EDC Science Weekly, Sept. 9 – 15, 2020 – HEEDS

EDC Science Weekly, Sept. 9 – 15, 2020

Post author:HEEDS
Post published:September 15, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Methods/Tools/Screening

Harmonized cross-species assessment of endocrine and metabolic disruptors by Ecotox FACTORIAL assay.

Virtual screening of potentially endocrine-disrupting chemicals against nuclear receptors and its application to identify PPARγ-bound fatty acids.

Risk of Bias Assessments and Evidence Syntheses for Observational Epidemiologic Studies of Environmental and Occupational Exposures: Strengths and Limitations.

A Cell-Based Method to Detect Agonist and Antagonist Activities of Endocrine-Disrupting Chemicals on GPER.

Synthesis and toxicity of halogenated bisphenol monosubstituted-ethers: Establishing a library for potential environmental transformation products of emerging contaminant.

Chemical pollution imposes limitations to the ecological status of European surface waters.

Commentaries

Should air pollution health effects assumptions be tested? Fine particulate matter and COVID-19 mortality as an example.

The Solution to Pollution, Maybe Not Dilution.

New directions in understanding the role of environmental contaminants in child development: Four themes.

Averting robo-bees: why free-flying robotic bees are a bad idea.

Recommendations of the Spanish Society of Neurology for the prevention of stroke. Interventions on lifestyle and air pollution

Reviews

Numerous EDCs

Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants.

Environmental exposures to endocrine disrupting chemicals (EDCs) and their role in endometriosis: a systematic literature review.

Placental microRNAs: Responders to environmental chemicals and mediators of pathophysiology of the human placenta.

Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology.

BPA/Phenols

Synthetic Phenolic Antioxidants: A Review of Environmental Occurrence, Fate, Human Exposure, and Toxicity.

Pesticides

Gut microbiota: a key factor in the host health effects induced by pesticide exposure？

Microplastics

Microplastics pollution in mangrove ecosystems: A critical review of current knowledge and future directions.

Plastic pollution in the marine environment.

Microplastics physicochemical properties, specific adsorption modeling and their interaction with pharmaceuticals and other emerging contaminants.

Air Pollution

Global nature of airborne particle toxicity and health effects: a focus on megacities, wildfires, dust storms and residential biomass burning.

Association between prenatal exposure to ambient particulate matter and risk of hypospadias in offspring: A systematic review and meta-analysis.

Relationship between particulate matter exposure and female breast cancer incidence and mortality: a systematic review and meta-analysis

Pharmaceuticals/Personal Care Products

Sorption of pharmaceuticals and personal care products on soil and soil components: Influencing factors and mechanisms

Treatment technologies for emerging contaminants in wastewater treatment plants: A review

Effects of antidepressants in the reproduction of aquatic organisms: a meta-analysis

Miscellaneous

Endocrine Insights into the Pathophysiology of Autism Spectrum Disorder.

Human Health Studies

BPA/Phthalates/Parabens

Prenatal exposure to bisphenol – A is associated with dysregulated perinatal innate cytokine response and elevated cord IgE level: a population-based birth cohort study.

An epigenome-wide association study identifies multiple DNA methylation markers of exposure to endocrine disruptors. [parabens, bisphenols, phthalates]

Fetal exposure to phthalates and bisphenols and childhood general and organ fat. A population-based prospective cohort study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The relationship between perinatal exposure to dioxins and serum steroid hormone levels in preschool-aged children at an e-waste region in China

Concentrations of organochlorine pesticides in placental tissue are not associated with risk for fetal orofacial clefts.

Prenatal environmental exposures and associations with teen births. [POPs, metals]

Perfluoroalkyl Substances

Association between exposure to perfluoroalkyl substances and metabolic syndrome and related outcomes among older residents living near a Science Park in Taiwan.

Pre- and post-diagnostic blood profiles of perfluoroalkyl acids in type 2 diabetes mellitus cases and controls.

Plasma perfluoroalkyls are associated with decreased levels of proteomic inflammatory markers in a cross-sectional study of an elderly population.

