EDC Science Weekly, May 12-18, 2021

Post author:HEEDS
Post published:May 18, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Interesting Article of the Week, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

May 20 Webinar: Putting the EU Chemicals Strategy for Sustainability into action: Responding to hazardous chemicals in plastic FCMs (Food Packaging Forum)

May 21 Virtual Town Hall: How Toxic Chemicals are Causing DIsastrous Consequences for Human Reproduction and Other Species (Center for Environmental Health)

May 24 Webinar: Exploring Critical Windows of Exposure to Heavy Metals in Health Disparity Cohorts (NIEHS)

June 9, Webinar: DDT Exposure in Grandmothers Linked to Obesity, Earlier Periods in Granddaughters: New Meaning of “Persistence” for an Environmental Chemical Banned 50 Years Ago (EDC Strategies Partnership)

June 10 (Register by June 7) Webinar: 25 Years After Our Stolen Future: What Have We Learned About Endocrine Disruption? (Society of Toxicology of Canada and The Intersectoral Centre for Endocrine Disruptor Analysis (ICEDA))

Interesting Article of the Week

Endocrine disrupting chemicals: strategies to protect present and future generations.

Methods/Tools/Screening

Predicting the Mass Spectra of Environmental Pollutants Using Computational Chemistry: A Case Study and Critical Evaluation.

Commentaries

Chemical exposures via personal care products and the disproportionate asthma burden among the US Black population.

The Atrazine Saga and its Importance to the Future of Toxicology, Science, and Environmental and Human Health.

Weathering Plastics as a Planetary Boundary Threat: Exposure, Fate, and Hazards.

The P-Sufficient Approach: A Strategy for Regulating PFAS as a Class. [EHP Science Selection]

Developmental Origins of Delayed Adult Immune Response: The AhR Connection. [EHP Science Selection]

Questions on nanoplastic.

Reviews

BPA/Phthalates

The effects of plasticizers on the ovary.

Bisphenol A as a Factor in the Mosaic of Autoimmunity.

Perfluoroalkyl Substances

Identification and Classification of Commercially Relevant Per- and Poly-fluoroalkyl Substances (PFAS).

Pesticides

Maternal Exposure to Pesticides and Risk of Autism Spectrum Disorders in Offspring: A Meta-analysis.

Pesticides and Parkinson’s disease: Current and future perspective.

A systematic scoping review of the methodological approaches and effects of pesticide exposure on solitary bees.

Potentially Toxic Elements

Adipotropic effects of heavy metals and their potential role in obesity.

Arsenic compounds: The wide application and mechanisms applied in acute promyelocytic leukemia and carcinogenic toxicology.

Microplastics

Ecological risks in a ‘plastic’ world: A threat to biological diversity?

Microplastics (MPs) Act as Sources and Vector of Pollutants-Impact Hazards and Preventive Measures.

Air Pollution

Particulate matter air pollutants and cardiovascular disease: Strategies for intervention.

Environmental perspective of COVID-19: Atmospheric and wastewater environment in relation to pandemic.

Pharmaceuticals/Personal Care Products

Occurrence of major organic UV filters in aquatic environment and their endocrine disruption potentials: A mini-review.

Miscellaneous

Review of the toxic effects of ionic liquids.

Understanding linkages between environmental risk factors and noncommunicable diseases-A review. [climate change]

Human Health Studies

BPA/Phthalates

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort.

Relationship of Urinary Phthalate Metabolites with Cardiometabolic Risk Factors and Oxidative Stress Markers in Children and Adolescents.

Perfluoroalkyl Substances

Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study.

Environmental exposure to perfluoroalkyl substances in early pregnancy, maternal glucose homeostasis and the risk of gestational diabetes: A prospective cohort study.

Exposure to novel and legacy per- and polyfluoroalkyl substances (PFASs) and associations with type 2 diabetes: A case-control study in East China.

Perfluoroalkyl substances and immune cell counts in adults from the Mid-Ohio Valley (USA).

Exposure to legacy and novel perfluoroalkyl substance disturbs the metabolic homeostasis in pregnant women and fetuses: A metabolome-wide association study.

Perfluoroalkyl and polyfluoroalkyl substances and body size and composition trajectories in midlife women: the study of women’s health across the nation 1999-2018.

Pesticides

Pesticide exposure and adverse health effects associated with farmwork in Northern Thailand.

