EDC Science Weekly, Sept. 9 – 15, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Sept. 22 webinar: Multi- and transgenerational outcomes of an exposure to a mixture of EDCs on puberty and maternal behavior in the female rat [EDC Strategies Partnership]

Sept. 23 committee meeting: Variability and Relevance of Current Laboratory Mammalian Toxicity Tests and Expectations for New Approach Methods (NAMs) for Use in Human Health Risk Assessment [The National Academies]

Oct 6-8 online workshop: Different perspectives on food contact materials: working together to make Food Contact Materials (FCMs) safer [Food Packaging Forum]

Jan 10-13 online conference PPTox VII: International Conference on Prenatal Programming and Toxicity [registration is open; abstracts due Nov 29]

Regulations/Policy

Addressing Urgent Questions for PFAS in the 21st Century. [see related Global action on harmful PFAS chemicals is long overdue: Study in Environmental Health News]

Scientific discrepancies in European regulatory proposals on endocrine disruptors-REACH regulation quo vadis?

Macro problems from microplastics: Toward a sustainable policy framework for managing microplastic waste in Africa.

Methods/Tools/Screening

An effective processing pipeline for harmonizing DNA methylation data from Illumina’s 450K and EPIC platforms for epidemiological studies.

Systematic Evaluation of the Effects of Toxicant Exposure on Survival in Zebrafish Embryos and Larvae.

Commentaries/Conference Summaries

Uranium Exposure in American Indian Communities: Health, Policy, and the Way Forward and related Cleaning Up after the Cold War: Experts Call for Action on Abandoned Uranium Mines on the Navajo Nation in EHP

Editorial: Coping With Pollution – the Effects of Environmental Contaminants on Plant Growth and Physiology.

Editorial: Endocrine Disruptors in Aquatic Vertebrates.

Time: A Key Driver of Uncertainty When Assessing the Risk of Environmental Plastics to Human Health.

Reviews

Numerous EDCs

Effects of endocrine disrupting chemicals on gonad development: Mechanistic insights from fish and mammals.

Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?

Influence of the Aryl Hydrocarbon Receptor Activating Environmental Pollutants on Autism Spectrum Disorder.

Endocrine Disruptors as a New Etiologic Factor of Bone Tissue Diseases (Review).

Thyroid Function: a Target for Endocrine Disruptors, Air Pollution, and Radiofrequencies.

Phthalates

Association between phthalate exposure and insulin resistance: a systematic review and meta-analysis update.

Phthalate metabolites: Characterization, toxicities, global distribution, and exposure assessment.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations between human internal chemical exposure to Persistent Organic Pollutants (POPs) and In Vitro Fertilization (IVF) outcomes: Systematic review and evidence map of human epidemiological evidence.

Perfluoroalkyl Substances

A review on degradation of perfluorinated compounds based on ultraviolet advanced oxidation.

Pesticides

Assessing the Risks to Bats from Plant Protection Products: A Review of the Recent EFSA Statement Regarding Toxicity and Exposure Routes.

Farming, Pesticides, and Brain Cancer: A 20-Year Updated Systematic Literature Review and Meta-Analysis.

Physiological Effects of Neonicotinoid Insecticides on Non-Target Aquatic Animals-An Updated Review.

Comprehensive framework for human health risk assessment of nanopesticides.

Potentially Toxic Elements

Children’s exposure to environmental lead: A review of potential sources, blood levels, and methods used to reduce exposure.

Arsenic: Various species with different effects on cytochrome P450 regulation in humans.

Microplastics

Interactions and effects of microplastics with heavy metals in aquatic and terrestrial environments.

Interactions between microplastics/nanoplastics and vascular plants.

Environmental Microplastic Particles vs. Engineered Plastic Microparticles-A Comparative Review.

Miscellaneous

The Zebrafish Model to Understand Epigenetics in Renal Diseases.

Human Health Studies

Numerous Chemicals

Sugarcane Workweek Study: Risk Factors for Daily Changes in Creatinine.

