EDC Science Weekly, Feb. 24 – Mar. 2, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Mar. 3: Endocrine Disrupting Chemicals: Effects on Mothers, and Interactions with Lifestyle, part of the Young EDC Scientists Showcase (YESS) webinar series.

Webinar Mar. 9: Endocrine Disrupting Chemicals and Maternal Reproductive Health Impacts, part of the Generation Chemical webinar series.

Forum Mar. 16: TSCA @5 Years: Opportunities to Act with Foresight, sponsored by The University of Michigan M-LEEaD Center.

Webinar Mar. 22: Fostering Community Engaged Research in Environmental Health Disparities, part of the NIH-EPA Environmental Health Disparities Research Webinar Series.

Regulations/Policy

Legislation against endocrine-disrupting compounds in drinking water: essential but not enough to ensure water safety.

Drinking Water Criteria for Arsenic in High-Income, Low-Dose Countries: The Effect of Legislation on Public Health.

Methods/Tools/Screening

Towards guidelines for time-trend reviews examining temporal variability in human biomonitoring data of pollutants.

Methodological issues in descriptive environmental epidemiology. The example of study Sentieri.

Is your environment making you older? Molecular biomarkers and new approaches to investigate the influences of environmental chemicals through aging.

Commentaries

COVID-19 Pandemic and Environmental Health: Effects and the Immediate Need for a Concise Risk Analysis.

Cardiovascular health and ambient air pollution: lower is not enough.

Reviews

Numerous EDCs

Endocrine disrupting chemicals and bone.

Fetal exposure to environmental chemicals; insights from placental perfusion studies.

A putative adverse outcome pathway network for disrupted female pubertal onset to improve testing and regulation of endocrine disrupting chemicals.

BPA/Phenols

Occurrence, potential ecological risks, and degradation of endocrine disrupter, nonylphenol, from the aqueous environment.

Pesticides

Insect decline: immediate action is needed.

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides.

A Review on the Health Effects of Pesticides Based on Host Gut Microbiome and Metabolomics.

Conflicts of interest and improvement through peer review: the case of IPBES report on pollinators.

Potentially Toxic Elements

Association between mercury exposure and thyroid hormones levels: a meta-analysis.

Lead Toxicity in Cereals: Mechanistic Insight Into Toxicity, Mode of Action, and Management.

Microplastics

Microplastic particles in the aquatic environment: A systematic review.

Microplastics and the functional traits of fishes: a global meta-analysis.

Studying microplastics: Lessons from evaluated literature on animal model organisms and experimental approaches.

Air Pollution

Long-term exposure to nitrogen dioxide and mortality: A systematic review and meta-analysis.

Pharmaceuticals/Personal Care Products

Risks associated with cosmetic ingredients.

Miscellaneous

A Review of the Talc Industry’s Influence on Federal Regulation and Scientific Standards for Asbestos in Talc.

Human Health Studies

Mixtures

Parental preconception exposure to phenol and phthalate mixtures and the risk of preterm birth.

The effects of increased pollution on COVID-19 cases and deaths.

BPA/Phenols

Study on the correlation of bisphenol A exposure, pro-inflammatory gene expression, and C-reactive protein with potential cardiovascular disease symptoms in young adults.

Urinary bisphenol A levels in prepubertal children with exogenous obesity according to presence of metabolic syndrome.

Prenatal exposure to bisphenols and cognitive function in children at 7 years of age in the Swedish SELMA study.

Phthalates

Gestational and peripubertal phthalate exposure in relation to attention performance in childhood and adolescence.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine Pesticide Tissue Levels in Benign and Malignant Breast Disease: A Comparative Exploratory Study.

Neurobehavioural and cognitive effects of prenatal exposure to organochlorine compounds in three year old children.

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substances and calcifications of the coronary and aortic arteries in adults with prediabetes: Results from the diabetes prevention program outcomes study.