Potentially Toxic Elements

Umbilical Cord Blood Metal Mixtures and Birth Size in Bangladeshi Children.

The effects of the exposure to neurotoxic elements on Italian schoolchildren behavior.

Associations between blood heavy metal(loid)s and serum heme oxygenase-1 in pregnant women: Do their distribution patterns matter?

Effects of soil lead exposure and land use characteristics on neurodevelopment among children under 3 years of age in northern Taiwan.

Biomarkers and Fatty Fish Intake: A Randomized Controlled Trial in Norwegian Preschool Children.

The relationship between chronic arsenic exposure and body measures among US adults: National Health and Nutrition Examination Survey 2009-2016.

Increased expression of apoptotic markers in human full-term placenta after exposure to elevated environmental cadmium levels during pregnancy.

Gestational blood levels of toxic metal and essential element mixtures and associations with global DNA methylation in pregnant women and their infants.

Aortic Elasticity and Arsenic Exposure: A Step Function rather than a Linear Function.

Air Pollution

Effects of short-term personal exposure to air pollution on platelet mitochondrial DNA methylation levels and the potential mitigation by L-arginine supplementation. [intervention study]

Associations between time-weighted personal air pollution exposure and amino acid metabolism in healthy adults. [intervention study]

Short-term effect of air pollution on attention function in adolescents (ATENC!Ó): A randomized controlled trial in high schools in Barcelona, Spain.

Association of PM_2.5 exposure with hospitalization for cardiovascular disease in elderly individuals in Japan.

Indoor pet allergen exposures modify the effects of chemical air pollutants on respiratory symptoms.

Associations Between Wildfire-Related PM_2.5 and Intensive Care Unit Admissions in the United States, 2006-2015.

Health Impact Assessment of the 2020 Washington State Wildfire Smoke Episode: Excess Health Burden Attributable to Increased PM_2.5 Exposures and Potential Exposure Reductions.

Adverse Health Effects in People with and without Pre-Existing Respiratory Conditions During Bushfire Smoke Exposure in the 2019/20 Australian Summer.

A prospective cohort study of ambient air pollution exposure and risk of uterine leiomyomata.

The association between ambient air pollution and birth defects in five major ethnic groups in Liuzhou, China.

PM_2.5 exposure exaggerates the risk of adverse birth outcomes in pregnant women with pre-existing hyperlipidemia: Modulation role of adipokines and lipidome.

Association of NO2 and Other Air Pollution Exposures With the Risk of Parkinson Disease.

Relationships between emissions of toxic airborne molecules and type 1 diabetes incidence in children: An ecologic study.

Clinical outcomes associated with long-term exposure to airborne particulate pollution in kidney transplant recipients.

Air pollution and hospitalization in megacities: empirical evidence from Pakistan.

Premature deaths attributable to long-term exposure to PM_2.5 in Turkey.

Dietary Pattern and Long-Term Effects of Particulate Matter on Blood Pressure: A Large Cross-Sectional Study in Chinese Adults.

Associations of traffic-related air pollution and greenery with academic outcomes among primary schoolchildren.

Association between particulate matter pollution and the incidence of mumps in 31 provinces from China.

Trade-offs between short-term mortality attributable to NO₂ and O₃ changes during the COVID-19 lockdown across major Spanish cities.

Impact of environmental factors and Sahara dust intrusions on incidence and severity of COVID-19 disease in Spain. Effect in the first and second pandemic waves.

Miscellaneous

Evaluation of hydroxylated metabolites of polycyclic aromatic hydrocarbons and biomarkers of early kidney damage in indigenous children from Ticul, Yucatán, Mexico.

Laboratory Studies

BPA/Phenols

Bisphenol A decreases expression of insulin-like factor 3 and induces histopathological changes in testes of rat.

Exploring the toxic interactions between Bisphenol A and glutathione peroxidase 6 from Arabidopsis thaliana.

The effects of in ovo administered bisphenol A on tibial growth plate histology in chicken.

Evidence of increased estrogenicity upon metabolism of Bisphenol F – Elucidation of the key metabolites.

Phthalates

Genomic and Hormonal Biomarkers of Phthalate-Induced Male Rat Reproductive Developmental Toxicity Part II: A Targeted RT-qPCR Array Approach that Defines a Unique Adverse Outcome Pathway.

Perinatal DEHP exposure induces sex- and tissue-specific DNA methylation changes in both juvenile and adult mice.

