EDC Science Weekly, June 16 – 22, 2021 – HEEDS

EDC Science Weekly, June 16 – 22, 2021

Post author:HEEDS
Post published:June 22, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar series: Current opportunities for better identification of endocrine disrupting chemicals at European Level (HEAL)

June 23 webinar: Let’s Talk About PFAS: The Case of the Missing Contaminants (STEEP SRP)

June 25 webinar: 5 Years After TSCA Reform: Strengthening Health Protection through Science (UCSF PRHE)

June 28 webinar: The Global Glyphosate Study: the most comprehensive study on world’s most-used pesticide ever (HEAL)

June 30 webinar: Suspect Screening and Chemical Exposures in Pregnant Women (EaRTH Center)

June 30 webinar: Per- and Polyfluoroalkyl Substances (PFAS) in Breast Milk: Findings of a New Study and Policies Needed to Protect Future Generations (CHE-Alaska)

July 14: Inaugural PFAS Conference (EWG)

Regulations/Policy

The EU endocrine disruptors’ regulation and the glyphosate controversy.

Methods/Tools/Screening

In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach. [review]

Exposure and Toxicity Characterization of Chemical Emissions and Chemicals in Products: Global Recommendations and Implementation in USEtox.

Reviews

Numerous EDCs

Potential risk of BPA and phthalates in commercial water bottles: a minireview.

Chemical contaminants in Brazilian drinking water: a systematic review.

BPA/Phenols

A comprehensive review on the analytical method, occurrence, transformation and toxicity of a reactive pollutant: BADGE.

Concentrations of bisphenol-A in adults from the general population: A systematic review and meta-analysis.

Effects of bisphenols on Blood-Testis Barrier protein expression in vitro: a systematic review and meta-analysis.

Parabens/Triclosan/Antimicrobials

Toxicity and removal of parabens from water: A critical review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review).

Perfluoroalkyl Substances

A Critical Review on Transplacental Transfer of Per- and Polyfluoroalkyl Substances: Prenatal Exposure Levels, Characteristics, and Mechanisms.

Flame Retardants

Organophosphate (OP) diesters and a review of sources, chemical properties, environmental occurrence, adverse effects, and future directions.

Polybrominated diphenyl ethers in the environmental systems: a review.

Pesticides

Pesticides: formulants, distribution pathways and effects on human health – a review.

Magnitude and determinants of neural tube defect in Africa: a systematic review and meta-analysis.

Reproductive toxicity due to herbicide exposure in freshwater organisms.

Exposure to glyphosate and risk of non-Hodgkin lymphoma: an updated meta-analysis.

Glyphosate: A Review on the Current Environmental Impacts from a Brazilian Perspective.

A global study of pesticides in bees: QuEChERS as a sample preparation methodology for their analysis – Critical review and perspective.

Microplastics/Nanomaterials

Dietary nanoparticles alter the composition and function of the gut microbiota in mice at dose levels relevant for human exposure.

Micro(nano)plastics as an emerging risk factor to the health of amphibian: A scientometric and systematic review.

Miscellaneous

Environmental Risk Factors for Childhood Cancer in an Era of Global Climate Change: A Scoping Review.

Analysis, occurrence, toxicity and environmental health risks of synthetic phenolic antioxidants: A review.

Environmental contamination and public health effects of electronic waste: an overview.

Human Health Studies

Mixtures

Effects of gestational exposures to chemical mixtures on birth weight using Bayesian factor analysis in the Health Outcome and Measures of Environment (HOME) Study.

Perfluoroalkyl Substances

Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands.

Exposure to isomers of per- and polyfluoroalkyl substances increases the risk of diabetes and impairs glucose-homeostasis in Chinese adults: Isomers of C8 health project.

Exposure to Perfluoroalkyl Substances During Pregnancy and Fetal BDNF Level: A Prospective Cohort Study.

Flame Retardants

The association between prenatal concentrations of polybrominated diphenyl ether and child cognitive and psychomotor function.

Pesticides

Associations between pesticide mixtures applied near home during pregnancy and early childhood with adolescent behavioral and emotional problems in the CHAMACOS study.

Residential exposure to carbamate, organophosphate, and pyrethroid insecticides in house dust and risk of childhood acute lymphoblastic leukemia.

Potentially Toxic Elements

Maternal gestational mercury exposure in relation to cord blood T cell alterations and placental gene expression signatures.

Early pregnancy exposure to metal mixture and birth outcomes – A prospective study in Project Viva.

Association of multi-metals exposure with intelligence quotient score of children: A prospective cohort study.

