EDC Science Weekly, Sept. 23 – 29, 2020

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studie

Methods/Tools/Screening

Classification of estrogenic compounds by coupling high content analysis and machine learning algorithms.

Bayesian hierarchical dose-response meta-analysis of epidemiological studies: Modeling and target population prediction methods. [case study using arsenic and bladder cancer]

Quantification of an Adverse Outcome Pathway network by Bayesian regression and Bayesian network modelling. [using a pesticide]

Matrix softness-mediated 3D zebrafish hepatocyte modulates response to endocrine disrupting chemicals.

Commentaries/Conference Summaries

Why have we been slow to act on air pollution as a public health issue? [Comment letter in BMJ]

Offline: COVID-19 is not a pandemic […it’s a “syndemic” – Comment in The Lancet]

Unheard, unseen and unprotected: DOHaD council’s call for action to protect the younger generation from the long-term effects of COVID-19.

Climate change and cancer: converging policies.

Reviews

Numerous EDCs

Organochlorine pesticides, brominated flame retardants, synthetic musks and polycyclic aromatic hydrocarbons in shrimps. An overview of occurrence and its implication on human exposure.

Environmental toxic agents: The impact of heavy metals and organochlorides on brain development.

GPER as a Receptor for Endocrine-Disrupting Chemicals (EDCs).

Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis.

BPA/Phenols

Update on the health effects of bisphenol A: Overwhelming evidence of harm. [important!]

Phthalates

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review.

Hazards of diethyl phthalate (DEP) exposure: A systematic review of animal toxicology studies.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated Biphenyls (PCBs): Risk Factors for Autism Spectrum Disorder?

A Review of the Functional Roles of the Zebrafish Aryl Hydrocarbon Receptors.

Flame Retardants

The Potential for Bio-Sustainable Organobromine-Containing Flame Retardant Formulations for Textile Applications-A Review.

Pesticides

From environment to clinic: the role of pesticides in antimicrobial resistance.

Potentially Toxic Elements

Developing a Health Impact Model for Adult Lead Exposure and Cardiovascular Disease Mortality.

Heavy metal pollution in the environment and their toxicological effects on humans.

Arsenic Methyltransferase and Methylation of Inorganic Arsenic.

Air Pollution

Outdoor air pollution and cancer: An overview of the current evidence and public health recommendations.

Effects of ambient particulate matter on vascular tissue: a review.

Pharmaceuticals/Personal Care Products

Safety Assessment of PEGylated Alkyl Glycerides as Used in Cosmetics.
Safety Assessment of Lecithin and Other Phosphoglycerides as Used in Cosmetics.
Safety Assessment of 2-Amino-3-Hydroxypyridine as Used in Cosmetics.

Miscellaneous

Zebrafish (Danio rerio) as an excellent vertebrate model for the development, reproductive, cardiovascular, and neural and ocular development toxicity study of hazardous chemicals.

Not Necessarily EDCs but Interesting for COVID-19

Endocrine aspects of ACE2 regulation: RAAS, steroid hormones and SARS-CoV-2.

SARS-CoV-2 and the possible connection to ERs, ACE2, and RAGE: Focus on susceptibility factors.

Responding to COVID-19 requires strong epidemiological evidence of environmental and societal determining factors.

Human Health Studies

BPA/Phenols

Nonfunctional adrenal incidentalomas may be related to bisphenol-A.

[A birth cohort study of the association between prenatal serum bisphenol A concentration and infant neurobehavior development]. [in Chinese]

Phthalates

[A study on the correlation of phthalate metabolites in umbilical cord blood of 161 newborns with birth indicators in Beijing]. [in Chinese]

Perfluoroalkyl Substances

Per- and Polyfluoroalkyl Substance Exposure, Gestational Weight Gain, and Postpartum Weight Changes in Project Viva.

Associations between perfluoroalkyl substances and lipid profile in a highly exposed young adult population in the Veneto Region.

Perfluoroalkyl substances are associated with elevated blood pressure and hypertension in highly exposed young adults.

Flame Retardants

Reproductive outcomes associated with flame retardants among couples seeking fertility treatment: a paternal perspective.

Potentially Toxic Elements

Neonatal Lead (Pb) Exposure and DNA Methylation Profiles in Dried Bloodspots.

Adverse health effects of lead exposure on physical growth, erythrocyte parameters and school performances for school-aged children in eastern China.

Environmental cadmium exposure and noncancer mortality in a general Japanese population in cadmium nonpolluted regions.

Association between selected urinary heavy metals and asthma in adults: a retrospective cross-sectional study of the US National Health and Nutrition Examination Survey.

Association between rice consumption and risk of cancer incidence in the California Teachers Study. [arsenic]

Air Pollution

Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology.

Prenatal PM_2.5 Exposure and the Risk of Adverse Births Outcomes: Results from Project ELEFANT.

Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study.

Long-term effects of ambient PM2.5 on hypertension in multi-ethnic population from Sichuan province, China: a study based on 2013 and 2018 health service surveys.

Outdoor air pollution and terminal duct lobular involution of the normal breast.

Potential role of particulate matter in the spreading of COVID-19 in Northern Italy: first observational study based on initial epidemic diffusion.

Effects of PM_2.5 on Third Grade Students’ Proficiency in Math and English Language Arts.