A mixture of 15 phthalates and pesticides below individual chemical no observed adverse effect levels (NOAELs) produces reproductive tract malformations in the male rat.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2´,3,4,4´,5,5´-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats.

Oleuropein attenuates the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-perturbing effects on pancreatic β-cells.

Perfluoroalkyl Substances

Maternal exposure of mice to sodium p-perfluorous nonenoxybenzene sulfonate causes endocrine disruption in both dams and offspring.

Pesticides

Acute and early life-stage toxicity of atrazine in sheepshead minnow (Cyprinodon variegatus).

Exposure impacts of Imazapyr formulation on larval development and thyroid histology of Xenopus laevis.

Inhibition of human sperm motility and capacitation by ziram is mediated by decreasing tyrosine protein kinase.

Potential Environmental Health Risk Analysis of Neonicotinoids and a Synergist.

Isoflucypram cardiovascular toxicity in zebrafish (Danio rerio).

Differences in kinetic metabolomics in Eisenia fetida under single and dual exposure of imidacloprid and dinotefuran at environmentally relevant concentrations.

Trematodes coupled with neonicotinoids: effects on blood cell profiles of a model amphibian.

Co-expression network of long non-coding RNA and mRNA reveals molecular phenotype changes in kidney development of prenatal chlorpyrifos exposure in a mouse model.

Perinatal exposure to chlorpyrifos and/or a high-fat diet is associated with liver damage in male rat offspring.

Lambda-cyhalothrin and its common metabolite differentially modulate thyroid disruption effects in Chinese lizards (Eremias argus).

The effects of fipronil on emotional and cognitive behaviors in mammals.

Oxidative stress and decreased dopamine levels induced by imidacloprid exposure cause behavioral changes in a neurodevelopmental disorder model in Drosophila melanogaster.

Potentially Toxic Elements

Cadmium disturbs epigenetic modification and induces DNA damage in mouse preimplantation embryos.

Cr (VI) induces abnormalities in glucose and lipid metabolism through ROS/Nrf2 signaling.

Microplastics

Assessment of the effect of long-term exposure to microplastics and depuration period in Sparus aurata Linnaeus, 1758: Liver and blood biomarkers.

Polystyrene microplastics-induced ROS overproduction disrupts the skeletal muscle regeneration by converting myoblasts into adipocytes.

Toxicity mechanisms of polystyrene microplastics in marine mussels revealed by high-coverage quantitative metabolomics using chemical isotope labeling liquid chromatography mass spectrometry.

Nanoplastic-Induced Genotoxicity and Intestinal Damage in Freshwater Benthic Clams (Corbicula fluminea): Comparison with Microplastics.

Air Pollution

Air pollution-induced tanning of human skin.

Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice.

Pharmaceuticals/Personal Care Products

Exposure to sevoflurane results in changes of transcription factor occupancy in sperm and inheritance of autism. [a general anesthetic]

Long-term exposure to environmentally relevant concentrations of ibuprofen and aluminum alters oxidative stress status on Danio rerio.

Tamoxifen treatment in the neonatal period affects glucose homeostasis in adult mice in a sex-dependent manner.

Mixtures

Combined lethal toxicities of pesticides with similar structures to Caenorhabditis elegans are not necessarily concentration additives.

Combined effects of different sizes of ZnO and ZIF-8 nanoparticles co-exposure with Cd²⁺ on HepG2 cells.

Health Effects and Life Stage Sensitivities in Zebrafish Exposed to an Estrogenic Wastewater Treatment Works Effluent.

Miscellaneous

Effect of prenatal exposure to Benzo[a]pyrene on ovarian toxicity and reproductive dysfunction: Protective effect of atorvastatin in the embryonic period.

Exposure/Environment Studies

BPA/Phenols

Pollution characteristics and mixture risk prediction of phenolic environmental estrogens in rivers of the Beijing-Tianjin-Hebei urban agglomeration, China.

Parabens/Triclosan/Antimicrobials

Occurrence of parabens, triclosan and triclocarban in paired human urine and indoor dust from two typical cities in China and its implications for human exposure.

Human exposure and health risk assessment of an increasingly used antibacterial alternative in personal care products: Chloroxylenol.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The state of persistent organic pollutants in South African estuaries: A review of environmental exposure and sources.

Peripubertal serum levels of dioxins, furans and PCBs in a cohort of Russian boys: can empirical grouping methods yield meaningful exposure variables?

