EDC Science Weekly, Sept. 16 – 22, 2020

Post author:HEEDS
Post published:September 22, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Methods/Tools/Screening

Performance of variable and function selection methods for estimating the nonlinear health effects of correlated chemical mixtures: A simulation study. [phenols and phthalates]

Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines.

Are bioplastics and plant-based materials safer than conventional plastics? In vitro toxicity and chemical composition.

Commentaries/Conference Summaries

20th Pollutant Responses in Marine Organisms (PRIMO 20): Global issues and fundamental mechanisms caused by pollutant stress in marine and freshwater organisms.

Fleece garments are cosy – but pollute land as well as water. [Research highlight in Nature]

Arsenic Exposure and Glucose Metabolism: Experimental Studies Suggest Implications for Type 2 Diabetes. [Science Selection in EHP]

Reviews

Numerous EDCs

Exposure to environmental neurotoxic substances and neurodevelopment in children from Latin America and the Caribbean.

Environmental Risk Factors: The role of oncology nurses in assessing and reducing the risk for exposure.

Ecotoxico-lipidomics: An emerging concept to understand chemical-metabolic relationships in comparative fish models.

BPA/Phenols

Toxicological Evaluation of Bisphenol A and Its Analogues.

Detrimental Effects of Bisphenol Compounds on Physiology and Reproduction in Fish: A Literature Review.

What is the Impact of Bisphenol A on Sperm Function and Related Signaling Pathways: A Mini-review?

Triclosan/Antimicrobials

Triclosan: antimicrobial mechanisms, antibiotics interactions, clinical applications, and human health.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Biomarkers of Metabolic Disorders and Neurobehavioral Diseases in a PCB- Exposed Population: What We Learned and the Implications for Future Research.

Perfluoroalkyl Substances

Review: Evolution of evidence on PFOA and health following the assessments of the C8 Science Panel.

Flame Retardants

Tetrabromobisphenol A (TBBPA): A controversial environmental pollutant.

Organophosphorus Flame Retardants: A Global Review of Indoor Contamination and Human Exposure in Europe and Epidemiological Evidence.

Pesticides

Herbicide Exposure and Toxicity to Aquatic Primary Producers.

A recent global review of hazardous chlorpyrifos pesticide in fruit and vegetables: Prevalence, remediation and actions needed.

A Critical Review of the Status of Pesticide Exposure Management in Malawi.

Assessing Agricultural Toxicity in Brazil: Advances and Opportunities in the 21st Century.

Potentially Toxic Elements

Association between Arsenic Exposure and Cardiovascular Disease.

An appraisal on molecular and biochemical signalling cascades during arsenic-induced hepatotoxicity.

Cadmium Exposure and Testis Susceptibility: a Systematic Review in Murine Models.

Metal toxicity and natural antidotes: prevention is better than cure.

Microplastics

Microplastics in Food: A Review on Analytical Methods and Challenges.

Air Pollution

The influence of air pollution on respiratory microbiome: A link to respiratory disease.

Environmental Nanoparticles, SARS-CoV-2 Brain Involvement, and Potential Acceleration of Alzheimer’s and Parkinson’s Diseases in Young Urbanites Exposed to Air Pollution.

Health effects of wildfire smoke in children and public health tools: a narrative review.

Miscellaneous

Association between leukemia incidence and mortality and residential petrochemical exposure: A systematic review and meta-analysis.

Human Health Studies

Numerous Chemicals

Associations between prenatal maternal exposure to per- and polyfluoroalkyl substances (PFAS) and polybrominated diphenyl ethers (PBDEs) and birth outcomes among pregnant women in San Francisco.

Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suriname.

Risk factors of Parkinson’s disease: Simultaneous assessment, interactions and etiological subtypes.

Phthalates

Phthalate levels in indoor dust and associations to croup in the SELMA study.

Perfluoroalkyl Substances

Serum concentrations of per- and polyfluoroalkyl substances and risk of renal cell carcinoma.

Pesticides

Environmental and socio-cultural impacts on global DNA methylation in the indigenous Huichol population of Nayarit, Mexico.

Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations.

Potentially Toxic Elements

Effects of early and recent mercury and lead exposure on the neurodevelopment of children with elevated mercury and/or developmental delays during lactation: A follow-up study.

