EDC Science Weekly, Mar. 24 – 30, 2021

Post author:HEEDS
Post published:March 30, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar March 30: Environmental chemical exposures and mechanisms underlying human placental dysfunction and disease (UCSF EaRTH Center)

Webinar March 31: Plastics, Endocrine Disrupting Chemicals and Health: Findings of a New Joint Report of the Endocrine Society and International Pollutants Elimination Network (IPEN) (CHE Alaska)

Webinar April 14: The Monsanto Papers (EDC Strategies Partnership)

Webinar April 15: Putting the EU Chemicals Strategy for Sustainability into action: Addressing EDCs and mixtures (Food Packaging Forum)

Call for Articles: Special Issue “Evaluating Chemical Exposures and Toxicity of Complex Mixtures and Multiple Stressors” in the journal Toxics.

Regulations/Policy

The science of spin: targeted strategies to manufacture doubt with detrimental effects on environmental and public health.

Methods/Tools/Screening

Per- and polyfluoroalkyl mixtures toxicity assessment “Proof-of-Concept” illustration for the hazard index approach.

Model choice for estimating the association between exposure to chemical mixtures and health outcomes: A simulation study.

Discovery of New Protein Targets of BPA Analogs and Derivatives Associated with Noncommunicable Diseases: A Virtual High-Throughput Screening.

Physiologically relevant estrogen receptor alpha pathway reporters for single cell imaging-based carcinogenic hazard assessment of estrogenic compounds.

Commentaries

Air pollution and chronic bronchitis: the evidence firms up.

Reviews

Numerous EDCs

Developmental programming of offspring adipose tissue biology and obesity risk.

Emerging Pollutants in Nigeria: A Systematic Review.

Endocrine-disrupting chemicals and child health.

The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?

Phthalates

A critical review on human internal exposure of phthalate metabolites and the associated health risks.

Perfluoroalkyl Substances

Critical Review on PFOA, Kidney Cancer, and Testicular Cancer.

Pesticides

Exposure to non-persistent pesticides and puberty timing: a systematic review of the epidemiological evidence.

Potentially Toxic Elements

Low-Level Cadmium Exposure and Atherosclerosis.

Toxic metals in toenails as biomarkers of exposure: a review.

Counteracting effects of heavy metals and antioxidants on male fertility.

Uranium Exposure in American Indian Communities: Health, Policy, and the Way Forward.

Metal Toxicity and Speciation: A Review.

Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects.

Mercury as a cause of membranous nephropathy and Guillain-Barre syndrome: case report and literature review.

Environmental and occupational exposure to metals (manganese, mercury, iron) and Parkinson’s disease in low and middle-income countries: a narrative review.

Associations of metals and neurodevelopment: a review of recent evidence on susceptibility factors.

Microplastics

Microplastics in aquatic environments: A review on occurrence, distribution, toxic effects, and implications for human health.

How do humans recognize and face challenges of microplastic pollution in marine environments? A bibliometric analysis.

Insight into the Interaction Between Microplastics and Microorganisms Based on a Bibliometric and Visualized Analysis.

Air Pollution

The role of the environment in shaping the trends of childhood asthma – an Asian perspective.

Advances on the immunotoxicity of outdoor particulate matter: A focus on physical and chemical properties and respiratory defence mechanisms.

Miscellaneous

The interplay between environmental exposures and COVID-19 risks in the health of children.

Effects of pollution on adolescent mental health: a systematic review protocol.

Human Health Studies

Numerous Chemicals

Cross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches.

Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study.

Gestational Exposure to Toxicants and Autistic Behaviors using Bayesian Quantile Regression.

Brominated flame retardants and organochlorine pesticides and incidence of uterine leiomyomata: A prospective ultrasound study.

Phthalates

Urinary Phthalate Biomarkers and Bone Mineral Density in Postmenopausal Women.

Associations between medication use and phthalate metabolites in urine and follicular fluid among women undergoing in vitro fertilization.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal exposure to mixtures of persistent endocrine-disrupting chemicals and birth size in a population-based cohort of British girls. [PFAS, PCBs, OCs]

Adverse health effects of PCBs on fine motor performance – analysis of a neurophysiological pathway in the HELPcB surveillance program.

