A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.
Contents: Events, Methods/Tools/Screening, Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies
Events
June 25 webinar: 5 Years After TSCA Reform: Strengthening Health Protection through Science (UCSF PRHE)
June 28 webinar: The Global Glyphosate Study: the most comprehensive study on world’s most-used pesticide ever (HEAL)
June 30 webinar: Suspect Screening and Chemical Exposures in Pregnant Women (EaRTH Center)
July 30: Application deadline for the Lou Guillette Jr. Outstanding Young Investigator Award (HEEDS)
Methods/Tools/Screening
Considerations for using reproduction data in toxicokinetic-toxicodynamic modelling.
New approach methods supporting read-across: Two neurotoxicity AOP-based IATA case studies.
Assessing the chemical-induced estrogenicity using in silico and in vitro methods.
Using Chemical Structure Information to Develop Predictive Models for In Vitro Toxicokinetic Parameters to Inform High-throughput Risk-assessment.
Confounding by Socioeconomic Status in Epidemiological Studies of Air Pollution and Health: Challenges and Opportunities.
Conference Summaries
Advancements of Xenobiotic Toxicity Screening for the Advancement of Human Health. [“The TOXI Chemical Exposures and Impact on Health” session at the 2020 Fall ACS meeting]
Reviews
Numerous EDCs
Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity. [part of the “Key Characteristics” approach]
Ecotoxicological epigenetics in invertebrates: Emerging tool for the evaluation of present and past pollution burden.
Impact of environmental chemicals on craniofacial skeletal development: Insights from investigations using zebrafish embryos.
Potential environmental toxicant exposure, metabolizing gene variants and risk of PCOS-A systematic review. [metals and pesticides]
Phthalates
Substitutes mimic the exposure behaviour of REACH regulated phthalates – A review of the German HBM system on the example of plasticizers.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Effects of Polychlorinated Biphenyls on Animal Reproductive Systems and Epigenetic Modifications.
Perfluoroalkyl Substances
Per- and poly-fluoroalkyl substance remediation from soil and sorbents: A review of adsorption behaviour and ultrasonic treatment.
Pesticides
Ecotoxicology of Glyphosate, Its Formulants, and Environmental Degradation Products.
Potentially Toxic Elements
Toxic metals in East African agro-ecosystems: Key risks for sustainable food production.
Cadmium and cardiovascular disease: An overview of pathophysiology, epidemiology, therapy, and predictive value.
Microplastics
Microplastics as an emerging source of particulate air pollution: A critical review.
Miscellaneous
Large scale meta-analysis of preclinical toxicity data for target characterisation and hypotheses generation.
Human Health Studies
Mixtures
Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery.
Analysis of Polycyclic Aromatic Hydrocarbons and Phthalate Esters in Soil and Food Grains from the Balkan Peninsula: Implication on DNA Adduct Formation by Aristolochic Acid I and Balkan Endemic Nephropathy.
Risk assessment of chemical mixtures by benchmark dose-principle component analysis approach in occupational exposure. [benzene, toluene, xylene, n-hexane]
BPA/Phenols
Urinary bisphenol A in women with polycystic ovary syndrome – a possible suppressive effect on steroidogenesis?
The associations of birth outcome differences in twins with prenatal exposure to bisphenol A and its alternatives.
Phthalates
Maternal phthalate and phthalate alternative metabolites and urinary biomarkers of estrogens and testosterones across pregnancy.
Effects of single and combined gestational phthalate exposure on blood pressure, blood glucose and gestational weight gain: A longitudinal analysis.
Exposure to phthalates and cardiovascular diseases in Chinese with type 2 diabetes.
Exposure to phthalates and environmental phenols in association with chronic kidney disease (CKD) among the general US population participating in multi-cycle NHANES (2005-2016).
Perfluoroalkyl Substances
Serum levels of perfluorooctanoic acid and perfluorooctane sulfonic acid in pregnant women: Maternal predictors and associations with birth outcomes in the PIPA Project.
Pesticides
Gestational exposure to organophosphate pesticides and longitudinally assessed behaviors related to ADHD and executive function.
