EDC Science Weekly: July 29 – Aug 4, 2020

Post author:HEEDS
Post published:August 4, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

The new fertilizer regulation: A starting point for cadmium control in European arable soils?

Methods/Tools/Screening

Amended Safety Assessment of Parabens as Used in Cosmetics.

High resolution effect-directed analysis of steroid hormone (ant)agonists in surface and wastewater quality monitoring.

Assessing the receptor-mediated activity of PAHs using AhR-, ERα- and PPARγ- CALUX bioassays.

Application of a Framework for Grouping and Mixtures Toxicity Assessment of PFAS: A Closer Examination of Dose Additivity Approaches.

Commentaries

Population-Based Birth Cohort Studies in Epidemiology. [intro to a special issue]

Celebrating 50+ Years of Research on the Reproductive Biology and Endocrinology of the Green Frog: An Overview. [intro to special issue]

The toxic reach of mercury and its compounds in human and animal food webs [editorial]

Global warming, climate change, air pollution and allergies. [editorial]

Bisphenol Exposure and Type 2 Diabetes: New Evidence for a Potential Risk Factor [EHP Science Selection]

They Came from the Dust: Indoor Endocrine Disruptors and Thyroid-Hormone Binding [EHP Science Selection]

Move Over, Traffic: Aircraft Emissions and Preterm Birth [EHP Science Selection]

Reviews

Numerous EDCs

Role of non-coding-RNAs in response to environmental stressors and consequences on human health.

Stress, Sex, and Sugar: Glucocorticoids and Sex-Steroid Crosstalk in the Sex-Specific Misprogramming of Metabolism.

The use of epilithic biofilms as bioaccumulators of pesticides and pharmaceuticals in aquatic environments.

BPA/Phthalates

Role of Antioxidants in Alleviating Bisphenol A Toxicity.

Exposure to Phthalate Esters and the Risk of Endometriosis.

Pesticides

Impact of pesticide exposure on adipose tissue development and function.

Parkinson’s disease and pesticides: Are microRNAs the missing link?

Challenges for Adoption of Integrated Pest Management (IPM): the Soybean Example.

Glyphosate-based herbicide formulations and reproductive toxicity in animals.

Potentially Toxic Elements

Implications for prenatal cadmium exposure and adverse health outcomes in adulthood.

Microplastics

Bio-Polyethylene (Bio-PE), Bio-Polypropylene (Bio-PP) and Bio-Poly(ethylene terephthalate) (Bio-PET): Recent Developments in Bio-Based Polymers Analogous to Petroleum-Derived Ones for Packaging and Engineering Applications.

Source, occurrence, migration and potential environmental risk of microplastics in sewage sludge and during sludge amendment to soil.

Microplastic contamination of drinking water: A systematic review.

Air Pollution

Air pollution and molecular changes in age-related diseases.

The impact of particulate matter 2.5 on the risk of preeclampsia: an updated systematic review and meta-analysis.

Miscellaneous

Paternal epigenetics: Mammalian sperm provide much more than DNA at fertilization.

New Mechanisms of Vascular Dysfunction in Cardiometabolic Patients: Focus on Epigenetics.

Inflammatory Biomarkers and Breast Cancer Risk: A Systematic Review of the Evidence and Future Potential for Intervention Research.

Molecular mechanisms of protective roles of isoflavones against chemicals-induced liver injuries.

Human Health Studies

BPA/Phenols

Urinary bisphenol A concentrations and in vitro fertilization outcomes among women from a fertility clinic.

Exposure to bisphenols and asthma morbidity among low-income urban children with asthma.

Bisphenol A exposure and risk of ischemic heart disease in the Spanish European Prospective Investigation into cancer and nutrition study.

Phthalates

Associations of phthalate exposure and endogenous hormones with self-reported sleep disruptions: results from the Midlife Women’s Health Study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Glutathione S-transferase activity and genetic polymorphisms associated with exposure to organochloride pesticides in Todos Santos, BCS, Mexico: a preliminary study.

Perfluoroalkyl Substances

Prenatal Exposure to Perfluoroalkyl Substances Associated with Increased Susceptibility to Liver Injury in Children.

Potentially Toxic Elements

Urinary heavy metals, DNA methylation, and subclinical atherosclerosis.

