EDC Science Weekly, June 23 – 29, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events,Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

June 30 webinar: Suspect Screening and Chemical Exposures in Pregnant Women (EaRTH Center)

June 30 webinar: Per- and Polyfluoroalkyl Substances (PFAS) in Breast Milk: Findings of a New Study and Policies Needed to Protect Future Generations (CHE-Alaska)

July 14: Inaugural PFAS Conference (EWG)

July 15 webinar: Throwaway Packaging, Forever Chemicals: European wide survey of PFAS in disposable food packaging and tableware and efforts to phase it out at top US Grocery and Fast-food Chains (EDC Strategies Partnership)

Regulations/Policy

Deep Dive into Plastic Monomers, Additives, and Processing Aids

Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection.

The “EU chemicals strategy for sustainability” questions regulatory toxicology as we know it: is it all rooted in sound scientific evidence? [editorial by German Federal Institute for Risk Assessment]

Methods/Tools/Screening

A Novel Multispecies Toxicokinetic Modeling Approach in Support of Chemical Risk Assessment.

Structure-based virtual screening of CYP1A1 inhibitors: towards rapid tier-one assessment of potential developmental toxicants.

Application of Text Mining in Risk Assessment of Chemical Mixtures: A Case Study of Polycyclic Aromatic Hydrocarbons (PAHs).

Reliability of the AR-CALUX® in Vitro method used to detect chemicals with (anti)androgen activity: results of an international ring trial.

Commentaries/Conference Summaries

Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do.

New research on reduction and/or elimination of hazardous substances in the design, manufacture and application of chemical products. [intro to a special issue]

Only “glyphosate” can stop glyphosate.

Bisphenol A measurement challenge. [a puzzle!]

Reviews

Numerous EDCs

Exploring the evidence for epigenetic regulation of environmental influences on child health across generations.

Can Xenobiotics Alter the Sex Ratio of Crocodilians in the Wild?

Impact of phthalates and bisphenols plasticizers on haemocyte immune function of aquatic invertebrates: A review on physiological, biochemical, and genomic aspects.

An overview of organic contaminants in indoor dust, their health impact, geographical distribution and recent extraction/analysis methods.

Perfluoroalkyl Substances

Per and poly-fluoroalkyl substances (PFAS) as a contaminant of emerging concern in surface water: A transboundary review of their occurrences and toxicity effects.

A review of responses of terrestrial organisms to perfluorinated compounds.

Pesticides

Systemic effects of the pesticide mancozeb – A literature review.

Passive environmental residential exposure to agricultural pesticides and hematological malignancies in the general population: a systematic review.

Glyphosate concentrations in global freshwaters: are aquatic organisms at risk?

Meta-analysis and review of pesticide non-target effects on phytoseiids, key biological control agents.

Potentially Toxic Elements

The Roles of Oxidative Stress in Regulating Autophagy in Methylmercury-induced Neurotoxicity.

Environmental and health hazards of military metal pollution.

Increased incidence of spontaneous abortions on exposure to cadmium and lead: a systematic review and meta-analysis.

The Safety of Schools Based on Heavy Metal Concentrations in Classrooms’ Dust: A Systematic Review and Meta-Analysis.

Microplastics/Nanoplastics

Evidence from in vitro and in vivo studies on the potential health repercussions of micro- and nanoplastics.

A review on occurrence, characteristics, toxicology and treatment of nanoplastic waste in the environment.

Pharmaceuticals/Personal Care Products

Steroid hormones in the aquatic environment.

Miscellaneous

Male reproductive toxicity of zearalenone-meta-analysis with mechanism review.

Sediment toxicity assessment using zebrafish (Danio rerio) as a model system: Historical review, research gaps and trends.

Human Health Studies

BPA/Phenols

Bisphenol A exposure, interaction with genetic variants and colorectal cancer via mediating oxidative stress biomarkers.

Exposure to 2,4-dichlorophenol, 2,4,6-trichlorophenol, pentachlorophenol and risk of thyroid cancer: a case-control study in China.

Parabens

Dietary exposure to parabens and body mass index in an adolescent Spanish population.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer.

The relationship between dietary exposure to persistent organic pollutants from fish consumption and type 2 diabetes among First Nations in Canada.

