EDC Science Weekly, Mar. 24 – 30, 2021

Post author:HEEDS
Post published:March 30, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar March 30: Environmental chemical exposures and mechanisms underlying human placental dysfunction and disease (UCSF EaRTH Center)

Webinar March 31: Plastics, Endocrine Disrupting Chemicals and Health: Findings of a New Joint Report of the Endocrine Society and International Pollutants Elimination Network (IPEN) (CHE Alaska)

Webinar April 14: The Monsanto Papers (EDC Strategies Partnership)

Webinar April 15: Putting the EU Chemicals Strategy for Sustainability into action: Addressing EDCs and mixtures (Food Packaging Forum)

Call for Articles: Special Issue “Evaluating Chemical Exposures and Toxicity of Complex Mixtures and Multiple Stressors” in the journal Toxics.

Regulations/Policy

The science of spin: targeted strategies to manufacture doubt with detrimental effects on environmental and public health.

Methods/Tools/Screening

Per- and polyfluoroalkyl mixtures toxicity assessment “Proof-of-Concept” illustration for the hazard index approach.

Model choice for estimating the association between exposure to chemical mixtures and health outcomes: A simulation study.

Discovery of New Protein Targets of BPA Analogs and Derivatives Associated with Noncommunicable Diseases: A Virtual High-Throughput Screening.

Physiologically relevant estrogen receptor alpha pathway reporters for single cell imaging-based carcinogenic hazard assessment of estrogenic compounds.

Commentaries

Air pollution and chronic bronchitis: the evidence firms up.

Reviews

Numerous EDCs

Developmental programming of offspring adipose tissue biology and obesity risk.

Emerging Pollutants in Nigeria: A Systematic Review.

Endocrine-disrupting chemicals and child health.

The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?

Phthalates

A critical review on human internal exposure of phthalate metabolites and the associated health risks.

Perfluoroalkyl Substances

Critical Review on PFOA, Kidney Cancer, and Testicular Cancer.

Pesticides

Exposure to non-persistent pesticides and puberty timing: a systematic review of the epidemiological evidence.

Potentially Toxic Elements

Low-Level Cadmium Exposure and Atherosclerosis.

Toxic metals in toenails as biomarkers of exposure: a review.

Counteracting effects of heavy metals and antioxidants on male fertility.

Uranium Exposure in American Indian Communities: Health, Policy, and the Way Forward.

Metal Toxicity and Speciation: A Review.

Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects.

Mercury as a cause of membranous nephropathy and Guillain-Barre syndrome: case report and literature review.

Environmental and occupational exposure to metals (manganese, mercury, iron) and Parkinson’s disease in low and middle-income countries: a narrative review.

Associations of metals and neurodevelopment: a review of recent evidence on susceptibility factors.

Microplastics

Microplastics in aquatic environments: A review on occurrence, distribution, toxic effects, and implications for human health.

How do humans recognize and face challenges of microplastic pollution in marine environments? A bibliometric analysis.

Insight into the Interaction Between Microplastics and Microorganisms Based on a Bibliometric and Visualized Analysis.

Air Pollution

The role of the environment in shaping the trends of childhood asthma – an Asian perspective.

Advances on the immunotoxicity of outdoor particulate matter: A focus on physical and chemical properties and respiratory defence mechanisms.

Miscellaneous

The interplay between environmental exposures and COVID-19 risks in the health of children.

Effects of pollution on adolescent mental health: a systematic review protocol.

Human Health Studies

Numerous Chemicals

Cross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches.

Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study.

Gestational Exposure to Toxicants and Autistic Behaviors using Bayesian Quantile Regression.

Brominated flame retardants and organochlorine pesticides and incidence of uterine leiomyomata: A prospective ultrasound study.

Phthalates

Urinary Phthalate Biomarkers and Bone Mineral Density in Postmenopausal Women.

Associations between medication use and phthalate metabolites in urine and follicular fluid among women undergoing in vitro fertilization.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal exposure to mixtures of persistent endocrine-disrupting chemicals and birth size in a population-based cohort of British girls. [PFAS, PCBs, OCs]

Adverse health effects of PCBs on fine motor performance – analysis of a neurophysiological pathway in the HELPcB surveillance program.

