EDC Science Weekly, Oct. 21 – 27, 2020

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinars

Protecting Children’s Environmental Health While Re-opening Schools: Recommendations from the Healthy Schools Network Oct 28

Generation Chemical: How Environmental Exposures are Affecting Reproductive Health and Development Oct 29

Indoor Air Quality in Schools and Childcare Facilities During COVID-19 Nov 10

Racial/ethnic Differences in EDC Exposures Nov 12

Environmental reproductive justice: Racial disparities in environmental pollution and chemical exposures Nov 18

Regulations/Policy

Microplastic regulation should be more precise to incentivize both innovation and environmental safety.

Methods/Tools/Screening

Profile of androgen receptor activators identified using high-throughput screen.

Cell-Based Bioassay to Screen Environmental Chemicals and Human Serum for Total Glucocorticogenic Activity.

Thresholds Derived From Common Measures in Rat Studies Are Predictive of Liver Tumorigenic Chemicals.

Data on chemical-gene interactions and biological categories enriched with genes sensitive to chemical exposures.

Commentaries/Conference Summaries

Application of US EPA IRIS systematic review methods to the health effects of phthalates: Lessons learned and path forward. [Editorial intro to a special issue of Environ Int.]

Environmental pollutants and the risk of neurological disorders. [Editorial intro to a special issue of Environ Sci Pollut Res Int.]

Meeting report on the NIDDK/AUA Workshop on Congenital Anomalies of External Genitalia: challenges and opportunities for translational research.

Reviews

Numerous EDCs

Endocrine Disruptors and the Induction of Insulin Resistance.

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR.

Migration of endocrine-disrupting chemicals into food from plastic packaging materials: an overview of chemical risk assessment, techniques to monitor migration, and international regulations.

Acquiring an evolutionary perspective in marine ecotoxicology to tackle emerging concerns in a rapidly changing ocean.

Endocrine disruptors and gut microbiome interactions.

Estrogens and development of the mouse and human external genitalia.

BPA

Bisphenol A in Africa: A review of environmental and biological levels.

Parabens/Triclosan/Antimicrobials

Impact of prenatal triclosan exposure on gestational age and anthropometric measures at birth: A systematic review and meta-analysis.

Perfluoroalkyl Substances

Male reproductive toxicity of perfluorooctanoate (PFOA): Rodent studies.

Pesticides

The association between maternal exposure to organophosphate pesticides and neonatal anthropometric measures: A systematic review and meta-analysis.

Herbicide Glyphosate: Toxicity and Microbial Degradation.

Microplastics

Microplastics in freshwater ecosystems: a recent review of occurrence, analysis, potential impacts, and research needs.

Microplastics as novel sedimentary particles in coastal wetlands: A review.

Toward a unified framework for investigating micro(nano)plastics in packaged beverages intended for human consumption.

Air Pollution

Prenatal Air Pollution Exposure and Neurodevelopment: A Review and Blueprint for a Harmonized Approach within ECHO.

Double Trouble: Combined Cardiovascular Effects of Particulate Matter Exposure and COVID-19.

Miscellaneous

The Androgen Receptor in Prostate Cancer: Effect of Structure, Ligands and Spliced Variants on Therapy.

Human Health Studies

Numerous Chemicals

Prediction of Malignant Breast Cancer Cases using Ensemble Machine Learning: A Case Study of Pesticides Prone Area. [metals, POPs, pesticides]

Endocrine disruptors, obesity, and cytokines – how relevant are they to PCOS? [bisphenols and parabens]

Phthalates and Bisphenol A: Presence in Blood Serum and Follicular Fluid of Italian Women Undergoing Assisted Reproduction Techniques.

BPA/Phenols

Serum Bisphenol A, glucose homeostasis, and gestational diabetes mellitus in Chinese pregnant women: a prospective study.

Triclosan/Antimicrobials

Triclosan exposure and in vitro fertilization treatment outcomes in women undergoing in vitro fertilization.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Serum Concentrations of Selected Organochlorines in Pregnant Women and Associations with Pregnancy Outcomes. A Cross-Sectional Study from Two Rural Settings in Cambodia.

Association between prenatal exposure to persistent organic pollutants and neurodevelopment in early life: A mother-child cohort (Shanghai, China).

Perfluoroalkyl Substances

Serum perfluoroalkyl substances in relation to lipid metabolism in Chinese pregnant women.

Polyfluoroalkyl chemicals and the risk of kidney stones in US adults: A population-based study.

Per- and Polyfluoroalkyl Substance and Cardio Metabolic Markers in Firefighters.

Flame Retardants

Serum levels of novel brominated flame retardants (NBFRs) in residents of a major BFR-producing region: Occurrence, impact factors and the relationship to thyroid and liver function.

