EDC Science Weekly, June 16 – 22, 2021 – HEEDS

EDC Science Weekly, June 16 – 22, 2021

Post author:HEEDS
Post published:June 22, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar series: Current opportunities for better identification of endocrine disrupting chemicals at European Level (HEAL)

June 23 webinar: Let’s Talk About PFAS: The Case of the Missing Contaminants (STEEP SRP)

June 25 webinar: 5 Years After TSCA Reform: Strengthening Health Protection through Science (UCSF PRHE)

June 28 webinar: The Global Glyphosate Study: the most comprehensive study on world’s most-used pesticide ever (HEAL)

June 30 webinar: Suspect Screening and Chemical Exposures in Pregnant Women (EaRTH Center)

June 30 webinar: Per- and Polyfluoroalkyl Substances (PFAS) in Breast Milk: Findings of a New Study and Policies Needed to Protect Future Generations (CHE-Alaska)

July 14: Inaugural PFAS Conference (EWG)

Regulations/Policy

The EU endocrine disruptors’ regulation and the glyphosate controversy.

Methods/Tools/Screening

In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach. [review]

Exposure and Toxicity Characterization of Chemical Emissions and Chemicals in Products: Global Recommendations and Implementation in USEtox.

Reviews

Numerous EDCs

Potential risk of BPA and phthalates in commercial water bottles: a minireview.

Chemical contaminants in Brazilian drinking water: a systematic review.

BPA/Phenols

A comprehensive review on the analytical method, occurrence, transformation and toxicity of a reactive pollutant: BADGE.

Concentrations of bisphenol-A in adults from the general population: A systematic review and meta-analysis.

Effects of bisphenols on Blood-Testis Barrier protein expression in vitro: a systematic review and meta-analysis.

Parabens/Triclosan/Antimicrobials

Toxicity and removal of parabens from water: A critical review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review).

Perfluoroalkyl Substances

A Critical Review on Transplacental Transfer of Per- and Polyfluoroalkyl Substances: Prenatal Exposure Levels, Characteristics, and Mechanisms.

Flame Retardants

Organophosphate (OP) diesters and a review of sources, chemical properties, environmental occurrence, adverse effects, and future directions.

Polybrominated diphenyl ethers in the environmental systems: a review.

Pesticides

Pesticides: formulants, distribution pathways and effects on human health – a review.

Magnitude and determinants of neural tube defect in Africa: a systematic review and meta-analysis.

Reproductive toxicity due to herbicide exposure in freshwater organisms.

Exposure to glyphosate and risk of non-Hodgkin lymphoma: an updated meta-analysis.

Glyphosate: A Review on the Current Environmental Impacts from a Brazilian Perspective.

A global study of pesticides in bees: QuEChERS as a sample preparation methodology for their analysis – Critical review and perspective.

Microplastics/Nanomaterials

Dietary nanoparticles alter the composition and function of the gut microbiota in mice at dose levels relevant for human exposure.

Micro(nano)plastics as an emerging risk factor to the health of amphibian: A scientometric and systematic review.

Miscellaneous

Environmental Risk Factors for Childhood Cancer in an Era of Global Climate Change: A Scoping Review.

Analysis, occurrence, toxicity and environmental health risks of synthetic phenolic antioxidants: A review.

Environmental contamination and public health effects of electronic waste: an overview.

Human Health Studies

Mixtures

Effects of gestational exposures to chemical mixtures on birth weight using Bayesian factor analysis in the Health Outcome and Measures of Environment (HOME) Study.

Perfluoroalkyl Substances

Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands.

Exposure to isomers of per- and polyfluoroalkyl substances increases the risk of diabetes and impairs glucose-homeostasis in Chinese adults: Isomers of C8 health project.

Exposure to Perfluoroalkyl Substances During Pregnancy and Fetal BDNF Level: A Prospective Cohort Study.

Flame Retardants

The association between prenatal concentrations of polybrominated diphenyl ether and child cognitive and psychomotor function.

Pesticides

Associations between pesticide mixtures applied near home during pregnancy and early childhood with adolescent behavioral and emotional problems in the CHAMACOS study.

Residential exposure to carbamate, organophosphate, and pyrethroid insecticides in house dust and risk of childhood acute lymphoblastic leukemia.

Potentially Toxic Elements

Maternal gestational mercury exposure in relation to cord blood T cell alterations and placental gene expression signatures.

Early pregnancy exposure to metal mixture and birth outcomes – A prospective study in Project Viva.

Association of multi-metals exposure with intelligence quotient score of children: A prospective cohort study.

