EDC Science Weekly, Apr. 28 – May 4, 2021

Post author:HEEDS
Post published:May 4, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events,Interesting Reasarch of the Week, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

May 6 Webinar: The Male Reproductive Health Crisis: Endocrine Disrupting Chemicals and Racial Inequities (The final webinar in the Generation Chemical webinar series)

May 11 Webinar: Suspect Screening, Prioritization, and Confirmation of Environmental Chemicals in Maternal-Newborn Pairs from San Francisco(EDC Strategies Partnership)

Interesting Research of the Week

Elimination of Intravenous Di-2-Ethylhexyl Phthalate Exposure Abrogates Most Neonatal Hypertension in Premature Infants with Bronchopulmonary Dysplasia

Regulations/Policy

How Can the Scope of a New Global Legally Binding Agreement on Plastic Pollution to Facilitate an Efficient Negotiation Be Clearly Defined?

Methods/Tools/Screening

CATMoS: Collaborative Acute Toxicity Modeling Suite.

Risk-Based Chemical Ranking and Generating a Prioritized Human Exposome Database.

The inter-individual variance can provide additional information for the ecotoxicologists beside the mean.

Developing QSAR Models with Defined Applicability Domains on PPARγ Binding Affinity Using Large Data Sets and Machine Learning Algorithms.

Sourcing data on chemical properties and hazard data from the US-EPA CompTox Chemicals Dashboard: A practical guide for human risk assessment.

Commentaries

Air pollution and children’s health: where next?

Control pollution, protect children, save lives.

Reviews

Numerous EDCs

Endocrine Disruption and Reproductive Disorders: Impacts onSexually Dimorphic Neuroendocrine Pathways.

Endocrine Disruptor Compounds-A Cause of Impaired Immune Tolerance Driving Inflammatory Disorders of Pregnancy?

Endocrine-Disrupting Chemicals and Infectious Diseases: From Endocrine Disruption to Immunosuppression.

Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions.

In Vitro and Vivo Identification, Metabolism and Action of Xenoestrogens: An Overview.

Antioxidative Molecules in Human Milk and Environmental Contaminants.

Phthalates

Perinatal Exposure to Phthalates: From Endocrine to Neurodevelopment Effects.

Perfluoroalkyl Substances

Perfluoroalkyl Chemicals and Male Reproductive Health: Do PFOA and PFOS Increase Risk for Male Infertility?

Comparative analysis of the physicochemical, toxicokinetic, and toxicological properties of ether-PFAS.

Flame Retardants

Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease.

Pesticides

Immunotoxicological effects of insecticides in exposed fishes.

Potentially Toxic Elements

Nutrition, One-Carbon Metabolism and Arsenic Methylation.

Essential Concepts for Interpreting the Dose-Response of Low-Level Arsenic Exposure in Epidemiological Studies.

Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic.

Bayesian semiparametric mixed effects models for meta-analysis of the literature data : An application to cadmium toxicity studies.

The Role of Toxic Metals and Metalloids in Nrf2 Signaling

Urine Cadmium as a Risk Factor for Osteoporosis and Osteopenia: A Meta-Analysis.

Microplastics/Nanoplastics/Nanomaterials

Adsorption, uptake and toxicity of micro- and nanoplastics: Effects on terrestrial plants and aquatic macrophytes.

Plastics and the microbiome: impacts and solutions.

Microplastic: A potential threat to human and animal health by interfering with the intestinal barrier function and changing the intestinal microenvironment.

Effects of microplastics on marine copepods.

Nanoplastics are neither microplastics nor engineered nanoparticles.

Placing nanoplastics in the context of global plastic pollution.

Microplastics remediation in aqueous systems: Strategies and technologies.

Are microplastics destabilizing the global network of terrestrial and aquatic ecosystem services?

The nexus of macroplastic and microplastic research and plastic regulation policies in the Philippines marine coastal environments.

Air Pollution

Exposure to air pollution and COVID-19 severity: a review of current insights, management and challenges.

Effect of Air Pollution on Obesity in Children: A Systematic Review and Meta-Analysis.

Associations between ambient air pollutants and blood pressure among children and adolescents: A systemic review and meta-analysis.

Miscellaneous

Epigenetic transgenerational inheritance, Gametogenesis and Germline Development.

Degradations of endocrine-disrupting chemicals and pharmaceutical compounds in wastewater with carbon-based nanomaterials: a critical review.

Suspect and non-target screening: the last frontier in environmental analysis.

NTP Review of Shift Work at Night, Light at Night, and Circadian Disruption

Immuno-Hormonal, Genetic and Metabolic Profiling of Newborns as a Basis for the Life-Long OneHealth Medical Record: A Scoping Review.