Pesticides

Menstrual Cycle Patterns and Irregularities in Hired Latinx Child Farmworkers.

Pesticide handling practices and self-reported morbidity symptoms among farmers.

Potentially Toxic Elements

Hair Metal Levels and Childhood Weight Gain.

Foetal exposure to heavy metals and risk of atopic diseases in early childhood.

Co-exposure of serum calcium, selenium and vanadium is nonlinearly associated with increased risk of type 2 diabetes mellitus in a Chinese population.

The Relationship between Cytokine Profile and Hypertension among the Mercury-Exposed Residents of Temirtau Region in Central Kazakhstan.

Are US adults with low-exposure to methylmercury at increased risk for depression? A study based on 2011-2016 National Health and Nutrition Examination Surveys (NHANES).

Evaluation of oxidative stress and pro-inflammatory cytokines in occupationally exposed cadmium workers.

Air Pollution

Associations of maternal exposure to fine particulate matter constituents during pregnancy with Apgar score and duration of labor: A retrospective study in Guangzhou, China, 2012-2017.

Differential association of air pollution exposure with neonatal and postneonatal mortality in England and Wales: A cohort study.

Impacts of discriminated PM_2.5 on global under-five and maternal mortality.

Long-term exposure to moderate fine particulate matter concentrations and cause-specific mortality in an ageing society.

Association of COVID-19 distribution with air quality, sociodemographic factors, and comorbidities: an ecological study of US states.

The Impact of Air Pollution on Hospitalization for Cardiovascular and Cerebrovascular Disease in Shenyang, China.

Long-term effects of PM_2·5 on neurological disorders in the American Medicare population: a longitudinal cohort study.

Wildfire and COVID-19 pandemic: effect of environmental pollution PM-2.5 and carbon monoxide on the dynamics of daily cases and deaths due to SARS-COV-2 infection in San-Francisco USA.

Urban environment during early-life and blood pressure in young children.

Air pollution during infancy and lung function development into adolescence: The GINIplus/LISA birth cohorts study.

Epidemiological Characteristics of Tuberculosis and Effects of meteorological factors and air pollutants on Tuberculosis in Shijiazhuang, China: A Distribution Lag Non-Linear Analysis.

Gestational Exposures to Outdoor Air Pollutants in Relation to Low Birth Weight: A Retrospective Observational Study.

Asthma Prevalence and Control among Schoolchildren Residing near Outdoor Air Pollution Sites.

Airborne particulate matter, population mobility and COVID-19: a multi-city study in China.

Spatiotemporal Big Data for PM_2.5 Exposure and Health Risk Assessment during COVID-19.

Changes of air quality and its associated health and economic burden in 31 provincial capital cities in China during COVID-19 pandemic.

Miscellaneous

Cancer Risk Assessment for Workers Exposed to Pollution Source, a Petrochemical Company, Iran.

Laboratory Studies

Numerous EDCs

Early life exposure to environmental contaminants (BDE-47, TBBPA, and BPS) produced persistent alterations in fecal microbiome in adult male mice.

Daily exposure to phthalates and alkylphenols alters miR biogenesis and expression in mice ovaries.

BPA/Phenols

Bisphenol A, bisphenol S and their glucuronidated metabolites modulate glycolysis and functional responses of human neutrophils.

Bisphenol A exposure increases epididymal susceptibility to infection in mice.

Melatonin ameliorates Bisphenol S induced testicular damages by modulating Nrf-2/HO-1 and SIRT-1/FOXO-1 expressions.

Phthalates

Typical phthalic acid esters induce apoptosis by regulating the PI3K/Akt/Bcl-2 signaling pathway in rat insulinoma cells.

Systematic Comparison of the Male Reproductive Tract in Fetal and Adult Wistar Rats exposed to DBP and DINP in utero during the Masculinisation Programming Window.

Effect of Notch pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate on 3T3-L1 cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Markers of acute toxicity of DDT exposure in pancreatic beta-cells determined by a proteomic approach.

Perfluoroalkyl Substances

Perfluorooctane Sulfonate (PFOS) and Perfluorohexane Sulfonate (PFHxS) Alters Protein Phosphorylation, Increase ROS Levels and DNA Fragmentation during In Vitro Capacitation of Boar Spermatozoa.

Flame Retardants

Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model.

Maternal transfer of environmentally relevant polybrominated diphenyl ethers (PBDEs) produces a diabetic phenotype and disrupts glucoregulatory hormones and hepatic endocannabinoids in adult mouse female offspring.

Binding and Activity of Tetrabromobisphenol A Mono-Ether Structural Analogs to Thyroid Hormone Transport Proteins and Receptors.