Perfluoroalkyl Substances

Association between urinary per- and poly-fluoroalkyl substances and COVID-19 susceptibility.

Flame Retardants

Concentrations of Polybrominated Diphenyl Ethers in Maternal Blood, Placental Size, and Risk for Fetal Growth Restriction: A Nested Case-control Study.

Maternal Urinary Organophosphate Esters and Alterations in Maternal and Neonatal Thyroid Hormones.

Pesticides

Organophosphate pesticide exposure during pregnancy and childhood and onset of juvenile delinquency by age 16 years: the CHAMACOS cohort.

Exposure to multiple pesticides and neurobehavioral outcomes among smallholder farmers in Uganda.

Urinary metabolites of non-persistent pesticides and serum hormones in Spanish adolescent males.

Environmental exposure to pesticides and Amyotrophic Lateral Sclerosis in the South of Spain.

Potentially Toxic Elements

High serum IgG subclass concentrations in children with e-waste Pb and Cd exposure.

Metal and essential element concentrations during pregnancy and associations with autism spectrum disorder and attention-deficit/hyperactivity disorder in children.

Circulatory cadmium positively correlates with epithelial-mesenchymal transition in patients with chronic obstructive pulmonary disease.

Maternal metal concentration during gestation and pediatric morbidity in children: an exploratory analysis.

Contribution of trace element exposure to gestational diabetes mellitus through disturbing the gut microbiome.

Exposure to multiple metals/metalloids and human semen quality: A cross-sectional study.

Exposure to metal mixtures in relation to blood pressure among children 5-7 years old: An observational study in Bangladesh.

Air Pollution

Fine Particles in Wildfire Smoke and Pediatric Respiratory Health in California.

An Examination of National Cancer Risk Based on Monitored Hazardous Air Pollutants.

Contribution of Long-Term Exposure to Outdoor Black Carbon to the Carcinogenicity of Air Pollution: Evidence regarding Risk of Cancer in the Gazel Cohort.

PM₁₀ correlates with COVID-19 infections 15 days later in Arequipa, Peru.

Associations of Particulate Matter Sizes and Chemical Constituents with Blood Lipids: A Panel Study in Guangzhou, China.

Short-term exposure to air pollution and biomarkers of cardiovascular effect: A repeated measures study.

Unprecedented Reduction in Air Pollution and Corresponding Short-term Premature Mortality Associated with COVID-19 Lockdown in Delhi, India.

Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: multilocation analysis in 398 cities.

Exposure to Diesel Exhaust and Plasma Cortisol Response: A Randomized Double-Blind Crossover Study.

Long-term impact of ambient air pollution on preterm birth in Xuzhou, China: a time series study.

Long-term exposure to outdoor air pollution and risk factors for cardiovascular disease within a cohort of older men in Perth.

Laboratory Studies

BPA/Phenols

Assessing potential indicator of endocrine-disrupting property of chemicals using soil invertebrates. [BPA, parabens, etc.]

An in vitro investigation of endocrine disrupting potentials of ten bisphenol analogues.

Bisphenol F exposure in adolescent heterogeneous stock (HS) rats affects growth and adiposity.

Roles of ERK/Akt signals in mitochondria-dependent and endoplasmic reticulum stress-triggered neuronal cell apoptosis induced by 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a major active metabolite of bisphenol A.

Evaluation of post-adolescence exposure to bisphenol A on reproductive outcomes of male rodent models.

Bisphenol A exposure induces apoptosis and impairs early embryonic development in Xenopus laevis.

Bisphenol A and Bisphenol S Induce Endocrine and Chromosomal Alterations in Brown Trout.

Phthalates

Single-cell transcriptome dissection of the toxic impact of Di (2-ethylhexyl) phthalate on primordial follicle assembly.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development.

Dichlorodiphenyltrichloroethane metabolites inhibit DNMT1 activity which confers methylation-specific modulation of the sex determination pathway.

Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis.

Perfluoroalkyl Substances

Maternal Preconception PFOS Exposure of Drosophila melanogaster Alters Reproductive Capacity, Development, Morphology and Nutrient Regulation.