Perfluoroalkyl Substances

Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring: a Faroese cohort study.

Prospective associations of mid-childhood plasma per- and polyfluoroalkyl substances and pubertal timing.

Per- and Polyfluoroalkyl Substances (PFAS) and Hormone Levels during the Menopausal Transition.

Pesticides

Prenatal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-dichlorophenoxyacetic acid and size at birth in urban pregnant women.

Assessment of Organophosphate Pesticides Exposure in Men with Idiopathic Abnormal Semen Analysis: A Cross-Sectional Pilot Study.

Pesticides and Chemicals as Potential Risk Factors of Aplastic Anemia: A Case-Control Study Among a Pakistani Population.

Potentially Toxic Elements

In Utero Exposure to Heavy Metals and Trace Elements and Childhood Blood Pressure in a U.S. Urban, Low-Income, Minority Birth Cohort. [see related Invited Perspective: Metal Mixtures and Child Health: The Complex Interplay of Essential and Toxic Elements.]

Prenatal exposure to a mixture of elements and neurobehavioral outcomes in mid-childhood: Results from Project Viva.

Cadmium Exposure and Coronary Artery Atherosclerosis: A Cross-Sectional Population-Based Study of Swedish Middle-Aged Adults.

Blood lead and cadmium levels are negatively associated with bone mineral density in young female adults.

Pharmaceuticals/Personal Care Products

Use of hair products in relation to ovarian cancer risk.

Miscellaneous

Cohort profile: The COPENHAGEN Minipuberty Study-A longitudinal prospective cohort of healthy full-term infants and their parents.

Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress.

Estimated number of cancers attributable to occupational exposures in France in 2017: an update using a new method for improved estimates.

Laboratory Studies

BPA/Phenols

Magnesium lithospermate B supplementation improved prenatal Bisphenol A exposure-induced metabolic abnormalities in male offspring.

Bisphenol analogs AF and S: Effects on cell status and production of angiogenesis-related factors by COV434 human granulosa cell line.

Phthalates

Role of Notch pathway in effect of mono-2-ethylhexyl phthalate on the proliferation and cell cycle of SH-SY5Y cell.

Taurine ameliorates cytotoxic effects of Di(2-ethylhexyl) phthalate on Leydig cells.

Mono-n-butyl phthalate distributes to the mouse ovary, liver and alters the expression of phthalate-metabolizing enzymes in both tissues.

Parabens/Triclosan/Antimicrobials

Triclosan regulates the Nrf2/HO-1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons.

Evaluation of Triclosan-induced reproductive impairments in the accessory reproductive organs and sperm indices in the mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A neuroanatomical mechanism linking perinatal TCDD exposure to lower urinary tract dysfunction in adulthood.

Influence of o,p’-DDT on Mucin 5 subtype A and C expression via regulation of NF-κB/AP-1 activation in human lung epithelial cells.

Perfluoroalkyl Substances

Dietary Exposure of Japanese Quail (Coturnix japonica) to Perfluorooctane Sulfonate (PFOS) and a Legacy Aqueous Film Forming Foam Containing PFOS: Effects on Reproduction and Chick Survivability and Growth.

Flame Retardants

FireMaster® 550 (FM 550) exposure during the perinatal period impacts partner preference behavior and nucleus accumbens core medium spiny neuron electrophysiology in adult male and female prairie voles, Microtus ochrogaster.

Disturbance of the Dlk1-Dio3 imprinted domain may underlie placental Dio3 suppression and extracellular thyroid hormone disturbance in placenta-derived JEG-3 cells following decabromodiphenyl ether (BDE209) exposure.

Pesticides

In Vitro and In Vivo Study on the Toxic Effects of Propiconazole Fungicide in the Pathogenesis of Liver Fibrosis.

Subchronic exposure to a glyphosate-based herbicide causes dysplasia in the digestive tract of Wistar rats.

Transcriptomic changes upon epoxiconazole exposure in a human stem cell-based model of developmental toxicity.

Resveratrol ameliorates malathion-induced estrus cycle disorder through attenuating the ovarian tissue oxidative stress, autophagy and apoptosis.