TBBPA targets converging key events of human oligodendrocyte development resulting in two novel AOPs.

Pesticides

Multiple stressors interact to impair the performance of bumblebee (Bombus terrestris) colonies.

Neonicotinoids disrupt circadian rhythms and sleep in honey bees.

Endoplasmic reticulum stress-related neuroinflammation and neural stem cells decrease in mice exposure to paraquat.

Potentially Toxic Elements

Exposure of zebrafish to environmentally relevant concentrations of mercury during early life stages impairs subsequent reproduction in adults but can be recovered in offspring.

Microplastics

Photo-Oxidative Degradation Mitigated the Developmental Toxicity of Polyamide Microplastics to Zebrafish Larvae by Modulating Macrophage-Triggered Proinflammatory Responses and Apoptosis.

Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice.

Effects of microplastic on arsenic accumulation in Chlamydomonas reinhardtii in a freshwater environment.

Pharmaceuticals/Personal Care Products

Acetaminophen modulates the expression of steroidogenesis-associated genes and estradiol levels in human placental JEG-3 cells.

Miscellaneous

Toxicity assessment of a novel oil dispersant based on silica nanoparticles using Fathead minnow.

Exposure/Environment Studies

Numerous EDCs

Impact of “healthier” materials interventions on dust concentrations of per- and polyfluoroalkyl substances, polybrominated diphenyl ethers, and organophosphate esters.

Occurrence of multiclass endocrine disrupting compounds in a drinking water supply system and associated risks.

Impact assessment of a large panel of organic and inorganic micropollutants released by wastewater treatment plants at the scale of France.

BPA/Phenols

Dental composites – a low-dose source of bisphenol A?

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Occurrence, distribution, and bioaccumulation of new and legacy persistent organic pollutants in an ecosystem on King George Island, maritime Antarctica.

Temporal Trends of Persistent Organic Pollutants across Africa after a Decade of MONET Passive Air Sampling.

Perfluoroalkyl Substances

Assessment of perfluoroalkyl substances in placenta by coupling salt assisted liquid-liquid extraction with dispersive liquid-liquid microextraction prior to liquid chromatography-tandem mass spectrometry.

Flame Retardants

Brominated and phosphate flame retardants from interior and surface dust of personal computers: insights into sources for human dermal exposure.

Polybrominated diphenyl ethers (PBDEs) in the Danjiangkou Reservoir, China: identification of priority PBDE congeners.

Pesticides

Short-term lab assessments and microcolonies are insufficient for the risk assessment of insecticides for bees.

Common insecticide disrupts aquatic communities: A mesocosm-to-field ecological risk assessment of fipronil and its degradates in U.S. streams.

Organophosphorus pesticides in greenhouse and open-field soils across China: Distribution characteristic, polluted pathway and health risk.

Investigating potential toxic effects of pollutants on population growth rates and probability of extinction for a representative squamate.

Potentially Toxic Elements

High occurrence of heavy metal tolerance genes in bacteria isolated from wastewater: A new concern?

Inorganic contaminants in Canadian First Nation community water systems.

Early Breeding Failure in Birds Due to Environmental Toxins: A Potentially Powerful but Hidden Effect of Contamination. [mercury]

Microplastics

Drinking plastics? – Quantification and qualification of microplastics in drinking water distribution systems by µFTIR and Py-GCMS.

Microplastics and other harmful substances released from disposable paper cups into hot water.

Breeding seabirds as vectors of microplastics from sea to land: Evidence from colonies in Arctic Canada.

High Abundances of Microplastic Pollution in Deep-Sea Sediments: Evidence from Antarctica and the Southern Ocean.

Effect of plastic film mulching on the distribution of plastic residues in agricultural fields.

Reusable masks for COVID-19: A missing piece of the microplastic problem during the global health crisis.

Air Pollution

Novel Organophosphate Esters in Airborne Particulate Matters: Occurrences, Precursors, and Selected Transformation Products.

Spatio-temporal assessment of ambient air quality, their health effects and improvement during COVID-19 lockdown in one of the most polluted cities of India.

A new method for dividing the scopes and priorities of air pollution control based on environmental justice.

Air-pollutant mass concentration changes during COVID-19 pandemic in Shanghai, China.

Examining the impact of lockdown (due to COVID-19) on ambient aerosols (PM_2.5): A study on Indo-Gangetic Plain (IGP) Cities, India.

Miscellaneous

Characterising the exposure of Australian firefighters to polycyclic aromatic hydrocarbons generated in simulated compartment fires.

Perceptions, Knowledge, and Practices Concerning Indoor Environmental Pollution of Parents or Future Parents.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.