[Analysis of the relationship between long-term exposure to PM2.5 and sex hormone levels of female sanitation workers in Urumqi]. [in Chinese]

Laboratory Studies

BPA/Phenols

Bisphenol A Exacerbates Allergic Inflammation in an Ovalbumin-Induced Mouse Model of Allergic Rhinitis.

BPA differentially regulates NPY expression in hypothalamic neurons through a mechanism involving oxidative stress.

Phytoestrogens by inhibiting the non-classical oestrogen receptor, overcome the adverse effect of bisphenol A on hFOB 1.19 cells.

Protective effect of crocin on bisphenol A – induced spatial learning and memory impairment in adult male rats: Role of oxidative stress and AMPA receptor.

Long-term exposure to “low-dose” bisphenol A decreases mitochondrial DNA copy number, and accelerates telomere shortening in human CD8 + T cells.

Phthalates

Impacts of Endocrine Disruptor di-n-Butyl Phthalate Ester on Microalga Chlorella vulgaris Verified by Approaches of Proteomics and Gene Ontology.

Lycopene prevents DEHP-induced liver lipid metabolism disorder by inhibiting HIF-1α-induced PPARα/PPARγ/FXR/LXR system.

Perfluoroalkyl Substances

Chemical Characterization of a Legacy Aqueous Film-Forming Foam Sample and Developmental Toxicity in Zebrafish (Danio rerio).

Perfluorooctanoic acid (PFOA) inhibits the gap junction intercellular communication and induces apoptosis in human ovarian granulosa cells.

Perfluorooctanoic acid in indoor particulate matter triggers oxidative stress and inflammation in corneal and retinal cells.

Flame Retardants

Maternal organophosphate flame-retardant exposure alters offspring energy and glucose homeostasis in a sexually dimorphic manner in mice.

Organophosphate flame retardants excite arcuate melanocortin circuitry and increase neuronal sensitivity to ghrelin in adult mice.

Exposure to tert-Butylphenyl Diphenyl Phosphate, an Organophosphate Ester Flame Retardant and Plasticizer, Alters Hedgehog Signaling in Murine Limb Bud Cultures.

Pesticides

Effects of atrazine and its two major derivatives on the photosynthetic physiology and carbon sequestration potential of a marine diatom.

Tissues injury and pathological changes in Hyla intermedia juveniles after chronic larval exposure to tebuconazole.

The effects of diazinon on the cell types and gene expression of the olfactory epithelium and whole-body hormone concentrations in the Persian sturgeon (Acipenser persicus).

Comparative immuno-modulatory effects of basil and sesame seed oils against diazinon-induced toxicity in rats; a focus on TNF-α immunolocalization.

Nephrotoxicity of cypermethrin in rats. Histopathological aspects.

Famoxadone-cymoxanil induced cardiotoxicity in zebrafish embryos.

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults.

Potentially Toxic Elements

Whole-transcriptome sequencing (RNA-seq) study of the ZFL zebrafish liver cell line after acute exposure to Cd²⁺ ions.

Moringa oleifera leaf extract attenuates Pb acetate-induced testicular damage in rats.

Tissue- and Sex-Specific DNA Methylation Changes in Mice Perinatally Exposed to Lead (Pb).

Effect of visnagin on altered steroidogenesis and spermatogenesis, and testicular injury induced by the heavy metal lead.

Experimental copper exposure, but not heat stress, leads to elevated intraovarian thyroid hormone levels in three-spined sticklebacks (Gasterosteus aculeatus).

Is Long-Term Heavy Metal Exposure Driving Carriage of Antibiotic Resistance in Environmental Opportunistic Pathogens: A Comprehensive Phenomic and Genomic Assessment Using Serratia sp. SRS-8-S-2018.

Microplastics

New insights into the toxic interactions of polyvinyl chloride microplastics with bovine serum albumin.

Enhanced cytotoxicity of photoaged phenol-formaldehyde resins microplastics: Combined effects of environmentally persistent free radicals, reactive oxygen species, and conjugated carbonyls.

No evidence of spherical microplastics (10-300 μm) translocation in adult rainbow trout (Oncorhynchus mykiss) after a two-week dietary exposure.

Mixtures

Combined toxic impacts of thiamethoxam and four pesticides on the rare minnow (Gobiocypris rarus).

Exposure/Environment Studies

Phthalates

Determination of phthalates in particulate matter and gaseous phase emitted in indoor air of offices.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Atmospheric concentration, source identification, and health risk assessment of persistent organic pollutants (POPs) in two countries: Peru and Turkey.

Perfluoroalkyl Substances

Significance of Perfluoroalkyl Substances (PFAS) in Food Packaging.

Pesticides

Molecular Assessment of Genes Linked to Immune Response Traits of Honey Bees in Conventional and Organically Managed Apiaries.

Potentially Toxic Elements

The impact of mercury on North American songbirds: effects, trends, and predictive factors.

Effects of Toxic Metal Contamination in the Tri-State Mining District on the Ecological Community and Human Health: A Systematic Review.

Pharmaceuticals/Personal Care Products

Occurrence and Spatiotemporal Dynamics of Pharmaceuticals in a Temperate-region Wastewater Effluent-dominated Stream: Variable Inputs and Differential Attenuation Yield Evolving Complex Exposure Mixtures.

Occurrence, distribution, and health risk assessment of quinolone antibiotics in water, sediment, and fish species of Qingshitan reservoir, South China.

Miscellaneous

Community Forum Identifies Opportunities to Engage with Eastern Kentucky Community Leaders about Chronic Disease and Environmental Pollution.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.