EDC Science Weekly, July 29 – Aug 4, 2021

Post author:HEEDS
Post published:August 4, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week. (Expect the next EDC Science Weekly in mid-August due to vacation).

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Sept 1: Nominations due for the Lou Guillette Jr. Outstanding Young Investigator Award

Regulations/Policy

Progress Towards an OECD Reporting Framework for Transcriptomics and Metabolomics in Regulatory Toxicology.

Risk from pesticide mixtures – The gap between risk assessment and reality.

Regulation of pesticide soil standards for protecting human health based on multiple uses of residential soil.

The Science for Profit Model-How and why corporations influence science and the use of science in policy and practice

Methods/Tools/Screening

Development of a Data Visualization Tool for Occupational Exposure to Chemicals of Concern for Breast Cancer Among California Working Women, 2010-2014.

Predicting zebrafish (Danio rerio) embryo developmental toxicity through a non-conformational QSAR approach.

A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify White and Brite Adipogens.

Aquatic Toxicity Calculation of Mixtures: A Chemical Activity Approach Incorporating a Bioavailability Reduction Concept.

Commentaries/Conference Summaries

Environmental Sources, Chemistry, Fate and Transport of Per- and Polyfluoroalkyl Substances: State of the Science, Key Knowledge Gaps, and Recommendations Presented at the August 2019 SETAC Focus Topic Meeting.

Looking for Proof in the Wrong Generation? [re Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort, included here earlier]

Reviews

Numerous EDCs

Endocrine disruptors of sex hormone activities.

BPA/Phenols

Molecular mechanisms of mammary gland remodeling: a review of the homeostatic versus bisphenol A disrupted microenvironment.

Bisphenol A and its analogues in outdoor and indoor air: Properties, sources and global levels.

Bisphenol A and male murine reproductive system: finding a link between plasticizer and compromised health.

Perfluoroalkyl Substances

Phytoremediation of poly- and perfluoroalkyl substances: A review on aquatic plants, influencing factors, and phytotoxicity.

Flame Retardants

Plant accumulation and transformation of brominated and organophosphate flame retardants: A review.

Human internal exposure to organophosphate esters: A short review of urinary monitoring on the basis of biological metabolism research.

Pesticides

Neurobehavioral, Neuromotor, and Neurocognitive Effects in Agricultural Workers and Their Children Exposed to Pyrethroid Pesticides: A Review.

A review on pesticides in flower production: A push to reduce human exposure and environmental contamination.

Farmers exposed to pesticides have almost five times more DNA damage: a meta-analysis study.

Potentially Toxic Elements

Influence of Microplastics on the Mobility, Bioavailability, and Toxicity of Heavy Metals: A Review.

JAK2/STAT3 in role of arsenic-induced cell proliferation: a systematic review and meta-analysis.

Probiotics and gut microbiome – Prospects and challenges in remediating heavy metal toxicity.

Autism spectrum disorder: trace elements imbalances and the pathogenesis and severity of autistic symptoms.

Microplastics

Microplastic degradation as a sustainable concurrent approach for producing biofuel and obliterating hazardous environmental effects: A state-of-the-art review.

Research progresses of microplastic pollution in freshwater systems.

Effect of (bio)plastics on soil environment: A review.

Microplastics in the environment: Sampling, pretreatment, analysis and occurrence based on current and newly-exploited chromatographic approaches.

Environmental occurrence, fate, impact, and potential solution of tire microplastics: Similarities and differences with tire wear particles.

Air Pollution

Air Pollution and Kidney Diseases: PM2.5 as an Emerging Culprit.

Air pollution and multiple sclerosis: a comprehensive review.

Miscellaneous

Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer.

Electronic wastes: A near inexhaustible and an unimaginably wealthy resource for water splitting electrocatalysts.

(Eco)toxicological tests for assessing impacts of chemical stress to aquatic ecosystems: Facts, challenges, and future.

Human Health Studies

Numerous Chemicals

Concentrations of tetanus and diphtheria antibodies in vaccinated Greenlandic children aged 7-12 years exposed to marine pollutants, a cross sectional study. [PFAS, PCBs, Hg]

A multi-pollutant assessment of preconception persistent endocrine disrupting chemicals and incident pregnancy loss. [PBDEs, POPs, metals, etc.]

Mixtures

Joint association of prenatal bisphenol-A and phthalates exposure with risk of atopic dermatitis in 6-month-old infants.