Perfluoroalkyl Substances

Association between urinary per- and poly-fluoroalkyl substances and COVID-19 susceptibility.

Flame Retardants

Concentrations of Polybrominated Diphenyl Ethers in Maternal Blood, Placental Size, and Risk for Fetal Growth Restriction: A Nested Case-control Study.

Maternal Urinary Organophosphate Esters and Alterations in Maternal and Neonatal Thyroid Hormones.

Pesticides

Organophosphate pesticide exposure during pregnancy and childhood and onset of juvenile delinquency by age 16 years: the CHAMACOS cohort.

Exposure to multiple pesticides and neurobehavioral outcomes among smallholder farmers in Uganda.

Urinary metabolites of non-persistent pesticides and serum hormones in Spanish adolescent males.

Environmental exposure to pesticides and Amyotrophic Lateral Sclerosis in the South of Spain.

Potentially Toxic Elements

High serum IgG subclass concentrations in children with e-waste Pb and Cd exposure.

Metal and essential element concentrations during pregnancy and associations with autism spectrum disorder and attention-deficit/hyperactivity disorder in children.

Circulatory cadmium positively correlates with epithelial-mesenchymal transition in patients with chronic obstructive pulmonary disease.

Maternal metal concentration during gestation and pediatric morbidity in children: an exploratory analysis.

Contribution of trace element exposure to gestational diabetes mellitus through disturbing the gut microbiome.

Exposure to multiple metals/metalloids and human semen quality: A cross-sectional study.

Exposure to metal mixtures in relation to blood pressure among children 5-7 years old: An observational study in Bangladesh.

Air Pollution

Fine Particles in Wildfire Smoke and Pediatric Respiratory Health in California.

An Examination of National Cancer Risk Based on Monitored Hazardous Air Pollutants.

Contribution of Long-Term Exposure to Outdoor Black Carbon to the Carcinogenicity of Air Pollution: Evidence regarding Risk of Cancer in the Gazel Cohort.

PM₁₀ correlates with COVID-19 infections 15 days later in Arequipa, Peru.

Associations of Particulate Matter Sizes and Chemical Constituents with Blood Lipids: A Panel Study in Guangzhou, China.

Short-term exposure to air pollution and biomarkers of cardiovascular effect: A repeated measures study.

Unprecedented Reduction in Air Pollution and Corresponding Short-term Premature Mortality Associated with COVID-19 Lockdown in Delhi, India.

Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: multilocation analysis in 398 cities.

Exposure to Diesel Exhaust and Plasma Cortisol Response: A Randomized Double-Blind Crossover Study.

Long-term impact of ambient air pollution on preterm birth in Xuzhou, China: a time series study.

Long-term exposure to outdoor air pollution and risk factors for cardiovascular disease within a cohort of older men in Perth.

Laboratory Studies

BPA/Phenols

Assessing potential indicator of endocrine-disrupting property of chemicals using soil invertebrates. [BPA, parabens, etc.]

An in vitro investigation of endocrine disrupting potentials of ten bisphenol analogues.

Bisphenol F exposure in adolescent heterogeneous stock (HS) rats affects growth and adiposity.

Roles of ERK/Akt signals in mitochondria-dependent and endoplasmic reticulum stress-triggered neuronal cell apoptosis induced by 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a major active metabolite of bisphenol A.

Evaluation of post-adolescence exposure to bisphenol A on reproductive outcomes of male rodent models.

Bisphenol A exposure induces apoptosis and impairs early embryonic development in Xenopus laevis.

Bisphenol A and Bisphenol S Induce Endocrine and Chromosomal Alterations in Brown Trout.

Phthalates

Single-cell transcriptome dissection of the toxic impact of Di (2-ethylhexyl) phthalate on primordial follicle assembly.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development.

Dichlorodiphenyltrichloroethane metabolites inhibit DNMT1 activity which confers methylation-specific modulation of the sex determination pathway.

Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis.

Perfluoroalkyl Substances

Maternal Preconception PFOS Exposure of Drosophila melanogaster Alters Reproductive Capacity, Development, Morphology and Nutrient Regulation.

