EDC Science Weekly, Jan. 6 – 12, 2021

Post author:HEEDS
Post published:January 12, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events,Resources, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Jan 13: An introduction to the “essential use” concept and its application to PFAS

Webinar Jan 28: Preconception Matters, Too: EDC Impacts on Reproductive Health and Development

Resources

Free new edition of the e-book, A Small Dose of Toxicology: The Health Effects of Common Chemicals, by Dr. Steven Gilbert. Available in English, Spanish, Arabic, Chinese, and German. Chapter 20 focuses on EDCs.

Methods/Tools/Screening

The Exposome in the Era of One Health.

The Confounder-Mediator Dilemma: Should We Control for Obesity to Estimate the Effect of Perfluoroalkyl Substances on Health Outcomes?

Integrating endocrine-related health effects into comparative human toxicity characterization.

Evaluation of Development of the Rat Uterus as a Toxicity Biomarker.

Acetylcholinesterase (AChE) Activity in Embryos of Zebrafish.

Early Life Stage Assays in Zebrafish.

Reaction Tracking and High-Throughput Screening of Active Compounds in Combinatorial Chemistry by Tandem Mass Spectrometry Molecular Networking.

Commentaries

A New Era for EHP‘s International Program.

Testicular Stem Cell Dysfunction Due to Environmental Insults Could Be Responsible for Deteriorating Reproductive Health of Men.

Significance of Environmental Input Data in Risk Assessment Analyses.

Introduction to the Theme “Old and New Toxicology: Interfaces with Pharmacology”.

Critique of the “Comment” etitled “Pyrethroid exposure: not so harmless after all” by Demeneix et al. (2020) published in The Lancet Diabetes Endocrinology.

Reviews

Numerous EDCs

Effects of endocrine disrupting chemicals in host health: Three-way interactions between environmental exposure, host phenotypic responses, and gut microbiota.

Brain Disorders and Chemical Pollutants: A Gap Junction Link?

Toxicant Effects on Mammalian Oocyte Mitochondria.

Bioanalytical methodologies for clinical investigation of endocrine-disrupting chemicals: a comprehensive update.

Parabens

Assessing the Public Health Implications of the Food Preservative Propylparaben: Has This Chemical Been Safely Used for Decades.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

How the AHR Became Important in Cancer: The Role of Chronically Active AHR in Cancer Aggression.

The aryl hydrocarbon receptor and the gut-brain axis.

The Aryl Hydrocarbon Receptor in Chronic Kidney Disease: Friend or Foe?

Flame Retardants

Flame retardants and neurodevelopment: An updated review of epidemiological literature.

Potentially Toxic Elements

Arsenic: A Global Environmental Challenge.

Mercury and Alzheimer’s disease: a look at the links and evidence.

Advances in Research on the Toxicological Effects of Selenium.

Relationship of Circulating Copper Level with Gestational Diabetes Mellitus: a Meta-Analysis and Systemic Review.

Microplastics

The organic output from mechanical-biological treatment plants as a source of microplastics: Mini-review on current knowledge, research methodology and future study perspectives.

Air Pollution

A mechanistic view on the neurotoxic effects of air pollution on central nervous system: risk for autism and neurodegenerative diseases.

Use of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum.

Cardiovascular health impacts of wildfire smoke exposure.

Short-term exposure to air pollution and hospital admission for pneumonia: a systematic review and meta-analysis.

Pharmaceuticals/Personal Care Products

Prevalence and hazardous impact of pharmaceutical and personal care products and antibiotics in environment: A review on emerging contaminants.

Spontaneous abortion in women occupationally exposed to inhalational anesthetics: a critical systematic review.

Miscellaneous

Environmental Justice in the American Public Health Context: Trends in the Scientific Literature at the Intersection Between Health, Environment, and Social Status.

Human Health Studies

Numerous Chemicals

Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts.

The Association of Ovarian Reserve with Exposure to Bisphenol A and Phthalate in Reproductive-aged Women.

Phthalates

Prenatal phthalate exposures and autism spectrum disorder symptoms in low-risk children.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Identification and prioritization of the potent components for combined exposure of multiple persistent organic pollutants associated with gestational diabetes mellitus.

A prospective ultrasound study of plasma polychlorinated biphenyl concentrations and incidence of uterine leiomyomata

Perfluoroalkyl Substances

Gestational and childhood exposure to per- and polyfluoroalkyl substances and cardiometabolic risk at age 12 years.

Impact of kidney hyperfiltration on concentrations of selected perfluoroalkyl acids among US adults for various disease groups.