Prenatal and postnatal exposures to four metals mixture and IQ in 6-year-old children: A prospective cohort study in South Korea.

BPA/Phenols

Increased Bisphenol A (BPA) Levels in Thai Children and Adolescents with Type 1 Diabetes Mellitus.

Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers.

Identification of the Bisphenol A (BPA) and the Two Analogues BPS and BPF in Cryptorchidism.

Phthalates

Associations between phthalic acid esters in household dust and childhood asthma in Shanghai, China.

Perfluoroalkyl Substances

Association between gestational PFAS exposure and Children’s adiposity in a diverse population.

Occurrence and distribution of per- and polyfluoroalkyl substances (PFASs) in human livers with liver cancer.

Pesticides

Urinary glyphosate concentration in pregnant women in relation to length of gestation.

Agricultural Pesticides and Shingles Risk in a Prospective Cohort of Licensed Pesticide Applicators.

Potentially Toxic Elements

Toxic elements in follicular fluid adversely influence the likelihood of pregnancy and live birth in women undergoing IVF.

Environmental exposure to metals and the risk of high blood pressure: a cross-sectional study from NHANES 2015-2016.

CoNaMad-Cohorte de Nacimiento de Madre de Dios/Madre de Dios Birth Cohort to Study Effects of in-utero Trace Metals Exposure in the Southern Peruvian Amazon.

Role of MT1A Polymorphism and Environmental Mercury Exposure on the Montreal Cognitive Assessment (MoCA).

Systemic inflammation mediates the association of heavy metal exposures with liver injury: A study in general Chinese urban adults.

Low‑Level Environmental Heavy Metals are Associated with Obesity Among Postmenopausal Women in a Southern State.

Blood’s Concentration of Lead and Arsenic Associated with Anemia in Peruvian Children.

Association between Pb, Cd, and Hg Exposure and Liver Injury among Korean Adults.

Air Pollution

Beyond the mean: Quantile regression to differentiate the distributional effects of ambient PM_2.5 constituents on sperm quality among men.

Acute responses of airway oxidative stress, inflammation, and hemodynamic markers to ambient PM_2.5 and their trace metal contents among healthy adolescences: A panel study in highly polluted versus low polluted regions.

Dose-response relationship between World Trade Center dust exposure and hepatic steatosis.

Miscellaneous

Diabetes control is associated with environmental quality in the USA.

Laboratory Studies

BPA/Phenols

Integration of data from the cell-based ERK1/2 ELISA and the Comparative Toxicogenomics Database deciphers the potential mode of action of bisphenol A and benzo[a]pyrene in lung neoplasm.

Structural basis for molecular recognition of G protein-coupled estrogen receptor by selected bisphenols.

Oxygen vacancies-enriched CoFe₂O₄ for peroxymonosulfate activation: The reactivity between radical-nonradical coupling way and bisphenol A.

Bisphenol A exposure induces neurobehavioral deficits and neurodegeneration through induction of oxidative stress and activated caspase-3 expression in zebrafish brain.

Phthalates

Study on active response of superoxide dismutase and relevant binding interaction with bioaccumulated phthalates and key metabolites in Eisenia fetida.

Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate.

Duration-dependent effects of high dose of phthalate exposure on semen quality in adult male rats.

Parabens/Triclosan/Antimicrobials

Hormesis Effect of Methyl Triclosan on Cell Proliferation and Migration in Human Hepatocyte L02 Cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A mechanism linking perinatal 2,3,7,8 tetrachlorodibenzo-p-dioxin exposure to lower urinary tract dysfunction in adulthood.

In utero and lactational PCB exposure drives anatomic changes in the juvenile mouse bladder.

Perfluoroalkyl Substances

Perfluorooctanoic acid exposure in early pregnancy induces oxidative stress in mice uterus and liver.

New compounds, old problems. The case of C6O4 – a substitute of PFOA – and its effects to the clam Ruditapes philippinarum.

Maternal exposure to sodium ρ-perfluorous nonenoxybenzene sulfonate during pregnancy and lactation disrupts intestinal barrier and may cause obstacles to the nutrient transport and metabolism in F0 and F1 generations of mice.

Behavioral effects of early-life exposure to perfluorooctanoic acid might synthetically link to multiple aspects of dopaminergic neuron development and dopamine functions in zebrafish larvae.