Effects of prenatal exposure and co-exposure to metallic or metalloid elements on early infant neurodevelopmental outcomes in areas with small-scale gold mining activities in Northern Tanzania.

Genetic polymorphisms in multispecific transporters mitigates mercury nephrotoxicity in an artisanal and small-scale gold mining community in Colombia.

Molecular Alterations in Spermatozoa of a Family Case Living in the Land of Fires. A First Look at Possible Transgenerational Effects of Pollutants.

Plasma cadmium is associated with increased risk of long-term kidney graft failure.

Arsenic and chromium levels in hair correlate with actinic keratosis/non melanoma skin cancer: results of an observational controlled study.

It Takes Time to Unravel the Ecology of War in Gaza, Palestine: Long-Term Changes in Maternal, Newborn and Toddlers’ Heavy Metal Loads, and Infant and Toddler Developmental Milestones in the Aftermath of the 2014 Military Attacks.

Exposure to Manganese in Drinking Water during Childhood and Association with Attention-Deficit Hyperactivity Disorder: A Nationwide Cohort Study.

Mercury exposure in relation to sleep duration, timing, and fragmentation among adolescents in Mexico City.

One man’s swordfish story: The link between Alzheimer’s disease and mercury exposure.

Lipid profile and Atherogenic Indices in Nigerians Occupationally Exposed to e-waste: A Cardiovascular Risk Assessment Study.

Air Pollution

Prenatal PM_2.5 Exposure and Behavioral Development in Children from Mexico City.

Prenatal exposure to ambient air pollution and adverse pregnancy outcomes in Ahvaz, Iran: a generalized additive model.

Correlation between exposure to fine particulate matter and hypertensive disorders of pregnancy in Shanghai, China.

Ambient Air Pollution and Risk of Pregnancy Loss among Women Undergoing Assisted Reproduction.

Chronic Low-Dose Exposure to Xenoestrogen Ambient Air Pollutants and Breast Cancer Risk: XENAIR Protocol for a Case-Control Study Nested Within the French E3N Cohort.

Association of Fine Particulate Matter and Risk of Stroke in Patients With Atrial Fibrillation.

Association between long-term exposure to air pollutants and cardiopulmonary mortality rates in South Korea.

Associations between personal PM2.5 elemental constituents and decline of kidney function in older individuals: The China BAPE study.

Vehicular traffic density and cognitive performance in the ELSA-Brasil study.

Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population.

Elevated levels of nitrous dioxide are associated with lower AMH levels: a real-world analysis.

Differential expression profiling of transcripts of IDH1, CEA, Cyfra21-1, and TPA in Stage IIIa non-small cell lung cancer (NSCLC) of smokers and non-smokers cases with air quality index.

The Impact of Baseline Incidence Rates on Burden of Disease Assessment of Air Pollution and Onset Childhood Asthma: Analysis of Data from the Contiguous United States.

Effects of long-term exposure to air pollutants on the spatial spread of COVID-19 in Catalonia, Spain.

The relationship between air pollution and COVID-19-related deaths: An application to three French cities.

Laboratory Studies

BPA/Phenols

Bisphenol A alters differentiation of Leydig cells in the rabbit fetal testis.

Bisphenol A and 17α-ethinylestradiol-induced Transgenerational Gene Expression Differences in the Brain-Pituitary-Testis Axis of Medaka, Oryzias latipes.

Perinatal exposure to Bisphenol A disturbs the early differentiation of male germ cells.

Parabens

Effect of ethylparaben on the growth and development of Drosophila melanogaster on preadult.

Disruption of normal adipocyte development and function by Methyl- and Propyl- Paraben Exposure.

Perfluoroalkyl Substances

Oxidative stress and mitochondrial membrane potential are involved in the cytotoxicity of perfluorododecanoic acid to neurons.

Flame Retardants

Perinatal exposure to FireMaster® 550 (FM550), brominated or organophosphate flame retardants produces sex and compound specific effects on adult Wistar rat socioemotional behavior.

The toxic effects and possible mechanisms of decabromodiphenyl ethane on mouse oocyte.

Organotins

Migration study of organotin compounds from food packaging by surface-enhanced Raman scattering.

Pesticides

Chlorpyrifos subthreshold exposure induces epithelial-mesenchymal transition in breast cancer cells.

