EDC Science Weekly, Apr. 21 – 27, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events,Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

April 28 Webinar: Protecting Your Child’s Health with Dr. Ruth Etzel (CHE-Alaska)

Apr. 28 Webinar: 5th Annual Mind the Store Retailer Report Card (Mind the Store and Toxic Free Future)

May 6 Webinar: The Male Reproductive Health Crisis: Endocrine Disrupting Chemicals and Racial Inequities (The final webinar in the Generation Chemical webinar series)

May 11 Webinar: Suspect Screening, Prioritization, and Confirmation of Environmental Chemicals in Maternal-Newborn Pairs from San Francisco(EDC Strategies Partnership)

May 30: Applications due for The Science Communication Fellowship Program for early career scientists (Science Communication Network)

Regulations/Policy

Assessment of the endocrine disrupting properties of bisphenol AF: a case study applying the European regulatory criteria and guidance.

Association of temporary Environmental Protection Agency regulation suspension with industrial economic viability and local air quality in California, United States. [written mainly by high school students!]

Methods/Tools/Screening

New tool available: PFAS-Tox Database

Bioactivity Profiling of Per- and Polyfluoroalkyl Substances (PFAS) Identifies Potential Toxicity Pathways Related to Molecular Structure.

Characterisation and validation of an in vitro transactivation assay based on the 22Rv1/MMTV_GR-KO cell line to detect human androgen receptor agonists and antagonists.

Identification of non-validated endocrine disrupting chemical characterization methods by screening of the literature using artificial intelligence and by database exploration.

Commentaries/Conference Summaries

Role of glyphosate in the emergence of antimicrobial resistance in bacteria?

Virtual Issue in Memoriam of Dr. Alan Poland (1940-2020) in Chem Res Toxicol

Reviews

Numerous EDCs

Dysregulation of autophagy acts as a pathogenic mechanism of non-alcoholic fatty liver disease (NAFLD) induced by common environmental pollutants.

Mixtures

Combined toxicity of endocrine-disrupting chemicals: A review

BPA/Phthalates

Bisphenol A and its effects on the systemic organs of children.

Ovarian Toxicity and Epigenetic Mechanisms of Phthalates and Their Metabolites.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Pesticide exposure and gender discrepancy in breast cancer.

Perfluoroalkyl Substances

Review on plant uptake of PFOS and PFOA for environmental cleanup: potential and implications.

Organotins

Toxicity of organotin compounds and the ecological risk of organic tin with co-existing contaminants in aquatic organisms.

Pesticides

Glyphosate: Uses Other Than in Glyphosate-Resistant Crops, Mode of Action, Degradation in Plants, and Effects on Non-target Plants and Agricultural Microbes.

Potentially Toxic Elements

The global research trend on cadmium in freshwater: a bibliometric review.

Arsenic methylation – Lessons from three decades of research.

Microplastics

Micro/nanoplastic mediated pathophysiological changes in rodents, rabbits, and chicken.

Microplastics in polar regions: An early warning to the world’s pristine ecosystem.

Air Pollution

Particulate Matter-Induced Cardiovascular Dysfunction: A Mechanistic Insight.

Air pollution and DNA methylation in adults: A systematic review and meta-analysis of observational studies.

Miscellaneous

Role of model organisms and nanocompounds in human health risk assessment.

Human Health Studies

BPA/Phenols/Phthalates

Associations of urinary bisphenol A and its alternatives bisphenol S and F concentrations with depressive symptoms among adults.

Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico.

Association between follicular fluid phthalate concentrations and extracellular vesicle microRNAs expression.

Perfluoroalkyl Substances

Gestational exposure to perfluoroalkyl substances and congenital heart defects: A nested case-control pilot study.

Life-course exposure to perfluoroalkyl substances in relation to markers of glucose homeostasis in early adulthood.

Pesticides

Occupational exposure to pesticides and central nervous system tumors: results from the CERENAT case-control study.

Pesticides expenditures by farming type and incidence of Parkinson disease in farmers: a French nationwide study.

Occupational use of agrochemicals results in inhibited cholinesterase activity and altered reproductive hormone levels in male farmers from Buea, Cameroon.

