EDC Science Weekly, Jan. 13 – 19, 2021

Post author:HEEDS
Post published:January 19, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Jan. 27: Promoting a Culture of Health: The Role of Racial Equity in Healing our Nation’s Health Disparities

Webinar Jan. 28: Preconception Matters, Too: EDC Impacts on Reproductive Health and Development

Regulations/Policy

NAM-supported read-across: From case studies to regulatory guidance in safety assessment.

Environmental risk assessment of technical mixtures under REACH – a regulatory perspective.

Methods/Tools/Screening

KnowTox: pipeline and case study for confident prediction of potential toxic effects of compounds in early phases of development.

Using the U.S. EPA CompTox Chemicals Dashboard to interpret targeted and non-targeted GC-MS analyses from human breath and other biological media.

Simultaneous determination of a suite of endogenous steroids by LC-APPI-MS: Application to the identification of endocrine disruptors in aquatic toxicology.

Inductive transfer learning for molecular activity prediction: Next-Gen QSAR Models with MolPMoFiT. [not EDCs but maybe useful]

Commentaries

Inferential challenges when assessing racial/ethnic health disparities in environmental research.

COVID-19 and clean air: an opportunity for radical change.

How to Make Voluntary Species Conservation Work for Pesticide Registrations.

Reviews

Numerous EDCs

The male mammary gland: a novel target of endocrine disrupting chemicals.

Obesity and Endocrine Disrupting Chemicals.

Exposure to toxic metals and per- and polyfluoroalkyl substances (PFAS) and the risk of preeclampsia and preterm birth in the United States: A review.

From Environmental to Possible Occupational Exposure to Risk Factors: What Role Do They Play in the Etiology of Endometriosis?

From inequitable to sustainable e-waste processing for reduction of impact on human health and the environment.

Chemical Risk Factors of Primary Liver Cancer: An Update.

Human Family 1-4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update.

Mixtures

Multivariate Curve Resolution: 50 years addressing the mixture analysis problem – A review.

Phthalates

Effects and mechanisms of phthalates’ action on neurological processes and neural health: a literature review.

Perfluoroalkyl Substances

Human Biomonitoring (HBM)-I values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) – description, derivation and discussion.

Pesticides

Pesticides-induced cardiovascular dysfunctions: Prevalence and associated mechanisms.

On recent meta-analyses of exposure to glyphosate and risk of non-Hodgkin’s lymphoma in humans.

Compounded conservatism in European re-entry worker risk assessment of pesticides.

Recent advances in the applications of nano-agrochemicals for sustainable agricultural development.

A scientometric analysis of ecotoxicological studies with the herbicide atrazine and microalgae and cyanobacteria as test organisms.

Potentially Toxic Elements

Role of metallic pollutants in neurodegeneration: effects of aluminum, lead, mercury, and arsenic in mediating brain impairment events and autism spectrum disorder.

Prenatal Environmental Metal Exposure and Preterm Birth: A Scoping Review.

Microplastics/Nanomaterials

Status Quo in Data Availability and Predictive Models of Nano-Mixture Toxicity.

Bibliometrics and visualization analysis regarding research on the development of microplastics.

Environmental factors-mediated behavior of microplastics and nanoplastics in water: A review.

Air Pollution

External Environmental Pollution as a Risk Factor for Asthma.

Effect of PM_2.5 exposure on circulating fibrinogen and IL-6 levels: A systematic review and meta-analysis.

Pharmaceuticals/Personal Care Products

Personal-Care Cosmetic Practices in Pakistan: Current Perspectives and Management.

Recombinant Protein Polymers: A Coming Wave of Personal Care Ingredients.

Occurrence and removal of 17α-ethynylestradiol (EE2) in municipal wastewater treatment plants: Current status and challenges.

Metformin environmental exposure: A systematic review.

Miscellaneous

Towards safe drinking water and clean cooking for all.

Human Health Studies

Numerous Chemicals

An exposomic approach with 138 chemical and non-chemical exposures to predict 32 biomarkers of male reproductive damages: A case study of college students in Chongqing, China.

Mixtures

Assessment of Grouped Weighted Quantile Sum Regression for Modeling Chemical Mixtures and Cancer Risk.

Exposure to polycyclic aromatic hydrocarbon mixtures and early kidney damage in Mexican indigenous population.

BPA/Parabens

Urinary bisphenol A concentrations and the risk of obesity in Korean adults.

High urinary concentrations of parabens and bisphenol A in very low birth weight infants.

A pilot study: Relationship between Bisphenol A, Bisphenol A glucuronide and sex steroid hormone levels in cord blood in a South African population.

Phthalates

Urinary phthalates and body mass index in preschool children: The MIREC Child Development Plus study.

