EDC Science Weekly, Apr. 28 – May 4, 2021

Post author:HEEDS
Post published:May 4, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events,Interesting Reasarch of the Week, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

May 6 Webinar: The Male Reproductive Health Crisis: Endocrine Disrupting Chemicals and Racial Inequities (The final webinar in the Generation Chemical webinar series)

May 11 Webinar: Suspect Screening, Prioritization, and Confirmation of Environmental Chemicals in Maternal-Newborn Pairs from San Francisco(EDC Strategies Partnership)

Interesting Research of the Week

Elimination of Intravenous Di-2-Ethylhexyl Phthalate Exposure Abrogates Most Neonatal Hypertension in Premature Infants with Bronchopulmonary Dysplasia

Regulations/Policy

How Can the Scope of a New Global Legally Binding Agreement on Plastic Pollution to Facilitate an Efficient Negotiation Be Clearly Defined?

Methods/Tools/Screening

CATMoS: Collaborative Acute Toxicity Modeling Suite.

Risk-Based Chemical Ranking and Generating a Prioritized Human Exposome Database.

The inter-individual variance can provide additional information for the ecotoxicologists beside the mean.

Developing QSAR Models with Defined Applicability Domains on PPARγ Binding Affinity Using Large Data Sets and Machine Learning Algorithms.

Sourcing data on chemical properties and hazard data from the US-EPA CompTox Chemicals Dashboard: A practical guide for human risk assessment.

Commentaries

Air pollution and children’s health: where next?

Control pollution, protect children, save lives.

Reviews

Numerous EDCs

Endocrine Disruption and Reproductive Disorders: Impacts onSexually Dimorphic Neuroendocrine Pathways.

Endocrine Disruptor Compounds-A Cause of Impaired Immune Tolerance Driving Inflammatory Disorders of Pregnancy?

Endocrine-Disrupting Chemicals and Infectious Diseases: From Endocrine Disruption to Immunosuppression.

Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions.

In Vitro and Vivo Identification, Metabolism and Action of Xenoestrogens: An Overview.

Antioxidative Molecules in Human Milk and Environmental Contaminants.

Phthalates

Perinatal Exposure to Phthalates: From Endocrine to Neurodevelopment Effects.

Perfluoroalkyl Substances

Perfluoroalkyl Chemicals and Male Reproductive Health: Do PFOA and PFOS Increase Risk for Male Infertility?

Comparative analysis of the physicochemical, toxicokinetic, and toxicological properties of ether-PFAS.

Flame Retardants

Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease.

Pesticides

Immunotoxicological effects of insecticides in exposed fishes.

Potentially Toxic Elements

Nutrition, One-Carbon Metabolism and Arsenic Methylation.

Essential Concepts for Interpreting the Dose-Response of Low-Level Arsenic Exposure in Epidemiological Studies.

Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic.

Bayesian semiparametric mixed effects models for meta-analysis of the literature data : An application to cadmium toxicity studies.

The Role of Toxic Metals and Metalloids in Nrf2 Signaling

Urine Cadmium as a Risk Factor for Osteoporosis and Osteopenia: A Meta-Analysis.

Microplastics/Nanoplastics/Nanomaterials

Adsorption, uptake and toxicity of micro- and nanoplastics: Effects on terrestrial plants and aquatic macrophytes.

Plastics and the microbiome: impacts and solutions.

Microplastic: A potential threat to human and animal health by interfering with the intestinal barrier function and changing the intestinal microenvironment.

Effects of microplastics on marine copepods.

Nanoplastics are neither microplastics nor engineered nanoparticles.

Placing nanoplastics in the context of global plastic pollution.

Microplastics remediation in aqueous systems: Strategies and technologies.

Are microplastics destabilizing the global network of terrestrial and aquatic ecosystem services?

The nexus of macroplastic and microplastic research and plastic regulation policies in the Philippines marine coastal environments.

Air Pollution

Exposure to air pollution and COVID-19 severity: a review of current insights, management and challenges.

Effect of Air Pollution on Obesity in Children: A Systematic Review and Meta-Analysis.

Associations between ambient air pollutants and blood pressure among children and adolescents: A systemic review and meta-analysis.

Miscellaneous

Epigenetic transgenerational inheritance, Gametogenesis and Germline Development.

Degradations of endocrine-disrupting chemicals and pharmaceutical compounds in wastewater with carbon-based nanomaterials: a critical review.

Suspect and non-target screening: the last frontier in environmental analysis.

NTP Review of Shift Work at Night, Light at Night, and Circadian Disruption

Immuno-Hormonal, Genetic and Metabolic Profiling of Newborns as a Basis for the Life-Long OneHealth Medical Record: A Scoping Review.