Prenatal exposure to per- and polyfluoroalkyl substances and cognitive development in infancy and toddlerhood.

Potentially Toxic Elements

Associations between Blood Lead Levels and Coronary Artery Stenosis Measured Using Coronary Computed Tomography Angiography.

Cadmium Exposure in Young Adulthood Is Associated with Risk of Nonalcoholic Fatty Liver Disease in Midlife.

Genetic variation and urine cadmium levels: ABCC1 effects in the Strong Heart Family Study.

Community-driven research in the canadian arctic: dietary exposure to methylmercury and gastric health outcomes.

Air Pollution

Beyond virology: environmental constraints of the first wave of COVID-19 cases in Italy.

Fine Particulate Matter Air Pollution and Mortality Risk Among US Cancer Patients and Survivors. accompanied by Does Air Pollution Reduce Cancer Survival? New Findings From SEER Program Cohorts.

Associations of residing greenness and long-term exposure to air pollution with glucose homeostasis markers.

Association of fine particulate matter with glucose and lipid metabolism: a longitudinal study in young adults.

A community-based study on associations between PM_2.5 and PM₁ exposure and heart rate variability using wearable low-cost sensing devices.

Long-term air pollution exposure associates with increased risk of coronary heart disease morbidity and mortality.

Assessing additive effects of air pollutants on mortality rate in Massachusetts.

Ambient air pollution and the development of overweight and obesity in children: a large longitudinal study.

Long-term exposure to ambient PM_2.5 and stroke mortality among urban residents in northern China.

Estimation of excess mortality due to long-term exposure to PM_2.5 in Continental United States using a high-spatiotemporal resolution model.

Seasonal association between ambient fine particulate matter and venous thromboembolism in Beijing, China: a time-series study.

Association between coronavirus disease 2019 (COVID-19) and long-term exposure to air pollution: Evidence from the first epidemic wave in China.

Short-term air pollution exposure is associated with lower severity and mixed features of manic episodes in hospitalized bipolar patients: a cross-sectional study in Milan, Italy.

Does psychosocial stress modify the association of fine particulate matter and ozone with cardiovascular health indicators?

Transition in air pollution, disease burden and health cost in China: A comparative study of long-term and short-term exposure.

Ambient PM_2.5 species and ultrafine particle exposure and their differential metabolomic signatures.

Significance between air pollutants, meteorological factors, and COVID-19 infections: probable evidences in India.

Prenatal particulate matter exposure and Intrauterine Fetal Death.

Ambient PM_2.5 species and ultrafine particle exposure and their differential metabolomic signatures.

The association between maternal exposure to outdoor air pollutants, inflammatory response, and birth weight in healthy women.

Chronic Exposure to Air Pollution and Risk of Mental Health Disorders Complicating Pregnancy.

Laboratory Studies

BPA/Phenols

Molecular mechanism study of BPAF-induced proliferation of ERα-negative SKBR-3 human breast cancer cells in vitro/in vivo.

Bisphenol A induces hepatic triglyceride level in adult male rare minnow Gobiocypris rarus.

The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish.

Phthalates

Comparison of In Vitro Endocrine Activity of Phthalates and Alternative Plasticizers.

Di-n-butyl phthalate diminishes testicular steroidogenesis by blocking the hypothalamic-pituitary-testicular axis: relationship with germ cell apoptosis in Japanese quail.

Triclosan

Triclosan regulates alternative splicing events of nerve-related genes through RNA-binding protein CELF2 to induce zebrafish neurotoxicity.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A computational insight into endocrine disruption by polychlorinated biphenyls via non-covalent interactions with human nuclear receptors.

In vitro effects of the endocrine disruptor p,p’DDT on human choriogonadotropin/luteinizing hormone receptor signalling.

Flame Retardants

Exposure of adult zebrafish (Danio rerio) to Tetrabromobisphenol A causes neurotoxicity in larval offspring, an adverse transgenerational effect.