Prenatal exposure to phthalates and maternal metabolic outcomes in a high-risk pregnant Latina population.

Urinary phthalate metabolite concentrations, oxidative stress and thyroid function biomarkers among patients with thyroid nodules.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Level of Organochlorine Pesticide in Prediabetic and Newly Diagnosed Diabetes Mellitus Patients with Varying Degree of Glucose Intolerance and Insulin Resistance among North Indian Population.

Long-term atmospheric exposure to PCB153 and breast cancer risk in a case-control study nested in the French E3N cohort from 1990 to 2011.

Serum concentrations of persistent organic pollutants and colorectal cancer risk: A case-cohort study within Korean National Cancer Center Community (KNCCC) cohort.

Perfluoroalkyl Substances

Perfluoroalkyl acids and their isomers, diabetes, anemia, and albuminuria: Variabilities with deteriorating kidney function.

Exposure to perfluoroalkyl substances (PFAS) and dyslipidemia, hypertension and obesity in adolescents. The Fit Futures study.

Potentially Toxic Elements

Single-cell transcriptomics uncovers phenotypic alterations in the monocytes in a Chinese population with chronic cadmium exposure.

Urine Tungsten and Chronic Kidney Disease in Rural Colorado.

Air Pollution

Prenatal Exposure to Airborne Particulate Matter of 1 μm or Less and Fetal Growth: A Birth Cohort Study in Beijing, China.

Association between short-term exposure to air pollution and sudden infant death syndrome.

Adverse Birth Outcomes Due to Exposure to Household Air Pollution from Unclean Cooking Fuel among Women of Reproductive Age in Nigeria.

Fine Particulate Matter and Markers of Alzheimer’s Disease Neuropathology at Autopsy in a Community-Based Cohort.

The Effects of Air Pollution, Sea Exposure and Altitude on COVID-19 Hospitalization Rates in Italy.

An external exposome-wide association study of COVID-19 mortality in the United States.

Laboratory Studies

BPA/Phenols

Bisphenol A promotes stress granule assembly and modulates the integrated stress response.

Bisphenol A disturbs metabolism of primary rat adipocytes without affecting adipokine secretion.

Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions.

Toxicity of bisphenol A on marine microalgae: Single- and multispecies bioassays based on equivalent initial cell biovolume.

Korean Red Ginseng suppresses bisphenol A-induced expression of cyclooxygenase-2 and cellular migration of A549 human lung cancer cell through inhibition of reactive oxygen species.

Selenium attenuates bisphenol A incurred damage and apoptosis in mice testes by regulating mitogen-activated protein kinase signalling.

Comprehensive supramolecular solvent-based sample treatment platform for evaluation of combined exposure to mixtures of bisphenols and derivatives by liquid chromatography-tandem mass spectrometry.

Greater toxic potency of bisphenol AF than bisphenol A in growth, reproduction, and transcription of genes in Daphnia magna.

Bioinformatics analysis and quantitative weight of evidence assessment to map the potential mode of actions of bisphenol A.

Phthalates

Comparative Analysis of Neurotoxicity of Six Phthalates in Zebrafish Embryos.

Benzyl butyl phthalate activates prophage, threatening the stable operation of waste activated sludge anaerobic digestion.

The effects of NONRATT008453.2 on autophagy in genital tubercle fibroblasts of rats with hypospadias induced by dibutyl phthalate.

System Biology-Guided Chemical Proteomics to Discover Protein Targets of Monoethylhexyl Phthalate in Regulating Cell Cycle.

Parabens

Application of grouping and read-across for the evaluation of parabens of different chain lengths with a particular focus on endocrine properties.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

DNA Methylation Patterns in CD4+ T Cells of Naïve and Influenza A Virus-Infected Mice Developmentally Exposed to an Aryl Hydrocarbon Receptor Ligand.

Perfluoroalkyl Substances

Chronic exposure to PFO4DA and PFO5DoDA, two perfluoroalkyl ether carboxylic acids (PFECAs), suppresses hepatic stress signals and disturbs glucose and lipid metabolism in male mice.

Relative Acute Toxicity of Three Per- and Polyfluoroalkyl Substances on Nine Species of Larval Amphibians.

Flame Retardants

In vitro biolayer interferometry analysis of acetylcholinesterase as a potential target of aryl-organophosphorus flame-retardants.

Pesticides

Chlorpyrifos with age-dependent effects in cardiac tissue of male rats.

Effects of chlorpyrifos on primary gill cell culture of Lake Van fish (Alburnus tarichi Güldenstaadt 1814).

Toxicant exposure during pregnancy increases protective proteins in the dam and a sexually dimorphic response in the fetus. [vinclozolin]

Integration of sperm ncRNA-directed DNA methylation and DNA methylation-directed histone retention in epigenetic transgenerational inheritance. [vinclozolin and DDT]

Characterizing the protracted neurobiological and neuroanatomical effects of paraquat in a murine model of Parkinson’s disease.