Prenatal Lead (Pb) Exposure and Peripheral Blood DNA Methylation (5mC) and Hydroxymethylation (5hmC) in Mexican Adolescents from the ELEMENT Birth Cohort.

DNA methylation at birth potentially mediates the association between prenatal lead (Pb) exposure and infant neurodevelopmental outcomes.

Prenatal blood levels of some toxic metals and the risk of spontaneous abortion.

Exposure to a mixture of metals and growth indicators in 6-11-year-old children from the 2013-16 NHANES.

Increased intestinal permeability with elevated peripheral blood endotoxin and inflammatory indices for e-waste lead exposure in children.

Global DNA (LINE-1) methylation is associated with lead exposure and certain job tasks performed by electronic waste workers.

Urinary Heavy Metals and Longitudinal Changes in Blood Pressure in Midlife Women: The Study of Women’s Health Across the Nation

Miscellaneous

Mortality temporal trends and cancer incidence profiles of residents in the petrochemical industrially contaminated town of Gela (Sicily, Italy).

Association of Blood Trihalomethane Concentrations with Risk of All-Cause and Cause-Specific Mortality in U.S. Adults: A Prospective Cohort Study.

Laboratory Studies

BPA/Phenols

Perinatal low-dose bisphenol AF exposure impairs synaptic plasticity and cognitive function of adult offspring in a sex-dependent manner.

Modulation of Folliculogenesis in Adult Laying Chickens by Bisphenol A and Bisphenol S: Perspectives on Ovarian Morphology and Gene Expression.

Bisphenol F promotes the secretion of pro-inflammatory cytokines in macrophages by enhanced glycolysis through PI3K-AKT signaling pathway.

Chitosan nanoparticles alleviated endocrine disruption, oxidative damage, and genotoxicity of Bisphenol-A- intoxicated female African catfish.

Cytotoxic and apoptotic data of BPA and BPA alternatives TMBPF, BPAF, and BPS in female adult rat and human stem cells.

Influence of octylphenol on gene expression of gonadotropins and their receptors, testicular structure and mating behavior of male Rana chensinensis.

Phthalates

The possible effects of mono butyl phthalate (MBP) and mono (2-ethylhexyl) phthalate (MEHP) on INS-1 pancreatic beta cells.

Evaluation of sex steroid hormones and reproductive irregularities in diethyl phthalate-exposed premature mice: modulatory effect of raw honey against potential anomalies.

Reproductive toxicity and underlying mechanisms of di(2-ethylhexyl) phthalate in nematode Caenorhabditis elegans.

Consequences of combined exposure to thermal stress and the plasticiser DEHP in Mytilus spp. differ by sex.

Promotion effects of DEHP on hepatocellular carcinoma models: up-regulation of PD-L1 by activating the JAK2/STAT3 pathway.

Parabens/Triclosan/Antimicrobials

Effect of triclosan (TCS) on the protein content and associated histological changes on tilapia, Oreochromis mossambicus (Peters, 1852).

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of curcumin on the bioavailability of dioxin-like pollutants in rats.

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality.

Historical record of polychlorinated biphenyls in a sediment core from Lake Biwa, Japan: Significance of unintentional emission and weathering signals revealed by full congener-specific analysis.

Perfluoroalkyl Substances

Quantitative Chemical Proteomics Reveals Interspecies Variations on Binding Schemes of L-FABP with Perfluorooctanesulfonate.

Developmental effects of PFOS, PFOA and GenX in a 3D human induced pluripotent stem cell differentiation model.

Antagonistic interaction between perfluorobutanesulfonate and probiotic on lipid and glucose metabolisms in the liver of zebrafish.

Flame Retardants

Multiplexed quantitative evaluation on mitochondrial toxicity of tris (2,3-dibromopropyl) phosphate in hepatocyte.

Pesticides

Biochemical and Behavioral Responses in Zebrafish Exposed to Imidacloprid Oxidative Damage and Antioxidant Responses.

Herbicide atrazine exposure induce oxidative stress, immune dysfunction and WSSV proliferation in red swamp crayfish Procambarus clarkii.

Evaluation of Atrazine Neurodevelopment Toxicity in vitro-Application of hESC-based Neural Differentiation Model.

Exposure to the herbicide butachlor activates hepatic stress signals and disturbs lipid metabolism in mice.

Chronic contact with imidacloprid during development may decrease female solitary bee foraging ability and increase male competitive ability for mates.

Pesticide-induced metabolic changes are amplified by food stress.

