RSS HEEDS New Science
  • New state law makes the case for class-based chemical regulation
    A recent paper published in Environmental Health Perspectives lays out the process behind Washington State’s new “Pollution Prevention” law, which aims to protect human health by regulating classes of hazardous chemicals. In short: The Pollution Prevention for Healthy People and Puget Sound Act was passed in 2019 and requires the assessment of chemical classes used […]
  • Agricultural plastic linked to build up of harmful chemicals in wheat
    The use of plastic films in farming has been linked to an accumulation of phthalates - an endocrine disrupting chemical with serious health effects - in both soil and wheat, according to a new study published in Science of the Total Environment. In short: Residue left behind by the breakdown of plastic films in fields […]
  • You’re inhaling flame retardants on your morning commute: Study
    The air inside our cars is full of harmful flame retardant chemicals — especially on hot days, according to a study published today in Environmental Science & Technology. Researchers found flame retardants in the cabin air of all 101 cars that they tested. All of the cars were from 2015 or newer and 99% contained […]
  • Chemists can now separate four common plastics at once. Will it work as well outside their lab?
    Less than 10% of the world’s plastic is recycled, while about 12% enters incinerators, burn pits, and other systems that release enormous amounts of carbon and toxics into the atmosphere. But the vast majority of the nearly 350 million metric tons of plastic produced every year returns to the Earth, averaging 500 years of slow […]
  • Current regulations miss threat of IQ loss from exposure to chemical mixtures
    Current methods for assessing hazardous chemicals fail to account for serious health threats - including IQ loss - posed by exposure to mixtures of different chemicals, according to a study published in the International Journal of Hygiene and Environmental Health. In short: The chemical mixture examined in this study consisted of chemicals toxic to the […]
  • PFAS exposure linked to higher cardiovascular mortality
    For the first time, researchers have demonstrated a clear link between PFAS exposure and an increased risk of cardiovascular-related deaths, a groundbreaking finding in environmental health studies.Tom Perkins reports for The Guardian.In short:A study in Veneto, Italy, has established a direct association between PFAS-contaminated drinking water and increased cardiovascular death rates.The study involved comparing health […]
  • Exposure to chemicals in plastics linked to cancer diagnoses: Study
    There’s an association between higher levels of phenols and per- and polyfluoroalkyl substances, commonly known as PFAS or “forever chemicals,” and previous diagnoses of different types of cancer, researchers from the University of South California found. The study, published in the Journal of Exposure Science and Environmental Epidemiology, looked at data from 10,000 people who […]
  • Estrogenic endocrine disruptor exposure linked to erectile dysfunction in mice
    In young adult male mice, lifelong exposure to an estrogenic endocrine disrupting chemical (EDC) caused changes to erectile tissue function that are indicative of erectile dysfunction, according to a study recently published in Communications Biology.In short:Exposure to the estrogenic drug DES caused erectile tissue dysfunction in the tissues of exposed mice.Directly exposing erectile tissues to […]
  • PlastChem: State-of-the-science of hazardous chemicals in plastic
    This new state-of-the science report from the PlastChem project addresses chemicals of concern in plastics and ways to address them.
  • American Heart Association: Children must be protected from health threats of environmental toxics
    The American Heart Association (AHA) recently published a scientific statement in Circulation highlighting evidence that children’s exposure to environmental pollutants may be a key risk factor for developing cardiovascular conditions throughout their lifespan. In short: There’s a well-established association between cardiovascular diseases and exposure to climate change, air pollution and endocrine disrupting chemicals. Early life […]

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Reviews and Commentaries on Endocrine Disrupting Chemicals (EDCs)

Articles

Chemicals Used in Plastic Materials: An Estimate of the Attributable Disease Burden and Costs in the United States.
Trasande L, Krithivasan R, Park K, Obsekov V, Belliveau M.  J Endocr Soc. 2024 Jan.

From Wingspread to CLARITY: a personal trajectory.
Soto AM, Schaeberle CM, Sonnenschein C. 
Nat Rev Endocrinol. 2021 Jan 29. 

Endocrine Disruptors: from Scientific Evidence to Human Health Protection
Demeneix B and Slama R.
Report for the European Parliament, 2019.

Scientific Principles for the Identification of Endocrine-Disrupting Chemicals: A Consensus Statement
Solecki R, Kortenkamp A, Bergman Å et al.
Arch Toxicol. 2017 Feb;91(2):1001-1006.

A Proposed Framework for the Systematic Review and Integrated Assessment (SYRINA) of Endocrine Disrupting Chemicals
Vandenberg LN, Ågerstrand M, Beronius A et al.
Environ Health. 2016 Jul 14;15(1):74. 

Minireview: Endocrine Disruptors: Past Lessons and Future Directions
Schug TT, Johnson AF, Birnbaum LS et al.
Mol Endocrinol. 2016 Aug;30(8):833-47. 