Pesticides

Exposure to pesticides in utero impacts the fetal immune system and response to vaccination in infancy.

Lifetime Pesticide Use and Monoclonal Gammopathy of Undetermined Significance in a Prospective Cohort of Male Farmers.

Potentially Toxic Elements

Meet-in-metabolite analysis: A novel strategy to identify connections between arsenic exposure and male infertility.

Prenatal exposure to multiple metals and birth outcomes: An observational study within the National Children’s Study cohort.

Prenatal metal mixtures and child blood pressure in the Rhea mother-child cohort in Greece.

Serum Cadmium Levels and Risk of Metabolic Syndrome: A Cross-Sectional Study.

The relationship between cadmium exposure and renal volume in inhabitants of a cadmium-polluted area of Japan.

Prospective association of metal levels with gestational diabetes mellitus and glucose: A retrospective cohort study from South China.

Analyses of maternal plasma cadmium, lead, and vanadium levels in the diagnosis and severity of late-onset preeclampsia: a prospective and comparative study

The association of cadmium and lead exposures with red cell distribution width.

Air Pollution

Long-term Exposure to Ozone and Sulfur Dioxide Increases the Incidence of Type 2 Diabetes Mellitus among Aged 30 to 50 adult population.

Longitudinal associations between ambient air pollution and insulin sensitivity: results from the KORA cohort study.

Long-term effects of fine particulate matter exposure on the progression of arterial stiffness.

A time series analysis of ambient air pollution and low birth weight in Xuzhou, China

Air Pollution Is Associated with Poor Cognitive Function in Taiwanese Adults

Estimation of pregnancy losses attributable to exposure to ambient fine particles in south Asia: an epidemiological case-control study.

Preconceptional and prenatal exposure to air pollution increases incidence of childhood pneumonia: A hypothesis of the (pre-)fetal origin of childhood pneumonia.

Ambient air pollutants and hospital visits for pneumonia: a case-crossover study in Qingdao, China.

Residential Proximity to Greenness Mitigates the Hemodynamic Effects of Ambient Air Pollution.

Proximity to traffic and exposure to polycyclic aromatic hydrocarbons in relation to Attention Deficit Hyperactivity Disorder and conduct disorder in U.S. children.

Trimester effects of source-specific PM₁₀ on birth weight outcomes in the Avon Longitudinal Study of Parents and Children (ALSPAC).

Metabolomic signatures of the long-term exposure to air pollution and temperature.

Life Course Air Pollution Exposure and Cognitive Decline: Modelled Historical Air Pollution Data and the Lothian Birth Cohort 1936.

Are environmental pollution and biodiversity levels associated to the spread and mortality of COVID-19? A four-month global analysis.

Miscellaneous

Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility.

Laboratory Studies

BPA/Phenols

Melatonin abated Bisphenol A-induced neurotoxicity via p53/PUMA/Drp-1 signaling.

Bisphenol A stabilizes Nrf2 via Ca²⁺ influx by direct activation of the IP₃ receptor.

Evaluation of testicular toxicity upon fetal exposure to bisphenol A using an organ culture method.

Bisphenol A (BPA) Affects the Enteric Nervous System in the Porcine Stomach.

Sex-dependent dysregulation of human neutrophil responses by bisphenol A.

Paternal bisphenol A exposure induces testis and sperm pathologies in mice offspring: Possibly due to oxidative stress?

Bisphenol F induces nonalcoholic fatty liver disease-like changes: Involvement of lysosome disorder in lipid droplet deposition.

Protective effect of myricetin on nonylphenol-induced testicular toxicity: biochemical, steroidogenic, hormonal, spermatogenic, and histological-based evidences.

Phthalates

Detrimental effects induced by diisononyl phthalate on development and behavior of Drosophila larva and potential mechanisms.

Di-(2-ethylhexyl) phthalate induces testicular endoplasmic reticulum stress and germ cell apoptosis in adolescent mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells.

Perfluoroalkyl Substances

Assessment of perfluorooctanoic acid toxicity in pancreatic cells.

Non-targeted metabolomics of multiple human cells revealing differential toxic effects of perfluorooctanoic acid.

Flame Retardants

Polybrominated diphenyl ethers exert genotoxic effects in pantropic spotted dolphin fibroblast cell lines.

Polybrominated Diphenyl Ethers in Human Follicular Fluid Dysregulate Mural and Cumulus Granulosa Cell Gene Expression.

Aging-induced changes in sperm DNA methylation are modified by low dose of perinatal flame retardants

Development of an adverse outcome pathway for nanoplastic toxicity in Daphnia pulex using proteomics.

