an industrialized impacted canal in South Africa.

Pesticides

Agricultural contaminants in amphibian breeding ponds: Occurrence, risk and correlation with agricultural land use.

Riparian strips as attenuation zones for the toxicity of pesticides in agricultural surface runoff: Relative influence of herbaceous vegetation and terrain slope on toxicity attenuation of 2,4-D.

Potentially Toxic Elements

The risk estimation and assessment of heavy metal exposure by biomonitoring in the breast milk of mothers in the Cukurova Region, Turkey.

Heavy Metal Concentrations in Malaysian Adults’ Hair and Associated Variables in Bukit Mertajam, Penang, Malaysia.

Bioaccessibility as a Determining Factor in the Bioavailability and Toxicokinetics of Cadmium Compounds.

Microplastics

Microplastic pollution in the surface sediment of Kongsfjorden, Svalbard, Arctic.

Distribution and potential sources of microplastics in sediments in remote lakes of Tibet, China.

Pharmaceuticals/Personal Care Products

Prioritization of antibiotic contaminants in China based on decennial national screening data and their persistence, bioaccumulation and toxicity.

Presence of pharmaceuticals and their metabolites in wild-living aquatic organisms – Current state of knowledge.

Mixtures

Use of large datasets of measured environmental concentrations for the ecological risk assessment of chemical mixtures in Italian streams: A case study.

Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Santé cohort.

Miscellaneous

Identifying Dermal Uptake as a Significant Pathway for Human Exposure to Typical Semivolatile Organic Compounds in an E-Waste Dismantling Site: The Relationship of Contaminant Levels in Handwipes and Urine Metabolites.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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