EDC Science Weekly, July 21-28, 2021

Post author:HEEDS
Post published:July 28, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Environmental Health Risk Assessment in the Federal Government: A Visual Overview and a Renewed Call for Coordination. [see related blog with infographic]

Heterogeneity and threshold effects of environmental regulation on health expenditure: Considering the mediating role of environmental pollution.

Regulatory Status of Pesticide Residues in Cannabis: Implications to Medical Use in Neurological Diseases.

Methods/Tools/Screening

Application of an in Vitro Assay to Identify Chemicals That Increase Estradiol and Progesterone Synthesis and Are Potential Breast Cancer Risk Factors. and see related: Invited Perspective: Prioritizing Chemical Testing and Evaluation Using Validated in Vitro Assays Relevant to Key Characteristics

Estimating Hepatotoxic Doses Using High-Content Imaging in Primary Hepatocytes.

Evaluating the Feasibility of Continuing Medical Education for Disseminating Emerging Science on the Breast Cancer and Environment Connection.

Argumentation Analysis of Risk Assessments: The Case of Perfluorooctanoic Acid.

Commentaries/Conference Summaries

Investigating Endocrine Disrupting Properties of Chemicals in Fish and Amphibians: Opportunities to Apply the 3Rs. [workshop summary]

New Determination Methods, Toxic Mechanisms, and Control Strategies (Preface to the Special Issue of Food and Chemical Toxicology on The Outcomes of Mycotoxins in Food).

Special issue on contamination, remediation and health for pollutants in natural aquatic, soil, sediments and atmospheric environments.

Reviews

Numerous EDCs

Environmental and Genetic Risk Factors of Congenital Anomalies: an Umbrella Review of Systematic Reviews and Meta-Analyses.

Recent Progress in Environmental Toxins-Induced Cardiotoxicity and Protective Potential of Natural Products.

Intrauterine Exposures and Maternal Health Status during Pregnancy in Relation to Later Child Health: A Review of Pregnancy Cohort Studies in Europe.

Phthalates

Environmental exposures, fetal testis development and function: phthalates and beyond.

Triclosan/Antimicrobials

Effect of Maternal Triclosan Exposure on Neonatal Birth Weight and Children Triclosan Exposure on Children’s BMI: A Meta-Analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological Evidence.

Release, transformation, and risk factors of polybrominated diphenyl ethers from landfills to the surrounding environments: A review.

Perfluoroalkyl Substances

Do perfluoroalkyl substances aggravate the occurrence of obesity-associated glucolipid metabolic disease?

Exposure to Perfluoroalkyl Chemicals and Cardiovascular Disease: Experimental and Epidemiological Evidence.

Flame Retardants

Mechanisms of organophosphate neurotoxicity.

Pesticides

Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review.

Glyphosate Herbicide: Reproductive Outcomes and Multigenerational Effects.

Potentially Toxic Elements

Mercury and Prenatal Growth: A Systematic Review.

Potentially toxic elements in groundwater: a hotspot research topic in environmental science and pollution research.

Microplastics

Adsorption behaviour and interaction of organic micropollutants with nano and microplastics – A review.

Are We Underestimating Anthropogenic Microfiber Pollution? A Critical Review of Occurrence, Methods and Reporting.

Microplastic contaminants in the aqueous environment, fate, toxicity consequences, and remediation strategies.

Disparities in Methods Used to Determine Microplastics in the Aquatic Environment: A Review of Legislation, Sampling Process and Instrumental Analysis.

Effects of microplastics pollution on plankton: A review.

Air Pollution

Gastrointestinal tissue as a “new” target of pollution exposure.

Effectiveness of indoor air purification intervention in improving cardiovascular health: A systematic review and meta-analysis of randomized controlled trials.

Miscellaneous

A systematic review of the use of silicone wristbands for environmental exposure assessment, with a focus on polycyclic aromatic hydrocarbons (PAHs).

Bibliometric analysis of studies involving e-waste: a critical review.

Human Health Studies

Numerous Chemicals

Longitudinal exposure to consumer product chemicals and changes in plasma oxylipins in pregnant women. [phenols, phthalates, OPEs]

Mixtures

Associations between Residential Proximity to Oil and Gas Drilling and Term Birth Weight and Small-for-Gestational-Age Infants in Texas: A Difference-in-Differences Analysis. [see related Invited Perspective: Oil and Gas Development and Adverse Birth Outcomes: What More Do We Need to Know?]

The Cumulative Risk of Prenatal Exposures to Chemical and Non-Chemical Stressors on Birth Outcomes in Suriname.