Organotins

Sex-specific Changes in Brain Estrogen Metabolism Induced by Acute Trimethyltin Exposure.

Pesticides

Pesticide-induced multigenerational effects on amphibian reproduction and metabolism.

Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion.

Cardiovascular damage associated with subchronic exposure to the glyphosate herbicide in Wistar rats.

Atrazine-induced cell-mediated immunotoxicity in rabbits and the ameliorating role of glycyrrhizic acid.

The protective effects of Ziziphora tenuior L. against chlorpyrifos induced toxicity: Involvement of inflammatory and cell death signaling pathway.

Paraquat Reduces the Female Fertility by Impairing the Oocyte Maturation in Mice.

Effects of maternal Diazinon exposure on frontal cerebral cortical development in mouse embryo.

Multi-biomarker assessment in the giant freshwater prawn Macrobrachium rosenbergii after deltamethrin exposure.

Detoxification gene expression, genotoxicity, and hepatorenal damage induced by subacute exposure to the new pyrethroid, imiprothrin, in rats.

Assessment of toxicity and environmental behavior of chiral ethiprole and its metabolites using zebrafish model.

Potentially Toxic Elements

Prolonged arsenic exposure increases tau phosphorylation in differentiated SH-SY5Y cells: The contribution of GSK3 and ERK1/2.

Mitigation of arsenic induced developmental cardiotoxicity by ferulic acid in zebrafish.

Reversible and irreversible transgenerational effects of metal exposure on nine generations of a tropical micro-crustacean.

Changes and relationship of N⁶-methyladenosine modification and Long non-coding RNAs in oxidative damage induced by cadmium in pancreatic β-cells.

Persistence and reversibility of arsenic-induced gut microbiome and metabolome shifts in male rats after 30-days recovery duration.

Microplastics

Immune response triggered by the ingestion of polyethylene microplastics in the dipteran larvae Chironomus riparius.

Size-dependent adverse effects of microplastics on intestinal microbiota and metabolic homeostasis in the marine medaka (Oryzias melastigma).

Pharmaceuticals/Personal Care Products

In vivo and in silico evaluations of survival and cardiac developmental toxicity of quinolone antibiotics in zebrafish embryos (Danio rerio).

Double-edged sword: Fluoxetine and ibuprofen as development jeopardizers and apoptosis’ inducers in common toad, Bufo bufo, tadpoles.

Mixtures

Integrated transcriptomics and metabolomics analyses reveal benzo[a]pyrene enhances the toxicity of mercury to the Manila clam, Ruditapes philippinarum.

Combined effects of polyethylene and organic contaminant on zebrafish (Danio rerio): Accumulation of 9-Nitroanthracene, biomarkers and intestinal microbiota.

Miscellaneous

Ecotoxicological assessment of palm oil mill effluent final discharge by zebrafish (Danio rerio) embryonic assay.

Exposure/Environment Studies

Numerous EDCs

Dietary intake and household exposures as predictors of urinary concentrations of high molecular weight phthalates and bisphenol A in a cohort of adolescents.

A reconnaissance study of pharmaceuticals, pesticides, perfluoroalkyl substances and organophosphorus flame retardants in the aquatic environment, wild plants and vegetables of two Saudi Arabia urban areas: Environmental and human health risk assessment.

Nontargeted Discovery of Novel Contaminants in the Great Lakes Region: A Comparison of Fish Fillets and Fish Consumers.

Increased coverage and high confidence in suspect screening of emerging contaminants in global environmental samples.

Network Analysis to Identify Communities Among Multiple Exposure Biomarkers Measured at Birth in Three Flemish General Population Samples.

BPA/Phenols

A new LC/MS method for specific determination of human systemic exposure to bisphenol A, F and S through their metabolites: Application to cord blood samples.

Human biomonitoring of bisphenol A along pregnancy: An exposure reconstruction of the EXHES-Spain cohort.