Trimester-Specific Associations of Prenatal Lead Exposure With Infant Cord Blood DNA Methylation at Birth.

Natriuretic peptides and echocardiographic parameters in Mexican children environmentally exposed to arsenic.

Air Pollution

Impact of indoor air pollution in nursery and primary schools on childhood asthma.

Biomedical REAl-Time Health Evaluation (BREATHE): toward an mHealth informatics platform.

Influence of Environmental Tobacco Smoke and Air Pollution on Fetal Growth: A Prospective Study.

Cooking fuels use and carotid intima-media thickness during early pregnancy of women in Myanmar.

Characterizations of PM_2.5-bound organic compounds and associated potential cancer risks on cooking emissions from dominated types of commercial restaurants in northwestern China.

Associations of long-term exposure to ambient air pollution with cardiac conduction abnormalities in Chinese adults: The CHCN-BTH cohort study.

The Association Between PM_2.5 and Depression in China.

Long-term exposure to low levels of air pollution and mortality adjusting for road traffic noise: A Danish Nurse Cohort study.

Maternal preconception and first trimester exposure to PM₁₀ and the risk of oral clefts in offspring: a population-based, case-control study.

Associations between acute exposure to ambient air pollution and length of stay for inpatients with ischemic heart disease: a multi-city analysis in central China.

Gender Differences in Association between Air Pollution and Daily Mortality in the Capital of the Green Lungs of Poland-Population-Based Study with 2,953,000 Person-Years of Follow-Up.

Global estimation of mortality, disability-adjusted life years and welfare cost from exposure to ambient air pollution

Independent and joint contributions of economic, social and physical environmental characteristics to mortality in the Detroit Metropolitan Area: A study of cumulative effects and pathways.

Long-term exposure to a mixture of industrial SO₂, NO₂, and PM_2.5 and anti-citrullinated protein antibody positivity.

Ambient air pollution exposure associated with glucose homeostasis during pregnancy and gestational diabetes mellitus.

Associations between childhood and adolescence exposure to air pollution and adult height in polish women.

Exposure to ambient air pollutants and the onset of dementia in Québec, Canada.

Pharmaceuticals

Lupus nephritis in a transgender woman on cross-sex hormone therapy: a case for the role of oestrogen in systemic lupus erythematosus.

Laboratory Studies

Numerous Chemicals

Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells.

BPA/Phenols

Effects of nonylphenol induced oxidative stress on apoptosis and autophagy in rat ovarian granulosa cells.

Potential role of CFTR in bisphenol A-induced malignant transformation of prostate cells via mitochondrial apoptosis.

Phthalates

Combined effects of obesity and di-(2-ethylhexyl) phthalate on testosterone levels and kisspeptin/GPR54 expression in hypothalamus and testes of male mice.

Citrate ester substitutes for di-2-ethylhexyl phthalate: In vivo reproductive and in vitro cytotoxicity assessments.

Dibutyl phthalate promotes juvenile Sertoli cell proliferation by decreasing the levels of the E3 ubiquitin ligase Pellino 2.

Triclosan

Developmental abnormalities and epigenetic alterations in medaka (Oryzias latipes) embryos induced by triclosan exposure.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Metabolic and Hematological Responses to Endotoxin-Induced Inflammation in Chicks Experiencing Embryonic TCDD Exposure.

Perfluoroalkyl Substances

Examining the degradation of environmentally-daunting per- and poly-fluoroalkyl substances from a fundamental chemical perspective.

PFOS-induced placental cell growth inhibition is partially mediated by lncRNA H19 through interacting with miR-19a and miR-19b.

Risk Assessment of Per- and Polyfluoroalkyl Substances (PFASs) Mixtures: A Relative Potency Factor Approach.

Flame Retardants

Tetrabromobisphenol A, terabromobisphenol S and other bromophenolic flame retardants cause cytotoxic effects and induce oxidative stress in human peripheral blood mononuclear cells (in vitro study).

Pesticides

Impact of Glyphosate on the Honey Bee Gut Microbiota: Effects of Intensity, Duration, and Timing of Exposure.

The glyphosate formulation Roundup® LB plus influences the global metabolome of pig gut microbiota in vitro.

Embryonic atrazine exposure and later in life behavioral and brain transcriptomic, epigenetic, and pathological alterations in adult male zebrafish.

Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment.

Peripheral T3 signaling is target of pesticides in zebrafish larvae and adult liver.

Neuroprotective effects of melatonin against neurotoxicity induced by intranasal sodium dimethyldithiocarbamate administration in mice.

Oxidative stress, DNA damage and apoptosis induced by tebuconazole in kidney of male Wistar rats.

Life-long dietary pesticides cocktail induces astrogliosis along with behavioral adaptations and activates p450 metabolic pathways.

LncRNA NR_030777 Alleviates Paraquat-induced Neurotoxicity by Regulating Zfp326 and Cpne5.

Optimization of the spontaneous tail coiling test for fast assessment of neurotoxic effects in the zebrafish embryo using an automated workflow in KNIME®.

Effect of chlorination on anti-acetylcholinesterase activity of organophosphorus insecticide solutions and contributions of the parent insecticides and their oxons to the activity

Potentially Toxic Elements

Toxic effects of waterborne lead (Pb) on bioaccumulation, serum biochemistry, oxidative stress and heat shock protein-related genes expression in Channa argus.

Arsenite induces dysfunction of regulatory T cells through acetylation control of the Foxp3 promoter.

Effects of oral exposure to arsenite on arsenic metabolism and transport in rat kidney.

Changes in energy metabolism and macrophage polarization: Potential mechanisms of arsenic-induced lung injury.

Mercury (Hg²⁺) interferes with physiological adaptations to freezing in the arctic earthworm Enchytraeus albidus.

Exposed to Mercury-Induced Oxidative Stress, Changes of Intestinal Microflora, and Association between them in Mice.

Anti-inflammatory, anti-apoptotic, and antioxidant actions of Middle Eastern Phoenix dactylifera extract on mercury-induced hepatotoxicity in vivo.

Cadmium exposure activates NADPH oxidase, renin-angiotensin system and cyclooxygenase 2 pathways in arteries, inducing hypertension and vascular damage.

Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders in mice: Involvements of AMPK/SIRT1 pathway and amyloid-tau-neuroinflammation axis.

The Neuroprotective effect of curcumin against Cd-induced neurotoxicity and hippocampal neurogenesis promotion through CREB-BDNF signaling pathway.

Fluoride Exposure Affects Glutamine Uptake in Müller Glia Cells.

Microplastics

Adsorption mechanism of cadmium on microplastics and their desorption behavior in sediment and gut environments: The roles of water pH, lead ions, natural organic matter and phenanthrene.

Exposure to microplastics cause gut damage, locomotor dysfunction, epigenetic silencing, and aggravate cadmium (Cd) toxicity in Drosophila.

Toxicological effects induced on early life stages of zebrafish (Danio rerio) after an acute exposure to microplastics alone or co-exposed with copper.

Adsorption of acetamiprid, chlorantraniliprole and flubendiamide on different type of microplastics present in alluvial soil.

Nano-Sized Polystyrene at 1 mg/L Concentrations Does Not Show Strong Disturbance on the Freshwater Microbial Community.

The interactions between microplastic polyvinyl chloride and marine diatoms: Physiological, morphological, and growth effects.

Air Pollution

Age differences in the pulmonary and vascular pathophysiologic processes after long-term real-time exposure to particulate matter in rats

Chemical modification of pro-inflammatory proteins by peroxynitrite increases activation of TLR4 and NF-κB: Implications for the health effects of air pollution and oxidative stress.

Pharmaceuticals

Developmental programming: Prenatal testosterone excess disrupts pancreatic islet developmental trajectory in female sheep.

Mixtures

Predicting the activation of the androgen receptor by mixtures of ligands using Generalized Concentration Addition.

Maternal exposure to mixtures of dienestrol, linuron and flutamide Part II: Endocrine-related gene expression assessment on male offspring rat testes.

Assessing the combined toxicity effects of three neonicotinoid pesticide mixtures on human neuroblastoma SK-N-SH and lepidopteran Sf-9 cells.

Acute and chronic combined effect of polystyrene microplastics and dibutyl phthalate on the marine copepod Tigriopus japonicus.

Miscellaneous

In vitro and in vivo screening for environmentally friendly benzophenone-type UV filters with beneficial tyrosinase inhibition activity.

