EDC Science Weekly: May 6 – 12, 2020 – HEEDS

EDC Science Weekly: May 6 – 12, 2020

Post author:HEEDS
Post published:May 12, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies.

Methods/Screening

Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology.

Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals-The FREIA Project.

Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries.

Applying knowledge-driven mechanistic inference to toxicogenomics.

A Mechanistic High-Content Analysis Assay Using a Chimeric Androgen Receptor That Rapidly Characterizes Androgenic Chemicals.

Reviews

Commentaries

The rapid development of computational toxicology. [editorial in Arch Toxicol]

Editorial: Special Issue on Fish, Mercury and Health. [editorial in Neurotoxicology]

Air pollution, racial disparities and COVID-19 mortality. [editorial in J Allergy Clin Immunol.]

Environmental toxicology and ecotoxicology: How clean is clean? Rethinking dose-response analysis.

Phthalates

Phthalate exposure and allergic diseases: Review of epidemiological and experimental evidence.

Grouping of phthalates for risk characterization of human exposures.

Perfluoroalkyl Substances

Early Life Exposure to Perfluoroalkyl Substances (PFAS) and ADHD: A Meta-Analysis of Nine European Population-Based Studies.

Pesticides

The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF.

Association between pesticide exposure and paraoxonase-1 (PON1) polymorphisms, and neurobehavioural outcomes in children: a systematic review.

Adverse effects of pesticides on the functions of immune system.

Pesticides-induced energy metabolic disorders.

An Overview on the Effect of Neonicotinoid Insecticides on Mammalian Cholinergic Functions through the Activation of Neuronal Nicotinic Acetylcholine Receptors.

Potentially Toxic Elements

Potentially toxic elements in toys and children’s jewelry: A critical review of recent advances in legislation and in scientific research.

Arsenic Exposure and Risk of Urothelial Cancer: Systematic Review and Meta-Analysis.

Arsenic intoxication: general aspects and chelating agents.

The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review.

Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses.

Microplastics

A methodological approach of the current literature on microplastic contamination in terrestrial environments: Current knowledge and baseline considerations.

Global distribution of microplastics and its impact on marine environment-a review.

Air Pollution

Exposure to air pollution and cognitive impairment risk: a meta-analysis of longitudinal cohort studies with dose-response analysis.

Environmental determinants of cardiovascular disease: lessons learned from air pollution.

Mixtures

Critical evaluation of human health risks due to hydraulic fracturing in natural gas and petroleum production.

Health risks for the population living near petrochemical industrial complexes. 2. Adverse health outcomes other than cancer.

Miscellaneous

The Impact of Environmental Chemicals on the Gut Microbiome. [numerous chemicals]

Zebrafish as an integrative vertebrate model to identify miRNA mechanisms regulating toxicity.

A Review on the 40th Anniversary of the First Regulation of Drinking Water Disinfection By-products.

Environmental Epigenetics and Genome Flexibility: Focus on 5-Hydroxymethylcytosine.

Human Health Studies

BPA/Phenols

Can environmental pollutant bisphenol A increase metabolic risk in polycystic ovary syndrome?

Phthalates

Prenatal exposure to phthalates and male reproductive system development: results from a Canadian pregnancy cohort study.

Characterization of phthalate exposure in relation to serum thyroid and growth hormones, and estimated daily intake levels in children exposed to phthalate-tainted products: A longitudinal cohort study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The association between dioxins and steroid hormones in general adult males: a cross-sectional study in an e-waste region of China.

Perfluoroalkyl Substances

The Relationship between Perfluoroalkyl Substances Concentrations and Thyroid Function in Early Childhood: A Prospective Cohort Study.

Perfluoroalkyl and polyfluroalkyl substances and maternal thyroid hormones in early pregnancy.

Flame Retardants

Polybrominated diphenyl ethers and decabromodiphenyl ethane in paired hair/serum and nail/serum from corresponding chemical manufacturing workers and their correlations to thyroid hormones, liver and kidney injury markers.

Pesticides

Integrated Approach to Evaluate the Association between Exposure to Pesticides and Idiopathic Premature Thelarche in Girls: The PEACH Project.

Genetic variants in xenobiotic detoxification enzymes, antioxidant defenses and hormonal pathways as biomarkers of susceptibility to prostate cancer.

Potentially Toxic Elements

A Comparison of Salivary Mercury Levels in Children with Attention Deficit/Hyperactivity Disorder When Compared to Age-matched Controls: A Case-control Observational Study.

Influence of metals from e-waste dismantling on telomerelength and mitochondrial DNA copy number in people living near recycling sites.

Air Pollution

Prenatal exposure to residential PM2.5 and anogenital distance in infants at birth: A birth cohort study from Shanghai, China.

Maternal PM2.5 exposure triggers preterm birth: a cross-sectional study in Wuhan, China.

Solid fuel use for heating and risks of breast and cervical cancer mortality in China.

Increased risk of gestational diabetes mellitus in women with higher prepregnancy ambient PM2.5 exposure.

Genome-wide DNA methylation analysis reveals significant impact of long-term ambient air pollution exposure on biological functions related to mitochondria and immune response.