Flame Retardants

Tetrabromobisphenol A acts a neurodevelopmental disruptor in early larval stages of Mytilus galloprovincialis.

An adverse outcome pathway based in vitro characterization of novel flame retardants-induced hepatic steatosis.

Tris (2,3-Dibromopropyl) Isocyanurate (TDBP-TAZTO or TBC) Shows Different Toxicity Depending on the Degree of Differentiation of the Human Neuroblastoma (SH-SY5Y) Cell Line.

Pesticides

Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma).

Alterations in blood parameters, DNA damage, oxidative stress and antioxidant enzymes and immune-related genes expression in Nile tilapia (Oreochromis niloticus) exposed to glyphosate-based herbicide.

Sub-Chronic Exposure to Environmental Concentrations of Chlorpyrifos Affect Swimming Activity of Rainbow Trout Larvae.

Acute toxicity of the insecticide EPN upon zebrafish (Danio rerio) embryos and its related adverse effects: Verification of abnormal cardiac development and seizure-like events.

Early life neonicotinoid exposure results in proximal benefits and ultimate carryover effects.

Toxicogenomic differentiation of functional responses to fipronil and imidacloprid in Daphnia magna.

Pinocembrin pretreatment counteracts the chlorpyrifos-induced HO-1 downregulation, mitochondrial dysfunction, and inflammation in the SH-SY5Y cells.

Potentially Toxic Elements

Investigation of the ameliorative effects of baicalin against arsenic trioxide-induced cardiac toxicity in mice.

Ameliorative mechanisms of turmeric-extracted curcumin on arsenic (As)-induced biochemical alterations, oxidative damage, and impaired organ functions in rats.

Characterizing the Low-Dose Effects of Methylmercury on the Early Stages of Embryo Development Using Cultured Human Embryonic Stem Cells.

Cadmium-induced transgenerational effects on tomato plants: A gift from parents to progenies.

Ameliorative effects of nutritional minerals on lead-induced hematological alterations in male Wistar albino rats.

Microplastics

Bioaccumulation of emerging contaminants in mussel (Mytilus galloprovincialis): Influence of microplastics. [PFAS, PPCPs, pesticides]

Sorption of endocrine disrupting compounds onto polyamide microplastics under different environmental conditions: Behaviour and mechanism.

Long-term exposure of Daphnia magna to polystyrene microplastic (PS-MP) leads to alterations of the proteome, morphology and life-history.

Polystyrene and Polyethylene Microplastics Decrease Cell Viability and Dysregulate Inflammatory and Oxidative Stress Markers of MDCK and L929 Cells In Vitro.

Pharmaceuticals/Personal Care Products

Aqueous stability and degradation of psychiatric and neuroactive compounds and its biological activity in Daphnia magna.

Mixtures

Single and combined effects of microplastics, pyrethroid and food resources on the life-history traits and microbiome of Chironomus riparius.

Effect of combined exposure to silica nanoparticles and cadmium chloride on female zebrafish ovaries.

Combined exposure to microplastics and zinc produces sex-specific responses in the water flea Daphnia magna.

Combined polystyrene microplastics and chlorpyrifos decrease levels of nutritional parameters in muscle of rainbow trout (Oncorhynchus mykiss).

The joint adverse effects of aged nanoscale plastic debris and their co-occurring benzo[α]pyrene in freshwater mussel (Anodonta anatina).

Co-exposure to nTiO₂ impairs arsenic metabolism and affects antioxidant capacity in the marine shrimp Litopenaeus vannamei.

Binary and ternary toxicological interactions of clothianidin and eight commonly used pesticides on honey bees (Apis mellifera).

Exposure/Environment Studies

BPA/Phenols

Distribution paths of endocrine disrupting phenolic compounds in waterbirds (Mergus merganser, Alca torda, Clangula hyemalis) from the Southern Baltic.

Phthalates

Concentrations of Seven Phthalate Monoesters in Infants and Toddlers Quantified in Urine Extracted from Diapers.

Parabens/Triclosan/Antimicrobials

Urinary level of un-metabolized parabens in women working in beauty salons.

Profiles of parabens, benzophenone-type ultraviolet filters, triclosan, and triclocarban in paired urine and indoor dust samples from Chinese university students: Implications for human exposure.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

PCDD/Fs and PCBs in Baltic fish – Recent data, risk for consumers.

