EDC Science Weekly, Nov. 25 – Dec. 1, 2020

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinars

Adverse effects of PFAS on Immune System Health: Complicating recovery during the COVID-19 Pandemic, Dec 2

Are fluoropolymers really of low concern for human and environmental health and separate from other PFAS?, Dec 3

Improving Health Outcomes at the Community Level: Chemical Risk Assessment Methods in Light of Lessons Learned with COVID-19, Dec 8

How Chemicals and Air Pollution Are Harming Fertility: Latest Evidence and What We Can Do, Dec 10

Conferences

The Beyond Genes Conference has a session Dec 4 on Heritable Impacts of Endocrine Disrupting Compounds and DES

Methods/Tools/Screening

A call for action on the development and implementation of new methodologies for safety assessment of chemical-based products in the EU – A short communication.

Pop-GUIDE: Population modeling Guidance, Use, Interpretation, and Development for Ecological Risk Assessment.

Exploring the Potential of ToxCast Data in Supporting Read-Across for Evaluation of Food Chemical Safety.

Commentaries/Conference Summaries

The high persistence of PFAS is sufficient for their management as a chemical class.

The COVID-19 pandemic and global environmental change: Emerging research needs.

Air of Uncertainty: Can We Study Pollution and COVID-19 in the Midst of a Pandemic? [Science Selection in EHP]

Reviews

Numerous EDCs

Sex-Biased Impact of Endocrine Disrupting Chemicals on Behavioral Development and Vulnerability to Disease: Of Mice and Children.

Parabens

A perspective on the safety of parabens as preservatives in wound care products.

Flame Retardants

A review of 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane in the environment and assessment of its persistence, bioaccumulation and toxicity.

The potential connections of adverse outcome pathways with the hazard identifications of typical organophosphate esters based on toxicity mechanisms.

Pesticides

Pesticide effects on fish cholinesterase variability and mean activity: A meta-analytic review.

Towards a mechanism-based approach for the prediction of nongenotoxic carcinogenic potential of agrochemicals.

Potentially Toxic Elements

Early Cardiovascular Risk in E-cigarette Users: the Potential Role of Metals.

Plant Polyphenols: Potential Antidotes for Lead Exposure.

Microplastics

Environmental prevalence, fate, impacts, and mitigation of microplastics-a critical review on present understanding and future research scope.

Non-biodegradable microplastics in soils: A brief review and challenge.

Pharmaceuticals/Personal Care Products

Early life factors for endometriosis: a systematic review. [DES]

Review of aquatic toxicity of pharmaceuticals and personal care products to algae.

Miscellaneous

Mapping the past, present and future research landscape of paternal effects.

The role of metabolism in toxicity of polycyclic aromatic hydrocarbons and their non-genotoxic modes of action.

Human Health Studies

Numerous Chemicals

Identifying environmental exposure profiles associated with timing of menarche: A two-step machine learning approach to examine multiple environmental exposures.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Mortality in Yusho patients exposed to polychlorinated biphenyls and polychlorinated dibenzofurans: a 50-year retrospective cohort study.

Perfluoroalkyl Substances

Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort.

Potentially Toxic Elements

In utero and peripubertal metals exposure in relation to reproductive hormones and sexual maturation and progression among boys in Mexico City.

Low-level cadmium exposure is associated with decreased cortical thickness, cortical area and trabecular bone volume fraction in elderly men: The MrOS Sweden study.

Toenail mercury levels positively correlate with obesity and abdominal obesity among Korean adults.

Association of arsenic exposure and cognitive impairment: A population-based cross-sectional study in China.

Blood cadmium levels as a marker for early lung cancer detection.

Air Pollution

Residential traffic exposure and lymphohematopoietic malignancies among children in the city of São Paulo, Brazil: An ecological study.

Household air pollution and under-five mortality in sub-Saharan Africa: an analysis of 14 demographic and health surveys.

Associations between land cover categories, gaseous PAH levels in ambient air and endocrine signaling predicted from gut bacterial metagenome of the elderly.

Improvement in life expectancy for ischemic heart diseases by achieving daily ambient PM_2.5 standards in China.

Relation between Accumulated Air Pollution Exposure and Sub-Clinical Cardiovascular Disease in 33,723 Danish 60-74-Year-Old Males from the Background Population (AIR-CARD): A Method Article.

Ambient air pollutants and their effect on COVID-19 mortality in the United States of America.

Association Between Ambient Air Pollution and Amyloid Positron Emission Tomography Positivity in Older Adults With Cognitive Impairment.

Regional and global contributions of air pollution to risk of death from COVID-19.

Ambient PM_2.5 exposure and rapid spread of COVID-19 in the United States.

