EDC Science Weekly, July 14-20, 2021

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Another note: I’ll probably start sending this newsletter out on Wednesdays instead of Tuesdays after today, FYI.

Events

July 27 webinar: Climate Change and Reproductive Health (the final webinar in the Generation Chemical webinar series)

Regulations/Policy

US EPA: Is there room to open a new window for evaluating potential sub-threshold effects and ecological risks?

Methods/Tools/Screening

A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity.

The 2021 update of the EPA’s adverse outcome pathway database.

Exploring 20 eV electron impact ionization in gas chromatography-tandem mass spectrometry for the determination of estrogenic compounds.

Taking full advantage of modelling to better assess environmental risk due to xenobiotics-the all-in-one facility MOSAIC.

Prediction of chemical reproductive toxicity to aquatic species using a machine learning model: An application in an ecological risk assessment of the Yangtze River, China.

Issues in the design, analysis, and application of rodent developmental neurotoxicology studies.

Counteracting Environmental Chemicals with Coenzyme Q10: An Educational Primer for Use with “Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Caenorhabditis elegans Germline”.

Commentaries/Conference Summaries

Reducing Prenatal Exposure to Toxic Environmental Agents: ACOG Committee Opinion, Number 832. and Reducing Prenatal Exposure to Toxic Environmental Agents: ACOG Committee Opinion Summary,Number 832.

Reviews

Numerous EDCs

Thyroid hormone system disrupting chemicals.

Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels.

Endocrine Disrupting Chemicals and Risk of Testicular Cancer A Systematic Review and Meta-analysis.

Effects of emerging pollutants on the occurrence and transfer of antibiotic resistance genes: A review.

Phthalates

Effects of Di-2-ethylhexyl phthalate on central nervous system functions: A narrative review.

Parabens/Triclosan/Antimicrobials

Opinion of the Scientific Committee on Consumer safety (SCCS) – Final Opinion on propylparaben (CAS No 94-13-3, EC No 202-307-7).

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The concentration of persistent organic pollutants in water resources: A global systematic review, meta-analysis and probabilistic risk assessment.

The association between environmental exposures to chlordanes, adiposity and diabetes-related features: a systematic review and meta-analysis.

Perfluoroalkyl Substances

Bioaccumulation, Biodistribution, Toxicology and Biomonitoring of Organofluorine Compounds in Aquatic Organisms.

Flame Retardants

Long-Range Transport, Trophic Transfer, and Ecological Risks of Organophosphate Esters in Remote Areas.

The cytoskeleton as a non-cholinergic target of organophosphate compounds.

Pesticides

Glyphosate effects on the female reproductive systems: a systematic review.

Environmental and Health Risks of Pesticide Use in Ethiopia.

Potentially Toxic Elements

Neurotoxicity of mercury: an old issue with contemporary significance.

Microplastics/Nanomaterials

Nanoparticles: Weighing the Pros and Cons from an Eco-genotoxicological Perspective.

Marine microplastics in the ASEAN region: A review of the current state of knowledge.

Legislation to limit the environmental plastic and microplastic pollution and their influence on human exposure.

Air Pollution

Air pollution and children’s health-a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter.

Miscellaneous

Biodegradable polymers and their nano-composites for the removal of endocrine-disrupting chemicals (EDCs) from wastewater: A review.

Physiological mediators of prenatal environmental influences in autism spectrum disorder.

Human Health Studies

Numerous Chemicals

A Comprehensive Non-targeted Analysis Study of the Prenatal Exposome.

Exposome of attention deficit hyperactivity disorder in Taiwanese children: exploring risks of endocrine-disrupting chemicals.

BPA/Phenols

Internal exposure of Chinese children from a typical coastal city to bisphenols and possible association with thyroid hormone levels.

Prenatal Bisphenol a Exposure, DNA Methylation, and Low Birth Weight: A Pilot Study in Taiwan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Plasma concentrations of persistent organic pollutants and pancreatic cancer risk.

The impact of left truncation of exposure in environmental case-control studies: evidence from breast cancer risk associated with airborne dioxin.

Perfluoroalkyl Substances

Associations of paternal and maternal per- and polyfluoroalkyl substances exposure with cord serum reproductive hormones, placental steroidogenic enzyme and birth weight.

Pesticides

Longitudinal assessment of kidney function in migrant farm workers.

Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes.

Occupational Insecticide Exposure and Risk of Non-Hodgkin Lymphoma: A Pooled Case-Control Study from the InterLymph Consortium.