Gut Microbiota and Environment in Coronary Artery Disease.

Prenatal and Perinatal Environmental Influences Shaping the Neonatal Immune System: A Focus on Asthma and Allergy Origins.

Cancer Incidence and Mortality among Petroleum Industry Workers and Residents Living in Oil Producing Communities: A Systematic Review and Meta-Analysis

Comparison of Recreational Fish Consumption Advisories Across the USA.

Climate change impacts on pollutants mobilization and interactive effects of climate change and pollutants on toxicity and bioaccumulation of pollutants in estuarine and marine biota and linkage to seafood security.

Human Health Studies

Numerous Chemicals

Xenoestrogen exposure and kidney function in the general population: Results of a community-based study by laboratory tests and questionnaire-based interviewing. [parabens, phthalates, phenols]

Impact of Endocrine-Disrupting Chemicals in Breast Milk on Postpartum Depression in Korean Mothers. [phthalates, BPA, parabens, triclosan]

Mixtures

Survey of psychiatric impairment among residents exposed to environmental pollution from a petrochemical complex.

BPA/Phenols

Prenatal Bisphenol A exposure and early childhood behavior and cognitive function: a Chinese birth cohort study.

Phthalates

Prenatal Phthalates Exposure and Cord Thyroid Hormones: A Birth Cohort Study in Southern Taiwan.

Parabens/Triclosan/Antimicrobials

Prenatal paraben exposure and atopic dermatitis-related outcomes among children.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Nutritional Intervention with Dried Bonito Broth for the Amelioration of Aggressive Behaviors in Children with Prenatal Exposure to Dioxins in Vietnam: A Pilot Study

The Association between Child and Parent Psychiatric Disorders in Families Exposed to Flood and/or Dioxin

Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types.

Perfluoroalkyl Substances

Associations of perfluorooctane sulfonate alternatives and serum lipids in Chinese adults.

Flame Retardants

Pregnancy exposure to organophosphate esters and the risk of attention-deficit hyperactivity disorder in the Norwegian mother, father and child cohort study.

Pesticides

Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study.

Potentially Toxic Elements

Arsenic Exposure, Arsenic Metabolism, and Glycemia: Results from a Clinical Population in New York City.

Cardiometabolic risk factors and mercury content in hair of women from a territory distant from mercury-rich geochemical zones (Cherepovets city, Northwest Russia).

Maternal methylmercury exposure through rice ingestion and child neurodevelopment in the first three years: a prospective cohort study in rural China.

Single and mixed effects of metallic elements in maternal serum during pregnancy on risk for fetal neural tube defects: A Bayesian kernel regression approach.

Blood lead levels in Peruvian adults are associated with proximity to mining and DNA methylation.

Blood lead, nutrient intake, and renal function among type 2 diabetic patients.

Air Pollution

Air pollution and trajectories of adolescent conduct problems: the roles of ethnicity and racism; evidence from the DASH longitudinal study.

The influence of fine particulate matter on the association between residential greenness and ovarian reserve.

Prenatal exposure to residential PM_2.5 and its chemical constituents and weight in preschool children: A longitudinal study from Shanghai, China.

Reduced Ambient PM_2.5 Was Associated with a Decreased Risk of Chronic Kidney Disease: A Longitudinal Cohort Study.

Association of Air Pollution Exposure in Childhood and Adolescence With Psychopathology at the Transition to Adulthood.

Ambient fine particulate matter exposure and incident mild cognitive impairment and dementia.

Associations between air pollution indicators and prevalent and incident diabetes in an African American cohort, the Jackson Heart Study.

Short-term effects of particulate matter on cardiovascular morbidity in Italy: a national analysis.

Effect of ambient fine particulates (PM_2.5) on hospital admissions for respiratory and cardiovascular diseases in Wuhan, China.

Long-term exposure to road traffic noise and incident myocardial infarction: A Danish Nurse Cohort study.

Multiple air pollutant exposure and lung cancer in Tehran, Iran.

Short-Term Associations of Ambient Fine Particulate Matter (PM_2.5) with All-Cause Hospital Admissions and Total Charges in 12 Japanese Cities.

The Association between Preterm Birth and Ambient Air Pollution Exposure in Shiyan, China, 2015-2017

Association between Ambient Air Pollution and MRI-Defined Brain Infarcts in Health Examinations in China

Racial Difference in the Association of Long-Term Exposure to Fine Particulate Matter (PM 2.5) and Cardiovascular Disease Mortality among Renal Transplant Recipients

Association of Air Pollutants with Incident Chronic Kidney Disease in a Nationally Representative Cohort of Korean Adults

The effect of prenatal temperature and PM_2.5 exposure on birthweight: Weekly windows of exposure throughout the pregnancy.