Short-term associations between ambient air pollution and acute atrial fibrillation episodes.

Long-term effects of high exposure to ambient fine particulate matter on coronary heart disease incidence: A population-based Chinese cohort study.

Ambient Air Pollution Exposure Association with Anaemia Prevalence and Haemoglobin Levels in Chinese Older Adults.

Association of particulate matter air pollution with leukocyte mitochondrial DNA copy number.

Role of the chronic air pollution levels in the Covid-19 outbreak risk in Italy.

Effect of ambient air pollutants and meteorological variables on COVID-19 incidence.

Preexisting coronary heart disease and susceptibility to long-term effects of traffic-related air pollution: A matched cohort analysis.

Miscellaneous

Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile.

Laboratory Studies

BPA/Phenols

Bisphenol a Exposure in Utero Disrupts Hypothalamic Gene Expression Particularly Genes Suspected in Autism Spectrum Disorders and Neuron and Hormone Signaling.

Melatonin Ameliorates BPA Induced Oxidative Stress in Human Red Blood Cells In vitro.

p-Nonylphenol Impairment of O steogenic Differentiation of Mesenchymal Stem Cells was found to be due to Oxidative Stress and Down Regulation of RUNX2 and BMP.

Comparative transcriptome analysis of the protective effects of Korean Red Ginseng against the influence of bisphenol A in the liver and uterus of ovariectomized mice.

In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness.

Impairment of learning and memory induced by perinatal exposure to BPA is associated with ERα-mediated alterations of synaptic plasticity and PKC/ERK/CREB signaling pathway in offspring rats.

Bisphenolic compounds alter gene expression in MCF-7 cells through interaction with estrogen receptor α.

Effects of Prenatal Exposure to a Low-Dose of Bisphenol A on Sex Differences in Emotional Behavior and Central Alpha2-Adrenergic Receptor Binding.

Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood.

Bisphenol-A induced antioxidants imbalance and cytokines alteration leading to immune suppression during larval development of Labeo rohita.

Phthalates

In utero exposure to DBP stimulates release of GnRH by increasing the secretion of PGE2 in the astrocytes of the hypothalamus in the offspring mice.

Effects of in utero exposure to diisodecyl phthalate on fetal testicular cells in rats.

Parabens/Triclosan/Antimicrobials

Toxicity of the cosmetic preservatives parabens, phenoxyethanol and chlorphenesin on human meibomian gland epithelial cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats.

Perfluoroalkyl Substances

Unexpected observations: Probiotic administration greatly aggravates the reproductive toxicity of perfluorobutanesulfonate in zebrafish.

Flame Retardants

Intergenerational transfer of Dechlorane Plus and the associated long-term effects on the structure and function of gut microbiota in offspring.

A comparison of the toxicity effects of tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) with tributyl phosphate (TNBP) reveals the mechanism of the apoptosis pathway in Asian freshwater clams (Corbicula fluminea).

Pesticides

Molecular and biochemical responses of vitellogenin in the mussel Mytilus galloprovincialis exposed to the glyphosate-based herbicide Roundup® Power 2.0.

Glyphosate exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after repeated administration of MPTP.

Acute toxicity dataset for QSAR modeling and predicting missing data of six pesticides.

The impact of menthol essential oil against inflammation, immunosuppression, and histopathological alterations induced by chlorpyrifos in Nile tilapia.

Conventional and nano-copper pesticides are equally toxic to the estuarine amphipod Leptocheirus plumulosus.

Chronic Systemic Exposure to Low-Dose Rotenone Induced Central and Peripheral Neuropathology and Motor Deficits in Mice: Reproducible Animal Model of Parkinson’s Disease.

Effects of abamectin-based and difenoconazole-based formulations and their mixtures in Daphnia magna: a multiple endpoint approach.

Exposure to pyrimethanil induces developmental toxicity and cardiotoxicity in zebrafish.

Sublethal and transgenerational effects of acetamiprid and imidacloprid on the predatory bug Orius sauteri (Poppius) (Hemiptera: Anthocoridae).

First evidence of transcriptional modulation by chlorothalonil in mussels Perna perna.

Impact of imidacloprid on the nutritional quality of adult black tiger shrimp (Penaeus monodon).

Effects of Deltamethrin Acute Exposure on Nav1.6 channels and Medium Spiny Neurons of the Nucleus Accumbens.

Postnatal exposure to low doses of Chlorpyrifos induces long-term effects on 5C-SRTT learning and performance, cholinergic and GABAergic systems and BDNF expression.

Repeated exposure of pyriproxyfen to pregnant female mice causes developmental abnormalities in prenatal pups.

Microplastics

Assessment of transcriptomic and apical responses of Daphnia magna exposed to a polyethylene microplastic in a 21-day chronic study.

Effects of exposure to waterborne polystyrene microspheres on lipid metabolism in the hepatopancreas of juvenile redclaw crayfish, Cherax quadricarinatus.

Air Pollution

Critical biomarkers for myocardial damage by fine particulate matter: Focused on PPARα-regulated energy metabolism.