Endpoints as human biomarkers in exposure assessment of triazoles fungicides.

Intake of fruits and vegetables by pesticide residue status in relation to cancer risk.

Potentially Toxic Elements

The changes of essential trace elements in residents from an e-waste site and the relationships between elements and hormones of the hypothalamic-pituitary-thyroid (HPT) axis.

Urinary arsenic and relative telomere length in 5-7 year old children in Bangladesh.

Associations of plasma metal concentrations with incident dyslipidemia: Prospective findings from the Dongfeng-Tongji cohort.

Metals and Breast Cancer Risk: A Prospective Study Using Toenail Biomarkers.

Environmental exposure to cadmium but not lead is associated with decreased semen quality parameters: quality regionalism of sperm properties.

The Mediating Role of Placental Weight Change in the Association Between Prenatal Exposure to Thallium and Birth Weight: A Prospective Birth Cohort Study.

Association of prenatal exposure to cadmium with neurodevelopment in children at 2 years of age: The Japan Environment and Children’s Study.

Comparing the Predictivity of Human Placental Gene, microRNA, and CpG Methylation Signatures in Relation to Perinatal Outcomes.

Prenatal heavy metal exposure, total immunoglobulin E, trajectory, and atopic diseases: A 15-year follow-up study of a Taiwanese birth cohort.

Pharmaceuticals/Personal Care Products

Prenatal Diethylstilbestrol Exposure and Cancer Risk in Males.

Laboratory Studies

BPA/Phenols

Resveratrol Butyrate Esters Inhibit Obesity Caused by Perinatal Exposure to Bisphenol A in Female Offspring Rats.

Comparative effects of genistein and bisphenol A on non-alcoholic fatty liver disease in laying hens.

Chronic exposure to low doses of bisphenol A alters hydromineral responses in rats.

Comparing effects and action mechanisms of BPA and BPS on HTR-8/SVneo placental cells.

Phthalates

In vitro and in silico investigations of endocrine disruption induced by metabolites of plasticizers through glucocorticoid receptor.

Comprehensive insights into the interactions of dicyclohexyl phthalate and its metabolite to human serum albumin.

DEHT is a suitable plasticizer option for phthalate-free storage of irradiated red blood cells.

Environmentally relevant perinatal exposure to DBP disturbs testicular development and puberty onset in male mice.

Parabens/Triclosan/Antimicrobials

Genomic markers for the biological responses of Triclosan stressed hatchlings of Labeo rohita.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Impaired Morphogenesis and Function of Rat Adrenal Zona Glomerulosa by Developmental Low-Dose Exposure to DDT Is Associated with Altered Oct4 Expression.

Polychlorinated biphenyls induce oxidative stress and metabolic responses in astrocytes.

The Aryl hydrocarbon receptor mediates reproductive toxicity of polychlorinated biphenyl congener 126 in rats.

Liver-specific decrease in Tff3 gene expression in infant mice perinatally exposed to 2,3,7,8-tetrabromodibenzofuran or 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Perfluoroalkyl Substances

Thyroid Disruptors: Extrathyroidal Sites of Chemical Action and Neurodevelopmental Outcome-an Examination Using Triclosan and Perfluorohexane Sulfonate (PFHxS).

Chronic low-level perfluorooctane sulfonate (PFOS) exposure promotes testicular steroidogenesis through enhanced histone acetylation.

Exposure to perfluorooctane sulfonate in vitro perturbs the quality of porcine oocytes via induction of apoptosis.

Flame Retardants

Impacts of PBDE-47 exposure before, during and after pregnancy on the maternal gut microbiome and its association with host metabolism.

PBDEs affect inflammatory and oncosuppressive mechanisms via the EZH2 methyltransferase in airway epithelial cells.

Changes in Human Erythrocyte Exposed to Organophosphate Flame Retardants: Tris(2-chloroethyl) Phosphate and Tris(1-chloro-2-propyl) Phosphate.

Organotins

Obesogenic and developmental effects of TBT on the gene expression of juvenile Japanese medaka (Oryzias latipes).

Pesticides

Gene-Environment Interactions in Developmental Neurotoxicity: a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres.

Pesticides and aging: Preweaning exposure to Chlorpyrifos induces a general hypomotricity state in late-adult rats.

Bioaccumulation, Metabolism and the Toxic Effects of Chlorfenapyr in Zebrafish (Danio rerio).

Effect of the phenylpyrrole fungicide fludioxonil on cell proliferation and cardiac differentiation in mouse embryonic stem cells.