Potentially Toxic Elements
Early pregnancy essential and non-essential metal mixtures and gestational glucose concentrations in the 2nd trimester: Results from project viva.
Assessment of dust trace elements in an e-waste recycling area and related children’s health risks.
A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children.
Toxic effects of selected trace elements contained in make-ups on female university students in Nigeria.
Air Pollution
Population ageing and deaths attributable to ambient PM 2·5 pollution: a global analysis of economic cost [“Globally, in 2016, PM2.5 was estimated to have caused 8.42 million attributable deaths” … more than COVID-19…]
Differential impacts of particulate air pollution exposure on early and late stages of spermatogenesis.
Laboratory Studies
BPA/Phenols
Subchronic nonylphenol exposure induced anxiety-like behavior and decreased expressions of regulators of synaptic plasticity in rats.
Combined effect of fulvestrant and low dose BPA: comparative implications on EMT, apoptosis, and TGF-β1 signaling in HepG2 cells.
Comparison of the materno-fetal transfer of fifteen structurally related bisphenol analogues using an ex vivo human placental perfusion model.
Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone.
Immunohistochemical expression of aromatase cyp19a1a and cyp19a1b in the ovary and brain of zebrafish (Danio rerio) exposed to different concentrations of bisphenol A.
Bisphenol A affects the pulse rate of Lumbriculus variegatus via an estrogenic mechanism.
Effects of bisphenol A exposure during cardiac cell differentiation.
Phthalates
Determination of modifications in rat liver due to phthalate uptake by SAM, RS, and ICP-OES.
Prenatal and breastfeeding exposure to low dose of diethylhexyl phthalate induces behavioral deficits and exacerbates oxidative stress in rat hippocampus.
Paternal preconception phthalate exposure alters sperm methylome and embryonic programming.
Parabens/Triclosan/Antimicrobials
Exposure to ethylparaben and propylparaben interfere with embryo implantation by compromising endometrial decidualization in early pregnant mice.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice.
Perfluoroalkyl Substances
Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early life allergic asthma.
Chronic Reproductive Toxicity Thresholds for Northern Bobwhite Quail (Colinus virginianus) Exposed to PFHxA and a Mixture of PFOS and PFHxA.
Exploring the integrity of targeted PFASs in extracted wastewater samples during transport and storage stages.
Differential susceptibility of rat primary neurons and neural stem cells to PFOS and PFOA toxicity.
Organotins
Tributyltin and high-refined carbohydrate diet lead to metabolic and reproductive abnormalities, exacerbating premature ovary failure features in the female rats.
Pesticides
Impaired mammalian sperm function and lower phosphorylation signaling caused by the herbicide Roundup® Ultra Plus are due to its surfactant component.
Assessing the ecological risk of pesticides should not ignore the impact of their transformation byproducts – The case of chlorantraniliprole.
Refinement of decision tree to assess the consequences of increased serum ALP in dogs: Additional analysis on toxicity studies of pesticides evaluated recently in Japan.
Guadipyr, a new insecticide, induces microbiota dysbiosis and immune disorders in the midgut of silkworms (Bombyx mori).
Xenopus laevis tadpoles exposed to metamifop: Changes in growth, behavioral endpoints, neurotransmitters, antioxidant system and thyroid development.
Toxic effects of broflanilide exposure on development of zebrafish (Danio rerio) embryos and its potential cardiotoxicity mechanism.
Neurotoxicity associated with chronic exposure to dichlorophenoxyacetic acid (2,4-D) – a simulation of environmental exposure in adult rats.
Potentially Toxic Elements
Potentiating response of D- Ribose-L-Cysteine on Sodium arsenate induced hormonal imbalance, spermatogenesis impairments and histomorphometric alterations in adult male Wistar rat.
Arsenic disrupts neuronal insulin signaling through increasing free PI3K-p85 and decreasing PI3K activity.
Microplastics/Nanoplastics
Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis.
Size-dependent transgenerational toxicity induced by nanoplastics in nematode Caenorhabditis elegans.
Nano-cell and nano-pollutant interactions constitute key elements in nanoparticle-pollutant combined cytotoxicity.