Glyphosate Interaction with eEF1α1 Indicates Altered Protein Synthesis: Evidence for Reduced Spermatogenesis and Cytostatic Effect.

Potentially Toxic Elements

Effects of arsenic and heavy metals on metabolic pathways in cells of human origin: Similarities and differences.

Reproductive toxicity of cadmium in pubertal male rats induced by cell apoptosis.

Parental exposures increase the vulnerability of copepod offspring to copper and a simulated marine heatwave.

Microplastics

Adsorption of micropollutants onto realistic microplastics: Role of microplastic nature, size, age, and NOM fouling.

Air Pollution

PM_2.5 promotes β cell damage by increasing inflammatory factors in mice with streptozotocin.

Pharmaceuticals/Personal Care Products

Ecotoxicological effects of new generation pollutants (nanoparticles, amoxicillin and white musk) on freshwater and marine phytoplankton species.

Effects of environmental norfloxacin concentrations on the intestinal health and function of juvenile common carp and potential risk to humans.

Mixtures

Quantitative in Vitro-to-in Vivo Extrapolation for Mixtures: A Case Study of Superfund Priority List Pesticides.

Pesticide mixture effects on liver protein abundance in HepaRG cells.

Multigenerational effects of a complex urban contaminant mixture on the behavior of larval and adult fish in multiple fitness contexts.

Developmental exposure to a POPs mixture or PFOS increased body weight and reduced swimming ability but had no effect on reproduction or behavior in zebrafish adults.

Miscellaneous

Sex-reversal and Histopathological Assessment of Potential Endocrine-Disrupting Effects of Graphene Oxide on Japanese medaka (Oryzias latipes) Larvae.

Toxicity and developmental effects of Arctic fuel oil types on early life stages of Atlantic cod (Gadus morhua).

Exposure/Environment Studies

Phthalates

Effect of plastic film mulching and film residues on phthalate esters concentrations in soil and plants, and its risk assessment.

Parabens/Triclosan/Antimicrobials

Development and validation of a new method for determination of methylparaben in Iran market infant formulae by HPLC.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

PCB plasma level in different occupational groups in Iran.

Perfluoroalkyl Substances

Temporal trends, 2000-2017, of perfluoroalkyl acid (PFAA) concentrations in serum of Swedish adolescents.

Distribution, partitioning behavior and potential source of legacy and alternative per- and polyfluoroalkyl substances (PFASs) in water and sediments from a subtropical Gulf, South China sea.

Flame Retardants

Polybrominated diphenyl ethers (PBDEs) in raw milk from different animal species and in infant formula. Occurrence and risk assessment.

Severe contamination and time trends of legacy and novel halogenated flame retardants in multiple environmental media from Lake Shihwa, Korea: Effectiveness of regulatory action.

Pesticides

Neonicotinoid Pesticides Cause Mass Fatalities of Native Bumble Bees: A Case Study From Wilsonville, Oregon, United States.

Simultaneous determination and risk assessment of highly toxic pesticides in the market-sold vegetables and fruits in China: A 4-year investigational study.

Potentially Toxic Elements

Heavy Metals in Indian Traditional Systems of Medicine: A Systematic Scoping Review and Recommendations for Integrative Medicine Practice.

Human biomonitoring of toxic and essential metals in younger elderly, octogenarians, nonagenarians and centenarians: Analysis of the Healthy Ageing and Biomarkers Cohort Study (HABCS) in China.

Microplastics

Microparticles and microplastics released from daily use of plastic feeding and water bottles and plastic injectors: potential risks to infants and children in China.

Microplastics contamination in food and beverages: Direct exposure to humans.

The impacts of weathering on concentration and bioaccessibility of organic pollutants associated with plastic pellets (nurdles) in coastal environments.

Air Pollution

Maternal exposure to polycyclic aromatic hydrocarbons in South Texas, evaluation of silicone wristbands as personal passive samplers.

Pharmaceuticals/Personal Care Products

Pharmaceuticals and other urban contaminants threaten Amazonian freshwater ecosystems.

Environmental contamination by pet pharmaceuticals: A hidden problem.

Occurrence and risk assessment of pharmaceuticals and personal care products (PPCPs) against COVID-19 in lakes and WWTP-river-estuary system in Wuhan, China.

Mixtures/Numerous Chemicals

Mutagenicity, health risk, and disease burden of exposure to organic micropollutants in water from a drinking water treatment plant in the Yangtze River Delta, China.

Endocrine-disrupting chemicals in a typical urbanized bay of Yellow Sea, China: Distribution, risk assessment, and identification of priority pollutants.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.