Peer-Reviewed and Unbiased Research, Rather than ‘Sound Science’, Should Be Used To Evaluate Endocrine-Disrupting Chemicals
Trasande L, Vandenberg LN, Bourguignon JP et al.
J Epidemiol Community Health. 2016 Nov;70(11):1051-1056.

Estimating Burden and Disease Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union
Trasande L, Zoeller RT, Hass U et al.
J Clin Endocrinol Metab. 2015 Apr;100(4):1245-55. 

Designing Endocrine Disruption Out of the Next Generation of Chemicals
Schug TT, Abagyan R, Blumberg B et al.
Green Chem. 2013 Jan;15(1):181-198.

Regulatory Decisions on Endocrine Disrupting Chemicals Should Be Based on the Principles of Endocrinology
Vandenberg LN, Colborn T, Hayes TB et al.
Reprod Toxicol. 2013 Jul;38:1-15. 

Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses
Vandenberg LN, Colborn T, Hayes TB et al.
Endocr Rev. 2012 Jun;33(3):378-455. 

Firm Human Evidence on Harms of Endocrine-Disrupting Chemicals Was Unlikely To Be Obtainable for Methodological Reasons
Lee DH, Jacobs D.
J Clin Epidemiol. 2019 Mar;107:107-115. 

Collections

Collection: Endocrine Disrupting Chemicals 2019, in The Endocrine Society Thematic Issue of Endocrine Society Journals.

Collection: Endocrine Disruption, in Nature Reviews Endocrinology, 2017.

Research Topic: Endocrine Disruptors and Metabolism, in Frontiers in Endocrinology, 2018-19.

Collection: Challenges in Environmental Health: Closing the Gap between Evidence and Environmental Regulations, in PLOS, 2017.

Publications by The Endocrine Disruption Exchange (TEDX)

Reports

Toxic Chemicals in Everyday Life
U.K. House of Commons Environmental Audit Committee
July 2019

The United Nations: Scientific Knowledge of Endocrine Disrupting Chemicals 
Three reports on EDCs, on identifying EDCs, the environmental effects of EDCs, and global regulatory frameworks.

Fracking Compendium, Sixth Edition
Physicians for Social Responsibility and Concerned Health Professionals of New York released the 6th edition of the Compendium in June 2019.

News

For news items on EDCs, see Environmental Health News

Scientific Society Statements on EDCs and Health

EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals
Gore AC, Chappell VA, Fenton SE et al.
Endocrine Reviews 2015 Dec;36(6):E1-E150. 
Also see:
EDC-2 Executive Summary
The first Endocrine Society Scientific Statement on EDCs (2009)

The International Federation of Gynecology and Obstetrics Opinion on Reproductive Health Impacts of Exposure to Toxic Environmental Chemicals  
Di Renzo GC, Conry JA, Blake J et al.
Int J Gynaecol Obstet. 2015 Dec;131(3):219-25. 

The American College of Obstetricians and Gynecologists: Committee Opinion on Exposure to Toxic Environmental Agents
2013; Reaffirmed 2018

Resources for Clinicians and Health Professionals

There Are Good Clinical, Scientific, and Social Reasons to Strengthen Links Between Biomedical and Environmental Research
Porta M and Vandenberg LN.
J Clin Epidemiol. 2019 Mar 21.

New Approaches to Cope with Possible Harms of Low-Dose Environmental Chemicals
Lee DH and Jacobs DR.
J Epidemiol Community Health. 2019 Mar;73(3):193-197.

Interventions to Address Environmental Metabolism-Disrupting Chemicals: Changing the Narrative to Empower Action to Restore Metabolic Health
Sargis RM, Heindel JJ, Padmanabhan V.
Front Endocrinol (Lausanne). 2019 Feb 4;10:33. 

Evidence of the Possible Harm of Endocrine-Disrupting Chemicals in Humans: Ongoing Debates and Key Issues
Lee DH
Endocrinol Metab (Seoul). 2018 Mar;33(1):44-52. 

The Role of Nutrition in Influencing Mechanisms Involved in Environmentally Mediated Diseases
Hennig B, Petriello MC, Gamble MV et al.
Rev Environ Health. 2018 Mar 28;33(1):87-97.

Developing a Clinical Approach to Air Pollution and Cardiovascular Health
Hadley MB, Baumgartner J, Vedanthan R.
Circulation. 2018 Feb 13;137(7):725-742. 

Disparities in Environmental Exposures to Endocrine-Disrupting Chemicals and Diabetes Risk in Vulnerable Populations [includes a Healthcare Provider Guide on EDCs for clinicians]
Ruiz D, Becerra M, Jagai JS et al.
Diabetes Care. 2018 Jan;41(1):193-205.