Immunometabolism-modulation and immunotoxicity evaluation of perfluorooctanoic acid in macrophage.

High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per- and polyfluoroalkyl substances (PFAS) as a platform for relative potency characterization.

Organotins

Simulated gastric hydrolysis and developmental toxicity of dibutyltin bis(2-ethylhexyl thioglycolate) in rats.

Pesticides

Metabolomics unveils the influence of dietary phytochemicals on residual pesticide concentrations in honey bees.

Sublethal exposure to deltamethrin stimulates reproduction and has limited effects on post-hatching maternal care in the European earwig.

Effects of Chlorpyrifos Over Reproductive Traits of Three Sympatric Freshwater Crustaceans.

Sub-lethal, Behavioral, and Developmental Effects of the Neonicotinoid Pesticide Imidacloprid on Larval Wood Frogs (Rana sylvatica).

Morphological, behavioral and genotoxic effects of glyphosate and 2,4-D mixture in tadpoles of two native species of South American amphibians.

Comparison of imidacloprid, propiconazole, and nanopropiconazole effects on the development, behavior, and gene expression biomarkers of the Pacific oyster (Magallana gigas).

Exposure to low doses of pesticides induces an immune response and the production of nitric oxide in honeybees.

Toxicity of the insecticide sulfoxaflor alone and in combination with the fungicide fluxapyroxad in three bee species.

Environmentally relevant pesticides induce biochemical changes in Nile tilapia (Oreochromis niloticus).

Toxicity and fate of chiral insecticide pyriproxyfen and its metabolites in zebrafish (Danio rerio).

Individual performances and biochemical pathways as altered by field-realistic exposures of current-use fungicides and their mixtures in a non-target species, Gammarus fossarum.

Low Doses of Glyphosate/Roundup Alter Blood-Testis Barrier Integrity in Juvenile Rats.

Development of a strategic approach for comprehensive detection of organophosphate pesticide metabolites in urine: Extrapolation of cadusafos and prothiofos metabolomics data of mice to humans.

Potentially Toxic Elements

Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis with regard to androgen receptor expression in rats.

THE ENDOCRINE DISRUPTING EFFECTS OF SODIUM ARSENITE IN THE RAT TESTIS IS NOT MEDIATED THROUGH MACROPHAGE ACTIVATION.

Arsenic-induced uterine apoptotic damage is protected by ethyl acetate fraction of Camellia sinensis (green tea) via Bcl-2-BAX through NF-κB regulations in Wistar rats.

Microplastics/Nanomaterials

Effects of microplastics on head kidney gene expression and enzymatic biomarkers in adult zebrafish.

Developmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations.

Akt and MAPK/ERK signaling regulate neurite extension in adult neural progenitor cells but do not directly mediate disruption of cytoskeletal structure and neurite dynamics by low-level silver nanoparticles.

Single and combined acute and subchronic toxic effects of microplastics and copper in zebrafish (Danio rerio) early life stages.

Microplastic ingestion in reared aquaculture fish: Biological responses to low-density polyethylene controlled diets in Sparus aurata.

Air Pollution

Ultrafine particles altered gut microbial population and metabolic profiles in a sex-specific manner in an obese mouse model.

Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice.

Pharmaceuticals/Personal Care Products

Dioctyl Sodium Sulfosuccinate as a Potential Endocrine Disruptor of Thyroid Hormone Activity in American bullfrog, Rana (Lithobates) catesbeiana, Tadpoles.

Biomarker responses and metabolism in Lumbricus terrestris exposed to drugs of environmental concern, an in vivo and in vitro approach.

Mixtures

Developmental co-exposure of TBBPA and titanium dioxide nanoparticle induced behavioral deficits in larval zebrafish.

Miscellaneous

Maternal exposure to phenanthrene during gestation disturbs glucose homeostasis in adult mouse offspring. [a PAH]

Exposure/Environment Studies

BPA/Phenols

Determination of Bisphenol Analogues in Infant Formula Products from India and Evaluating the Health Risk in Infants Asssociated with Their Exposure.

Phthalates

Secular trends of urinary phthalate metabolites in 7-year old children and association with building characteristics: Hokkaido study on environment and children’s health.