Organotins

Dysregulation of lipid metabolism in PLHC-1 and ZFL cells exposed to tributyltin an all-trans retinoic acid.

Pesticides

Effects of Dinotefuran on Brain miRNA Expression Profiles in Young Adult Honey Bees (Hymenopptera: Apidae).

Studying the effects of profenofos, an endocrine disruptor, on organogenesis of zebrafish.

Monitoring of glyphosate-DNA interaction and synergistic genotoxic effect of glyphosate and 2,4-dichlorophenoxyacetic acid using an electrochemical biosensor.

Predictive classification-based QSTR models for toxicity study of diverse pesticides on multiple avian species.

Acute and chronic toxicity tests of systemic insecticides, four neonicotinoids and fipronil, using the tadpoles of the western clawed frog Silurana tropicalis.

Transcriptomics analysis of hepatotoxicity induced by the pesticides imazalil, thiacloprid and clothianidin alone or in binary mixtures in a 28-day study in female Wistar rats.

Transcriptomic profiling of atrazine phytotoxicity and comparative study of atrazine uptake, movement, and metabolism in Potamogeton crispus and Myriophyllum spicatum.

Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells.

Potentially Toxic Elements

Protective Effect of Vitamin D3 Against Pb-Induced Neurotoxicity by Regulating the Nrf2 and NF-κB Pathways.

Transgenerational male reproductive effect of prenatal arsenic exposure: abnormal spermatogenesis with Igf2/H19 epigenetic alteration in CD1 mouse.

Nrf2 deficiency aggravates the kidney injury induced by subacute cadmium exposure in mice.

Different Routes of Administration Lead to Different Oxidative Damage and Tissue Disorganization Levels on the Subacute Cadmium Toxicity in the Liver.

Pancreatic Islets Accumulate Cadmium in a Rodent Model of Cadmium-Induced Hyperglycemia.

Cadmium exposure reduces invasion of the human trophoblast-derived HTR-8/SVneo cells by inhibiting cell adhesion and matrix metalloproteinase-9 secretion.

Protective effects of selenium and zinc against potassium dichromate-induced thyroid disruption, oxidative stress, and DNA damage in pregnant Wistar rats.

Roles of oxidative stress, apoptosis, and inflammation in metal-induced dysfunction of beta pancreatic cells isolated from CD1 mice.

Microplastics

The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase-1 signaling pathway and oxidative stress in Wistar rats.

Development of an adverse outcome pathway for nanoplastic toxicity in Daphnia pulex using proteomics.

Neurodevelopmental Toxicity of Polystyrene Nanoplastics in Caenorhabditis elegans and the Regulating Effect of Presenilin.

Experimental evidence of physiological and behavioral effects of microplastic ingestion in Sparus aurata.

Air Pollution

In Utero Exposure to Fine Particles Decreases Early Birth Weight of Rat Offspring and TLR4/NF-κB Expression in Lungs.

Identification of toxicity pathway of diesel particulate matter using AOP of PPARγ inactivation leading to pulmonary fibrosis.

Exposure to diesel exhaust particles results in altered lung microbial profiles, associated with increased reactive oxygen species/reactive nitrogen species and inflammation, in C57Bl/6 wildtype mice on a high-fat diet.

Environmental pollution and COVID-19: the molecular terms and predominant disease outcomes of their sweetheart agreement.

Intratracheally instillated diesel PM_2.5 significantly altered the structure and composition of indigenous murine gut microbiota.

Pharmaceuticals/Personal Care Products

Assessment of the in vitro developmental toxicity of diethylstilbestrol and estradiol in the zebrafish embryotoxicity test.

Mixtures

Emerging contaminant occurrence and toxic effects on zebrafish embryos to assess the adverse effects caused by mixtures of substances in the environment.

Effects of a mixture of glyphosate, 17α-ethynylestradiol and amyl salicylate on cellular and biochemical parameters of the mussel Mytilus galloprovincialis.

Miscellaneous

Integrated QSAR and Adverse Outcome Pathway Analysis of Chemicals Released on 3D Printing Using Acrylonitrile Butadiene Styrene.

Exposure/Environment Studies

Numerous EDCs

Exposure of the French population to bisphenols, phthalates, parabens, glycol ethers, brominated flame retardants, and perfluorinated compounds in 2014-2016: Results from the Esteban study.

Iranian population exposures to heavy metals, PAHs, and pesticides and their intake routes: a study protocol of a national population health survey.

BPA/Phenols

Electrochemical detection of bisphenols in food: A review.