Miscellaneous

Meconium androgens are correlated with ASD-related phenotypic traits in early childhood in a familial enriched risk cohort.

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.

Laboratory Studies

BPA/Phenols

Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway.

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine.

In Vitro Metabolism of Five Bisphenol A Analogs Studied by LC-HRMS/MS.

The phenotypic and transcriptomic effects of developmental exposure to nanomolar levels of estrone and bisphenol A in zebrafish.

Effects on the liver lipidome of rat offspring prenatally exposed to bisphenol A.

Phthalates

Di (2-ethylhexyl) phthalate impairs primordial follicle assembly by increasing PDE3A expression in oocytes.

Parabens/Triclosan/Antimicrobials

Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Ultrastructural Mechanisms of Impaired Aldosterone Synthesis in Rats Exposed to DDT during Prenatal and Postnatal Development.

Evolution of Hominin Detoxification: Neanderthal and Modern Human Ah Receptor Respond Similarly to TCDD.

TCDD Attenuates EAE Through Induction of FasL on B Cells and Inhibition of IgG Production.

Perfluoroalkyl Substances

Binding of Per- and Polyfluoroalkyl Substances to the Human Pregnane X Receptor.

Epigenetic Modifications, and Alterations in Cell Cycle and Apoptosis Pathway in A549 Lung Carcinoma Cell Line upon Exposure to Perfluoroalkyl Substances.

Flame Retardants

Tris (1,3-dichloro-2-propyl) phosphate exposure disrupts the gut microbiome and its associated metabolites in mice.

Tris(2-chloroethyl) Phosphate (TCEP) Elicits Hepatotoxicity by Activating Human Cancer Pathway Genes in HepG2 Cells.

Mechanisms of transplacental transport and barrier of polybrominated diphenyl ethers: A comprehensive human, Sprague-Dawley rat, BeWo cell and molecular docking study.

In Utero and lactational exposure to an environmentally relevant mixture of brominated flame retardants induces a premature development of the mammary glands.

Pesticides

Quantitative in Vitro to in Vivo Extrapolation (QIVIVE) for Predicting Reduced Anogenital Distance Produced by Anti-Androgenic Pesticides in a Rodent Model for Male Reproductive Disorders.

Concentration- and time-dependent toxicity of commonly encountered pesticides and pesticide mixtures to honeybees (Apis mellifera L.).

Positive Correlation between Pesticide Consumption and Longevity in Solitary Bees: Are We Overlooking Fitness Trade-Offs?

Cytotoxic and estrogenic activity of chlorpyrifos and its metabolite 3,5,6-trichloro-2-pyridinol. Study of marine yeasts as potential toxicity indicators.

Binding properties to nicotinic acetylcholine receptors can explain differential toxicity of neonicotinoid insecticides in Chironomidae.

Herbicides glyphosate and glufosinate ammonium negatively affect human sperm mitochondria respiration efficiency.

Effects of glyphosate-based herbicide-contaminated diets on reproductive organ toxicity and hypothalamic-pituitary-ovarian axis hormones in weaned piglets.

Different Effects of an N-Phenylimide Herbicide on Heme Biosynthesis between Human and Rat Erythroid Cells.

Chemicals with increasingly complex modes of action result in greater variation in sensitivity between earthworm species.

Molecular mechanisms of developmental toxicities of azoxystrobin and pyraclostrobin toward zebrafish (Danio rerio) embryos: Visualization of abnormal development using two transgenic lines.

Enantioselective Bioaccumulation of the Chiral Insecticide Indoxacarb in Zebrafish (Danio rerio).

Potentially Toxic Elements

Delay in puberty indices of Wistar rats caused by Cadmium. Focus on the redox system in reproductive organs.

Chlorogenic acid abates male reproductive dysfunction in arsenic-exposed mice via attenuation of testicular oxido-inflammatory stress and apoptotic responses.

Chronic Developmental Lead Exposure increases μ-Opiate Receptor Levels in the Adolescent Rat Brain.

Microplastics/Nanomaterials

Toxicological effects of microplastics in Litopenaeus vannamei as indicated by an integrated microbiome, proteomic and metabolomic approach.

A Clearance Period after Soluble Lead Nanoparticle Inhalation Did Not Ameliorate the Negative Effects on Target Tissues Due to Decreased Immune Response.

An assessment of the concentration of pharmaceuticals adsorbed on microplastics.

Investigations of acute effects of polystyrene and polyvinyl chloride micro- and nanoplastics in an advanced in vitro triple culture model of the healthy and inflamed intestine.

Air Pollution

An Embryonic Zebrafish Model to Screen Disruption of Gut-Vascular Barrier upon Exposure to Ambient Ultrafine Particles.