Polystyrene microplastics induce apoptosis via ROS-mediated p53 signaling pathway in zebrafish.
Leachability of microplastic from different plastic materials.
Mixtures
Ecotoxicological risk assessment of metal cocktails based on maximum cumulative ratio during multi-generational exposures.
Exposure/Environment Studies
Phthalates
Determination of Phthalate Esters in Cosmetics and Baby Care Products by a Biosorbent Based on Lawsone Capped Chitosan and Followed by Liquid Chromatography.
Occurrence and migration of phthalates in adhesive materials to fruits and vegetables.
Parabens/Triclosan/Antimicrobials
Urinary parabens and their potential sources of exposure among Korean children and adolescents: Korean National Environmental Health Survey 2015-2017.
Urinary triclosan in south China adults and implications for human exposure.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
First nationwide exposure profile of major persistent organic pollutants among Korean adults and their determinants: Korean National Environmental Health Survey Cycle 3 (2015-2017).
Global status of dioxin emission and China’s role in reducing the emission.
Population-level effects of polychlorinated biphenyl (PCB) exposure on highly vulnerable Indo-Pacific humpback dolphins from their largest habitat.
Perfluoroalkyl Substances
Perfluoroalkyl contaminants in eggs from backyard chickens reared in Italy.
Perfluoroalkylated acids (PFAAs) accumulate in field-exposed snails (Cepaea sp.) and affect their oxidative status.
Legacy and emerging per- and polyfluoroalkyl substances (PFAS) in sediments from the East China Sea and the Yellow Sea: Occurrence, source apportionment and environmental risk assessment.
Toxicity Threshold of Perfluorocarbon Liquids for Intraocular Use: Dose-Response Assessment of In Vitro Cytotoxicity of Possible Contaminants.
Detection of ultrashort-chain and other per- and polyfluoroalkyl substances (PFAS) in U.S. bottled water.
A ‘Concentrate-&-Destroy’ technology for enhanced removal and destruction of per- and polyfluoroalkyl substances in municipal landfill leachate.
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) in groundwater at a reclaimed water recharge facility.
Flame Retardants
Reshaping the active pocket of promiscuous lactonases for degrading bulky organophosphate flame retardants.
Characterizing exposures to flame retardants, dioxins, and furans among firefighters responding to controlled residential fires.
Investigation of novel brominated triazine-based flame retardant (TDBP-TAZTO) and its transformation products emitted from fire-retarded textile manufacturing facility and its downstream sewage treatment plant.
Pesticides
Quantification of Nonpersistent Pesticides in Small Volumes of Human Breast Milk with Ultrahigh Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry.
Pesticides are the dominant stressors for vulnerable insects in lowland streams.
Cumulative risk assessment of dietary exposure to triazole fungicides from 13 daily-consumed foods in China.
What is the deal with the Green Deal: Will the new strategy help to improve European freshwater quality beyond the Water Framework Directive?
Potentially Toxic Elements
Mercury in wild animals and fish and health risk for indigenous Amazonians.
Domestic cats as environmental lead sentinels in low-income populations: a One Health pilot study sampling the fur of animals presented to a high-volume spay/neuter clinic.
Does Arsenic Contamination Affect DNA Methylation Patterns in a Wild Bird Population? An Experimental Approach.
Microplastics
The effect of microplastics on behaviors of chiral imidazolinone herbicides in the aquatic environment: Residue, degradation and distribution.
Biodegradable plastics in the air and soil environment: Low degradation rate and high microplastics formation.
Evaluation of microfiber release from jeans: the impact of different washing conditions.
Mixtures/Numerous Chemicals
Trends in environmental chemical concentrations in the Canadian population: Biomonitoring data from the Canadian Health Measures Survey 2007-2017.
Seasonal variation in oestrogenic potency and biological effects of wastewater treatment works effluents assessed using ERE-GFP transgenic zebrafish embryo-larvae.
Miscellaneous
“Novel” Synthetic Antioxidants in House Dust from Multiple Locations in the Asia-Pacific Region and the United States.
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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.
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