Flame Retardants

Maternal urinary concentrations of organophosphate ester metabolites: associations with gestational weight gain, early life anthropometry, and infant eating behaviors among mothers-infant pairs in Rhode Island.

Pesticides

Pesticide use and incident Parkinson’s disease in a cohort of farmers and their spouses.

Early-life carbamate exposure and intelligence quotient of seven-year-old children.

Oxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1, GSTT1 in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan.

Multi-biomarker responses to pesticides in an agricultural population from Central Brazil.

Potentially Toxic Elements

Association Between Circulating Plasmacytoid Dendritic Cell Percentage and Blood Lead Levels in Children.

Associations of a Metal Mixture Measured in Multiple Biomarkers with IQ: Evidence from Italian Adolescents Living near Ferroalloy Industry

Association between blood cadmium and vitamin D levels in the Yangtze Plain of China in the context of rapid urbanization.

Exposure to multiple metals and prevalence for preeclampsia in Taiyuan, China.

Associations of prenatal heavy metals exposure with placental characteristics and birth weight in Hangzhou Birth Cohort: Multi-pollutant models based on elastic net regression.

Integrative genomics and pathway analysis identified prevalent FA-BRCA pathway alterations in arsenic-associated urinary bladder carcinoma chronic arsenic accumulation in cancer tissues hampers the FA-BRCA pathway.

Co-exposure effects of arsenic and fluoride on intelligence and oxidative stress in school-aged children: a cohort study.

Air Pollution

Methodological Considerations for Epidemiological Studies of Air Pollution and the SARS and COVID-19 Coronavirus Outbreaks.

Ambiguous Associations of Air Pollution with Mortality in Massachusetts.

Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM₂ _.5 in air pollution-induced cardiopulmonary damage among adults.

Ambient air pollution and asthma onset in Taiwanese adults.

Effects of Low Exposure to Traffic Related Air Pollution on Childhood Asthma Onset by Age 10 Years.

Is PM₁ similar to PM_2.5? A new insight into the association of PM₁ and PM_2.5 with children’s lung function.

A Global Analysis of Associations between Fine Particle Air Pollution and Cardiovascular Risk Factors: Feasibility Study on Data Linkage.

Impact of Air Pollution on Cognitive Impairment in Older People: A Cohort Study in Rural and Suburban China.

A case-crossover study on the effect of short-term exposure to moderate levels of air pollution on the risk of heart failure.

The Gender-Based Differences in Vulnerability to Ambient Air Pollution and Cerebrovascular Disease Mortality: Evidences Based on 26781 Deaths.

Asymmetric link between environmental pollution and COVID-19 in the top ten affected states of US: A novel estimations from quantile-on-quantile approach.

Exposure to ambient air pollution and executive function among Chinese primary schoolchildren

Impact of air pollution exposure during various periods of pregnancy on term birth weight: a large-sample, retrospective population-based cohort study

Laboratory Studies

BPA/Phenols

Bisphenol S increases the obesogenic effects of a high-glucose diet through regulating lipid metabolism in Caenorhabditis elegans.

Evaluation of green tea extract and epigallocatechin gallate effects on bisphenol A-induced vascular toxicity in isolated rat aorta and cytotoxicity in human umbilical vein endothelial cells.

Quantitative proteomic analysis of mouse testis uncovers cellular pathways associated with bisphenol A (BPA)-induced male infertility.

Fetal Bisphenol-A Induced Changes in Murine Behavior and Brain Gene Expression Persist in Aged Offspring.

Phthalates

A moderate physiological dose of benzyl butyl phthalate exacerbates the high fat diet-induced diabesity in male mice.

Non-phthalate plasticizer DEHT preserves adequate blood component quality during storage in PVC blood bags.

Triclosan/Antimicrobials

Triclocarban affects earthworms during long-term exposure: Behavior, cytotoxicity, oxidative stress and genotoxicity assessments.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Ryanodine Receptor Type 2: A Molecular Target for Dichlorodiphenyltrichloroethane (DDT)- and Dichlorodiphenyldichloroethylene (DDE)-Mediated Cardiotoxicity.

Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on T Cell Differentiation in Primary Biliary Cholangitis.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice.

Perfluoroalkyl Substances

Lethal and sublethal toxicity of perfluorooctanoic acid (PFOA) in chronic tests with Hyalella azteca (amphipod) and early-life stage tests with Pimephales promelas (fathead minnow).

Flame Retardants

Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants.

Effects of tris(2-chloroethyl) phosphate exposure on chicken embryos in a shell-less incubation system.

Pesticides

Genome-wide analysis of DNA methylation in testis of male rat exposed to chlorpyrifos.

Evaluation of dimethoate toxicity on fertilization and on embryonic development of Paracentrotus lividus (Lamarck, 1816).

Comparative assessment of the acute toxicity, haematological and genotoxic effects of ten commonly used pesticides on the African Catfish, Clarias gariepinus Burchell 1822.

Neonicotinoid-containing insecticide disruption of growth, locomotion, and fertility in Caenorhabditis elegans.

Effect of different doses of 2,4-dichlorophenoxyacetic acid (2,4-D) on cardiac parameters in male Wistar rats.

Lethal and Teratogenic Impacts of Imazapyr, Diquat Dibromide, and Glufosinate Ammonium Herbicide Formulations Using Frog Embryo Teratogenesis Assay-Xenopus (FETAX).

Metabolomic profiles in brains of juvenile steelhead (Oncorhynchus mykiss) following bifenthrin treatment.

Cardiovascular Performance Measurement in Water Fleas by Utilizing High-Speed Videography and ImageJ Software and Its Application for Pesticide Toxicity Assessment.

Embryonic toxicity of 3,4-dichloroaniline (3,4-DCA) on Javanese medaka (Oryzias javanicus Bleeker, 1854).

Cypermethrin Impairs Hippocampal Neurogenesis and Cognitive Functions by Altering Neural Fate Decisions in the Rat Brain.

Gut microbiota influence on oral bioaccessibility and intestinal transport of pesticides in Chaenomeles speciosa.

Flupyradifurone reduces nectar consumption and foraging but does not alter honey bee recruitment dancing.

Potentially Toxic Elements

DNMT1-mediated Foxp3 gene promoter hypermethylation involved in immune dysfunction caused by arsenic in human lymphocytes.

Arsenic Accumulation of Realgar Altered by Disruption of Gut Microbiota in Mice.

Neuroprotective effect of Costus afer on low dose heavy metal mixture (lead, cadmium and mercury) induced neurotoxicity via antioxidant, anti-inflammatory activities.

Ginkgo biloba attenuated hepatotoxicity induced by combined exposure to cadmium and fluoride via modulating the redox imbalance, Bax/Bcl-2 and NF-kB signaling pathways in male rats.

In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta

Microplastics

Mild toxicity of polystyrene and polymethylmethacrylate microplastics in Paracentrotus lividus early life stages.

Air Pollution

Alteration of DNA methylation induced by PM_2.5 in human bronchial epithelial cells.

Maternal PM_2.5 exposure and abnormal placental nutrient transport.

Fine Particulate Matter (PM_2.5) upregulates expression of Inflammasome NLRP1 via ROS/NF-κB signaling in HaCaT Cells.

Pharmaceuticals/Personal Care Products

Developmental toxicity triggered by benzyl alcohol in the early stage of zebrafish embryos: Cardiovascular defects with inhibited liver formation and degenerated neurogenesis

Comparative transcriptomics implicate mitochondrial and neurodevelopmental impairments in larval zebrafish (Danio rerio) exposed to two selective serotonin reuptake inhibitors (SSRIs)

Mixtures

The Combined Algae Test for the Evaluation of Mixture Toxicity in Environmental Samples.

Prediction of the Joint Toxicity of Multiple Engineered Nanoparticles: The Integration of Classic Mixture Models and In Silico Methods.

Quantitative evaluation and the toxicity mechanism of synergism within three organophosphorus pesticide mixtures to Chlorella pyrenoidosa.

Miscellaneous

Epigenome-wide association study for transgenerational disease sperm epimutation biomarkers following ancestral exposure to jet fuel hydrocarbons.