Oral mucosa changes associated with chronic oral and inhalation exposure to 2,4-dichlorophenoxiacetic acid (2,4-D) in Wistar rats.

Non-linear model analysis of the relationship between cholinesterase activity in rats exposed to 2, 2-dichlorovinyl dimethylphosphate (dichlorvos) and its metabolite concentrations in urine.

The influence of tolfenpyrad on fitness, development, and reproduction in parents and offspring of Coccinella septempunctata.

Larvae of stingless bee Scaptotrigona bipunctata exposed to organophosphorus pesticide develop into lighter, smaller and deformed adult workers.

Effects of developmental exposure to pesticides in wax and pollen on honey bee (Apis mellifera) queen reproductive phenotypes.

Survival rate and changes in foraging performances of solitary bees exposed to a novel insecticide.

Thiamethoxam exposure deregulates short ORF gene expression in the honey bee and compromises immune response to bacteria.

Potentially Toxic Elements

Sex-Specific Alterations in Cardiac DNA Methylation in Adult Mice by Perinatal Lead Exposure.

Intestinal response characteristic and potential microbial dysbiosis in digestive tract of Bufo gargarizans after exposure to cadmium and lead, alone or combined.

Lead and mercury 28 day exposure at small concentrations reduces smooth muscle relaxation by decreasing cGMP.

Prepubertal exposure to a high dose of cadmium induces hypothalamic injury through transcriptome profiling alteration and neuronal degeneration in female rats.

Selenium-Alleviated Testicular Toxicity by Modulating Inflammation, Heat Shock Response, and Autophagy Under Oxidative Stress in Lead-Treated Chickens.

Microplastics/Nanomaterials

Comparison of transgenerational reproductive toxicity induced by pristine and amino modified nanoplastics in Caenorhabditis elegans.

Toxicity of polystyrene nanoplastics and zinc oxide to mice.

Environmentally Relevant Iron Oxide Nanoparticles Produce Limited Acute Pulmonary Effects in Rats at Realistic Exposure Levels.

Plastisphere enrich antibiotic resistance genes and potential pathogenic bacteria in sewage with pharmaceuticals.

Size-dependent chronic toxicity of fragmented polyethylene microplastics to Daphnia magna.

Induction of protective response to polystyrene nanoparticles associated with methylation regulation in Caenorhabditis elegans.

Air Pollution

Monkeys fight more in polluted air.

Perinatal Exposure to Diesel Exhaust-Origin Secondary Organic Aerosol Induces Autism-Like Behavior in Rats.

Ovariectomy reduces the cardiac cytoprotection in rats exposed to particulate air pollutant.

Pharmaceuticals/Personal Care Products

Assessing effects of aromatase inhibition on fishes with group-synchronous oocyte development using western mosquitofish (Gambusia affinis) as a model. [fadrozole]

Conversion of Estrone to 17β-Estradiol: A Potential Confounding Factor in Assessing Risks of Environmental Estrogens to Fish.

Environmentally relevant concentrations of sertraline disrupts behavior and the brain and liver transcriptome of juvenile yellow catfish (Tachysurus fulvidraco): Implications for the feeding and growth axis.

Mixtures

Assessment of chemical mixtures using biomarkers of combined biological activity: A screening study in human placentas.

Generation-specific and interactive effects of pesticide and antidepressant exposure in a fish model call for multi-stressor and multigenerational testing.

Joint toxicity assessment reveals synergistic effect of chlorpyrifos and dichlorvos to common carp (Cyprinus carpio).

Miscellaneous

Exposure of androgen mimicking environmental chemicals enhances proliferation of prostate cancer (LNCaP) cells by inducing AR expression and epigenetic modifications. [benzo[a]pyrene, dichlorvos, genistein and β-endosulfan]

Prenatal androgen exposure causes a sexually dimorphic transgenerational increase in offspring susceptibility to anxiety disorders.

Exposure/Environment Studies

Numerous Chemicals

ExHuMId: A curated resource and analysis of Exposome of Human Milk across India.

BPA/Phenols

Development and feasibility of randomized trial to reduce urinary bisphenols in women with obesity.

The Association Between Urinary BPA Levels and Medical Equipment Among Pediatric Intensive Care Patients.

Phthalates

Spatial distribution, historical trend, and ecological risk assessment of phthalate esters in sediment from Taihu Lake, China.

Seasonal distribution and ecological risks of phthalic acid esters in surface water of Taihu Lake, China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Concentrations of Persistent Organic Pollutants in Women’s Serum in the European Arctic Russia.