Potentially Toxic Elements

Association between urinary arsenic, blood cadmium, blood lead, and blood mercury levels and serum prostate-specific antigen in a population-based cohort of men in the United States.

Exposure to heavy metals and trace minerals in first trimester and maternal blood pressure change over gestation.

Air Pollution

Association between long-term exposure to fine particulate matter and diabetic retinopathy among diabetic patients: A national cross-sectional study in China.

Threshold effects of COVID-19-confirmed cases on change in pollutants changes: evidence from the Chinese top ten cities.

Fine particulate matter and body weight status among older adults in China: Impacts and pathways.

Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women’s Health Initiative and Atherosclerosis Risk in Communities Study.

Adverse effects of short-term personal exposure to fine particulate matter on the lung function of patients with chronic obstructive pulmonary disease and asthma: a longitudinal panel study in Beijing, China.

Long-term PM_2.5 exposure and survival among cardiovascular disease patients in Beijing, China.

Breast cancer incidence and the air pollution level in the communes of Chile: an ecological study.

Miscellaneous

Regional and ethnic differences in semen quality and reproductive hormones in Russia: a Siberian population-based cohort study of young men.

Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl accident.

Laboratory Studies

BPA/Phenols

Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus.

Maternal exposure to low doses of bisphenol A affects learning and memory in male rat offspring with abnormal N-methyl-d-aspartate receptors in the hippocampus.

Protective effects of selenium on Bisphenol A-induced oxidative stress in mouse testicular mitochondria and sperm motility.

Consequences of the exposure to bisphenol A in cell membrane models at the molecular level and hamster ovary cells viability.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Transgenerational epigenetic and transcriptomic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rat.

Perfluoroalkyl Substances

Interference of C6O4 on platelet aggregation pathways: Cues on the new-generation of perfluoro-alkyl substance.

Flame Retardants

Low concentration Tetrabromobisphenol A (TBBPA) elevating overall metabolism by inducing activation of the Ras signaling pathway.

Sublethal effects of DBE-DBCH diastereomers on physiology, behavior, and gene expression of Daphnia magna.

Phenotypically Anchored mRNA and miRNA Expression Profiling in Zebrafish Reveals Flame Retardant Chemical Toxicity Networks.

Organotins

Global Neurotoxicity: Quantitative Analysis of Rat Brain Toxicity Following Exposure to Trimethyltin.

Pesticides

The sublethal effects of neonicotinoids on spiders are independent of their nutritional status.

Investigating Acute and Subchronic Effects of Neonicotinoids on Northwestern Salamander Larvae.

A Method to Screen for Consistency of Effect in Laboratory Toxicity Tests: A Case Study with Anurans and the Herbicide Atrazine.

Effects of Chlorpyrifos on Serine Hydrolase Activities, Lipid Mediators, and Immune Responses in Lungs of Neonatal and Adult Mice.

Potentially Toxic Elements

Risk of neurodegenerative disease due to tau phosphorylation changes and arsenic exposure via drinking water.

Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARγ pathway against oxidative injury in mice hippocampus.

Antibiotic perturbation of the murine gut microbiome introduces inter-individual susceptibility to arsenic.

Microplastics/Nanomaterials

Perinatal exposure to silver nanoparticles reprograms immunometabolism and promotes pancreatic beta-cell death and kidney damage in mice.

Adverse biological effects of ingested polystyrene microplastics using Drosophila melanogaster as a model in vivo organism.

Reactive oxygen species: the root cause of nanoparticle-induced toxicity in Drosophila melanogaster.

Impacts to Larval Fathead Minnows Vary between Preconsumer and Environmental Microplastics.

Polystyrene microplastics induce blood-testis barrier disruption regulated by the MAPK-Nrf2 signaling pathway in rats.

Air Pollution

Effect of sulfur dioxide exposure on histopathology and morphometry of pancreatic islet cells and glycemic indices in Wistar rats.

The impact of chronic exposure to air pollution over oxidative stress parameters and brain histology.

Pharmaceuticals/Personal Care Products

Potentiation of lethal and sub-lethal effects of benzophenone and oxybenzone by UV light in zebrafish embryos.