Phthalates

Effect of phthalates exposure during perinatal period on hormonal profile in Mexican males during their first months of life.

Association of phthalate exposure with autistic traits in children.

The relationship between urinary phthalate metabolites and polycystic ovary syndrome in women undergoing in vitro fertilization: Nested case-control study.

Association of phthalate exposure and airway dysfunction, with mediation by serum periostin.

Perfluoroalkyl Substances

Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and associations with attention-deficit/hyperactivity disorder and autism spectrum disorder in children.

Associations of single and multiple per- and polyfluoroalkyl substance (PFAS) exposure with vitamin D biomarkers in African American women during pregnancy.

Elevated levels of perfluoroalkyl substances in breast cancer patients within the Greater Manila Area.

Maternal Perfluoroalkyl Substances, Thyroid Hormones, and DIO Genes: A Spanish Cross-sectional Study.

Potentially Toxic Elements

Cadmium (Cd) and Lead (Pb) topsoil levels and incidence of childhood leukemias.

Associations between endocrine-disrupting heavy metals in maternal hair and gestational diabetes mellitus: A nested case-control study in China.

Effects of heavy metal, vitamin, and curry consumption on metabolic syndrome during menopause: a Korean community-based cross-sectional study.

Association between heavy metals, high-sensitivity C-reaction protein and 10-year risk of cardiovascular diseases among adult Korean population.

Blood Arsenic Levels as a Marker of Breast Cancer Risk among BRCA1 Carriers.

Maternal urinary cadmium concentrations in early pregnancy in relation to prenatal and postpartum size of offspring.

Cancer mortality in a population-based cohort of American Indians – The strong heart study.

Prenatal methylmercury exposure is associated with decrease heart rate variability in children.

Arsenic exposure and metabolism in relation to blood pressure changes in pregnant women.

Urinary metals and metal mixtures and timing of natural menopause in midlife women: The Study of Women’s Health Across the Nation.

Lifestyle Factors and Parkinson’s Disease Risk in a Rural New England Case-Control Study.

Association of Mercury Exposure and Maternal Sociodemographics on Birth Outcomes of Indigenous and Tribal Women in Suriname

The association between blood metals and hypertension in the GuLF study.

Association between heavy metals, high-sensitivity C-reaction protein and 10-year risk of cardiovascular diseases among adult Korean population.

Air Pollution

Environmental Air Pollutants Inhaled during Pregnancy Are Associated with Altered Cord Blood Immune Cell Profiles.

Mid-pregnancy PM_2.5 exposure affects sex-specific growth trajectories via ARRDC3 methylation.

Long-Term Exposure to Fine and Coarse Particulate Matter and COVID-19 Incidence and Mortality Rate in Chile during 2020.

Pharmaceuticals/Personal Care Products

The Association between Sex Hormones, Pubertal Milestones and Benzophenone-3 Exposure, Measured by Urinary Biomarker or Questionnaire.

Laboratory Studies

BPA/Phenols

Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-β estradiol.

The antagonistic effect of bisphenol A and nonylphenol on liver and kidney injury in rats.

Bisphenol A Modulates Autophagy and Exacerbates Chronic Kidney Damage in Mice.

Liver histopathological alteration and dysfunction after bisphenol A administration in male rats and protective effects of naringin.

Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells.

Bisphenol a Interferes with Uterine Artery Features and Impairs Rat Feto-Placental Growth

Proteomic profile of the effects of low-dose bisphenol A on zebrafish ovaries.

Peripubertal Bisphenol A Exposure Imparts Detrimental Age-Related Changes in Body Composition, Cognition, and H₂S Production Capacities.

Phthalates

Di(2-ethylhexyl)phthalate exposure exacerbates metabolic disorders in diet-induced obese mice.

Binding and detoxification ability of lactobacillus acidophilus towards di-n-butyl phthalate: Change of MAPK pathway in Caco-2 cell model.

Triclosan/Antimicrobials

Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A mixture of persistent organic pollutants detected in human follicular fluid increases progesterone secretion and mitochondrial activity in human granulosa HGrC1 cells.

MicroRNA-based host response to toxicant exposure is influenced by the presence of gut microbial populations.

The protective effects of capsaicin on oxidative damage-induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats.

Sub-Chronic Effects of Slight PAH- and PCB-Contaminated Mesocosms in Paracentrotus lividus Lmk: A Multi-Endpoint Approach and De Novo Transcriptomic.