Gut Microbiota and Environment in Coronary Artery Disease.

Prenatal and Perinatal Environmental Influences Shaping the Neonatal Immune System: A Focus on Asthma and Allergy Origins.

Cancer Incidence and Mortality among Petroleum Industry Workers and Residents Living in Oil Producing Communities: A Systematic Review and Meta-Analysis

Comparison of Recreational Fish Consumption Advisories Across the USA.

Climate change impacts on pollutants mobilization and interactive effects of climate change and pollutants on toxicity and bioaccumulation of pollutants in estuarine and marine biota and linkage to seafood security.

Human Health Studies

Numerous Chemicals

Xenoestrogen exposure and kidney function in the general population: Results of a community-based study by laboratory tests and questionnaire-based interviewing. [parabens, phthalates, phenols]

Impact of Endocrine-Disrupting Chemicals in Breast Milk on Postpartum Depression in Korean Mothers. [phthalates, BPA, parabens, triclosan]

Mixtures

Survey of psychiatric impairment among residents exposed to environmental pollution from a petrochemical complex.

BPA/Phenols

Prenatal Bisphenol A exposure and early childhood behavior and cognitive function: a Chinese birth cohort study.

Phthalates

Prenatal Phthalates Exposure and Cord Thyroid Hormones: A Birth Cohort Study in Southern Taiwan.

Parabens/Triclosan/Antimicrobials

Prenatal paraben exposure and atopic dermatitis-related outcomes among children.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Nutritional Intervention with Dried Bonito Broth for the Amelioration of Aggressive Behaviors in Children with Prenatal Exposure to Dioxins in Vietnam: A Pilot Study

The Association between Child and Parent Psychiatric Disorders in Families Exposed to Flood and/or Dioxin

Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types.

Perfluoroalkyl Substances

Associations of perfluorooctane sulfonate alternatives and serum lipids in Chinese adults.

Flame Retardants

Pregnancy exposure to organophosphate esters and the risk of attention-deficit hyperactivity disorder in the Norwegian mother, father and child cohort study.

Pesticides

Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study.

Potentially Toxic Elements

Arsenic Exposure, Arsenic Metabolism, and Glycemia: Results from a Clinical Population in New York City.

Cardiometabolic risk factors and mercury content in hair of women from a territory distant from mercury-rich geochemical zones (Cherepovets city, Northwest Russia).

Maternal methylmercury exposure through rice ingestion and child neurodevelopment in the first three years: a prospective cohort study in rural China.

Single and mixed effects of metallic elements in maternal serum during pregnancy on risk for fetal neural tube defects: A Bayesian kernel regression approach.

Blood lead levels in Peruvian adults are associated with proximity to mining and DNA methylation.

Blood lead, nutrient intake, and renal function among type 2 diabetic patients.

Air Pollution

Air pollution and trajectories of adolescent conduct problems: the roles of ethnicity and racism; evidence from the DASH longitudinal study.

The influence of fine particulate matter on the association between residential greenness and ovarian reserve.

Prenatal exposure to residential PM_2.5 and its chemical constituents and weight in preschool children: A longitudinal study from Shanghai, China.

Reduced Ambient PM_2.5 Was Associated with a Decreased Risk of Chronic Kidney Disease: A Longitudinal Cohort Study.

Association of Air Pollution Exposure in Childhood and Adolescence With Psychopathology at the Transition to Adulthood.

Ambient fine particulate matter exposure and incident mild cognitive impairment and dementia.

Associations between air pollution indicators and prevalent and incident diabetes in an African American cohort, the Jackson Heart Study.

Short-term effects of particulate matter on cardiovascular morbidity in Italy: a national analysis.

Effect of ambient fine particulates (PM_2.5) on hospital admissions for respiratory and cardiovascular diseases in Wuhan, China.

Long-term exposure to road traffic noise and incident myocardial infarction: A Danish Nurse Cohort study.

Multiple air pollutant exposure and lung cancer in Tehran, Iran.

Short-Term Associations of Ambient Fine Particulate Matter (PM_2.5) with All-Cause Hospital Admissions and Total Charges in 12 Japanese Cities.

The Association between Preterm Birth and Ambient Air Pollution Exposure in Shiyan, China, 2015-2017

Association between Ambient Air Pollution and MRI-Defined Brain Infarcts in Health Examinations in China

Racial Difference in the Association of Long-Term Exposure to Fine Particulate Matter (PM 2.5) and Cardiovascular Disease Mortality among Renal Transplant Recipients

Association of Air Pollutants with Incident Chronic Kidney Disease in a Nationally Representative Cohort of Korean Adults

The effect of prenatal temperature and PM_2.5 exposure on birthweight: Weekly windows of exposure throughout the pregnancy.

