EDC Science Weekly, Mar. 25 – 31, 2020 – HEEDS

EDC Science Weekly, Mar. 25 – 31, 2020

Post author:HEEDS
Post published:March 31, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Stay safe everyone!

Contents: Regulations/Policy, Methods/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies.

Regulations/Policy

(Q)SAR tools for the prediction of mutagenic properties – Are they ready for application in pesticide regulation?

Methods/Screening

Synergy between Experiments and Computations: A Green Channel for Revealing Metabolic Mechanism of Xenobiotics in Chemical Toxicology.

Towards a spatiotemporally explicit toxicokinetic-toxicodynamic model for earthworm toxicity.

Reviews

BPA/Phenols

Cardiovascular toxicity and mechanism of bisphenol A and emerging risk of bisphenol S.

Flame Retardants

Effects of Brominated and Organophosphate Ester Flame Retardants on Male Reproduction.

Pesticides

Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s Disease.

Potentially Toxic Elements

Cell organelles as targets of mammalian cadmium toxicity.

The mercury science-policy interface: History, evolution and progress of the Minamata Convention.

Toxic Metal Implications on Agricultural Soils, Plants, Animals, Aquatic life and Human Health.

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches.

New mercury compound spotted in mass poisoning. [news item]

Air Pollution

New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing.

Air Pollution and Health: The Need for a Medical Reading of Environmental Monitoring Data.

A Systematic Review and Meta-Analysis of Short-Term Ambient Ozone Exposure and COPD Hospitalizations.

Pharmaceuticals

Effects of oral contraceptives on thyroid function and vice versa.

Occurrence of caffeine in the freshwater environment: Implications for ecopharmacovigilance.

Miscellaneous

Environmental Factors as Modulators of the Relationship between Obstructive Sleep Apnea and Lesions in the Circulatory System.

The dog as a sentinel species for environmental effects on human fertility.

Signaling pathways of oxidative stress in aquatic organisms exposed to xenobiotics.

Human Health Studies

BPA/Phenols

Associations of maternal phthalate and bisphenol urine concentrations during pregnancy with childhood blood pressure in a population-based prospective cohort study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs, PAHs

Visual contrast sensitivity in school-age Guadeloupean children exposed to chlordecone.

Association of prenatal exposure to PAHs with anti-Müllerian hormone (AMH) levels and birth outcomes of newborns.

Perfluoroalkyl Substances

Transplacental Transfer of Per- and Polyfluoroalkyl Substances (PFASs): Differences between Preterm and Full-term Delivery and Associations with Placental Transporter mRNA Expression.

Maternal serum perfluoroalkyl substance mixtures and thyroid hormone concentrations in maternal and cord sera: The HOME Study.

Perfluoroalkyl substances in early pregnancy and risk of hypertensive disorders of pregnancy: A prospective cohort study.

Potentially Toxic Elements

Analysis of lead, arsenic and calcium content in the hair of children with autism spectrum disorder.

Blood BTEXS and heavy metal levels are associated with liver injury and systemic inflammation in Gulf states residents.

Heavy metals interfere with plasma metabolites, including lipids and amino acids, in patients with breast cancer.

Metal Levels, Genetic Instability, and Renal Markers in Electronic Waste Workers in Thailand.

Association between Blood Heavy Metal Levels and Predicted 10-Year Risk for A First Atherosclerosis Cardiovascular Disease in the General Korean Population.

Inorganic arsenic methylation capacity and breast cancer by immunohistochemical subtypes in northern Mexican women.

Air Pollution

Diabetes mortality burden attributable to short-term effect of PM10 in China.

The association between particulate matter 2.5 and hospitalization and mortality rates of heart failure: The CAPACITY study.

Interaction between residential greenness and air pollution mortality: analysis of the Chinese Longitudinal Healthy Longevity Survey.

Impact of air pollution on breast cancer incidence and mortality: a nationwide analysis in South Korea.

Ambient air pollution and the risk of pediatric-onset inflammatory bowel disease: A population-based cohort study.

Association of exposure to air pollution and telomere length in preschool children.

Association Between Outdoor Air Pollution and Risk of Malignant and Benign Brain Tumors: The Multiethnic Cohort Study.

Association between exposure to air pollution and prefrontal cortical volume in adults: A cross-sectional study from the UK biobank.

Temperature modulation of the adverse consequences on human mortality due to exposure to fine particulates: A study of multiple cities in China.

Pharmaceuticals

Effects of Oral Contraceptive Androgenicity on Visuospatial and Social-Emotional Cognition: A Prospective Observational Trial.

Miscellaneous

The NYU Children’s Health and Environment Study.

People Are Taller in Countries With Better Environmental Conditions.

Laboratory Studies

BPA/Phenols

Bisphenol A analogues (BPS and BPF) present a greater obesogenic capacity in 3T3-L1 cell line.