BPA/Phenols

Associations of maternal bisphenol urine concentrations during pregnancy with neonatal metabolomic profiles.

Phthalates

Periconceptional Use of Phthalate-Containing Medications and Secondary Sex Ratio.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Assessment of genotoxicity and oxidative stress in pregnant women contaminated to organochlorine pesticides and its correlation with pregnancy outcome.

Perfluoroalkyl Substances

Exposure to per- and polyfluoroalkyl substances associates with an altered lipid composition of breast milk.

Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts.

Flame Retardants

Exposure to polybrominated diphenyl ether-47 increases the risk of post-partum depression.

Pesticides

Effect of modifiable risk factors in Parkinson’s disease: A case-control study looking at common dietary factors, toxicants, and anti-inflammatory medications.

Epigenome-Wide DNA Methylation and Pesticide Use in the Agricultural Lung Health Study.

Potentially Toxic Elements

Arsenic exposure and human blood DNA methylation and hydroxymethylation profiles in two diverse populations from Bangladesh and Spain.

Prenatal exposure to neurotoxic metals and micronutrients and neurodevelopmental outcomes in early school age children from Poland.

Associations between multiple heavy metals exposure and glycated hemoglobin in a Chinese population.

Association of lead and cadmium exposure with kidney stone incidence: A study on the non-occupational population in Nandan of China.

Does Exposure of Lead and Cadmium Affect the Endometriosis?

The Association of Renal Function and Plasma Metals Modified by EGFR and TNF-α Gene Polymorphisms in Metal Industrial Workers and General Population.

Effects of lead, cadmium, copper and zinc levels on the male reproductive function.

Air Pollution

Prenatal exposure to wildfire-related air pollution and birth defects in Brazil.

Miscellaneous

Public knowledge and opinion of epigenetics and epigenetic concepts.

Laboratory Studies

BPA/Phenols

Probiotic Administration Mitigates Bisphenol A Reproductive Toxicity in Zebrafish.

Bisphenol A derivatives act as novel coactivator binding inhibitors for estrogen receptor β.

Impact of bisphenol-A and synthetic estradiol on brain, behavior, gonads and sex hormones in a sexually labile coral reef fish.

Analyzing the synergistic adverse effects of BPA and its substitute, BHPF, on ulcerative colitis through comparative metabolomics.

Neurotoxicity and neuroinflammatory effects of bisphenol A in male rats: the neuroprotective role of grape seed proanthocyanidins.

Quantitative Structure-Activity Relationship Enables the Rational Design of Lipid Droplet-Targeting Carbon Dots for Visualizing Bisphenol A-Induced Nonalcoholic Fatty Liver Disease-like Changes.

Phthalates

DEHP exposure to lactating mice affects ovarian hormone production and antral follicle development of offspring.

Butyl Benzyl Phthalate Promotes Adipogenesis in 3T3-L1 Cells via the miRNA-34a-5p Signaling Pathway in the Absence of Exogenous Adipogenic Stimuli.

Parabens/Triclosan/Antimicrobials

Dermal exposure to the immunomodulatory antimicrobial chemical triclosan alters the skin barrier integrity and microbiome in mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Nonmonotonic response of type 2 diabetes by low concentration organochlorine pesticide mixture: Findings from multi-omics in zebrafish.

Toxicity evaluation and oxidative stress response of fumaronitrile, a persistent organic pollutant (POP) of industrial waste water on tilapia fish (Oreochromis mossambicus).

Perfluoroalkyl Substances

Suppression of Th2 cytokines as a potential mechanism for reduced antibody response following PFOA exposure in female B6C3F1 mice.

Rapid Characterization of Human Serum Albumin Binding for Per- and Polyfluoroalkyl Substances Using Differential Scanning Fluorimetry.

Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: Roles of peroxisome proliferator activated receptor alpha.

PFOA regulate adenosine receptors and downstream concentration-response cAMP-PKA pathway revealed by integrated omics and molecular dynamics analyses.

Perfluorooctane sulfonate induces autophagy-dependent lysosomal membrane permeabilization by weakened interaction between tyrosinated alpha-tubulin and spinster 1.