Immunometabolism-modulation and immunotoxicity evaluation of perfluorooctanoic acid in macrophage.

High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per- and polyfluoroalkyl substances (PFAS) as a platform for relative potency characterization.

Organotins

Simulated gastric hydrolysis and developmental toxicity of dibutyltin bis(2-ethylhexyl thioglycolate) in rats.

Pesticides

Metabolomics unveils the influence of dietary phytochemicals on residual pesticide concentrations in honey bees.

Sublethal exposure to deltamethrin stimulates reproduction and has limited effects on post-hatching maternal care in the European earwig.

Effects of Chlorpyrifos Over Reproductive Traits of Three Sympatric Freshwater Crustaceans.

Sub-lethal, Behavioral, and Developmental Effects of the Neonicotinoid Pesticide Imidacloprid on Larval Wood Frogs (Rana sylvatica).

Morphological, behavioral and genotoxic effects of glyphosate and 2,4-D mixture in tadpoles of two native species of South American amphibians.

Comparison of imidacloprid, propiconazole, and nanopropiconazole effects on the development, behavior, and gene expression biomarkers of the Pacific oyster (Magallana gigas).

Exposure to low doses of pesticides induces an immune response and the production of nitric oxide in honeybees.

Toxicity of the insecticide sulfoxaflor alone and in combination with the fungicide fluxapyroxad in three bee species.

Environmentally relevant pesticides induce biochemical changes in Nile tilapia (Oreochromis niloticus).

Toxicity and fate of chiral insecticide pyriproxyfen and its metabolites in zebrafish (Danio rerio).

Individual performances and biochemical pathways as altered by field-realistic exposures of current-use fungicides and their mixtures in a non-target species, Gammarus fossarum.

Low Doses of Glyphosate/Roundup Alter Blood-Testis Barrier Integrity in Juvenile Rats.

Development of a strategic approach for comprehensive detection of organophosphate pesticide metabolites in urine: Extrapolation of cadusafos and prothiofos metabolomics data of mice to humans.

Potentially Toxic Elements

Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis with regard to androgen receptor expression in rats.

THE ENDOCRINE DISRUPTING EFFECTS OF SODIUM ARSENITE IN THE RAT TESTIS IS NOT MEDIATED THROUGH MACROPHAGE ACTIVATION.

Arsenic-induced uterine apoptotic damage is protected by ethyl acetate fraction of Camellia sinensis (green tea) via Bcl-2-BAX through NF-κB regulations in Wistar rats.

Microplastics/Nanomaterials

Effects of microplastics on head kidney gene expression and enzymatic biomarkers in adult zebrafish.

Developmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations.

Akt and MAPK/ERK signaling regulate neurite extension in adult neural progenitor cells but do not directly mediate disruption of cytoskeletal structure and neurite dynamics by low-level silver nanoparticles.

Single and combined acute and subchronic toxic effects of microplastics and copper in zebrafish (Danio rerio) early life stages.

Microplastic ingestion in reared aquaculture fish: Biological responses to low-density polyethylene controlled diets in Sparus aurata.

Air Pollution

Ultrafine particles altered gut microbial population and metabolic profiles in a sex-specific manner in an obese mouse model.

Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice.

Pharmaceuticals/Personal Care Products

Dioctyl Sodium Sulfosuccinate as a Potential Endocrine Disruptor of Thyroid Hormone Activity in American bullfrog, Rana (Lithobates) catesbeiana, Tadpoles.

Biomarker responses and metabolism in Lumbricus terrestris exposed to drugs of environmental concern, an in vivo and in vitro approach.

Mixtures

Developmental co-exposure of TBBPA and titanium dioxide nanoparticle induced behavioral deficits in larval zebrafish.

Miscellaneous

Maternal exposure to phenanthrene during gestation disturbs glucose homeostasis in adult mouse offspring. [a PAH]

Exposure/Environment Studies

BPA/Phenols

Determination of Bisphenol Analogues in Infant Formula Products from India and Evaluating the Health Risk in Infants Asssociated with Their Exposure.

Phthalates

Secular trends of urinary phthalate metabolites in 7-year old children and association with building characteristics: Hokkaido study on environment and children’s health.