Mixtures

Exposure to Landfill Leachates Affects the Embryonic Development of Zebrafish, Danio rerio: A Case Study in Yucatan, Mexico.

Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?

Miscellaneous

Dietary Exposure to Low Levels of Crude Oil Affects Physiological and Morphological Phenotype in Adults and Their Eggs and Hatchlings of the King Quail (Coturnix chinensis).

Exposure/Environment Studies

BPA/Phenols

Bioaccumulation of phenolic endocrine disruptors in the clam Rangia cuneata: storage in shells and influence of size and sex.

Urinary bisphenol A and its alternatives among pregnant women: Predictors and risk assessment.

Bisphenol A as degradation product of monomers used in resin-based dental materials.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Identification of Environmental Liquid-Crystal Monomers: A Class of New Persistent Organic Pollutants-Fluorinated Biphenyls and Analogues-Emitted from E-Waste Dismantling.

Temporal-spatial survey of PAHs and PCBs in the Atlantic Iberian northwest coastline, and evaluation of their sources and risks for both humans and aquatic organisms.

Using Polychlorinated Naphthalene Concentrations in the Soil from a Southeast China E-Waste Recycling Area in a Novel Screening-Level Multipathway Human Cancer Risk Assessment.

Perfluoroalkyl Substances

Perfluorooctane sulfonate decreases the performance of a sequencing batch reactor system and changes the sludge microbial community.

The effectiveness of PFAS management options on groundwater quality in contaminated land using numerical modelling.

Atmospheric Fate of a New Polyfluoroalkyl Building Block, C₃F₇OCHFCF₂SCH₂CH₂OH.

Occurrence of per- and polyfluoroalkyl substances (PFASs) in wastewater of major cities across China in 2014 and 2016.

Diffusion of perfluoroalkyl acids through clay-rich soil.

Flame Retardants

Ecotoxico Linking of Phthalates and Flame-Retardant Combustion Byproducts with Coral Solar Bleaching.

Establishment of a Target, Suspect, and Functional Group-Dependent Screening Strategy for Organophosphate Esters (OPEs): “Into the Unknown” of OPEs in the Sediment of Taihu Lake, China.

Organophosphorus flame retardants (OPFRs) in the seawater and sediments of the Qinzhou Bay, Northern Beibu Gulf: Occurrence, distribution, and ecological risks.

Pesticides

Sediment archives reveal irreversible shifts in plankton communities after World War II and agricultural pollution.

First application of an Integrated Biological Response index to assess the ecotoxicological status of honeybees from rural and urban areas.

The use of the Hazard Quotient approach to assess the potential risk to honeybees (Apis mellifera) posed by pesticide residues detected in bee-relevant matrices is not appropriate.

Potentially Toxic Elements

Occurrence of Lead and Other Toxic Metals Derived from Drinking-Water Systems in Three West African Countries.

Fish, rice, and human hair mercury concentrations and health risks in typical Hg-contaminated areas and fish-rich areas, China.

Analysis of the Mercury Distribution in Blood as a Potential Tool for Exposure Assessment – Results from Two Artisanal and Small-Scale Gold Mining Areas in Zimbabwe.

Bioaccumulation of mercury and transcriptional responses in tusk (Brosme brosme), a deep-water fish from a Norwegian fjord.

Vitamin-mineral supplements do not guarantee the minimum recommendations and may imply risks of mercury poisoning in dogs and cats.

Variation of Total Mercury Concentrations in Different Tissues of Three Neotropical Caimans: Implications for Minimally Invasive Biomonitoring.

Microplastics

Ingestion of synthetic particles by fin whales feeding off western Iceland in summer.

High frequency of micro- and meso-plastics ingestion in a sample of neonate sea turtles from a major rookery.

Air Pollution

Dual effects of environmental regulation on PM_2.5 pollution: evidence from 280 cities in China.

Miscellaneous

Source, Characterization of Indoor Dust PAHs and the Health Risk on Chinese Children.

Double-endpoint Genotoxicity Quantification and PAHs Characterization of Drinking Water Source alongside Polluted Yinghe River with High Tumor Mortality.

A method for the analysis of 121 multi-class environmental chemicals in urine by high-performance liquid chromatography-tandem mass spectrometry.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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