Polluted porpoises: Generational transfer of organic contaminants in harbour porpoises from the southern North Sea.

The sorption of persistent organic pollutants in microplastics from the coastal environment.

Significant release of unintentionally produced non-Aroclor polychlorinated biphenyl (PCB) congeners PCB 47, PCB 51 and PCB 68 from a silicone rubber production site in North Rhine-Westphalia, Germany.

First report of organochlorine pesticides (OCPs) in coral tissues and the surrounding air-seawater system from the South China Sea: Distribution, source, and environmental fate.

Concentrations and geographical patterns of persistent organic pollutants (POPs) in meat from semi-domesticated reindeer (Rangifer tarandus tarandus L.) in Norway.

Chloroorganic (DDT) and organophosphate (malathion) insecticides impair the motor function of the bovine cervix.

Unraveling Congener-Specific Transfer of Non-Dioxin-Like Polychlorinated Biphenyls (ndl-PCBs) from Feed into Chicken Meat.

Perfluoroalkyl Substances

Temporal trends of concentrations of per- and polyfluoroalkyl substances among adults with overweight and obesity in the United States: Results from the Diabetes Prevention Program and NHANES.

Insights into the impacts of bioturbation by multiple benthic organisms on the bioavailability and toxic effects of perfluorooctane sulfonate in sediment.

Detection and removal of poly and perfluoroalkyl polluting substances for sustainable environment.

Accumulation of PFAS by livestock – determination of transfer factors from water to serum for cattle and sheep in Australia.

Towards deployable electrochemical sensors for per- and polyfluoroalkyl substances (PFAS).

A community based PFAS phytoremediation project at the former Loring Airforce Base.

Flame Retardants

Characteristics of legacy and novel brominated flame retardants in water and sediment surrounding two e-waste dismantling regions in Taizhou, eastern China.

Pesticides

Temporal variability of organophosphate insecticide metabolites over one year in Chinese adults.

Monitoring of pesticides in surface water, pesticides removal efficiency in drinking water treatment plant and potential health risk to consumers using Monte Carlo simulation in Behbahan City, Iran.

Bioaccumulation of current-use herbicides in fish from a global biodiversity hotspot: Lake St Lucia, South Africa.

Potentially Toxic Elements

Lead concentrations in breast milk of Moroccan nursing mothers and associated factors of exposure: CONTAMILK STUDY.

Connecting inorganic mercury and lead measurements in blood to dietary sources of exposure that may impact child development.

An Evaluation of Fish Tissue Monitoring Alternatives for Mercury and Selenium: Fish Muscle Biopsy Samples Versus Homogenized Whole Fillets.

Holistic health risk assessment in an artisanal mercury mining region in Mexico.

Assessment of Lead and Mercury Exposure Levels in the General Population of Korea Using Integrated National Biomonitoring Data.

Nurse sharks, space rockets and cargo ships: Metals and oxidative stress in a benthic, resident and large-sized mesopredator, Ginglymostoma cirratum.

Mercury and selenium levels in archive samples of wild Atlantic bluefin tuna from the Mediterranean Sea.

Rapid temporal decline of mercury in Greenland halibut (Reinhardtius hippoglossoides).

Arsenic speciation in fish from Baltic Sea close to chemical munitions dumpsites.

Microplastics

Importance of seasonal sea ice in the western Arctic ocean to the Arctic and global microplastic budgets.

Spatiotemporal distribution of microplastics in surface water, biofilms, and sediments in the world’s largest drinking water diversion project.

The role of plastic debris in the biogeochemical cycle of mercury in Lake Erie and San Francisco Bay.

Marine macrophytes retain microplastics.

Pharmaceuticals/Personal Care Products

What is in Nigerian waters? Target and non-target screening analysis for organic chemicals.

Prioritization and environmental risk assessment of pharmaceuticals mixtures from Brazilian surface waters.

Occurrence and ecological risk assessment of pharmaceuticals and cocaine in the urban drainage channels of Santos beaches (São Paulo, Brazil): a neglected, but sensitive issue.

Application of a fast and sensitive method for the determination of contaminants of emerging concern in wastewater using a quick, easy, cheap, effective, rugged and safe-based extraction and liquid chromatography coupled to mass spectrometry.

Miscellaneous

Simple monitoring of endocrine-disrupting chemicals using transgenic Arabidopsis plants expressing medaka estrogen receptor.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.