In Vitro to In Vivo Concordance of Toxicity Using the Human Proximal Tubule Cell Line HK-2.

Exposure/Environment Studies

BPA/Phenols/Phthalates

Dietary contribution to body burden of bisphenol A and bisphenol S among mother-children pairs

Impact of rainfall on the occurrence, spatiotemporal distribution, and partition trend of micropollutants in Taihu Lake, China: Bisphenol A and 4-nonylphenol as examples.

Association between dietary contribution of ultra-processed foods and urinary concentrations of phthalates and bisphenol in a nationally representative sample of the US population aged 6 years and older.

Distribution, partitioning behavior, and ecological risk assessment of phthalate esters in sediment particle-pore water systems from the main stream of the Haihe River, Northern China.

Personal Care Products

The associations between personal care products use and urinary concentrations of phthalates, parabens, and triclosan in various age groups: The Korean National Environmental Health Survey Cycle 3 2015-2017

A citizen science approach estimating titanium dioxide released from personal care products.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Concentrations of some legacy pollutants have increased in South Australian bottlenose dolphins from 1989 to 2014.

Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus).

A baseline for POPs contamination in Australian seabirds: little penguins vs. short-tailed shearwaters.

Foraging behavior, contaminant exposure risk, and the stress response in wild California condors (Gymnogyps californianus). [POPs and lead]

Perfluoroalkyl Substances

Resolving unknown isomers of emerging per- and polyfluoroalkyl substances (PFASs) in environmental samples using COSMO-RS-derived retention factor and mass fragmentation patterns.

Flame Retardants

Legacy and novel halogenated flame retardants in seawater and atmosphere of the Bohai Sea: Spatial trends, seasonal variations, and influencing factors.

Global emissions of Dechlorane Plus

Pet hair as a potential sentinel of human exposure: Investigating partitioning and exposures from OPEs and PAHs in indoor dust, air, and pet hair from China.

Organotins

Survey of imposex in Nucella lapillus as an indicator of tributyltin pollution in Northern Irish coastal waters, 2004 to 2017.

Pesticides

Ecosystem ecology: Models for acute toxicity of pesticides towards Daphnia magna.

Estimated dietary pesticide exposure from plant-based foods using NMF-derived profiles in a large sample of French adults.

Seasonal glyphosate and AMPA levels in urine of children and adolescents living in rural regions of Northeastern Slovenia.

Potentially Toxic Elements

Residential dust lead levels and the risk of childhood lead poisoning in United States children.

Demographic predictors of urinary arsenic in a low-income predominantly Hispanic pregnancy cohort in Los Angeles.

Arsenic burden in e-waste recycling workers – A cross-sectional study at the Agbogbloshie e-waste recycling site, Ghana.

Arsenic in leafy vegetable plants grown on mine water-contaminated soils: Uptake, human health risk and remedial effects of biochar.

A Study on Hair Mercury Levels of University Students.

Biological factors affecting total mercury and methylmercury levels in Antarctic penguins.

Mercury concentrations in store-bought shrimp.

The Availability and Accumulation of Heavy Metals in Greenhouse Soils Associated with Intensive Fertilizer Application

Heavy Metals and PAHs in Meat, Milk, and Seafood From Augusta Area (Southern Italy): Contamination Levels, Dietary Intake, and Human Exposure Assessment.

Chromium Pollution in European Water, Sources, Health Risk, and Remediation Strategies: An Overview.

Distribution and origin of potentially toxic elements in a multi-aquifer system.

Microplastics

Quantification of plankton-sized microplastics in a productive coastal Arctic marine ecosystem.

Rapid fragmentation of microplastics by the freshwater amphipod Gammarus duebeni (Lillj.).

Air Pollution

COVID-19 lockdowns cause global air pollution declines.

Air Quality during COVID-19 in Four Megacities: Lessons and Challenges for Public Health.

Nonuniform impacts of COVID-19 lockdown on air quality over the United States.

Air quality improvement in response to intensified control strategies in Beijing during 2013-2019

Disparities in PM_2.5 air pollution in the United States.

Toxic atmospheric pollutants from crematoria ovens: characterization, emission factors, and modeling.

How efficiently can HEPA purifiers remove priority fine and ultrafine particles from indoor air?

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on November 1, 2024 at 12:53 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on November 1, 2024 at 11:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.
Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.