Ozone-induced changes in oxidative stress parameters in brain regions of adult, middle-age, and senescent Brown Norway rats.

Exposure to Air Pollution Disrupts Circadian Rhythm through Alterations in Chromatin Dynamics.

Neuropathology changed by 3- and 6-months low-level PM_2.5 inhalation exposure in spontaneously hypertensive rats.

Mixtures

Interactive effects of cadmium and Benzo[a]pyrene in adult zebrafish (Danio rerio) during short-term aqueous co-exposure.

Mixture effects of food-relevant polycyclic aromatic hydrocarbons on the activation of nuclear receptors and gene expression, benzo[a]pyrene metabolite profile and DNA damage in HepaRG cells.

Mixture toxicity effects of chloramphenicol, thiamphenicol, florfenicol in Daphnia magna under different temperatures.

Miscellaneous

Transgenerational metabolic disorders and reproduction defects induced by benzo[a]pyrene in Xenopus tropicalis.

Sex-Dependent Effects on Liver Inflammation and Gut Microbial Dysbiosis After Continuous Developmental Exposure to Trichloroethylene in Autoimmune-Prone Mice.

Exposure/Environment Studies

BPA/Phenols

Occurrence, environmental implications and risk assessment of Bisphenol A in association with colloidal particles in an urban tropical river in Malaysia.

Phthalates

Phthalate Plasticizers in Children’s Products and Estimation of Exposure: Importance of Migration Rate.

Phthalates in House and Dormitory Dust: Occurrence, Human Exposure and Risk Assessment.

Quantification, Distribution, Effects of Di (2-ethylhexyl) Phthalate Contamination: Risk Analysis and Mitigation Strategies in Urban Environment.

Parabens

Accurate Assessment of Parabens Exposure in Healthy Chinese Female Adults: Findings from a Multi-pathway Exposure Assessment Coupled with Intervention Study.

Exposure of Chinese adult females to parabens from personal care products: Estimation of intake via dermal contact and health risks.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Human biomonitoring of persistent organic pollutants in elderly people from the Canary Islands (Spain): A temporal trend analysis from the PREDIMED and PREDIMED-Plus cohorts.

Perfluoroalkyl Substances

Alteration of neuro-dopamine and steroid hormone homeostasis in wild Bank voles in relation to tissue concentrations of PFAS at a Nordic skiing area.

Pesticides

Can SPEcies At Risk of pesticides (SPEAR) indices detect effects of target stressors among multiple interacting stressors?

The dietary risk index system: a tool to track pesticide dietary risks.

Risk Assessment of Glyphosate Exposures from Pilot Study with Simulated Heavy Residential Consumer Application of Roundup^® using a Margin of Safety (MOS) Approach.

Potentially Toxic Elements

Mislabelling and high mercury content hampers the efforts of market-based seafood initiatives in Peru.

Accumulation of Toxic Elements in Bone and Bone Marrow of Deer Living in Various Ecosystems. A Case Study of Farmed and Wild-Living Deer.

The Twilight Zone as a Major Foraging Habitat and Mercury Source for the Great White Shark.

Untangling causes of variation in mercury concentration between flight feathers.

Dried blood spots to characterize mercury speciation and exposure in a Colombian artisanal and small-scale gold mining community.

The applicability of fingernail lead and cadmium levels as subchronic exposure biomarkers for preschool children.

Element Levels and Predictors of Exposure in the Hair of Ethiopian Children.

Microplastics

Microplastics in glaciers of the Tibetan Plateau: Evidence for the long-range transport of microplastics.

Plastics Are an Insignificant Carrier of Riverine Organic Pollutants to the Coastal Oceans.

Air Pollution

Polycyclic aromatic compounds (PACs) in the Canadian environment: Sources and emissions.

Estimating the Potential Health Benefits of Air Quality Warnings.

Impact of SARS-CoV-2 lockdown and de-escalation on air-quality parameters.

Pharmaceuticals/Personal Care Products

Acculturation and endocrine disrupting chemical-associated personal care product use among US-based foreign-born Chinese women of reproductive age.

Mixtures/Numerous EDCs

Contaminants of emerging concern in drinking water: Quality assessment by combining chemical and biological analysis.

Comparison of life cycle toxicity assessment methods for municipal wastewater treatment with the inclusion of direct emissions of metals, PPCPs and EDCs.

Miscellaneous

Toxicological Risk Analysis in Data-Poor Countries: A Narrative Approach to Feed an “Awareness Raising-Community Empowerment” Vortex.

Effect-based trigger values for mixtures of chemicals in surface water detected with in vitro bioassays.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.