Perfluoroalkyl Substances

Per- and Polyfluoroalkyl Substances (PFAS) in Breast Milk: Concerning Trends for Current-Use PFAS. [also see the article in the Guardian on this study]

Environmental Source Tracking of Per- and Polyfluoroalkyl Substances within a Forensic Context: Current and Future Techniques.

Biomarkers of poly- and perfluoroalkyl substances (PFAS) in Sub-Arctic and Arctic communities in Canada.

Method Development and Validation of Per- and Polyfluoroalkyl Substances in Foods from FDA’s Total Diet Study Program.

Source allocation of per- and polyfluoroalkyl substances (PFAS) with supervised machine learning: Classification performance and the role of feature selection in an expanded dataset.

Risk Assessment of Perfluorooctane Sulfonate (PFOS) using Dynamic Age Dependent Physiologically based Pharmacokinetic Model (PBPK) across human lifetime.

Flame Retardants

Spatial pattern analysis reveals multiple sources of organophosphorus flame retardants in coastal waters.

Distribution characteristics and risk assessment of TBBPA in seawater and zooplankton in northern sea areas, China.

Pesticides

Pesticides in a case study on no-tillage farming systems and surrounding forest patches in Brazil.

Reassessment of the experimental skin permeability coefficients of polycyclic aromatic hydrocarbons and organophosphorus pesticides.

Elemental plasma content and urinary excretion in vineyard farmers occupationally exposed to pesticides in southern Brazil.

Pesticides in US Rivers: Regional differences in use, occurrence, and environmental toxicity, 2013 to 2017.

Potentially Toxic Elements

Genome-wide DNA methylation analysis of dogs with high lead exposure living near a lead mining area in Kabwe, Zambia.

Blood lead levels and their associated risk factors in Chinese adults from 1980 to 2018.

Childhood lead exposure of Amerindian communities in French Guiana: an isotopic approach to tracing sources.

Bivalve haemocyte adhesion, aggregation and phagocytosis: a tool to reckon arsenic induced threats to freshwater ecosystem.

Associations between private well water and community water supply arsenic concentrations in the conterminous United States.

Pollution evaluation and children’s multimedia exposure of atmospheric arsenic deposition in the Pearl River Delta, China.

Arsenic bioaccumulation in the soil fauna alters its gut microbiome and microbial arsenic biotransformation capacity.

Interactions between mercury and environmental factors: A chemometric assessment in seafood from an eutrophic estuary in southeastern Brazil.

Mercury in blood, hair, and feces from subsistence fish-eating riverines of the Madeira River Basin (Western Amazon).

Trophic transfer and dietary exposure risk of mercury in aquatic organisms from urbanized coastal ecosystems.

Evaluating source-oriented human health risk of potentially toxic elements: A new exploration of multiple age groups division.

Microplastics

Big eyes can’t see microplastics: Feeding selectivity and eco-morphological adaptations in oral cavity affect microplastic uptake in mud-dwelling amphibious mudskipper fish.

Elevated CYP1A expression detected in pinfish collected from a coastal lagoon in the southern Texas Gulf Coast: indicative of exposure to microplastics or pollutants?

Marine algae facilitate transfer of microplastics and associated pollutants into food webs.

Air Pollution

Environmental impact and human health risks of air pollutants near a large chemical/petrochemical complex: Case study in Tarragona, Spain.

Pharmaceuticals/Personal Care Products

Antibiotic residues in the aquatic environment – current perspective and risk considerations.

Pharmaceutical contaminants in shallow groundwater and their implication to poor sanitation facilities in low-income countries.

Four scenarios of environmental risk of diclofenac in European groundwater ecosystems.

Miscellaneous

ToxChip PCR Arrays for Two Arctic-Breeding Seabirds: Applications for Regional Environmental Assessments.

A critical review on the distribution and ecological risk assessment of steroid hormones in the environment in China.

Pollution level and health risk assessment of polycyclic aromatic hydrocarbons in marine fish from two coastal regions, the South China Sea.

Occurrence, latitudinal gradient and potential sources of perchlorate in the atmosphere across the hemispheres (31°N to 80°S).

Blue justice: A survey for eliciting perceptions of environmental justice among coastal planners’ and small-scale fishers in Northern-Norway.

Health Lens Analysis: A Strategy to Engage Community in Environmental Health Research in Action.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.