Thiamethoxam-induced oxidative stress, lipid peroxidation, and disturbance of steroidogenic genes in male rats: Palliative role of Saussurea lappa and Silybum marianum.

Potentially Toxic Elements

Arsenic exposure induces a bimodal toxicity response in zebrafish.

Microplastics/Nanomaterials

Dose-Dependent Effect of Polystyrene Microplastics on the Testicular Tissues of the Male Sprague Dawley Rats.

Damage to the Blood Brain Barrier Structure and Function from Nano Titanium Dioxide Exposure Involves the Destruction of Key Tight Junction Proteins in the Mouse Brain.

Effect of Short-Term Exposure to Titanium Dioxide Nanoparticles on Intestinal Absorption of Glucose by Ex Vivo Everted Rat Gut Sac Model.

Pharmaceuticals/Personal Care Products

Sex- and Developmental Stage-Related Differences in the Hepatic Transcriptome of Japanese Quail (Coturnix japonica) Exposed to 17β-Trenbolone.

Mixtures

Individual and synergistic toxic effects of carbendazim and chlorpyrifos on zebrafish embryonic development.

Pesticide mixture toxicity assessment through in situ and laboratory approaches using embryo-larval stages of the pacific oyster (Magallana gigas).

Systemically Achievable Doses of Beer Flavonoids Induce Estrogenicity in Human Endometrial Cells and Cause Synergistic Effects With Selected Pesticides.

Arsenic and antimony co-induced nephrotoxicity via autophagy and pyroptosis through ROS-mediated pathway in vivo and in vitro.

Exposure/Environment Studies

BPA/Phenols

Determination of Free Bisphenol A in Commercially Packaged Ready-to-Consume Carbonated/Non-Carbonated and Non-Alcoholic Beverages with Immunoaffinity Column Purification and UPLC with Fluorescence Detector, First Action 2019.07.

Comparison of DAD and FLD Detection for Identification of Selected Bisphenols in Human Breast Milk Samples and Their Quantitative Analysis by LC-MS/MS.

Phthalates

Analysis and health risk assessment of phthalate esters (PAEs) in indoor dust of preschool and elementary school centers in city of Tehran, Iran.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Levels of metals and persistent organic pollutants in traditional foods consumed by First Nations living on-reserve in Canada.

Perfluoroalkyl Substances

Fluorine mass balance analysis of selected environmental samples from Norway.

Ship navigation disturbance alters multiphase distribution of perfluoroalkyl acids and increases their ecological risk in waterways.

Characterization of the distribution, source, and potential ecological risk of perfluorinated alkyl substances (PFASs) in the inland river basin of Longgang District, South China.

Pesticides

A spatially explicit model for estimating risks of pesticide exposure to bird populations.

Pesticides do not significantly reduce arthropod pest densities in the presence of natural enemies.

Wastewater-based epidemiology as a novel tool to evaluate human exposure to pesticides: Triazines and organophosphates as case studies.

Is there an urban pesticide signature? Urban streams in five U.S. regions share common dissolved-phase pesticides but differ in predicted aquatic toxicity.

Conservation genomics reveals pesticide and pathogen exposure in the declining bumble bee Bombus terricola.

Potentially Toxic Elements

Dietary Influences on Urinary Fluoride over the Course of Pregnancy and at One-Year Postpartum.

Regionally representative hair mercury levels in Canadian First Nations adults living on reserves.

Fecal Methylmercury Correlates With Gut Microbiota Taxa in Pacific Walruses (Odobenus rosmarus divergens).

Pharmaceuticals/Personal Care Products

Pharmaceuticals and alkylphenols in transplanted Pacific oysters (Crassostrea gigas): Spatial variation and growth effects.

Uptake and translocation of UV-filters and synthetic musk compounds into edible parts of tomato grown in amended soils.

Wide-scope screening of pharmaceuticals, illicit drugs and their metabolites in the Amazon River.

Mixtures

Mining of Consumer Product Ingredient and Purchasing Data to Identify Potential Chemical Coexposures.

Miscellaneous

Occurrence and ecological risks of 156 pharmaceuticals and 296 pesticides in seawater from mariculture areas of Northeast China.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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