Comprehensive in vitro metabolism study of bisphenol A using liquid chromatography-high resolution tandem mass spectrometry.

Parental exposure to bisphenol A affects pharyngeal cartilage development and causes global transcriptomic changes in zebrafish (Danio rerio) offspring.

Maternal administration of bisphenol A alters the microglial profile in the neocortex of mouse weanlings.

Bisphenol-A exposure during gestation and lactation causes visual perception deficits in rat pups following a decrease in IL-1β expression in the primary visual cortex.

Phthalates

The synergistic or adjuvant effect of DINP combined with OVA as a possible mechanism to promote an immune response.

Opposite effects of high- and low-dose di-(2-ethylhexyl) phthalate (DEHP) exposure on puberty onset, oestrous cycle regularity and hypothalamic kisspeptin expression in female rats.

Parabens/Triclosan/Antimicrobials

Triclocarban-induced responses of endogenous and xenobiotic metabolism in human hepatic cells: Toxicity assessment based on nontargeted metabolomics approach.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Thymoquinone protection against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induced nephrotoxicity in rats.

In utero and lactational 2,3,7,8-tetrachlorodibenzo-p–dioxin (TCDD) exposure exacerbates urinary dysfunction in hormone-treated C57BL/6J mice through a non-malignant mechanism involving proteomic changes in the prostate that differ from those elicited by testosterone and estradiol.

Biphasic Dose-Response Induced by PCB150 and PCB180 in HeLa Cells and Potential Molecular Mechanisms.

Molecular characterization and expression of arginine vasotocin V1a2 receptor in Atlantic croaker brain: Potential mechanisms of its downregulation by PCB77.

Titanium dioxide nanoparticles enhanced thyroid endocrine disruption of pentachlorophenol rather than neurobehavioral defects in zebrafish larvae.

Environmental pollutants modulate transcriptional activity of nuclear receptors of whales in vitro.

Perfluoroalkyl Substances

Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) acutely affect human α1β2γ2L GABAA receptor and spontaneous neuronal network function in vitro.

Per- and polyfluoroalkyl substances (PFAS) differentially inhibit placental trophoblast migration and invasion in vitro.

Effect of GenX on P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance-Associated Protein 2 at the Blood-Brain Barrier.

Flame Retardants

In Utero and Lactational Exposure to Flame Retardants Disrupts Rat Ovarian Follicular Development and Advances Puberty.

Tissue-specific bioaccumulation, metabolism and excretion of tris (2-ethylhexyl) phosphate (TEHP) in rare minnow (Gobiocyprisrarus).

Toxic effect and mechanism of tris (1,3-dichloro-2-propyl)phosphate (TDCPP) on the marine alga Phaeodactylum tricornutum.

The toxicity, bioaccumulation and debromination of BDE-47 and BDE-209 in Chlorella sp. under multiple exposure modes.

Organotins

Disruption of fertility, placenta, pregnancy outcome, and multigenerational inheritance of hepatic steatosis by organotin exposure from contaminated seafood in rats.

Pesticides

Effect of chronic exposure to monocrotophos on white adipose tissue in rats and its association with metabolic dyshomeostasis.

Exposure of the African mound building termite, Macrotermes bellicosus workers to commercially formulated 2,4-D and atrazine caused high mortality and impaired locomotor response.

Glyphosate induces lymphocyte cell dysfunction and apoptosis via regulation of miR-203 targeting of PIK3R1 in common carp (Cyprinus carpio L.).

Inhibitory Effects of Cypermethrin on Interactions of the Androgen Receptor with Coactivators ARA70 and ARA55.

Molecular interactions of vinclozolin metabolites with human estrogen receptors 1GWR-α and 1QKM and androgen receptor 2AM9-β: Implication for endocrine disruption.

Red Beetroot Extract Abrogates Chlorpyrifos-Induced Cortical Damage in Rats.

Effects of several organophosphates on hepatic cytochrome P450 activities in rats.

Potentially Toxic Elements

Comparative metal accumulation and toxicogenetic damage induction in three neotropical fish species with distinct foraging habits and feeding preferences.

Alleviating effects of reduced graphene oxide against lead-induced cytotoxicity and oxidative stress in human alveolar epithelial (A549) cells.

Lead (Pb) as a Factor Initiating and Potentiating Inflammation in Human THP-1 Macrophages.

The effects of chronic cadmium exposure on the gut of Bufo gargarizans larvae at metamorphic climax: Histopathological impairments, microbiota changes and intestinal remodeling disruption.

Microplastics

Photodegradation Elevated the Toxicity of Polystyrene Microplastics to Grouper (<i>Epinephelus moara</i>) through Disrupting Hepatic Lipid Homeostasis.

Air Pollution

Airborne environmental fine particles induce intense inflammatory response regardless of the absence of heavy metal elements.

Pharmaceuticals

Norethindrone alters mating behaviors, ovary histology, hormone production and transcriptional expression of steroidogenic genes in zebrafish (Danio rerio).