Laboratory Studies

Mixtures

Toxicological Assessment of Oral Co-Exposure to Bisphenol A (BPA) and Bis(2-ethylhexyl) Phthalate (DEHP) in Juvenile Rats at Environmentally Relevant Dose Levels: Evaluation of the Synergic, Additive or Antagonistic Effects.

An Experimental Approach to Study the Effects of Realistic Environmental Mixture of Linuron and Propamocarb on Zebrafish Synaptogenesis.

BPA/Phenols

4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a Major Active Metabolite of Bisphenol A, Triggers Pancreatic β-Cell Death via a JNK/AMPKα Activation-Regulated Endoplasmic Reticulum Stress-Mediated Apoptotic Pathway.

Bisphenol A, Bisphenol F, and Bisphenol S: The Bad and the Ugly. Where Is the Good?

Multigenerational and transgenerational impact of paternal bisphenol A exposure on male fertility in a mouse model.

Ventricular Fibrosis and Coronary Remodeling Following Short-Term Exposure of Healthy and Malnourished Mice to Bisphenol A.

Zebrafish Optomotor Response and Morphology Are Altered by Transient, Developmental Exposure to Bisphenol-A

Bisphenol B stimulates Leydig cell proliferation but inhibits maturation in late pubertal rats.

Comparative Neurodevelopment Effects of Bisphenol A and Bisphenol F on Rat Fetal Neural Stem Cell Models

High-fat diet accelerate hepatic fatty acids synthesis in offspring male rats induced by perinatal exposure to nonylphenol.

Alkyphenol Exposure Alters Steroidogenesis in Male Lizard Podarcis siculus.

Effects of bisphenol A or diethyl phthalate on cartilage development and the swimming behavior of zebrafish (Danio rerio) through maternal exposure.

Phthalates

Transcriptomic responses predict the toxic effect of parental co-exposure to dibutyl phthalate and diisobutyl phthalate on the early development of zebrafish offspring.

Transgenerational Effects of Di(2-Ethylhexyl) Phthalate on Anogenital Distance, Sperm Functions and DNA Methylation in Rat Offspring.

The Production of Testosterone and Gene Expression in Neonatal Testes of Rats Exposed to Diisoheptyl Phthalate During Pregnancy is Inhibited.

Maternal Exposure to Dibutyl Phthalate (DBP) or Diethylstilbestrol (DES) Leads to Long-Term Changes in Hypothalamic Gene Expression and Sexual Behavior.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

EDCs Reorganize Brain-Behavior Phenotypic Relationships in Rats. [PCBs and vinclozolin]

Perfluoroalkyl Substances

N-Acetyl cysteine abates hepatorenal toxicities induced by perfluorooctanoic acid exposure in male rats.

Flame Retardants

Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant.

Organotins

Assessing the Association of Mitochondrial Function and Inflammasome Activation in Murine Macrophages Exposed to Select Mitotoxic Tri-Organotin Compounds.

Pesticides

Subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers.

Transgenerational exposure to warming reduces the sensitivity to a pesticide under warming.

Exposure Impacts of Diquat dibromide herbicide formulation on amphibian larval development.

Physiological effects of the interaction between Nosema ceranae and sequential and overlapping exposure to glyphosate and difenoconazole in the honey bee Apis mellifera.

Impact of Chronic Exposure to Sublethal Doses of Glyphosate on Honey Bee Immunity, Gut Microbiota and Infection by Pathogens.

2,4-DCP compromises the fertilization capacity of mouse oocytes.

Glyphosate Herbicide Induces Changes in the Growth Pattern and Somatic Indices of Crossbred Red Tilapia (O. niloticus × O. mossambicus).

In silico and in vitro assessment of androgen receptor antagonists.

Microplastics/Nanoplastics/Nanomaterials

Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction.

Ingestion and Toxicity of Polystyrene Microplastics in Freshwater Bivalves.

Molecular Impacts of Dietary Exposure to Nanoplastics Combined or Not with Arsenic in the Caribbean Mangrove Oysters (Isognomon alatus).

Microplastics alone or co-exposed with copper induce neurotoxicity and behavioral alterations on zebrafish larvae after a subchronic exposure.

Pharmaceuticals/Personal Care Products

Human-relevant concentrations of the antifungal drug clotrimazole disrupts maternal and fetal steroid hormone profiles in rats.

Miscellaneous

Disturbed phospholipid metabolism by three polycyclic aromatic hydrocarbons in Oryza sativa.

Exposure/Environment Studies

BPA/Phenols

A Review on Current Trends of Polymers in Orthodontics: BPA-Free and Smart Materials.