Parabens/Triclosan/Antimicrobials

Correlation study of parabens in urine, serum, and seminal plasma of adult men in Beijing, China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Identification of common genetic variants associated with serum concentrations of p, p’-DDE in non-occupational populations in eastern China.

Individual Prey Specialization Drives PCBs in Icelandic Killer Whales.

Perfluoroalkyl Substances

Determination of perfluoroalkyl substances (PFAS) in human hair by liquid chromatography-high accurate mass spectrometry (LC-QTOF).

Exposure assessment of PFAS-contaminated sites using avian eggs as a biomonitoring tool: a frame of reference and a case study in the Po River valley (Northern Italy).

Per- and Polyfluoroalkyl Substances in Outdoor and Indoor Dust from Mainland China: Contributions of Unknown Precursors and Implications for Human Exposure.

Regional occurrence of perfluoroalkane substances in human milk for the global monitoring plan under the Stockholm Convention on Persistent Organic Pollutants during 2016-2019.

Legacy and emerging per- and polyfluorinated alkyl substances (PFASs) in sediment and edible fish from the Eastern Red Sea.

Flame Retardants

Probing Legacy and Alternative Flame Retardants in the Air of Chinese Cities.

Pesticides

Profiles and risk assessment of legacy and current use pesticides in urban rivers in Beijing, China.

Polycyclic aromatic hydrocarbons, pesticides, and metals in olive: analysis and probabilistic risk assessment.

Levels of pesticide residues in fruits and vegetables in the Turkish domestic markets.

Annual abundance of common Kestrels (Falco tinnunculus) is negatively associated with second generation anticoagulant rodenticides.

Occurrence of carbamazepine, diclofenac, and their related metabolites and transformation products in a French aquatic environment and preliminary risk assessment.

Method for the simultaneous analysis of 300 pesticide residues in hair by LC-MS/MS and GC-MS/MS, and its application to biomonitoring of agricultural workers.

Potentially Toxic Elements

Essential and non-essential elements in biological samples of inhabitants residing in Nenets Autonomous Okrug of the Russian Arctic.

Effects of native forest and human-modified land covers on the accumulation of toxic metals and metalloids in the tropical bee Tetragonisca angustula.

Status and trends of mercury pollution of the atmosphere and terrestrial ecosystems in Poland.

Evaluation of homing pigeon feather tissue as a biomonitor of environmental metal concentrations in China.

Response of mercury accumulation to anthropogenic pollution in the past 1000 years based on Lake Huguangyan sediments, Southern China.

Heavy Metals Content in Great Shearwater (Ardenna Gravis): Accumulation, Distribution and Biomarkers of Effect in Different Tissues.

Buyer beware: Inexpensive, high cadmium jewelry can pose severe health risks.

Mercury and neurochemical biomarkers in multiple brain regions of five Arctic marine mammals.

Health risk assessment of heavy metals in dust particles precipitated on the screen of computer monitors.

Air Pollution

Does air pollution upsurge in megacities after Covid-19 lockdown? A spatial approach.

Lockdown measures and air quality: evidence from Italian provinces.

Personal exposure monitoring of PM_2.5 among US diplomats in Kathmandu during the COVID-19 lockdown, March to June 2020.

Pharmaceuticals/Personal Care Products

Evaluation of ibuprofen and diclofenac in the main rivers of Colombia and striped catfish Pseudoplatystoma magdaleniatum.

Mixtures

Recognition and Prioritization of Chemical Mixtures and Transformation Products in Chinese Estuarine Waters by Suspect Screening Analysis.

Miscellaneous

The European human biomonitoring platform – Design and implementation of a laboratory quality assurance/quality control (QA/QC) programme for selected priority chemicals.

Quality assurance and harmonization for targeted biomonitoring measurements of environmental organic chemicals across the Children’s Health Exposure Analysis Resource laboratory network.

Seasonal variability, long-term distribution (2001-2014), and risk assessment of polar organic micropollutants in the Baltic Sea. [numerous chemicals]

Water quality assessment of the Ganges River during COVID-19 lockdown.

Simultaneous Determination of Typical Chlorinated, Oxygenated, and European Union Priority Polycyclic Aromatic Hydrocarbons in Milk Samples and Milk Powders.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.