Perfluoroalkyl Substances

A Roadmap to the Structure-Related Metabolism Pathways of Per- and Polyfluoroalkyl Substances in the Early Life Stages of Zebrafish (Danio rerio). [see related Invited Perspective: PFAS Bioconcentration and Biotransformation in Early Life Stage Zebrafish and Its Implications for Human Health Protection.]

Lactic acid bacteria alleviate liver damage caused by perfluorooctanoic acid exposure via antioxidant capacity, biosorption capacity and gut microbiota regulation.

Anti-oxidant mechanisms of Chlorella pyrenoidosa under acute GenX exposure.

Perfluorooctane sulfonate interferes with non-genomic estrogen receptor signaling pathway, inhibits ERK1/2 activation and induces apoptosis in mouse spermatocyte-derived cells.

Flame Retardants

DFT studies on pyrolysis mechanisms of tetrabromobisphenol A (TBBPA).

Oxidative stress and endoplasmic reticulum stress contributed to hepatotoxicity of decabromodiphenyl ethane (DBDPE) in L-02 cells.

Effects of polystyrene and triphenyl phosphate on growth, photosynthesis and oxidative stress of Chaetoceros meülleri.

Synthetic organic chemicals (flame retardants and pesticides) with neurotoxic potential induced behavioral impairment on zebrafish (Danio rerio): a non-invasive approach for neurotoxicology.

An eco-friendly NP flame retardant for durable flame-retardant treatment of cotton fabric.

Organotins

An ancestral nuclear receptor couple, PPAR-RXR, is exploited by organotins.

Pesticides

Mitochondria of teleost radial glia: A novel target of neuroendocrine disruption by environmental chemicals?

The pyriproxyfen metabolite, 4′-OH-PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection.

Comparison of the toxicity of pure compounds and commercial formulations of imidacloprid and acetamiprid on HT-29 cells: Single and mixture exposure.

Bbc3 loss enhances survival and protein clearance in neurons exposed to the organophosphate pesticide chlorpyrifos.

Ecotoxicity of chlorpyrifos on earthworm Eisenia fetida (Savigny, 1826): Modifications in oxidative biomarkers.

The role of ascorbic acid combined exposure on Imidacloprid-induced oxidative stress and genotoxicity in Nile tilapia.

Impairment of caprine oocyte maturation in vitro and alteration of granulosa cells functions by widely used fungicide mancozeb.

Using Transcriptomics and Metabolomics to Understand Species Differences in Sensitivity to Chlorpyrifos in Japanese Quail and Double-Crested Cormorant Embryos.

Enantioselective toxicity and mechanism of chiral fungicide penflufen based on experiments and computational chemistry.

Captan exposure disrupts ovarian homeostasis and affects oocytes quality via mitochondrial dysfunction induced apoptosis.

Epigenetic Effects Promoted by Neonicotinoid Thiacloprid Exposure.

Assessment of Biochemical, Hematological and Behavioral Biomarkers of Cyprinus carpio on exposure to a type-II Pyrethroid insecticide Alpha-cypermethrin.

Potentially Toxic Elements

Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability.

Exposure to cadmium induces neuroinflammation and impairs ciliogenesis in hESC-derived 3D cerebral organoids.

Wild Garlic Allium triquetrum L. Alleviates Lead Acetate-Induced Testicular Injuries in Rats.

Quercetin Protects Human Thyroid Cells against Cadmium Toxicity

Toxic effects of fluoride in intestinal epithelial cells and the mitigating effect of methanol extract of coconut haustorium by enhancing de novo glutathione biosynthesis.

Microplastics

Exposure to metals premixed with microplastics increases toxicity through bioconcentration and impairs antioxidant defense and cholinergic response in a marine mysid.

Functionalized Nanoplastics (NPs) Increase the Toxicity of Metals in Fish Cell Lines.

Mixtures

Study on the Joint Toxicity of BPZ, BPS, BPC and BPF to Zebrafish.

Experimental respiratory exposure to putative Gulf War toxins promotes persistent alveolar macrophage recruitment and pulmonary inflammation.

Alpha-Lipoic Acid Protects Co-Exposure to Lead and Zinc Oxide Nanoparticles Induced Neuro, Immuno and Male Reproductive Toxicity in Rats.

Joint toxicity of lead and cadmium on the behavior of zebrafish larvae: An antagonism.

Interactive Metal Mixture Toxicity to Daphnia magna Populations as an Emergent Property in a Dynamic Energy Budget Individual-Based Model.

Miscellaneous

Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio.