Particulate Matter Decreases Intestinal Barrier-Associated Proteins Levels in 3D Human Intestinal Model.

In ovo very early-in-life exposure to diesel exhaust induced cardiopulmonary toxicity in a hatchling chick model.

Mixtures

Gut microbiota perturbations and neurodevelopmental impacts in offspring rats concurrently exposure to inorganic arsenic and fluoride.

Mixture toxicity of chlorpyrifos-methyl, pirimiphos-methyl, and nonylphenol in Atlantic salmon (Salmo salar) hepatocytes.

Individual and combined toxicogenetic effects of microplastics and heavy metals (Cd, Pb, and Zn) perturb gut microbiota homeostasis and gonadal development in marine medaka (Oryzias melastigma).

Miscellaneous

Rethinking toxicity testing: Influence of aging on the outcome of long-term toxicity testing and possible remediation.

Nuclear factor of activated T cells as a marker of in vivo low-dose dibenzo[a,h]anthracene exposure.

Assessment of zebrafish embryo photomotor response sensitivity and phase-specific patterns following acute- and long-duration exposure to neurotoxic chemicals and chemical weapon precursors. [includes pesticides and more]

Exposure/Environment Studies

BPA/Phenols

Biomonitoring of co-exposure to bisphenols by consumers of canned foodstuffs.

Phthalates

Phthalate metabolites concentrations in amniotic fluid and maternal urine: Cumulative exposure and risk assessment.

Plasticizer exposure of infants during cardiac surgery.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Concentrations, Sources, and Potential Human Health Risks of PCDD/Fs, dl-PCBs, and PAHs in Rural Atmosphere Around Chemical Plants in Jiangsu Province, China.

Perfluoroalkyl Substances

Novel and legacy per- and polyfluoroalkyl substances in bald eagle eggs from the Great Lakes region.

Multicompartment occurrence and partitioning of alternative and legacy per- and polyfluoroalkyl substances in an impacted river in China.

Investigation of levels of perfluoroalkyl substances in surface water, sediment and fish tissue in New Jersey, USA.

Flame Retardants

Flame retardants, dioxins, and furans in air and on firefighters’ protective ensembles during controlled residential firefighting.

Pesticides

Assessment of children’s exposure to currently used pesticides in Wallonia, Belgium.

APIStrip, a new tool for environmental contaminant sampling through honeybee colonies.

The impact of anti-sea lice pesticides, azamethiphos and deltamethrin, on European lobster (Homarus gammarus) larvae in the Norwegian marine environment.

Urinary Metabolites of Neonicotinoid Insecticides: Levels and Recommendations for Future Biomonitoring Studies in China.

Potentially Toxic Elements

Concentration, Spatial Distribution, Contamination Degree and Human Health Risk Assessment of Heavy Metals in Urban Soils across China between 2003 and 2019-A Systematic Review.

Carcinogenic and non-carcinogenic health risk of arsenic ingestion via drinking water in Langat River Basin, Malaysia.

Arsenic contamination of Bangladesh aquifers exacerbated by clay layers.

Mercury interactions with algal and plastic microparticles: Comparative role as vectors of metals for the mussel, Mytilus galloprovincialis.

Are soft tissues of urban rats good indicators of exposure to heavy metal pollution? A study conducted in one of the most polluted basins of Buenos Aires, Argentina.

Effects of seafood consumption on mercury exposure in Norwegian pregnant women: A randomized controlled trial.

Microplastics

A methodological approach of the current literature on microplastic contamination in terrestrial environments: Current knowledge and baseline considerations.

Between source and sea: The role of wastewater treatment in reducing marine microplastics.

Microplastic Fallout in Different Indoor Environments.

Assessment of microplastics release from polyester fabrics: The impact of different washing conditions.

Microplastic accumulation in the gastrointestinal tracts in birds of prey in central Florida, USA.

Microplastic abundance, distribution and composition in the mid-west Pacific Ocean.

Assessing the sorption of pharmaceuticals to microplastics through in-situ experiments in New York City waterways.

Pump-underway ship intake: An unexploited opportunity for Marine Strategy Framework Directive (MSFD) microplastic monitoring needs on coastal and oceanic waters.

Air Pollution

Seasonal variation of endocrine disrupting potentials of pollutant mixtures associated with various size-fractions of inhalable air particulate matter.

Effect of lockdown amid COVID-19 pandemic on air quality of the megacity Delhi, India.

COVID-19 pandemic: Impacts on the air quality during the partial lockdown in São Paulo state, Brazil.

Indoor particulate matter during HOMEChem: Concentrations, size distributions, and exposures.

Pharmaceuticals

Spatial and temporal variations of antibiotics in a tidal river.

Mixtures

Chemical characterization in hydraulic fracturing flowback and produced water (HF-FPW) of shale gas in Sichuan of China.

Shale gas development in China: Implications for indoor and outdoor air quality and greenhouse gas emissions.

Miscellaneous

Performance Comparison of Different Constructed Wetlands Designs for the Removal of Personal Care Products.

Environmental and biological monitoring in the workplace: A 10-year South African retrospective analysis.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.