The Nrf2a pathway impacts zebrafish offspring development with maternal preconception exposure to perfluorobutanesulfonic acid.

Cardiovascular Properties of the Androgen-Induced PCOS Model in Rats: The Role of Oxidative Stress.

Flame Retardants

Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis.

Ionic copper strengthens the toxicity of tetrabromobisphenol A (TBBPA) to denitrification by decreasing substrate transport and electron transfer.

An In Vitro Comparative Study of the Effects of Tetrabromobisphenol A and Tetrabromobisphenol S on Human Erythrocyte Membranes-Changes in ATP Level, Perturbations in Membrane Fluidity, Alterations in Conformational State and Damage to Proteins.

The Effects of Dietary PBDE Exposure and Rearing Temperature on Tadpole Growth, Development, and Their Underlying Processes.

Decabromodiphenyl ether causes insulin resistance and glucose and lipid metabolism disorders in mice.

Lactational polychlorinated biphenyls exposure induces epigenetic alterations in the Leydig cells of progeny rats.

Organotins

Prenatal Trimethyltin Exposure Induces Long-Term DNA Methylation Changes in the Male Mouse Hippocampus.

Pesticides

An integrated approach, based on mass spectrometry, for the assessment of imidacloprid metabolism and penetration into mouse brain and fetus after oral treatment.

Aminomethylphosphonic acid (AMPA) alters oxidative status during embryonic development in an amphibian species.

Triadimefon suppresses fetal adrenal gland development after in utero exposure.

Short-Term and Long-Term Carcinogenic Effects of Food Contaminants (4-Hydroxynonenal and Pesticides) on Colorectal Human Cells: Involvement of Genotoxic and Non-Genomic Mechanisms.

Evaluation of toxicological effects of organophosphorus pesticide metabolites on human HepG2 cells.

Chlorpyrifos Disrupts Acetylcholine Metabolism Across Model Blood-Brain Barrier.

Paraquat-induced cholesterol biosynthesis proteins dysregulation in human brain microvascular endothelial cells.

Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition.

Ginger reserves testicular spermatogenesis and steroidogenesis in difenoconazole-intoxicated rats by conducting oxidative stress, apoptosis and proliferation.

Potentially Toxic Elements

Early-life lead exposure induces long-term toxicity in the central nervous system: From zebrafish larvae to juveniles and adults.

Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses.

The effects of cadmium on the development of Drosophila and its transgenerational inheritance effect.

Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca²⁺ homeostasis.

Cadmium induces renal inflammation by activating the NLRP3 inflammasome through ROS/MAPK/NF-κB pathway in vitro and in vivo.

Pollutants enhance IgE sensitization in the gut via local alteration of vitamin D-metabolizing enzymes. [Cd]

Microplastics/Nanomaterials

A Multi-Life Stage Comparison of Silver Nanoparticles Toxicity on the Early Development of Three Canadian Fish Species.

Glyphosate and glufosinate ammonium, herbicides commonly used on genetically modified crops, and their interaction with microplastics: Ecotoxicity in anuran tadpoles.

Air Pollution

PM2.5 Exposure of Mice during Spermatogenesis: A Role of Inhibitor κB Kinase 2 in Pro-Opiomelanocortin Neurons.

Pharmaceuticals/Personal Care Products

Developmental toxicity assessment of 4-MBC in Danio rerio embryo-larval stages.

Miscellaneous

Experimental data-sets on sex reversal and histopathological assessment of potential endocrine disrupting effects of graphene oxide on Japanese medaka (Oryzias latipes) larvae at the onset of maturity.

Single molecule real-time sequencing revealing novel insights on the response to estrogen and androgen exposure in freshwater snails.

Exposure/Environment Studies

Numerous Chemicals

Biomonitoring of Phthalates, Bisphenols and Parabens in Children: Exposure, Predictors and Risk Assessment.