Exposure/Environment Studies

Phthalates

Phthalates in Chinese vehicular environments: Source emissions, concentrations, and human exposure.

The effect of warming on phthalate levels in intravenous fluid bags.

Parabens

An in vitro assessment for human skin exposure to parabens using magnetic solid phase extraction coupled with HPLC.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Human health risk assessments of organochlorine pesticides in some food crops from Esa-Oke farm settlement, Osun State, Nigeria.

Limitations on Development of Polychlorinated Biphenyl Tissue Concentration Thresholds for Survival, Growth, and Reproduction in Fish.

Characterizing baseline legacy chemical contamination in urban estuaries for disaster-research through systematic evidence mapping: A case study.

Perfluoroalkyl Substances

Distribution characteristics of per- and polyfluoroalkyl substances (PFASs) in human urines of acrylic fiber plant and chemical plant.

Internal exposure to perfluoroalkyl substances (PFAS) in vegans and omnivores.

High Concentrations of Perfluoroalkyl Acids in Arctic Seawater Driven by Early Thawing Sea Ice.

Effects of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonic Acid (PFOS) on Soil Microbial Community.

Per-, poly-fluoroalkyl substances (PFASs) pollution in benthic riverine ecosystem: Integrating microbial community coalescence and biogeochemistry with sediment distribution.

Legacy and emerging poly- and perfluorochemicals in seawater and sediment from East China Sea.

First Report on the Bioaccumulation and Trophic Transfer of Perfluoroalkyl Ether Carboxylic Acids in Estuarine Food Web.

Concentrations and human exposure assessment of per and polyfluoroalkyl substances in farmed marine shellfish in South Africa.

Per-, poly-fluoroalkyl substances (PFASs) pollution in benthic riverine ecosystem: Integrating microbial community coalescence and biogeochemistry with sediment distribution.

Flame Retardants

Emerging Brominated Flame Retardants 2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (EHTBB) and Bis(2-ethylhexyl)-tetrabromophthalate (BEH-TEBP) in Chinese Food and Their Health Implications.

Brominated Flame Retardants in Children’s Room: Concentration, Composition, and Health Risk Assessment

Pesticides

Agricultural pesticide residues in water from a karstic aquifer in Yucatan, Mexico, pose a risk to children’s health.

Household pesticide exposure: an online survey and shelf research in the Metropolitan Region of Rio de Janeiro, Brazil.

Concentrations and distributions of neonicotinoids in drinking water treatment plants in South Korea.

Widespread agrochemicals differentially affect zooplankton biomass and community structure.

Identification of Pesticide Transformation Products in Surface Water Using Suspect Screening Combined with National Monitoring Data.

Can Wolf Spider Mothers Detect Insecticides in Environment? Does the Silk of the Egg-Sac Protect Juveniles from Insecticides?

Honey bee queen health is unaffected by contact exposure to pesticides commonly found in beeswax.

Potentially Toxic Elements

Potential for Manganese-Induced Neurologic Harm to Formula-Fed Infants: A Risk Assessment of Total Oral Exposure [see related Manganese Intake in Babies: Drinking Water plus Formula Can Cause High Exposures]

Human health risk of mercury in street dust: A case study of children in the vicinity of compact fluorescence lamp factory, Hanoi, Vietnam.

Health risk assessment of As due to rice ingestion based on iAs distribution and actual consumption patterns for the residents in Beijing: a cross-sectional study.

An integrative approach to define chemical exposure threshold limits for endangered sea turtles.

Microplastics

The plastic Trojan horse: Biofilms increase microplastic uptake in marine filter feeders impacting microbial transfer and organism health.

Characterization and comparison of microplastic occurrence in point and non-point pollution sources.

Source, sea and sink-A holistic approach to understanding plastic pollution in the Southern Caribbean.

The ecology of the plastisphere: Microbial composition, function, assembly, and network in the freshwater and seawater ecosystems.

Pharmaceuticals/Personal Care Products

Evaluation of ibuprofen contamination in local urban rivers and its effects on immune parameters of juvenile grass carp.

Mixtures

Analysis of Estrogenic Activity in Maryland Coastal Bays Using the MCF-7 Cell Proliferation Assay.

Miscellaneous

Short- and medium-chain chlorinated paraffins in human blood serum of Czech population.

Hair and nails as noninvasive bioindicators of human exposure to chlorinated paraffins: Contamination patterns and potential influencing factors.

Remobilization of pollutants during extreme flood events poses severe risks to human and environmental health.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

If you enjoy this newsletter, please feel free to donate here! Thank you!

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.