Prenatal Lead (Pb) Exposure and Peripheral Blood DNA Methylation (5mC) and Hydroxymethylation (5hmC) in Mexican Adolescents from the ELEMENT Birth Cohort.

DNA methylation at birth potentially mediates the association between prenatal lead (Pb) exposure and infant neurodevelopmental outcomes.

Prenatal blood levels of some toxic metals and the risk of spontaneous abortion.

Exposure to a mixture of metals and growth indicators in 6-11-year-old children from the 2013-16 NHANES.

Increased intestinal permeability with elevated peripheral blood endotoxin and inflammatory indices for e-waste lead exposure in children.

Global DNA (LINE-1) methylation is associated with lead exposure and certain job tasks performed by electronic waste workers.

Urinary Heavy Metals and Longitudinal Changes in Blood Pressure in Midlife Women: The Study of Women’s Health Across the Nation

Miscellaneous

Mortality temporal trends and cancer incidence profiles of residents in the petrochemical industrially contaminated town of Gela (Sicily, Italy).

Association of Blood Trihalomethane Concentrations with Risk of All-Cause and Cause-Specific Mortality in U.S. Adults: A Prospective Cohort Study.

Laboratory Studies

BPA/Phenols

Perinatal low-dose bisphenol AF exposure impairs synaptic plasticity and cognitive function of adult offspring in a sex-dependent manner.

Modulation of Folliculogenesis in Adult Laying Chickens by Bisphenol A and Bisphenol S: Perspectives on Ovarian Morphology and Gene Expression.

Bisphenol F promotes the secretion of pro-inflammatory cytokines in macrophages by enhanced glycolysis through PI3K-AKT signaling pathway.

Chitosan nanoparticles alleviated endocrine disruption, oxidative damage, and genotoxicity of Bisphenol-A- intoxicated female African catfish.

Cytotoxic and apoptotic data of BPA and BPA alternatives TMBPF, BPAF, and BPS in female adult rat and human stem cells.

Influence of octylphenol on gene expression of gonadotropins and their receptors, testicular structure and mating behavior of male Rana chensinensis.

Phthalates

The possible effects of mono butyl phthalate (MBP) and mono (2-ethylhexyl) phthalate (MEHP) on INS-1 pancreatic beta cells.

Evaluation of sex steroid hormones and reproductive irregularities in diethyl phthalate-exposed premature mice: modulatory effect of raw honey against potential anomalies.

Reproductive toxicity and underlying mechanisms of di(2-ethylhexyl) phthalate in nematode Caenorhabditis elegans.

Consequences of combined exposure to thermal stress and the plasticiser DEHP in Mytilus spp. differ by sex.

Promotion effects of DEHP on hepatocellular carcinoma models: up-regulation of PD-L1 by activating the JAK2/STAT3 pathway.

Parabens/Triclosan/Antimicrobials

Effect of triclosan (TCS) on the protein content and associated histological changes on tilapia, Oreochromis mossambicus (Peters, 1852).

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of curcumin on the bioavailability of dioxin-like pollutants in rats.

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality.

Historical record of polychlorinated biphenyls in a sediment core from Lake Biwa, Japan: Significance of unintentional emission and weathering signals revealed by full congener-specific analysis.

Perfluoroalkyl Substances

Quantitative Chemical Proteomics Reveals Interspecies Variations on Binding Schemes of L-FABP with Perfluorooctanesulfonate.

Developmental effects of PFOS, PFOA and GenX in a 3D human induced pluripotent stem cell differentiation model.

Antagonistic interaction between perfluorobutanesulfonate and probiotic on lipid and glucose metabolisms in the liver of zebrafish.

Flame Retardants

Multiplexed quantitative evaluation on mitochondrial toxicity of tris (2,3-dibromopropyl) phosphate in hepatocyte.

Pesticides

Biochemical and Behavioral Responses in Zebrafish Exposed to Imidacloprid Oxidative Damage and Antioxidant Responses.

Herbicide atrazine exposure induce oxidative stress, immune dysfunction and WSSV proliferation in red swamp crayfish Procambarus clarkii.

Evaluation of Atrazine Neurodevelopment Toxicity in vitro-Application of hESC-based Neural Differentiation Model.

Exposure to the herbicide butachlor activates hepatic stress signals and disturbs lipid metabolism in mice.

Chronic contact with imidacloprid during development may decrease female solitary bee foraging ability and increase male competitive ability for mates.

Pesticide-induced metabolic changes are amplified by food stress.