Exposure/Environment Studies

BPA/Phenols/Phthalates/Parabens

Characteristics of exposure to multiple environmental chemicals among pregnant women in Wuhan, China. [metals, phthalates, parabens, phenols, etc.]

The internal exposure of phthalate metabolites and bisphenols in waste incineration plant workers and the associated health risks.

Biomonitoring and temporal trends of bisphenols exposure in Japanese school children.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Levels and profiles of persistent organic pollutants in breast milk in China and their potential health risks to breastfed infants: A review.

Common eider and herring gull as contaminant indicators of different ecological niches of an urban fjord system. [POPs and metals]

Perfluoroalkyl Substances

Temporal Trends in Prenatal Exposure (1998-2018) to Emerging and Legacy Per- and Polyfluoroalkyl Substances (PFASs) in Cord Plasma from Beijing Cord Blood Bank, China

Contrasting long term temporal trends in perfluoroalkyl substances (PFAS) in eggs of the northern gannet (Morus bassanus) from two UK colonies

Flame Retardants

Feces are Effective Biological Samples for Measuring Pesticides and Flame Retardants in Primates.

Legacy and novel flame retardants in water and sediment from highly industrialized bays of Korea: Occurrence, source tracking, decadal time trend, and ecological risks.

Pesticides

Improving risk assessment by predicting the survival of field gammarids exposed to dynamic pesticide mixtures.

Sub-lethal effects of permethrin exposure on a passerine: implications for managing ectoparasites in wild bird nests.

Results of 2-Year Ring-Testing of a Semi-Field Study Design to Investigate Potential Impacts of Plant Protection Products on the Solitary Bees Osmia Bicornis (Linnaeus, 1758) and Osmia Cornuta (Latreille, 1805) (Hymenoptera, Megachilidae) and a Proposal of a Suitable Test Design.

Decline in Distribution and Abundance: Urban Hedgehogs under Pressure.

Potentially Toxic Elements

Traces of heavy metals in children toenails as a bio-indicator of environmental exposure in Forlì (Northern Italy): an observational study.

Oral bioaccessibility of potentially toxic elements (PTEs) and related health risk in urban playground soil from a medieval bell metal industrial town Khagra, India.

Retrospective blood lead assessment from archived clotted erythrocyte fraction in a cohort of lead-exposed mother-child dyads.

Arsenic exposure from food exceeds that from drinking water in endemic area of Bihar, India.

Betaine and choline status modify the effects of folic acid and creatine supplementation on arsenic methylation in a randomized controlled trial of Bangladeshi adults

Microplastics

Evaluating the presence of microplastics in striped dolphins (Stenella coeruleoalba) stranded in the Western Mediterranean Sea.

Differences in microplastic abundances within demersal communities highlight the importance of an ecosystem-based approach to microplastic monitoring.

Air Pollution

Polycycl. Aromatic Hydrocarbon Exposure of Children in Typical Household Coal Combustion Environments: Seasonal Variations, Sources, and Carcinogenic Risks.

Impact of COVID -19 pandemic lockdown on distribution of inorganic pollutants in selected cities of Nigeria.

Impacts of nationwide lockdown due to COVID-19 outbreak on air quality in Bangladesh: a spatiotemporal analysis.

Impact of COVID-19 lockdown on NO₂, O₃, PM_2.5 and PM₁₀ concentrations and assessing air quality changes in Baghdad, Iraq.

Pharmaceuticals/Personal Care Products

Rainbow darter (Etheostoma caeruleum) from a river impacted by municipal wastewater effluents have altered gut content microbiomes

Identification of indicator PPCPs in landfill leachates and livestock wastewaters using multi-residue analysis of 70 PPCPs: Analytical method development and application in Yangtze River Delta, China

Occurrence and removal of chemicals of emerging concern in wastewater treatment plants and their impact on receiving water systems.

Miscellaneous

Body Representations of Internal Pollution: The Risk Perception of the Circulation of Environmental Contaminants in Pregnant and Breastfeeding Women in Spain

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.