Bisphenol S is present in culture media used for ART and cell culture.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Resistance to Cyp3a induction by polychlorinated biphenyls, including non-dioxin-like PCB153, in gills of killifish (Fundulus heteroclitus) from New Bedford Harbor.

Persistent pollutants exceed toxic thresholds in a freshwater top predator decades after legislative control.

Deep seafloor plastics as the source and sink of organic pollutants in the northern South China Sea.

Perfluoroalkyl Substances

Effectiveness of household water purifiers in removing perfluoroalkyl substances from drinking water.

Developing Hazard Rating Calculation Methodologies for Per- and Polyfluoroalkyl Substances.

Perfluoroalkyl substances in the urine and hair of preschool children, airborne particles in kindergartens, and drinking water in Hong Kong.

Urine concentrations of perfluoroalkyl acids in children and contributions of dietary factors: a cross-sectional study from Shanghai, China

Understanding PFAAs exposure in a generalist seabird species breeding in the vicinity of a fluorochemical plant: Influence of maternal transfer and diet.

Per- and polyfluoroalkyl substances and their alternatives in black-tailed gull (Larus crassirostris) eggs from South Korea islands during 2012-2018.

Legacy and emerging per- and polyfluoroalkyl substances (PFASs) in Australian biosolids.

Flame Retardants

Exposure levels, determinants and risk assessment of organophosphate flame retardants and plasticizers in adolescents (14-15 years) from the Flemish Environment and Health Study.

Transplacental Behaviors of Organophosphate Tri- and Diesters Based on Paired Human Maternal and Cord Whole Blood: Efficiencies and Impact Factors.

Ornamental houseplants as potential biosamplers for indoor pollution of organophosphorus flame retardants.

Human Health Risk Assessment by Dietary Intake and Spatial Distribution Pattern of Polybrominated Diphenyl Ethers and Dechloran Plus from Selected Cities of Pakistan.

Brominated flame retardants (BFRs) in PM_2.5 associated with various source sectors in southern China.

Pesticides

Pesticide Toxicity Hazard of Agriculture: Regional and Commodity Hotspots in Australia.

Honeybee colonies compensate for pesticide-induced effects on royal jelly composition and brood survival with increased brood production.

Consumer Preference, Quality, and Safety of Organic and Conventional Fresh Fruits, Vegetables, and Cereals.

Potentially Toxic Elements

Revisiting the Village Where Arsenic Contamination of Underground Water Was First Discovered in Bangladesh: Twenty-Five Years Later.

Metal(loid) exposure on children from a historical metallurgical site.

Mercury in neonatal and juvenile blacktip sharks (Carcharhinus limbatus). Part I: exposure assessment.

Inventory of Pb emissions from one of the largest historic Pb smelter worldwide: 118-year legacy of Pb pollution in northern Mexico.

Evidence of chronic cadmium exposure identified in the critically endangered Christmas Island flying-fox (Pteropus natalis).

Assessment of some heavy metals in crude oil workers from Kurdistan Region, northern Iraq.

Microplastics

Wastewater treatment alters microbial colonization of microplastics.

Characteristics of expanded polystyrene microplastics on island beaches in the Pearl River Estuary: abundance, size, surface texture and their metals-carrying capacity.

Air Pollution

Four Decades of United States Mobile Source Pollutants: Spatial-Temporal Trends Assessed by Ground-Based Monitors, Air Quality Models, and Satellites.

Increased air pollution exposure among the Chinese population during the national quarantine in 2020.

Polycyclic aromatic compounds (PACs) in the Canadian environment: Ambient air and deposition.

Whether COVID-19 lockdown in Delhi and Kolkata improved the ambient air quality of the two cities?

COVID-19: Has social isolation reduced the emission of pollutants in the megacity of São Paulo-Brazil?

COVID-19 lockdowns reduce the Black carbon and polycyclic aromatic hydrocarbons of the Asian atmosphere: source apportionment and health hazard evaluation.

Pharmaceuticals/Personal Care Products

Pharmaceuticals and personal care products in the seawater around a typical subtropical tourist city of China and associated ecological risk.

Determination of 38 pharmaceuticals and personal care products in water by lyophilization combined with liquid chromatography-tandem mass spectrometry.

Mixtures

An Integrated Biomarker Approach Using Flounder to Improve Chemical Risk Assessments in the Heavily Polluted Seine Estuary.

Miscellaneous

Exposure Assessment of Toxicologically Relevant Volatile Organic Compounds Emitted from Polymer-Based Costume Masks.

Human Exposure to Chlorinated Paraffins via Inhalation and Dust Ingestion in a Norwegian Cohort.

The impact of integrating environmental health into medical school curricula: a survey-based study.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.