Organochlorine compounds pose health risks to the Qinling Giant Panda (Ailuropoda melanoleuca qinlingensis).

Levels and patterns of polychlorinated dibenzo-p-dioxins and dibenzofurans and polychlorinated biphenyls in foodstuffs of animal origin from Chinese markets and implications of dietary exposure.

Polychlorinated biphenyls are associated with reduced testes weights in harbour porpoises (Phocoena phocoena).

Estimation of dietary intake and sources of organohalogenated contaminants among infants: 24-h duplicate diet survey in Fukuoka, Japan.

Polychlorinated biphenyls in indoor dust from urban dwellings of Lahore, Pakistan: Congener profile, toxicity equivalency, and human health implications.

Perfluoroalkyl Substances

Distribution behavior and risk assessment of emerging perfluoroalkyl acids in multiple environmental media at Luoma Lake, East China.

Health and social concerns about living in three communities affected by per- and polyfluoroalkyl substances (PFAS): A qualitative study in Australia.

Suspect and Nontarget Screening Revealed Class-Specific Temporal Trends (2000-2017) of Poly- and Perfluoroalkyl Substances in St. Lawrence Beluga Whales.

PFAS soil and groundwater contamination via industrial airborne emission and land deposition in SW Vermont and Eastern New York State, USA.

Paper product production identified as the main source of per- and polyfluoroalkyl substances (PFAS) in a Norwegian lake: Source and historic emission tracking.

Legacy and emerging per- and poly-fluoroalkyl substances in surface seawater from northwestern Pacific to Southern Ocean: Evidences of current and historical release.

Determination and risk assessment of perfluorinated alkylated substances (PFASs) in pork liver from mainland, China.

Flame Retardants

Emission of Dioxin-like Compounds and Flame Retardants from Commercial Facilities Handling Deca-BDE and Their Downstream Sewage Treatment Plants.

4,5,6,7-Tetrabromo-2,3-dihydro-1,1,3-trimethyl-3-(2,3,4,5-tetrabromophenyl)-1H-indene (OBTMPI): Levels in humans and in silico toxicological profiles.

Pesticides

Insect decline in the Anthropocene: Death by a thousand cuts intro to special issue which includes articles like these and more:

A window to the world of global insect declines: Moth biodiversity trends are complex and heterogeneous.

The decline of butterflies in Europe: Problems, significance, and possible solutions.

Pesticides in Drinking Water-A Review.

In silico prediction of chemical acute contact toxicity on honey bees via machine learning methods.

Long-term effects of a catastrophic insecticide spill on stream invertebrates.

Monitoring of pesticides in drinking water: finding the right balance between under- and over-monitoring – experience from the Czech Republic.

Repeated insecticide pulses increase harmful effects on stream macroinvertebrate biodiversity and function.

Potentially Toxic Elements

Exposures in nail salons to trace elements in nail polish from impurities or pigment ingredients – A pilot study.

Mercury in neonatal and juvenile blacktip sharks (Carcharhinus limbatus). Part II: Effects assessment.

Microplastics

You are what you eat: Microplastics in the feces of young men living in Beijing.

Microplastics in seafood as an emerging threat to marine environment: A case study in Goa, west coast of India.

Pervasive distribution of polyester fibres in the Arctic Ocean is driven by Atlantic inputs.

Assessing small-scale freshwater microplastics pollution, land-use, source-to-sink conduits, and pollution risks: Perspectives from Japanese rivers polluted with microplastics.

Honeybees as active samplers for microplastics.

Air Pollution

“Freedom to Breathe”: Youth Participatory Action Research (YPAR) to Investigate Air Pollution Inequities in Richmond, CA.

Reduction in concentration of PM_2.5 in India’s top most polluted cities: with special reference to post-lockdown period.

Pharmaceuticals/Personal Care Products

Filaggrin Polymorphisms and the Uptake of Chemicals through the Skin-A Human Experimental Study. [pyrene, pyrimethanil, and oxybenzone]

Occurrence of pharmaceutical residues, personal care products, lifestyle chemicals, illicit drugs and metabolites in wastewater and receiving surface waters of Krakow agglomeration in South Poland.

Improving urban drainage systems to mitigate PPCPs pollution in surface water: A watershed perspective.

Plastisphere enrich antibiotic resistance genes and potential pathogenic bacteria in sewage with pharmaceuticals.

Miscellaneous

Analysis of urinary metabolites of polycyclic aromatic hydrocarbons in precarious workers of highly exposed occupational scenarios in Mexico.

Polycyclic aromatic hydrocarbons, antibiotic resistance genes, toxicity in the exposed to anthropogenic pressure soils of the Southern Russia.

Chlorinated paraffins in infant foods from the Chinese market and estimated dietary intake by infants.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.