Glyphosate Interaction with eEF1α1 Indicates Altered Protein Synthesis: Evidence for Reduced Spermatogenesis and Cytostatic Effect.

Potentially Toxic Elements

Effects of arsenic and heavy metals on metabolic pathways in cells of human origin: Similarities and differences.

Reproductive toxicity of cadmium in pubertal male rats induced by cell apoptosis.

Parental exposures increase the vulnerability of copepod offspring to copper and a simulated marine heatwave.

Microplastics

Adsorption of micropollutants onto realistic microplastics: Role of microplastic nature, size, age, and NOM fouling.

Air Pollution

PM_2.5 promotes β cell damage by increasing inflammatory factors in mice with streptozotocin.

Pharmaceuticals/Personal Care Products

Ecotoxicological effects of new generation pollutants (nanoparticles, amoxicillin and white musk) on freshwater and marine phytoplankton species.

Effects of environmental norfloxacin concentrations on the intestinal health and function of juvenile common carp and potential risk to humans.

Mixtures

Quantitative in Vitro-to-in Vivo Extrapolation for Mixtures: A Case Study of Superfund Priority List Pesticides.

Pesticide mixture effects on liver protein abundance in HepaRG cells.

Multigenerational effects of a complex urban contaminant mixture on the behavior of larval and adult fish in multiple fitness contexts.

Developmental exposure to a POPs mixture or PFOS increased body weight and reduced swimming ability but had no effect on reproduction or behavior in zebrafish adults.

Miscellaneous

Sex-reversal and Histopathological Assessment of Potential Endocrine-Disrupting Effects of Graphene Oxide on Japanese medaka (Oryzias latipes) Larvae.

Toxicity and developmental effects of Arctic fuel oil types on early life stages of Atlantic cod (Gadus morhua).

Exposure/Environment Studies

Phthalates

Effect of plastic film mulching and film residues on phthalate esters concentrations in soil and plants, and its risk assessment.

Parabens/Triclosan/Antimicrobials

Development and validation of a new method for determination of methylparaben in Iran market infant formulae by HPLC.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

PCB plasma level in different occupational groups in Iran.

Perfluoroalkyl Substances

Temporal trends, 2000-2017, of perfluoroalkyl acid (PFAA) concentrations in serum of Swedish adolescents.

Distribution, partitioning behavior and potential source of legacy and alternative per- and polyfluoroalkyl substances (PFASs) in water and sediments from a subtropical Gulf, South China sea.

Flame Retardants

Polybrominated diphenyl ethers (PBDEs) in raw milk from different animal species and in infant formula. Occurrence and risk assessment.

Severe contamination and time trends of legacy and novel halogenated flame retardants in multiple environmental media from Lake Shihwa, Korea: Effectiveness of regulatory action.

Pesticides

Neonicotinoid Pesticides Cause Mass Fatalities of Native Bumble Bees: A Case Study From Wilsonville, Oregon, United States.

Simultaneous determination and risk assessment of highly toxic pesticides in the market-sold vegetables and fruits in China: A 4-year investigational study.

Potentially Toxic Elements

Heavy Metals in Indian Traditional Systems of Medicine: A Systematic Scoping Review and Recommendations for Integrative Medicine Practice.

Human biomonitoring of toxic and essential metals in younger elderly, octogenarians, nonagenarians and centenarians: Analysis of the Healthy Ageing and Biomarkers Cohort Study (HABCS) in China.

Microplastics

Microparticles and microplastics released from daily use of plastic feeding and water bottles and plastic injectors: potential risks to infants and children in China.

Microplastics contamination in food and beverages: Direct exposure to humans.

The impacts of weathering on concentration and bioaccessibility of organic pollutants associated with plastic pellets (nurdles) in coastal environments.

Air Pollution

Maternal exposure to polycyclic aromatic hydrocarbons in South Texas, evaluation of silicone wristbands as personal passive samplers.

Pharmaceuticals/Personal Care Products

Pharmaceuticals and other urban contaminants threaten Amazonian freshwater ecosystems.

Environmental contamination by pet pharmaceuticals: A hidden problem.

Occurrence and risk assessment of pharmaceuticals and personal care products (PPCPs) against COVID-19 in lakes and WWTP-river-estuary system in Wuhan, China.

Mixtures/Numerous Chemicals

Mutagenicity, health risk, and disease burden of exposure to organic micropollutants in water from a drinking water treatment plant in the Yangtze River Delta, China.

Endocrine-disrupting chemicals in a typical urbanized bay of Yellow Sea, China: Distribution, risk assessment, and identification of priority pollutants.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
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Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
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Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.