BPA/Phenols

Comprehensive Identification of Liquid Crystal Monomers-Biphenyls, Cyanobiphenyls, Fluorinated Biphenyls, and their Analogues-in Waste LCD Panels and the First Estimate of their Global Release into the Environment.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated dioxins, furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in food from Italy: Estimates of dietary intake and assessment.

Effects of metals and persistent organic pollutants on the fitness and health of juveniles of the endangered european sturgeon Acipenser sturio Exposed to W1ater and sediments of the garonne and dordogne rivers.

Organochlorine pesticide residues in plants and their possible ecotoxicological and agri food impacts.

Perfluoroalkyl Substances

Distribution of perfluoroalkyl substances (PFASs) in water, sediment, and fish tissue, and the potential human health risks due to fish consumption in Lake Hawassa, Ethiopia.

Determination of 56 per- and polyfluoroalkyl substances in top predators and their prey from Northern Europe by LC-MS/MS.

Model-based investigation of the formation, transmission, and health risk of perfluorooctanoic acid, a member of PFASs group, in drinking water distribution systems.

Transport and environmental risks of perfluoroalkyl acids in a large irrigation and drainage system for agricultural production.

Flame Retardants

Occurrence of novel organophosphate esters derived from organophosphite antioxidants in an e-waste dismantling area: Associations between hand wipes and dust.

Organophosphate Esters in Indoor Environment and Metabolites in Human Urine Collected from a Shanghai University.

Pesticides

The lampricide 3-trifluoromethyl-4-nitrophenol causes temporary metabolic disturbances in juvenile lake sturgeon (Acipenser fulvescens): implications for sea lamprey control and fish conservation.

Potentially Toxic Elements

Levels, oral bioaccessibility and health risk of sand-bound potentially harmful elements (PHEs) in public playgrounds: Exploring magnetic properties as a pollution proxy.

Lead Pollution, Demographics, and Environmental Health Risks: The Case of Philadelphia, USA.

Arsenic exposure analysis for children living in central China: From ingestion exposure to biomarkers.

Mercury Exposure in Munduruku Indigenous Communities from Brazilian Amazon: Methodological Background and an Overview of the Principal Results.

Impacts of the Goldmining and Chronic Methylmercury Exposure on the Good-Living and Mental Health of Munduruku Native Communities in the Amazon Basin.

Mercury Exposure among E-Waste Recycling Workers in Colombia: Perceptions of Safety, Risk, and Access to Health Information.

Bluefin tuna reveal global patterns of mercury pollution and bioavailability in the world’s oceans.

Knowledge and Beliefs Associated with Environmental Health Literacy: A Case Study Focused on Toxic Metals Contamination of Well Water.

Heavy Metals and Trace Elements in Human Breast Milk from Industrial/Mining and Agricultural Zones of Southeastern Spain.

Microplastics

Presence of airborne microplastics in human lung tissue.

Occurrence and distribution of microplastics in water supply systems: In water and pipe scales.

Evidence of Microplastic Translocation in Wild-Caught Fish and Implications for Microplastic Accumulation Dynamics in Food Webs.

Multibiomarker responses to polycyclic aromatic hydrocarbons and microplastics in thumbprint emperor Lethrinus harak from a South Pacific locally managed marine area.

Microplastics and anthropogenic fibre concentrations in lakes reflect surrounding land use.

Air Pollution

Local- and regional-scale racial and ethnic disparities in air pollution determined by long-term mobile monitoring.

Pharmaceuticals/Personal Care Products

Occurrence and distribution of endocrine disrupting chemicals and pharmaceuticals in the river Bouregreg (Rabat, Morocco).

Sunscreen use is not associated with increased blood concentrations of benzene among US adults: Data from the National Health and Nutrition Examination Survey (NHANES) 2003-2006 and 2009-2018.

The occurrence of non-steroidal anti-inflammatory drugs (NSAIDs) in Malaysian urban domestic wastewater.

Mixtures

Passive sampling and in vitro assays to monitor antiandrogens in a river affected by wastewater discharge.

Miscellaneous

Wildfires can increase regulated nitrate, arsenic, and disinfection byproduct violations and concentrations in public drinking water supplies.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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