Phthalates

Human metabolism and urinary excretion kinetics of di-n-butyl adipate (DnBA) after oral and dermal administration in three volunteers.

Potential health risks of maternal phthalate exposure during the first trimester – The Saudi Early Autism and Environment Study (SEAES).

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Accumulation characteristics and estimated dietary intakes of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls in plant-origin foodstuffs from Chinese markets.

Time trends of persistent organic pollutants (POPs) and Chemicals of Emerging Arctic Concern (CEAC) in Arctic air from 25 years of monitoring.

Occurrence, distribution, and risk of organochlorine pesticides in food and greenness assessment of method.

Distribution and toxicity of persistent organic pollutants and methoxylated polybrominated diphenylethers in different tissues of the green turtle Chelonia mydas.

Perfluoroalkyl Substances

Emerging contaminants, coerced ignorance and environmental health concerns: The case of per- and polyfluoroalkyl substances (PFAS).

Spatial and Temporal Trends of Perfluoroalkyl Substances in Global Ocean and Coastal Waters.

Occurrence, source apportionment, plant bioaccumulation and human exposure of legacy and emerging per- and polyfluoroalkyl substances in soil and plant leaves near a landfill in China.

Monitoring Analysis of Perfluoroalkyl Substances and F-53B in Bottled Water, Tea and Juice Samples by LC-MS/MS.

Flame Retardants

Chemical exposures from upholstered furniture with various flame retardant technologies.

Exposure evaluation and risk assessment of polybrominated diphenyl ethers in dust from microenvironments in Nsukka, Nigeria.

Occurrence and risk evaluation of organophosphorus flame retardants in two urban rivers in Yangtze River Delta.

Polybrominated diphenyl ethers (PBDEs) concentrations in soil and plants around municipal dumpsites in Abuja, Nigeria.

Pesticides

Vulnerability of Aquatic Insect Species to Insecticides, Depending on Their Flight Period and Adult Life Span.

[Challenges and strides in the control of pesticide residues in Brazil: 15 years of the Program for Analysis of Pesticide Residues in Food Products]. [in Portuguese, accompanied by Pesticides: the hidden poisons on our table.]

Effects of commercial formulations of glyphosate on marine crustaceans and implications for risk assessment under temperature changes.

A Comparison of Pesticide Risk Beliefs between Farmers and Farmworkers: Implications for Risk Communication and Education.

Potentially Toxic Elements

Dietary intake and urinary excretion of methylated arsenicals of Japanese adults consuming marine foods and rice.

Plasma and red blood cells distribution of total mercury, inorganic mercury, and selenium in maternal and cord blood from a group of Japanese women.

Regional variations and relationships among cytokine profiles, white blood cell counts, and blood mercury concentrations in Steller sea lion (Eumetopias jubatus) pups.

Arsenic Poisoning due to High Consumption of Canned Sardines in Jeddah, Saudi Arabia.

Assessment of heavy metal content of commonly consumed herbal medicines in Sindh, Pakistan.

Multi-decadal trends in mercury and methylmercury concentrations in the brown watersnake (Nerodia taxispilota).

Influence of culinary treatment on the concentration and on the bioavailability of cadmium, chromium, copper, and lead in seafood.

Microplastics

Natural and anthropogenic effects on microplastic distribution in a hypersaline lagoon.

Air Pollution

Health-based evaluation of ambient air measurements of PM_2.5 and volatile organic compounds near a Marcellus Shale unconventional natural gas well pad site and a school campus.

Can particulate matter be identified as the primary cause of the rapid spread of CoViD-19 in some areas of Northern Italy?

Pharmaceuticals/Personal Care Products

Pharmaceuticals in two watersheds in Eastern China and their ecological risks.

Miscellaneous

The mysterious mass death of marine organisms on the Kamchatka Peninsula: A consequence of a technogenic impact on the environment or a natural phenomenon?

Embryonic shell shape as an early indicator of pollution in marine gastropods.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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