Evaluation of hematological parameters, oxidative stress and DNA damage in the cichlid Australoheros facetus exposed to the fungicide azoxystrobin.

Toxicities of Neonicotinoid-Containing Pesticide Mixtures on Nontarget Organisms.

In silico characterization of adipokinetic hormone receptor and screening for pesticide candidates against stick insect, Carausius morosus.

Melanophryniscus admirabilis tadpoles’ responses to sulfentrazone and glyphosate-based herbicides: an approach on metabolism and antioxidant defenses.

Exposure Impacts of Environmentally Relevant Concentrations of a Glufosinate Ammonium Herbicide Formulation on Larval Development and Thyroid Histology of Xenopus laevis.

Bifenthrin exposure causes hyperactivity in early larval stages of an endangered fish species at concentrations that occur during their hatching season.

Molecular mechanism of reproductive toxicity induced by beta-cypermethrin in zebrafish.

Cypermethrin- and fipronil-based insecticides cause biochemical changes in Physalaemus gracilis tadpoles.

Effects of Polyhydroxyfullerenes on Organophosphate-Induced Toxicity in Mice.

Herbicide Widespread: The Effects of Pethoxamid on Nonalcoholic Fatty Liver Steatosis In Vitro.

Protective effects of molecular hydrogen on hepatotoxicity induced by sub-chronic exposure to chlorpyrifos in rats.

Determination of malathion’s toxic effect on Lens culinaris Medik cell cycle.

Potentially Toxic Elements

Inorganic arsenic-mediated upregulation of AS3MT promotes proliferation of nonsmall cell lung cancer cells by regulating cell cycle genes.

Using the Metabolome to Understand the Mechanisms Linking Chronic Arsenic Exposure to Microglia Activation, and Learning and Memory Impairment.

Dietary cadmium exposure causes elevation of blood ApoE with triglyceride level in mice.

Hibiscus sabdariffa extract protects against cadmium-induced ovarian toxicity in adult Wistar rats.

Effect of age on the mercury sensitivity of zebrafish (Danio rerio) sperm.

Lead exposure induces metabolic reprogramming in rat models.

The effects of chronic lead exposure on the ovaries of female juvenile Japanese quails (Coturnix japonica): Developmental delay, histopathological alterations, hormone release disruption and gene expression disorder.

Microplastics/Nanoparticles

Metal sorption onto nanoscale plastic debris and trojan horse effects in Daphnia magna: Role of dissolved organic matter.

Key Physicochemical Properties Dictating Gastrointestinal Bioaccessibility of Microplastics-Associated Organic Xenobiotics: Insights from a Deep Learning Approach.

Bioavailability of Microplastics to Marine Zooplankton: Effect of Shape and Infochemicals.

Water dispersible ZnSe/ZnS quantum dots: Assessment of cellular integration, toxicity and bio-distribution.

Air Pollution

Assessment of the effects of atmospheric pollutants using the animal model Caenorhabditis elegans.

Childhood co-exposure of cold stress and PM_2.5 aggravates the susceptibility and severity of asthma in adulthood of mice.

In vitro exposure to ambient fine and ultrafine particles alters dopamine uptake and release, and D₂ receptor affinity and signaling.

Mixtures

Multi-omics analysis reveals that co-exposure to phthalates and metals disturbs urea cycle and choline metabolism.

Impact of groundwater samples and leachates from Gbagede dumpsite, Amoyo, Kwara State, Nigeria, on testes and prostate of male Wistar rats: A biochemical and histological study.

Combined toxicity of silica nanoparticles and cadmium chloride on the cardiovascular system of zebrafish (Danio rerio) larvae.

Genotoxicity of mixture of imidacloprid, imazalil and tebuconazole.

Miscellaneous

Is hull cleaning wastewater a potential source of developmental toxicity on coastal non-target organisms?

Effects of chronic nitrate exposure on the intestinal morphology, immune status, barrier function, and microbiota of juvenile turbot (Scophthalmus maximus).

Exposure/Environment Studies

BPA/Parabens/Phthalates

Plasticisers and preservatives in commercial milk products: A comprehensive study on packages used in the Spanish market. [BPA, parabens, phthalates]

Sandy beaches as hotspots of bisphenol A.