Dietary Exposures and Intake Doses to Bisphenol A and Triclosan in 188 Duplicate-Single Solid Food Items Consumed by US Adults.

Phthalates

Phthalate Exposures in the Neonatal Intensive Care Unit

Human risk assessment of di-isobutyl phthalate through the application of a developed physiologically based pharmacokinetic model of di-isobutyl phthalate and its major metabolite mono-isobutyl phthalate.

Parabens/Triclosan/Antimicrobials

Next Generation Risk Assessment for Skin Sensitisation: A Case Study with Propyl Paraben.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Burden and Risk of Polychlorinated Naphthalenes in Chinese Human Milk and a Global Comparison of Human Exposure.

Organohalogens: A persisting burden in Slovenia?

Mussels drive polychlorinated biphenyl (PCB) biomagnification in a coastal food web.

Bioaccumulation of legacy organic contaminants in pregnant Indo-Pacific humpback dolphins (Sousa chinensis): Unique features on the transplacental transfer.

Perfluoroalkyl Substances

Prevalence and Predictors of Per- and Polyfluoroalkyl Substances (PFAS) Serum Levels among Members of a Suburban US Volunteer Fire Department.

Towards a Long-Chain Perfluoroalkyl Replacement: Water and Oil Repellent Perfluoropolyether-Based Polyurethane Oligomers

Perfluoroalkyl substances in drinking water sources along the Yangtze River in Jiangsu Province, China: Human health and ecological risk assessment.

Flame Retardants

Polybrominated Diphenyl Ethers and Heavy Metals in a Regulated E-Waste Recycling Site, Eastern China: Implications for Risk Management

Pesticides

Exposure to permethrin used as a home insecticide: A case study comparing model predictions and excretion of metabolites.

Pesticide Exposure of Residents Living Close to Agricultural Fields in the Netherlands: Protocol for an Observational Study.

High-Resolution Metabolomic Assessment of Pesticide Exposure in Central Valley, California.

Cumulative Pesticides Exposure of Children and Their Parents Living near Vineyards by Hair Analysis.

In situ formation of environmental endocrine disruptors from phytosterol degradation: a temporal model for agricultural soils.

Agrochemical occurrence on co-located wildflowers and wild bees collected near beef cattle feed yards and row crops.

Environmental Risk of Pesticides for Fish in Small- and Medium-Sized Streams of Switzerland.

Effects of agricultural stressors on growth and an immune status indicator in wood frog (Lithobates sylvaticus) tadpoles and metamorphs.

Potentially Toxic Elements

Heavy metals drinking water contamination and health risk assessment among primary school children of Pakistan.

Heavy Metals in Acrylic Color Paints Intended for the School Children Use: A Potential Threat to the Children of Early Age

Permafrost Thaw Increases Methylmercury Formation in Subarctic Fennoscandia.

Interannual Variability of Air-Sea Exchange of Mercury in the Global Ocean: The “Seesaw Effect” in the Equatorial Pacific and Contributions to the Atmosphere.

Geolocators link marine mercury with levels in wild seabirds throughout their annual cycle: Consequences for trans-ecosystem biotransport.

Metagenome-Assembled Genome Sequences of Novel Prokaryotic Species from the Mercury-Contaminated East Fork Poplar Creek, Oak Ridge, Tennessee, USA.

Air Pollution

PM_2.5 polluters disproportionately and systemically affect people of color in the United States.

Short-term impacts of air pollutants in three megacities of India during COVID-19 lockdown.

Health, Transport and the Environment: The Impacts of the COVID-19 Lockdown on Air Pollution.

Impact of COVID-19 on PM_2.5 Pollution in Fastest-growing Megacity Dhaka, Bangladesh.

Toxic Organic Contaminants in Airborne Particles: Levels, Potential Sources and Risk Assessment

Pharmaceuticals/Personal Care Products

National-scale down-the-drain environmental risk assessment of oxybenzone in the United States.

Occurrence and Human Health Risk Assessment of Pharmaceuticals and Hormones in Drinking Water Sources in the Metropolitan Area of Turin in Italy

Long-term exposure of marine mussels to paracetamol: is time a healer or a killer?

Mixtures

Using Estrogenic Activity and Nontargeted Chemical Analysis to Identify Contaminants in Sewage Sludge.

A review of combined sewer overflows as a source of wastewater-derived emerging contaminants in the environment and their management.

Miscellaneous

The National Institute of Health and the Italian Poison Centers Network: results of a collaborative study for the surveillance of exposures to chemicals.

Environmental Impact of the Presence, Distribution, and Use of Artificial Sweeteners as Emerging Sources of Pollution.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.