Cardiac toxicity assessment of pendimethalin in zebrafish embryos.

Corticosterone and chlorpyrifos oxon exposure elicits spatiotemporal MAPK phosphoprotein signaling in a mouse brain.

Subchronic neurotoxicity of diazinon in albino mice: Impact of oxidative stress, AChE activity, and gene expression disturbances in the cerebral cortex and hippocampus on mood, spatial learning, and memory function.

Evaluating Multiple Biochemical Markers in Xenopus laevis Tadpoles Exposed to the Pesticides Thiacloprid and Trifloxystrobin in Single and Mixed Forms.

A subchronic low-dose exposure of a glyphosate-based herbicide induces depressive and anxious-like behavior in mice: quercetin therapeutic approach.

Reproductive fitness of honey bee queens exposed to thiamethoxam during development.

The Utility of a Bumble Bee (Bombus spp. [Hymenoptera: Apidae]) Brood Test for Evaluating the Effects of Pesticides.

Potentially Toxic Elements

Curcumin functions as an anti-inflammatory and antioxidant agent on arsenic-induced hepatic and kidney injury by inhibiting MAPKs/NF-κB and activating Nrf2 pathways.

Cadmium exposure induces cardiac glucometabolic dysregulation and lipid accumulation independent of pyruvate dehydrogenase activity.

Co-exposure to fluoride and arsenic disrupts intestinal flora balance and induces testicular autophagy in offspring rats.

Microplastics

Accumulation and Distribution of Fluorescent Microplastics in the Early Life Stages of Zebrafish.

Air Pollution

Ambient fine particulate matter exposure disrupts circadian rhythm and oscillation of the HPA axis in a mouse model.

Prenatal air pollution exposure to diesel exhaust induces cardiometabolic disorders in adulthood in a sex-specific manner.

Pharmaceuticals/Personal Care Products

Effects of 4-epianhydrotetracycline on oxidative stress in zebrafish (Danio rerio) embryos

Mixtures

An eight-compound mixture but not corresponding concentrations of individual chemicals induces triglyceride accumulation in human liver cells.

Miscellaneous

Developmental thyroid disruption causes long-term impacts on immune cell function and transcriptional responses to pathogen in a small fish model.

Exposure/Environment Studies

BPA/Phenols

Influence of living in the same home on biomonitored levels of consumer product chemicals. [phenols, parabens, etc.]

Urinary bisphenol levels in plastic industry workers.

Ethoxylated Butoxyethanol-BADGE Adducts-New Potential Migrants from Epoxy Resin Can Coating Material.

Simultaneous determination of 9 environmental pollutants including bisphenol A in vegetable oil by solid phase extraction-liquid chromatography-tandem mass spectrometry.

Phthalates

Prenatal phthalate exposure measurement: A comparison of metabolites quantified in prenatal maternal urine and newborn’s meconium.

An integrated exposure and pharmacokinetic modeling framework for assessing population-scale risks of phthalates and their substitutes.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Estimating the dietary exposure and risk of persistent organic pollutants in China: A national analysis.

A comprehensive assessment of endocrine-disrupting chemicals in an Indian food basket: Levels, dietary intakes, and comparison with European data.

Thyroid function and immune status in perch (Perca fluviatilis) from lakes contaminated with PFASs or PCBs.

Perfluoroalkyl Substances

Uptake of perfluorinated alkyl acids by crops: results from a field study.

A new framework for modeling the effect of salt on interfacial adsorption of PFAS in environmental systems.

Flame Retardants

Legacy brominated flame retardants in human milk from the general population in Beijing, China: Biomonitoring, temporal trends from 2011 to 2018, and nursing infant’s exposure assessment.

Optimization and validation of a two-step method for the determination of polybrominated diphenyl ethers in Croatian house dust samples.

Pesticides

Glyphosate and aminomethylphosphonic acid (AMPA) in urine of children and adolescents in Germany – Human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V).

Probabilistic health risk assessment of chlorpyrifos exposure among applicators on rice farms in Ghana.

Assessing pesticides exposure effects on the reproductive performance of a declining aerial insectivore.

Potentially Toxic Elements

Natural and Conventional Cosmetics-Mercury Exposure Assessment.

Metal exposure and biomarker levels among e-cigarette users in Spain.

Miscellaneous

Emerging contaminants in Brazilian aquatic environment: identifying targets of potential concern based on occurrence and ecological risk.

Human variability in polymorphic CYP2D6 metabolism: Implications for the risk assessment of chemicals in food and emerging designer drugs.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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