Laboratory Studies

Mixtures

Toxicological Assessment of Oral Co-Exposure to Bisphenol A (BPA) and Bis(2-ethylhexyl) Phthalate (DEHP) in Juvenile Rats at Environmentally Relevant Dose Levels: Evaluation of the Synergic, Additive or Antagonistic Effects.

An Experimental Approach to Study the Effects of Realistic Environmental Mixture of Linuron and Propamocarb on Zebrafish Synaptogenesis.

BPA/Phenols

4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a Major Active Metabolite of Bisphenol A, Triggers Pancreatic β-Cell Death via a JNK/AMPKα Activation-Regulated Endoplasmic Reticulum Stress-Mediated Apoptotic Pathway.

Bisphenol A, Bisphenol F, and Bisphenol S: The Bad and the Ugly. Where Is the Good?

Multigenerational and transgenerational impact of paternal bisphenol A exposure on male fertility in a mouse model.

Ventricular Fibrosis and Coronary Remodeling Following Short-Term Exposure of Healthy and Malnourished Mice to Bisphenol A.

Zebrafish Optomotor Response and Morphology Are Altered by Transient, Developmental Exposure to Bisphenol-A

Bisphenol B stimulates Leydig cell proliferation but inhibits maturation in late pubertal rats.

Comparative Neurodevelopment Effects of Bisphenol A and Bisphenol F on Rat Fetal Neural Stem Cell Models

High-fat diet accelerate hepatic fatty acids synthesis in offspring male rats induced by perinatal exposure to nonylphenol.

Alkyphenol Exposure Alters Steroidogenesis in Male Lizard Podarcis siculus.

Effects of bisphenol A or diethyl phthalate on cartilage development and the swimming behavior of zebrafish (Danio rerio) through maternal exposure.

Phthalates

Transcriptomic responses predict the toxic effect of parental co-exposure to dibutyl phthalate and diisobutyl phthalate on the early development of zebrafish offspring.

Transgenerational Effects of Di(2-Ethylhexyl) Phthalate on Anogenital Distance, Sperm Functions and DNA Methylation in Rat Offspring.

The Production of Testosterone and Gene Expression in Neonatal Testes of Rats Exposed to Diisoheptyl Phthalate During Pregnancy is Inhibited.

Maternal Exposure to Dibutyl Phthalate (DBP) or Diethylstilbestrol (DES) Leads to Long-Term Changes in Hypothalamic Gene Expression and Sexual Behavior.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

EDCs Reorganize Brain-Behavior Phenotypic Relationships in Rats. [PCBs and vinclozolin]

Perfluoroalkyl Substances

N-Acetyl cysteine abates hepatorenal toxicities induced by perfluorooctanoic acid exposure in male rats.

Flame Retardants

Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant.

Organotins

Assessing the Association of Mitochondrial Function and Inflammasome Activation in Murine Macrophages Exposed to Select Mitotoxic Tri-Organotin Compounds.

Pesticides

Subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers.

Transgenerational exposure to warming reduces the sensitivity to a pesticide under warming.

Exposure Impacts of Diquat dibromide herbicide formulation on amphibian larval development.

Physiological effects of the interaction between Nosema ceranae and sequential and overlapping exposure to glyphosate and difenoconazole in the honey bee Apis mellifera.

Impact of Chronic Exposure to Sublethal Doses of Glyphosate on Honey Bee Immunity, Gut Microbiota and Infection by Pathogens.

2,4-DCP compromises the fertilization capacity of mouse oocytes.

Glyphosate Herbicide Induces Changes in the Growth Pattern and Somatic Indices of Crossbred Red Tilapia (O. niloticus × O. mossambicus).

In silico and in vitro assessment of androgen receptor antagonists.

Microplastics/Nanoplastics/Nanomaterials

Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction.

Ingestion and Toxicity of Polystyrene Microplastics in Freshwater Bivalves.

Molecular Impacts of Dietary Exposure to Nanoplastics Combined or Not with Arsenic in the Caribbean Mangrove Oysters (Isognomon alatus).

Microplastics alone or co-exposed with copper induce neurotoxicity and behavioral alterations on zebrafish larvae after a subchronic exposure.

Pharmaceuticals/Personal Care Products

Human-relevant concentrations of the antifungal drug clotrimazole disrupts maternal and fetal steroid hormone profiles in rats.

Miscellaneous

Disturbed phospholipid metabolism by three polycyclic aromatic hydrocarbons in Oryza sativa.

Exposure/Environment Studies

BPA/Phenols

A Review on Current Trends of Polymers in Orthodontics: BPA-Free and Smart Materials.