Parabens/Triclosan/Antimicrobials

Correlation study of parabens in urine, serum, and seminal plasma of adult men in Beijing, China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Identification of common genetic variants associated with serum concentrations of p, p’-DDE in non-occupational populations in eastern China.

Individual Prey Specialization Drives PCBs in Icelandic Killer Whales.

Perfluoroalkyl Substances

Determination of perfluoroalkyl substances (PFAS) in human hair by liquid chromatography-high accurate mass spectrometry (LC-QTOF).

Exposure assessment of PFAS-contaminated sites using avian eggs as a biomonitoring tool: a frame of reference and a case study in the Po River valley (Northern Italy).

Per- and Polyfluoroalkyl Substances in Outdoor and Indoor Dust from Mainland China: Contributions of Unknown Precursors and Implications for Human Exposure.

Regional occurrence of perfluoroalkane substances in human milk for the global monitoring plan under the Stockholm Convention on Persistent Organic Pollutants during 2016-2019.

Legacy and emerging per- and polyfluorinated alkyl substances (PFASs) in sediment and edible fish from the Eastern Red Sea.

Flame Retardants

Probing Legacy and Alternative Flame Retardants in the Air of Chinese Cities.

Pesticides

Profiles and risk assessment of legacy and current use pesticides in urban rivers in Beijing, China.

Polycyclic aromatic hydrocarbons, pesticides, and metals in olive: analysis and probabilistic risk assessment.

Levels of pesticide residues in fruits and vegetables in the Turkish domestic markets.

Annual abundance of common Kestrels (Falco tinnunculus) is negatively associated with second generation anticoagulant rodenticides.

Occurrence of carbamazepine, diclofenac, and their related metabolites and transformation products in a French aquatic environment and preliminary risk assessment.

Method for the simultaneous analysis of 300 pesticide residues in hair by LC-MS/MS and GC-MS/MS, and its application to biomonitoring of agricultural workers.

Potentially Toxic Elements

Essential and non-essential elements in biological samples of inhabitants residing in Nenets Autonomous Okrug of the Russian Arctic.

Effects of native forest and human-modified land covers on the accumulation of toxic metals and metalloids in the tropical bee Tetragonisca angustula.

Status and trends of mercury pollution of the atmosphere and terrestrial ecosystems in Poland.

Evaluation of homing pigeon feather tissue as a biomonitor of environmental metal concentrations in China.

Response of mercury accumulation to anthropogenic pollution in the past 1000 years based on Lake Huguangyan sediments, Southern China.

Heavy Metals Content in Great Shearwater (Ardenna Gravis): Accumulation, Distribution and Biomarkers of Effect in Different Tissues.

Buyer beware: Inexpensive, high cadmium jewelry can pose severe health risks.

Mercury and neurochemical biomarkers in multiple brain regions of five Arctic marine mammals.

Health risk assessment of heavy metals in dust particles precipitated on the screen of computer monitors.

Air Pollution

Does air pollution upsurge in megacities after Covid-19 lockdown? A spatial approach.

Lockdown measures and air quality: evidence from Italian provinces.

Personal exposure monitoring of PM_2.5 among US diplomats in Kathmandu during the COVID-19 lockdown, March to June 2020.

Pharmaceuticals/Personal Care Products

Evaluation of ibuprofen and diclofenac in the main rivers of Colombia and striped catfish Pseudoplatystoma magdaleniatum.

Mixtures

Recognition and Prioritization of Chemical Mixtures and Transformation Products in Chinese Estuarine Waters by Suspect Screening Analysis.

Miscellaneous

The European human biomonitoring platform – Design and implementation of a laboratory quality assurance/quality control (QA/QC) programme for selected priority chemicals.

Quality assurance and harmonization for targeted biomonitoring measurements of environmental organic chemicals across the Children’s Health Exposure Analysis Resource laboratory network.

Seasonal variability, long-term distribution (2001-2014), and risk assessment of polar organic micropollutants in the Baltic Sea. [numerous chemicals]

Water quality assessment of the Ganges River during COVID-19 lockdown.

Simultaneous Determination of Typical Chlorinated, Oxygenated, and European Union Priority Polycyclic Aromatic Hydrocarbons in Milk Samples and Milk Powders.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.