Mixtures

Defining embryonic developmental effects of chemical mixtures using the embryonic stem cell test.

Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat. [phthalates, pesticides, UV-filters, BPA, butyl-paraben, and paracetamol in mixture and mixtures by subgroup]

Exposure/Environment Studies

BPA/Phenols

Human in vitro percutaneous absorption of bisphenol S and bisphenol A: A comparative study.

Bisphenol A, octylphenols and nonylphenols in fish muscle determined by LC/ESI-MS/MS after affinity chromatography clean up.

Phthalates

Occupational Exposure of Plastics Workers to Diisononyl Phthalate (DiNP) and Di(2-propylheptyl) Phthalate (DPHP) in Finland.

Intakes of phthalates by Japanese children and the contribution of indoor air quality in their residences.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Health risk assessment to dioxins, furans and PCBs in young children: The first French evaluation.

Perfluoroalkyl Substances

High throughput analysis of 21 perfluorinated compounds in drinking water, tap water, river water and plant effluent from southern China by supramolecular solvents-based microextraction coupled with HPLC-Orbitrap HRMS.

Flame Retardants

Estimating polybrominated diphenyl ether (PBDE) exposure through seafood consumption in Switzerland using international food trade data.

Assessment of organophosphate flame retardants in Mediterranean Boops boops and their relationship to anthropization levels and microplastic ingestion.

Pesticides

Identification of a pesticide exposure based market basket suitable for cumulative dietary risk assessments and food monitoring programmes.

A nationwide study of the occurrence and distribution of atrazine and its degradates in tap water and groundwater in China: Assessment of human exposure potential.

Assessment of human exposure to selected pesticides in Norway by wastewater analysis.

World of earthworms with pesticides and insecticides

Potentially Toxic Elements

Dietary contributions to increased background lead, mercury, and cadmium in 9-11 Year old children: Accounting for racial differences.

Mercury, lead, arsenic, and cadmium in Norwegian seafood products and consumer exposure.

Estimating inorganic arsenic exposure from rice intake in Chinese Urban Population.

Total mercury and methylmercury in Chinese rice and dietary exposure assessment.

Health Risk Assessment of Metals (Cu, Pb, Zn, Cr, Cd, As, Hg, Se) in Angling Fish with Different Lengths Collected from Liuzhou, China.

Environmental Pollution Effect Analysis of Lead Compounds in China Based on Life Cycle.

Insectivorous bats as biomonitor of metal exposure in the megalopolis of Mexico and rural environments in Central Mexico.

Cancer and Non-Cancer Risk Concerns from Metals in Electronic Cigarette Liquids and Aerosols.

Longitudinally monitored lifetime changes in blood heavy metal concentrations and their health effects in urban birds.

Genetic analysis in earthworm population from area contaminated with radionuclides and heavy metals.

Arsenic, chromium, and other elements of concern in fish from remote boreal lakes and rivers: Drivers of variation and implications for subsistence consumption.

Variation in genetic diversity of tree sparrow (Passer montanus) population in long-term environmental heavy metal polluted areas.

Microplastics/Litter

Estimating the size distribution of plastics ingested by animals.

Investigating the composition and distribution of microplastics surface biofilms in coral areas.

‘The Plastic Nile’: First Evidence of Microplastic Contamination in Fish from the Nile River (Cairo, Egypt).

Towards improved understanding of the ingestion and trophic transfer of microplastic particles – Critical review and implications for future research.

Spatial variability and influence of biological parameters on microplastic ingestion by Boops boops (L.) along the Italian coasts (Western Mediterranean Sea).

Investigating the distribution and regional occurrence of anthropogenic litter in English marine protected areas using 25 years of citizen-science beach clean data.

Air Pollution

Air quality intervention during the Nanjing youth olympic games altered PM sources, chemical composition, and toxicological responses.

Pharmaceuticals

Distribution and human health risk assessment of antibiotic residues in large-scale drinking water sources in Chongqing area of the Yangtze River.

Concentrations levels and effects of 17alpha-Ethinylestradiol in freshwater and marine waters and bivalves: A review.

Communication

How to Educate Pregnant Women about Endocrine Disruptors?

What’s in Your Body of Water? A Pilot Study Using Metaphoric Framing to Reduce the Psychological Distance in Pharmaceutical Pollution Risk Communication.

Exploring the impact of environmental regulations on happiness: new evidence from China.

Miscellaneous

Reconnaissance of Surface Water Estrogenicity and the Prevalence of Intersex in Smallmouth Bass (Micropterus Dolomieu) Inhabiting New Jersey.

Tracing the occurrence of organophosphate ester along the river flow path and textile wastewater treatment processes by using dissolved organic matters as an indicator.

Analysis of Cumulative Cancer Risk Associated with Disinfection Byproducts in United States Drinking Water.

A theorem on a product of lognormal variables and hybrid models for children’s exposure to soil contaminants.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.