Quantification of bisphenols in Korean urine using online solid-phase extraction-high-performance liquid chromatography-tandem mass spectrometry.

Temporal Trends of Exposure to Phthalates and Phthalate Alternatives in California Pregnant Women during 2007-2013: Comparison with Other Populations.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Environmental exposure to persistent organic pollutants measured in breast milk of lactating women from an urban area in central Poland.

Determination of polychlorinated biphenyls and organochlorine pesticides in Chinese mitten crabs (Eriocheir sinensis) using modified QuEChERS followed by GC-MS.

Liver histopathology of Baltic grey seals (Halichoerus grypus) over three decades.

New insights into the bioaccumulation of persistent organic pollutants in remote alpine lakes located in Himalayas, Pakistan.

Pathologic findings and causes of death in bottlenose dolphins Tursiops truncatus stranded along the Georgia coast, USA (2007-2013).

Perfluoroalkyl Substances

Emerging per- and polyfluoroalkyl substances (PFAS) in human milk from Sweden and China.

Human biomonitoring of per- and polyfluoroalkyl substances in German blood plasma samples from 1982 to 2019.

PFAS concentrations in soils: Background levels versus contaminated sites.

Temporal trends of per- and polyfluoroalkyl substances in Delaware River fish, USA.

Occurrence and dietary intake of Perfluoroalkyl substances in foods of the residents in Beijing, China.

Environmental and dietary exposure of perfluorooctanoic acid and perfluorooctanesulfonic acid in the Nakdong River, Korea.

Flame Retardants

Catching flame retardants and pesticides in silicone wristbands: Evidence of exposure to current and legacy pollutants in Uruguayan children.

Organophosphate Diesters (Di-OPEs) Play a Critical Role in Understanding Global Organophosphate Esters (OPEs) in Fishmeal.

Pesticides

Profiles of urinary neonicotinoids and dialkylphosphates in populations in nine countries.

Evaluating imidacloprid exposure among grape field male workers using biological and environmental assessment tools: An exploratory study.

Evaluation of 1-year urinary excretion of eight metabolites of synthetic pyrethroids, chlorpyrifos, and neonicotinoids.

ARPEGES: a Bayesian belief network to assess the risk of pesticide contamination for the river network of France.

Pesticide mixtures show potential toxicity to aquatic life in U.S. streams, water years 2013-2017.

Ecological impacts of pesticides on Astyanax jacuhiensis (Characiformes: Characidae) from the Uruguay river, Brazil.

Residue Levels of Pesticides on Fruits for Use in Wildlife Risk Assessments.

Potentially Toxic Elements

Potential impacts of mercury released from thawing permafrost.

Health risk assessment of arsenic exposure among the residents in Ndilǫ, Dettah, and Yellowknife, Northwest Territories, Canada.

Arsenic-contaminated groundwater and its potential health risk: A case study in Long An and Tien Giang provinces of the Mekong Delta, Vietnam.

Arsenic health risk assessment and the evaluation of groundwater quality using GWQI and multivariate statistical analysis in rural areas, Hashtroud, Iran.

Foraging ecology differentiates life stages and mercury exposure in common terns (Sterna hirundo).

Long-term exposure to chromium contaminated waters and the associated human health risk in a highly contaminated industrialised region.

Assessing the population-wide exposure to lead pollution in Kabwe, Zambia: an econometric estimation based on survey data.

Lead and cadmium in infant milk and cereal based formulae marketed in Nigeria: a probabilistic non-carcinogenic human health risk assessment.

The Gut Microbial Community Structure of the North American River Otter (Lontra canadensis) in the Alberta Oil Sands Region in Canada: Relationship with Local Environmental Variables and Metal Body Burden.

Microplastics

Microplastic emissions from household washing machines: preliminary findings from Greater Kuala Lumpur (Malaysia).

Air Pollution

Impacts of a climate change initiative on air pollutant emissions: Insights from the Covenant of Mayors.

Associations between socioeconomic status and ultrafine particulate exposure in the school commute: An environmental inequality study for Toronto, Canada.

Pharmaceuticals/Personal Care Products

High Concentrations of Pharmaceuticals in a Nigeria River Catchment.

Miscellaneous

The Management of Health Hazards Related to Municipal Solid Waste on Fire in Europe: An Environmental Justice Issue?

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.