Dietary Exposures and Intake Doses to Bisphenol A and Triclosan in 188 Duplicate-Single Solid Food Items Consumed by US Adults.

Phthalates

Phthalate Exposures in the Neonatal Intensive Care Unit

Human risk assessment of di-isobutyl phthalate through the application of a developed physiologically based pharmacokinetic model of di-isobutyl phthalate and its major metabolite mono-isobutyl phthalate.

Parabens/Triclosan/Antimicrobials

Next Generation Risk Assessment for Skin Sensitisation: A Case Study with Propyl Paraben.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Burden and Risk of Polychlorinated Naphthalenes in Chinese Human Milk and a Global Comparison of Human Exposure.

Organohalogens: A persisting burden in Slovenia?

Mussels drive polychlorinated biphenyl (PCB) biomagnification in a coastal food web.

Bioaccumulation of legacy organic contaminants in pregnant Indo-Pacific humpback dolphins (Sousa chinensis): Unique features on the transplacental transfer.

Perfluoroalkyl Substances

Prevalence and Predictors of Per- and Polyfluoroalkyl Substances (PFAS) Serum Levels among Members of a Suburban US Volunteer Fire Department.

Towards a Long-Chain Perfluoroalkyl Replacement: Water and Oil Repellent Perfluoropolyether-Based Polyurethane Oligomers

Perfluoroalkyl substances in drinking water sources along the Yangtze River in Jiangsu Province, China: Human health and ecological risk assessment.

Flame Retardants

Polybrominated Diphenyl Ethers and Heavy Metals in a Regulated E-Waste Recycling Site, Eastern China: Implications for Risk Management

Pesticides

Exposure to permethrin used as a home insecticide: A case study comparing model predictions and excretion of metabolites.

Pesticide Exposure of Residents Living Close to Agricultural Fields in the Netherlands: Protocol for an Observational Study.

High-Resolution Metabolomic Assessment of Pesticide Exposure in Central Valley, California.

Cumulative Pesticides Exposure of Children and Their Parents Living near Vineyards by Hair Analysis.

In situ formation of environmental endocrine disruptors from phytosterol degradation: a temporal model for agricultural soils.

Agrochemical occurrence on co-located wildflowers and wild bees collected near beef cattle feed yards and row crops.

Environmental Risk of Pesticides for Fish in Small- and Medium-Sized Streams of Switzerland.

Effects of agricultural stressors on growth and an immune status indicator in wood frog (Lithobates sylvaticus) tadpoles and metamorphs.

Potentially Toxic Elements

Heavy metals drinking water contamination and health risk assessment among primary school children of Pakistan.

Heavy Metals in Acrylic Color Paints Intended for the School Children Use: A Potential Threat to the Children of Early Age

Permafrost Thaw Increases Methylmercury Formation in Subarctic Fennoscandia.

Interannual Variability of Air-Sea Exchange of Mercury in the Global Ocean: The “Seesaw Effect” in the Equatorial Pacific and Contributions to the Atmosphere.

Geolocators link marine mercury with levels in wild seabirds throughout their annual cycle: Consequences for trans-ecosystem biotransport.

Metagenome-Assembled Genome Sequences of Novel Prokaryotic Species from the Mercury-Contaminated East Fork Poplar Creek, Oak Ridge, Tennessee, USA.

Air Pollution

PM_2.5 polluters disproportionately and systemically affect people of color in the United States.

Short-term impacts of air pollutants in three megacities of India during COVID-19 lockdown.

Health, Transport and the Environment: The Impacts of the COVID-19 Lockdown on Air Pollution.

Impact of COVID-19 on PM_2.5 Pollution in Fastest-growing Megacity Dhaka, Bangladesh.

Toxic Organic Contaminants in Airborne Particles: Levels, Potential Sources and Risk Assessment

Pharmaceuticals/Personal Care Products

National-scale down-the-drain environmental risk assessment of oxybenzone in the United States.

Occurrence and Human Health Risk Assessment of Pharmaceuticals and Hormones in Drinking Water Sources in the Metropolitan Area of Turin in Italy

Long-term exposure of marine mussels to paracetamol: is time a healer or a killer?

Mixtures

Using Estrogenic Activity and Nontargeted Chemical Analysis to Identify Contaminants in Sewage Sludge.

A review of combined sewer overflows as a source of wastewater-derived emerging contaminants in the environment and their management.

Miscellaneous

The National Institute of Health and the Italian Poison Centers Network: results of a collaborative study for the surveillance of exposures to chemicals.

Environmental Impact of the Presence, Distribution, and Use of Artificial Sweeteners as Emerging Sources of Pollution.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

If you enjoy this newsletter, please feel free to donate here! Thank you!

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.